Potential Cbd Oil Side Effects You Need To Know
With all of the research studies uncovering the incredible health benefits of cannabidiol oil, you may begin to question whether or not hemp derived CBD oil has any potentially harmful side effects.
As with any drug, pharmaceutical or holistic, cannabidiol has effects on your body. So today we are going to discuss what causes these side-effects and the steps you can take to combat them.
But before you automatically jump to the conclusion that CBD has harmful side-effects, Iâd like to say that the effects discussed below are rare and occur in only the most extreme cases.
Potential side effects that may be experienced with the use of CBD include:
- Dry Mouth
- Inhibition of Hepatic Drug Metabolism
- Increased Tremors in Parkinsonâs Disease Patients
As you can see, when the side-effects of cannabidiol are compared to those of pharmaceuticals they are extremely minor!
Letâs now look into the potential side effects of CBD in greater depth.
Dysgeusia Anorexia Dyspepsia Hiccups Nausea And Vomiting
In uremic patients, dysgeusia commonly manifests as a metallic or a foul taste in the mouth. In addition, anorexia, dyspepsia, hiccups, nausea, and vomiting are frequent components of the uremic syndrome. Persistent vomiting may bring about dehydration , electrolyte disturbances, and wasting.8 With regard to therapy for nausea and vomiting, apart from dialysis, symptomatic improvement can be obtained with phenothiazines or metoclopramide, given either parenterally or rectally.
In hemodialysis patients, maintaining a blood urea level above 50â¯mmol/L for periods of 7 to 90 days through the use of a urea-enriched dialysis solution can bring about vomiting.9 A rapid reduction of a very high blood urea level can lead to a constellation of manifestations known as the dialysis disequilibrium syndrome . Salient features of the syndrome include nausea and vomiting. DDS is believed to be the consequence of cerebral edema engendered by either the entry of water into brain cells during dialysis, secondary to the rapid decline in extracellular fluid osmolality, or by the induction of a dialysis-induced acidosis of the cerebrospinal fluid and of the brain.10
Peter W. Schofield, Richard L. Doty, in, 2019
Preventing Tooth Decay Due To Dry Mouth
Not only does saliva help digest food and make it possible for you to chew and swallow, it is the natural mouth cleanser. Without saliva, tooth decay and gum disease are more likely. If you have a dry mouth, to fight tooth decay and gum disease, you need to be extra careful about following good oral hygiene habits, which consist of:
- Brushing your teeth at least twice a day , after every meal and before bedtime
- Flossing your teeth every day
- Using a toothpaste that contains fluoride
- Visiting your dentist for a checkup and cleaning at least twice a year your dentist may recommend a daily fluoride rinse or fluoride gel to keep your teeth healthy.
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Types Of Bad Breath And Their Causes
50 million people suffer from chronic halitosis in the US, but many dont seek help because theyre embarrassed. Thats a shame because although bad breath is often caused by oral problems, other bad breath causes are associated with other health problems. And bad breath can be a sign of serious disease.
Studies suggest 5-10% of bad breath causes are due to disease outside the mouth. Thats 2-5 million people whose bodies are warning them of a serious problem.
Eating Swallowing And Saliva Management
Some people with Parkinsons may find they have difficulties with eating, swallowing and saliva control at some stage of their journey with Parkinsons.
Parkinsons can cause the muscles in the jaw and face to become stiff which affects the control of chewing and swallowing.
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What Are The Most Common Causes Of Dry Mouth
Dry mouth happens when something causes the salivary glands to produce less saliva. The most common causes of dry mouth are:
Hundreds of medications can reduce your bodyâs saliva production. If you check the information that comes with your medication, you may see âdry mouthâ listed as a side effect.
Some medicines known to cause dry mouth include:
Other causes include:
- Dehydration: Sometimes, your body lacks enough fluids. For example, if youâre sick, donât drink enough, or sweat a lot, you may get dehydrated.
- Mouth-breathing: You may breathe through your mouth at night, especially if you have a stuffy nose .
- Medical conditions: Dry mouth can be a sign of a more serious condition, such as diabetes, Alzheimerâs disease, stroke and Sjogrenâs syndrome. Sjogrenâs syndrome is an autoimmune disease that causes the body to attack the glands that produce moisture. It occurs mostly in women who have gone through menopause.
Eating And Swallowing Problems And Parkinsons
Research suggests that eating and swallowing difficulties affect about a 90% of all people with Parkinsons. The true figure may be even higher as some people do not report the problem to their health care team.
Swallowing is a motor function that includes three stages.
- The first stage is the oral phase: food is chewed and mixed with saliva to form a soft ball called bolus. The tongue then pushes the bolus to the back of the mouth, triggering the swallow reflex.
- The second stage is the pharyngeal phase: it is the involuntary closure of the larynx by the epiglottis and vocal cords, which temporarily inhibites breathing. These actions prevent food from going ‘down the wrong pipe’ into the trachea .
- The third stage is the esophageal phase: the bolus moves into the esophagus, the muscular tube that contracts to push the bolus into the stomach.
Unfortunately, many people with Parkinsons experience swallowing problems due to reduced control and muscle tone of the jaw, lips, tongue and throat muscles, especially in later stages of the condition. Eating and swallowing becomes slower and requires more effort.
People with Parkinsons are at particular risk of aspiration due to a delay in the triggering of their swallow reflex. This compromises the effectiveness of the airway protection while swallowing. This can lead to aspiration pneumonia due to a lack of coughing if food enters the windpipe, allowing food to reach the lungs unchecked.
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Calcarea Carb Due To Nasal Polyps And Frequent Cold
It is a well-indicated medicine for cases of loss of smell from nasal polyps. Along with polyps a tendency to have frequent colds is also present in persons needing this medicine. They may have alternate nasal dryness and blocked nose with yellow offensive mucus. They may also have ulceration or scabs in the nostrils.
Sjogrens Syndrome Can Be Misdiagnosed As Multiple Sclerosis Symptoms Are Similar
Sjogrenâs syndrome can actually cause symptoms similar to multiple sclerosis .
Sjogrenâs syndrome is an autoimmune disease that is commonly associated with dry mouth due to decreased salivary gland secretion, and dry eyes due to decreased lacrimal gland secretion.
However, SS can become systemic, affecting many areas of the body, including the nervous system.
As a result, symptoms similar to multiple sclerosis can result from Sjogrenâs syndrome.
âNeurological manifestations of Sjogrenâs syndrome are protean . Parkinsonâs-like is unusual, but MS-like is not uncommon,â explains Ali D. Askari, MD, Professor of Medicine â Case Western Reserve University Chief, Division of Rheumatology â University Hospitals Case Medical Center Director, Rheumatology â University Hospitals Case Medical Center. Because SS commonly affects the joints, specialists in this disorder are often rheumatologists.
âIn one study 20 percent of patients with what was called primary progressive multiple sclerosis turned out to have Sjogrenâs syndrome.â
MRI findings on the brain, says Dr. Askari, can be very similar between Sjogrenâs syndrome and multiple sclerosis.
âOther important neurologic manifestations seen in Sjogrenâs syndrome include Parkinsonâs-like or hemi-Parkinsonism with movement abnormalities including stiffness and tremors.
And this is because brain lesions are also seen with multiple sclerosis.
Objective Measures Of Flow/volume
Objective measurements of milliliters or milligrams secretion per minute typically center around gathering saliva at regular intervals over given time periods.68,69 Sampling methods include collecting saliva from cups placed over salivary ducts, expectoration into pots or tubes, weighing of gauze or cotton rolls held at given loci in the mouth, use of centrifuges to extract saliva from the gauze to quantify the volume of saliva absorbed or allowing saliva to dribble from the mouth with the head held forwards over receptacles.
As secretion is sensitive to a number of influences, gathering ideally occurs under controlled conditions. Posture is controlled the environment is quiet, with absence or minimization of visual, olfactory or gustatory stimuli known to prompt increased flow. Comparability of stimulated flow across patients and time demands use of standard stimulatory material and doses . To assure inter- and intra-individual comparability, evaluations ideally happen at the same time of day at the same point in the drug cycle in the same relationship to meal times . Onoff status and fluctuations need to be monitored as well as presence and severity of dyskinesias that may affect measurements.70
Side Effects Not Requiring Immediate Medical Attention
Some side effects of carbidopa / levodopa may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
- difficulty having a bowel movement
- ear congestion
- stomach discomfort, upset, or pain
- unusual dreams
- bad, unusual, or unpleasant taste
- hair loss or thinning of the hair
- lack or loss of strength
- redness of the face, neck, arms, and occasionally, upper chest
- seeing double
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Slow Muscles Carrying Food To Your Stomach
Parkinsons may also slow down the muscles carrying food down into your stomach. Food moving slowly down your food pipe to your stomach can make you feel full up. But once it arrives at your stomach you realise youre still hungry. By this time the food on your plate may have gone cold and be unappealing.
Management Of Saliva Flow
The British NICE guidelines for PD2 recommend referral to a speech-language clinician for assessment and treatment of drooling, though overall management is multidisciplinary. The guidelines advocate behavioral methods of intervention in the first instance, followed by consideration of pharmacological or surgical options if/when these are ineffective.
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Weird Taste In Your Mouth These Drugs Could Be The Cause
First, a little reminder about taste. Our sensory system for taste is remarkably sensitive, made possible by our taste buds. Taste buds are each made up of taste receptor cells which bind to small molecules related to flavor. Through sensory nerves, the receptors relay the taste information to the brain and this allows us to discern five basic tastes .
An unpleasant taste or lack of taste can affect appetite, and even lead to depression. If your taste buds dont seem right, rule out sinus or nasal issues, viral upper respiratory infections, or other common causes, then take a look at your meds.
With certain medications, these changes in taste may occur:
- Stimulants used in the treatment of ADHD may cause a bitter taste in your mouth. Adderall and methylphenidate decrease the threshold for the bitter taste in your mouth, making you more sensitive to the perception that something is bitter.
- Altitude sickness prevention in travelers can be overcome with Diamox which may also leave you with a bitter taste in your mouth.
Loss of sour taste:
- Isotretinoin is used for the treatment of severe acne, and you may notice the loss of sour taste while taking it. Isotretinoin disrupts ion channels, leading to loss of sour taste.
Persistent sweet, sour, salty, bitter or metallic taste :
- Captopril, enalapril and lisinopril are ACE inhibitors used to lower blood pressure. They cause disrupted taste, likely by causing zinc deficiency.
List Of Medications That Cause Dry Mouth
In real most of medications can cause dry mouth in human. Because of most of medications require liquid to work properly, dryness in mouth is come to normal condition after the meds usage. Find below most popular medications that can cause dry mouth:
Studies recommend medications used to treat hypertension like alpha blockers and beta blockers have side effects including dry mouth. Scientists also discovered calcium channel blockers can prevent saliva secretion. Specialists state ACE inhibitors used for dealing with high blood pressure as well as diabetes and kidney issues can likewise cause oral dryness.
Urinary Incontinence Drugs
Some drugs recommended to treat urinary incontinence caused by nerve over activity can cause dry mouth. Research studies show antimuscarinic drugs help counter the muscular convulsions that contribute to urinary frequency. However, this antimuscarinic residential or commercial property likewise impacts your bodyâs ability to secrete saliva â leaving you with that dry mouth sensation.
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Nightmares Or Night Terrors
If you have ever woken up from a dream in a cold sweat, you know a nightmare or night terror is a horrific event. Many medications, especially those that might work in the brain, can cause abnormal or vivid dreams. For example, medications used to help patients quit smoking can cause nightmares:
However, some smoking cessation studies have shown that after 12 weeks of use, close to half of users were able to quit smoking, so check with your doctor. You might be able to lower your dose to help with the dreaming side effect.
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Risk Factors For Drooling In Pd
If susceptibility to anterior drooling is not related to hypersalivation, other factors must be at work. Suggested candidates have been dysphagia, oro-facial rigidity/hypomimia, lingual bradykinesia, cognitive status, male gender and more advanced disease stage.23,24,28,31,39,43,50,51 Individuals with non-tremor dominant PD phenotypes were at higher risk of drooling.31,52 The precise contribution of these factors remains unsettled. The uncertainty rests partly on general issues above regarding why estimates of drooling prevalence and flow rates exist, but variability in individual profiles of impairment and disability also contributes.
Susceptibility of males probably relates to greater absolute flow rate when body mass and gland sizes are not controlled for though not all studies have found a male predominance.23,24,29 Relationship to greater disease severity likely reflects increased rigidity, poorer cognitive status and more marked dysphagia of later stages, and, in as far as medications may alter the picture, higher medication dependency.21
L-dopa can influence variables in swallowing efficiency,3,58 and thus indirectly change drooling. Currently, dysphagia study outcomes do not afford sufficient evidence to conclude a positive, neutral or negative effect of possible swallowing changes on sialorrhoea.
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How Do You Know If You Or Your Loved One Has A Problem With Swallowing
Swallowing difficulties can start very subtly and initially not be obvious to either the person with PD or their loved ones. There are signs to look out for before swallowing difficulty becomes overt . Some of the signs you should pay attention to include:
- Slow rate of eating people with difficulty swallowing may slow down their eating in order to avoid coughing or choking
- Fatigue during eating or decreased enjoyment of food
- A sensation that food is sticking in the throat
- Coughing or excessive throat clearing during eating
- Difficulty in swallowing pills
- Unexplained weight loss people with difficulty swallowing may reduce their consumption in an attempt to eat without coughing or choking
- Change in dietary habits people with difficult swallowing may alter their diet in order to avoid foods that cause difficulty. This may not be a choice made consciously
- Diagnosis of a pneumonia this could be caused by aspiration, or entry of a foreign substance into the airway
If you think there might be a swallowing issue, it is important to speak with your doctor about it. There are steps you can take to properly assess the situation and improve your swallowing function. This can in turn reduce your risk of choking, make eating more enjoyable, and lessen the chances of unwanted weight loss and/or other discomforts.
What Causes Dry Mouth In People With Parkinsons
Dry mouth can be caused by several factors including:
- Medications: Prescription and over the counter medicines are some of the most common causes of dry mouth. Reducing, stopping or changing certain medications can relieve dry mouth.
- Age: Advanced age alone is not a cause of dry mouth but half of those over age 60 take multiple maintenance medications that can trigger it.
- Medical conditions: Diabetes, Sjögrens Syndrome and Parkinsons disease can all cause you to experience dry mouth.
There are several connections between Parkinsons disease and dry mouth. Repeated swallowing consumes the available saliva that keeps the mouth moist. It is often related to the drugs used to manage PD, particularly anticholinergics. A physician may be able to change or adjust medications and dosages to reduce dry mouth.4
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