Thursday, July 28, 2022

Keto Diet And Parkinson’s Disease

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Vlog #93 The Ketogenic Diet And Parkinson’s Disease

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Parkinsons And Weight Gain

Parkinsons medication does not tend to make people gain weight, but a small number of people may experience impulsive and compulsive behaviour. This is a side effect of some Parkinsons medication, particularly dopamine agonists and, in some cases, levodopa.

Impulsive behaviour is when a person cant resist the temptation to carry out certain activities. These are often activities that give an immediate reward or pleasure, such as gambling, hypersexuality and overeating.

So, someone may eat large amounts of food in a short period of time because they cant control their appetite, and as a result, they gain weight.

If you think youre experiencing this behaviour, speak to your GP, specialist or Parkinsons nurse.

We dont advise anyone to stop taking or to change their Parkinsons medication without the advice of their specialist or Parkinsons nurse.

Any changes have to be made slowly and gradually, and should always be carried out and reviewed by a specialist, because of the risk of side effects and withdrawal symptoms.

Someone experiencing impulsive or compulsive behaviour may not realise they have a problem. So it’s important that their carer is aware of these side effects.

Deep brain stimulation and weight gain

Some people with Parkinsons may put on weight quickly after having deep brain stimulation, a surgery sometimes used to treat the condition.

If you think youre experiencing this behaviour, speak to your GP, specialist or Parkinsons nurse.

Interview With Bill Curtis

This is an excellent interview with William Curtis. I met Mr. Curtis at the Tripping Over the Truth conference in November 2017. Mr. Curtis was diagnosed with Parkinsons in 2010 and has been keeping his symptoms in check using what he calls intermittent ketosis and exogenous ketones. He also has a website. The video is well worth watching if you have or care for someone with Parkinsons.

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We Dont Know The Long

While it is certainly the case that clinical trials evaluating the long-term effects of KD are yet to be conducted, the long-term effects of the current dietary recommendations appear to be clear. In the United States, for nearly 40 years, the Dietary Guidelines for Americans which strong evidence suggests people have been adhering to, has likely contributed to the doubling the obesity rate, with nearly 75% of adults either overweight or obese . In addition, this eating pattern associates strongly with the development of the spectrum of chronic metabolic diseases that continue to increase in prevalence .

Cause For Parkinsons Disease

Ketofy

The primary cause of the disease is attributed to genetic disorders and/or environmental triggers such as infections, impact of insecticides, psychological stress, etc.

These conditions are known to impact the mitochondrial functions of the body due to excess oxidative stress. Usually, the body has agencies to counter the impact of oxidative stress. However, under severe stress, as observed in PD, the agencies cease to operate. This allows the production of free radicals that damage the cells that produce dopamine in the brain.

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Patient Flow And Baseline Characteristics

Details of patient flow, including all study exclusions and withdrawals, are shown in Figure . We randomized 47 patients, of which 44 commenced the diets and 38 completed the study 6 patients withdrew for reasons unrelated to the diets and 3 patients withdrew as a result of dietrelated difficulties. Randomized patient baseline characteristics are shown in Table . There were no significant betweengroup differences in any baseline characteristics.

Except for % variables, values are presented as mean±standard deviation.

Baseline values were obtained by averaging the two baseline clinical visits 1 patient withdrew postrandomization, several hours before their scheduled second baseline visit, so the first visit was used as the baseline value.

Treating Parkinsons Disease With Ketogenic Diet

Treating Parkinsons Disease with Ketogenic Diet: A Deep-dive Analysis

Parkinsons disease is a progressive neuro-degenerative disorder that affects neurons that produce dopamine in the substantia nigra portion of the brain. The symptoms for PD usually takes years to develop.Advertisements

The reduced production of dopamine leads to symptoms such as tremors, difficulty in movement, depression, confusion, and pain. It considerably reduces the quality of life of the patient.

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Keto Diet Brando Carter

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Neuroprotective Functions Of The Ketogenic Diet On Cognition In Neurological Disease

Keto Diet & Parkinson’s Disease with William Curtis

As mentioned, the ketogenic diet plays a major role at the metabolic and neuronal levels, whereby its therapeutic properties are relevant for certain diseases. According to scientific literature, important therapeutic evidence exists about this diet in certain diseases and, thanks to recent findings, evidence is also emerging about the ketogenic diet as applied to new neurological diseases, placing special emphasis on the cognitive benefits of this type of diet.

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Ketogenic Diet In Neuromuscular And Neurodegenerative Diseases

Antonio Paoli

1Department of Biomedical Sciences, University of Padova, Via Marzolo 3, 35031 Padova, Italy

2Sport and Exercise Sciences Research Unit, University of Palermo, Via Eleonora Duse 2, 90146 Palermo, Italy

Academic Editor:

Abstract

An increasing number of data demonstrate the utility of ketogenic diets in a variety of metabolic diseases as obesity, metabolic syndrome, and diabetes. In regard to neurological disorders, ketogenic diet is recognized as an effective treatment for pharmacoresistant epilepsy but emerging data suggests that ketogenic diet could be also useful in amyotrophic lateral sclerosis, Alzheimer, Parkinsons disease, and some mitochondriopathies. Although these diseases have different pathogenesis and features, there are some common mechanisms that could explain the effects of ketogenic diets. These mechanisms are to provide an efficient source of energy for the treatment of certain types of neurodegenerative diseases characterized by focal brain hypometabolism to decrease the oxidative damage associated with various kinds of metabolic stress to increase the mitochondrial biogenesis pathways and to take advantage of the capacity of ketones to bypass the defect in complex I activity implicated in some neurological diseases. These mechanisms will be discussed in this review.

1. Introduction

2. Inside the Ketogenic Diet

Blood levels
< 7.3

3. Ketogenic Diet Simulates Fasting and Its Molecular Effects

5. Mitochondrial Disorders and Ketogenic Diet

Putting It All Together

Many aspects of Parkinsons disease are still a mystery. The motor and non-motor symptoms make it a difficult disease to cope with, prevent, and reverse, but there are some ways to help.

For example, the use of the ketogenic diet in the treatment of Parkinsons disease appears to be very promising. There is a lack of clinical data, however, on the practical application of using the diet and ketone supplements for Parkinsons disease. That being said, there is now a lot of lab and animal work as well as case studies of people implementing the diet for themselves and experiencing powerful effects.

Because of the current state of the evidence, it is best to look at the ketogenic diet as an effective supplementary treatment for Parkinsons disease, used to complement current medications. The strictness of the diet doesnt seem to matter as much as getting into ketosis does. To find out how to follow the diet and get into ketosis within the next week, read through our comprehensive beginners guide to the ketogenic diet.

Once you are following the ketogenic diet in a way that works for you and your lifestyle, feel free to improve the results of your treatment even further by:

P.S. Have a look at the Keto Academy, our foolproof 30-day keto meal planner. It has all the tools, information, and recipes needed for you to succeed.

+ The food will always fit to your macros and cooking preferences!

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Incentivize Health Efficacy App

Technology Stack: MEAN stack React Native

  • HIPAA compliance to secure sensitive patient data.
  • Product information display and diagnosis- estimated date the patient started consuming the product, estimated end of treatment, recurrence and quantity consumed of the product, physician that prescribed the medication.
  • Patients can log in their mood every day and share stats with doctor for tracking progress in their mental health conditions.
  • Admin analytics – graphs based on results of raffles
  • Linking of monitoring devices Fitbit, Samsung Gear, Apple watch to collect calories, steps and sleep.

Study 1 Vanitallie Et Al

Vlog #93 The Ketogenic Diet And Parkinson

The first study, conducted in 2005, assigned 7 participants with Parkinsons to the keto diet for 4-weeks to determine if symptoms could improve on this diet. 5 participants completed the study. Urine ketones were measured daily. The macronutrient breakdown as a percent of total calories was 90% fat, 2% carbohydrate and 8% protein.

Outcomes: Unified Parkinsons Disease Rating Scale scores improved in all 5 participants. Among symptoms that improved were resting tremor, freezing, balance, gait, mood and energy level. Although 2 participants did not follow the diet as strictly as others, they were still able to achieve ketosis and improve UPDRS scores. All participants had a body mass index above 28 and lost an average of 6.1 kg during the study period.

Limitations: the assigned diet was inadequate in protein which may have improved levodopa absorption making it difficult to determine if the observed improvements were due to this or due to the effects of the diet. In addition, there was no control group, a very small sample size was followed for a short duration and the potential of a placebo effect must be kept in mind when interpreting these outcomes.

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Is The Keto Diet Right For Me

The keto diet can cause appetite suppression and as seen in all 3 studies weight loss. For some people with Parkinsons who are carrying extra weight this may be appropriate but for many struggling with poor appetite and unplanned loss of weight this dietary pattern may not be suitable.

If not well formulated the keto diet can lack fibre. A lack of dietary fibre can lead to or exacerbate constipation. to learn how to get an adequate amount of fibre on a keto diet.

The keto diet is very high in fat. If you suffer from gastroparesis or slow stomach emptying consuming very high-fat meals can cause symptoms such as nausea, stomach pain and bloating. As fat empties more slowly from the stomach this dietary pattern may not be suitable.

The Cause Of Parkinsons Disease

Due to the complexity of Parkinsons disease, the cause has yet to be elucidated. However, we do know that it results from a complex interplay between genetic and environmental factors that affect numerous cell processes.

In general, most of the issues that are experienced by people with Parkinsons disease seem to be caused by nerve cell damage and cell death as a result of mitochondrial dysfunction and oxidative damage. More specifically, the mitochondrial dysfunction and oxidative damage cause the deterioration of dopamine-producing cells in the substantia nigra, a part of the brain that plays a vital role in reward-seeking behavior and movement.

As the dopamine-producing cells continue to get damaged, the person will experience many of the common symptoms of Parkinsons disease, like:

  • tremors
  • depression
  • pain

The disease is usually diagnosed once the first motor symptoms are noticed . As the disease advances , the non-motor symptoms become more troublesome than the motor symptoms as the patients cognitive function and will to live deteriorate.

However, not every patient follows the same course after they are diagnosed. There is a great variability between patients in the progression of the disease. The one consistency between patients is that the current drugs available to treat Parkinsons disease lose their effectiveness over time and can cause undesirable side effects.

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What Can I Do To Help With Swallowing

Make sure you are comfortable at meal times. The following suggestions may help make it easier to eat:

  • Take your time and eat in a comfortable, quiet place.
  • If you feel you are taking too long and food is getting cold, consider eating smaller, more frequent meals and snacks, or food that is easier to eat.
  • You can buy heated plates to keep food warm for longer or consider serving smaller portions so that a second portion can be kept warm or reheated if its safe to do so.
  • Posture is important to trigger a good swallow. Try eating sitting upright in your chair.
  • Try planning your meals for when your medication is working. Avoid trying to eat large meals when you are ‘off’.
  • If you wear dentures try to ensure they fit comfortably. Ask for a review by your dentist if you are concerned.
  • Try to eat when you are less tired, this may mean moving your main meal to lunchtime rather than in the evening.

How Can Ketogenic Diet Treat Pd

59. Diet & Parkinsonâs disease: Going “ketoâ?

The Ketogenic diet helps the brain cells to shift from glucose, its usual source of energy, to ketones, produced in the liver due to restricted carb intake.

Ketones are proven to boost antioxidant activity in the brain and control the production of free radicals. This further reduces the stress and damage to brain cells and its ability to produce dopamine.

Considering the impact of ketones on the mitochondrial function of brain cells, Ketogenic diet has been considered an alternative treatment to reduce the conditions associated with PD.

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A Ruledme Keto Diet Vs A Low

In this randomized controlled trial, 47 patients were selected and 38 of them completed the 8-week dietary protocol. 20 of the patients who completed the study were on the low-fat diet, and 18 followed the keto diet.

Each diet plan was designed to provide similar calorie and protein content. The primary differences between the two diets were in carb, fat, and fiber content.

To give you a better idea of each diet, heres a chart with the average macronutrient and calorie intake of each group:

Low-fat Diet
3311

However, this was not a controlled feeding trial where every piece of food was measured precisely before consumption, so it is highly unlikely that the subjects ate the recommended amount.

The study followed a more realistic dietary change protocol including 4week diet plans including weekly shopping lists, daily menus, and simple, satisfying recipes. Along with the diet plan, each subject received tips on how to stay on the diet and troubleshoot common issues.

To help them craft a legitimate keto diet plan that is both satisfying and healthy, the researchers reached out to us, and we provided them with some of our most popular Ruled.me keto recipes and other diet tips, which they used as the basis for their keto diet meal plan.

In essence, the researchers created an abridged version of our Keto Academy for their Parkinsons disease patients. If youd like to take a look at the keto meal plan and information that each subject received, follow this link.

Dietary Strategies For Fending Off Parkinsons

Youve probably heard that fasting can cleanse your body and improve your health. But did you know that it might help people manage the symptoms of neurodegenerative disorders including Alzheimers and Parkinsons?

Fasting helps turn fat into ketone bodies encouraging a healthy transformation in the structure of synapses that are critical for learning and memory, as well as overall brain health.

Mattson suggests two ways to try out a calorie-restricted diet. First, theres the 5:2 diet. On two nonconsecutive days each week you consume a total of 500 calories each day. On the other five days, just stick with a normal diet. This is usually around 2,000 calories for women or 2,500 for men.

The second option is to experiment with a time-restricted diet, where you condense eating into a single eight-hour period every day. This gives your body the remaining 16 hours to begin burning fat and creating ketones.

Dr. Mattson recommends beginning slowly. Start with moderate fasting one day per week. Once your body gets used to it, add a second day. Symptoms such as headaches, lightheadedness, and grouchiness are common in the beginning but typically pass.

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I Am Overweight What Can I Do

It’s easy to gain weight if you become less active but are eating the same amount of food.

If you are trying to lose weight, here are some tips to start with:

  • Don’t eat fried food regularly grill, dry fry, microwave, bake, steam, poach or boil, without adding fat or oils. Instead, use marinades, adding extra herbs, stock and spices for flavour.
  • Use skimmed or semi-skimmed milk instead of full fat.
  • Try eating healthier snacks like diet yoghurts, nuts, fruit, crumpets or teacakes.
  • Have sugar-free, no added sugar or low-calorie drinks and use artificial sweetener instead of sugar.

If you have other health conditions as well as Parkinsons, such as circulation problems, high cholesterol, heart disease or diabetes, and are concerned about being overweight, speak to your GP, specialist, Parkinsons nurse or ask to see a registered dietitian.

Foods Containing Saturated Fat And Cholesterol

Keto Diet for Parkinson

Some studies suggest that dietary fat intake may increase the risk of Parkinsons.

Although having a higher intake of cholesterol can elevate a persons Parkinsons risk, having a higher intake of polyunsaturated fatty acids may reduce the risk.

Therefore, a person with Parkinsons may wish to reduce their intake of cholesterol to help control the symptoms of the condition. They may also wish to reduce the amount of saturated fat in their diet.

However, further studies are required to explore the link between dietary fat and Parkinsons.

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