Friday, March 1, 2024

Drugs For Parkinson’s Dementia

Falls In People With Parkinson’s

Could a dementia drug prevent falls in Parkinson’s?

Parkinson’s affects 127,000* people in the UK and approximately 7 million worldwide.

70% of people with Parkinson’s will fall at least once per year, with over a third experiencing falls repeatedly, resulting in fractures, broken bones and hospital admissions.

Parkinson’s UK Research Fellow Dr Emily Henderson and her team at the University of Bristol studied 130 people with Parkinson’s who had fallen in the past year.

Half the group was given rivastigmine capsules and the other half was given a placebo for an 8-month period.

Lewy Bodies And Parkinsons Disease

A person with Parkinsons disease may develop dementia and have problems with reasoning and thinking. Lewy bodies are a feature of several brain disorders, including Parkinsons disease and Alzheimers disease, and they may cause rigid muscles and problems with movement and posture.

Research suggests that the similarity of the symptoms of Parkinsons disease and Lewy body dementia may be indicative of a shared link to how the brain processes alpha-synuclein.

It is not possible to test for the presence of Lewy bodies, so researchers must try to determine their effects by carrying out postmortem studies.

There is currently no cure for dementia. However, medication can alleviate the symptoms, while a team of medical professionals and therapists may help a person develop strategies to manage their daily activities.

What Other Information Should I Know

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

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Before Taking This Medicine

You should not take rivastigmine if you are allergic to rivastigmine or similar medicines, such as felbamate, meprobamate, or carisoprodol.

You should not take oral rivastigmine if you have ever had severe redness, itching, or skin irritation caused by wearing a rivastigmine transdermal skin patch.

Tell your doctor if you have ever had:

  • an ulcer or stomach bleeding

  • a seizure

Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.

What Is The Self

Dementia

Protein in the diet may affect the absorption of levodopa, the major medication used to treat Parkinson’s disease. Fluctuations in the level of levodopa may worsen some behavioral and cognitive symptoms. A low-protein diet may reduce fluctuations in dopamine levels. In some patients with these fluctuations, dietary changes can improve symptoms. However, it is important to ensure that the person is getting adequate calories and other nutrients.

People with Parkinson’s disease should remain as active as possible. Physical therapy helps the person maintain mobility.

In general, people with Parkinson’s disease plus dementia should no longer drive vehicles. Movement problems may prevent quick reactions in hazardous driving situations. Certain medications, especially those given to treat symptoms of dementia, may make them less alert. However, this should be determined on an individual basis and in compliance with the laws of the state.

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How Is Parkinsons Disease Diagnosed

Diagnosing Parkinsons disease is sometimes difficult, since early symptoms can mimic other disorders and there are no specific blood or other laboratory tests to diagnose the disease. Imaging tests, such as CT or MRI scans, may be used to rule out other disorders that cause similar symptoms.

To diagnose Parkinsons disease, you will be asked about your medical history and family history of neurologic disorders as well as your current symptoms, medications and possible exposure to toxins. Your doctor will look for signs of tremor and muscle rigidity, watch you walk, check your posture and coordination and look for slowness of movement.

If you think you may have Parkinsons disease, you should probably see a neurologist, preferably a movement disorders-trained neurologist. The treatment decisions made early in the illness can affect the long-term success of the treatment.

How Can We Support The Sleep/wake Cycle Of Pdd

For people with PDD who are confused about the day-night cycle, some daily strategies can be helpful. At night, starting a lights out routine that happens at the same hour every day, where all curtains are closed and lights are turned off, can help the person understand that it is sleep time. During the day, opening the curtains, allowing the person with PDD to spend as much time in the daylight as possible, avoiding naps, and organizing stimulating activities, can be helpful. Having lots of calendars and clocks in every room might also help a person with PDD be less confused about the time of day.

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Number Of People Affected

Parkinsons disease is thought to affect about 2 percent of Americans over 65. Of those, about 50 to 80 percent will go on to develop Parkinsons-related dementia.1 The Parkinsons Foundation estimates that nearly 1 million Americans will be living with Parkinsons by 2020. The disease affects 1.5 times more men than women.7

Approximately 5.8 million Americans are currently living with Alzheimers disease. That number is expected to increase to 14 million by 2050.8 There is little difference between numbers of men and women who develop Alzheimers, but there are more women with the disease, because women tend to live longer than men.3

What This Could Mean For Families

Dealing with Dementia in Parkinson’s Disease

There is an urgent need for more tools for clinicians to provide better care and treatment for people living with Alzheimers and all dementia today, while research continues for a cure, Carrillo said.

The Alzheimers Association looks forward to learning about the next steps for this drug, including the companys discussions with the FDA. We encourage a rigorous review and discussion of any potential side effects and safety concerns, she added.

Cummings says there has not been a new drug approved to treat Alzheimers since 2003.

If pimavanserin is approved, it could be a significant for families with loved ones who have Alzheimers.

It would be a very exciting thing. The ability to ameliorate those kinds of symptoms makes a huge difference for caregivers, he said.

He says the drug potentially could be used to treat other types of dementia.

By including five types of dementia in the study, we essentially showed that all major types of dementia respond to pimavanserin, he explained.

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How Should This Medicine Be Used

Rivastigmine comes as a capsule and solution to take by mouth. It is usually taken twice a day with meals in the morning and evening. Follow the directions on your prescription label carefully and ask your doctor or pharmacist to explain any part you do not understand. Take rivastigmine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will start you on a low dose of rivastigmine and slowly increase your dose, not more than once every 2 weeks.

Rivastigmine may improve the ability to think and remember or slow the loss of these abilities but does not cure Alzheimer’s disease or dementia in people with Parkinson’s disease. Continue to take rivastigmine even if you feel well. Do not stop taking rivastigmine without talking to your doctor.

If you are taking rivastigmine oral solution, ask your pharmacist or doctor for a copy of the manufacturer’s instructions for use. Carefully read these instructions. Always use the oral dosing syringe that comes with rivastigmine solution to measure your dose.Talk to your doctor or pharmacist if you have questions about how to measure your dose of rivastigmine solution.

Parkinson’s Disease Dementia Surgery And Gene Therapy

  • Great strides have been made in the surgical treatment of Parkinson’s disease. Several different procedures are now available, and they are successful in many patients in relieving movement symptoms. Unfortunately, surgery has no effect on cognitive symptoms. In fact, most people with dementia are not candidates for surgery.
  • Gene therapy is in its infancy there are ongoing human and animal trials with various methods to insert genes into neuronal cells to reduce or stop Parkinson’s disease symptoms by causing cells to produce dopamine coded by the newly inserted genes. Early results with the treatment termed ProSavin are encouraging. However, it is not clear if such therapy could prevent or reverse Parkinson’s disease dementia.

Recommended Reading: Parkinson’s Disease Treatment Guidelines

Is Parkinsons Disease Inherited

Scientists have discovered gene mutations that are associated with Parkinsons disease.

There is some belief that some cases of early-onset Parkinsons disease disease starting before age 50 may be inherited. Scientists identified a gene mutation in people with Parkinsons disease whose brains contain Lewy bodies, which are clumps of the protein alpha-synuclein. Scientists are trying to understand the function of this protein and its relationship to genetic mutations that are sometimes seen in Parkinsons disease and in people with a type of dementia called Lewy body dementia.

Several other gene mutations have been found to play a role in Parkinsons disease. Mutations in these genes cause abnormal cell functioning, which affects the nerve cells ability to release dopamine and causes nerve cell death. Researchers are still trying to discover what causes these genes to mutate in order to understand how gene mutations influence the development of Parkinsons disease.

Scientists think that about 10% to 15% of persons with Parkinsons disease may have a genetic mutation that predisposes them to development of the disease. There are also environmental factors involved that are not fully understood.

A Step Towards Better Treatments

Parkinsons Disease Dopamine Acetylcholine Balance

Dr Arthur Roach, Director of Research at Parkinson’s UK, said:

“People affected by Parkinson’s, their carers, and health and social care professionals have said that preventing falls and improving balance is the biggest unmet need for people living with the condition, outside of finding a cure.

“This study shows that there may be drugs already available, being used for other purposes, that can be tested to help treat Parkinson’s.

“These results take us a step closer to improving the quality of life and finding better treatments for people with Parkinson’s. But we still need more information before we recommend that people with Parkinson’s are prescribed rivastigmine for falls.”

*This article mentions statistics which have since been updated. 2018 data shows that the number of people diagnosed with Parkinson’s in the UK is around 145,000.

Watch other research videos on falls and Parkinson’s for more from Dr Emily Henderson and people affected by Parkinson’s who’ve taken part in drug trials.

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What Should I Do If I Forget A Dose

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

If you miss taking rivastigmine for more than a few days, talk to your doctor before starting to take it again. You will probably have to restart taking it at a lower dose.

What Other Things Help

There are various ways to help a person with PDD. Speech therapy may help improve communication between people with PDD and others. Physical therapy may help strengthen and stretch stiff muscles and help to prevent falls.

Research has shown that physical exercise helps to enhance brain health and improves mood and general fitness. A balanced diet, enough sleep and limited alcohol intake are other important ways to promote good brain health. Other illnesses that affect the brain, such as diabetes, high blood pressure and high cholesterol, should also be treated if present.

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Consider Drug Risks Versus Benefits For The Individual Patient

You have to be very careful, and so its super important that clinicians are aware of the differences between these three drugs , the risks and the benefits, and that these are the ones that are applied rather than the classical dopamine blockers, he adds.

The acetylcholinesterase inhibitors rivastigmine and donepezil can be helpful for psychosis in patients with PD and DLB, and may improve memory as well, according to Dr. Okun. Theres certainly a subset of people with Lewy bodies that do really well with that medication.

Quetiapine can help patients with sleep, and this could account for some of the benefits it provides for patients with psychosis, he adds.

Psychosis in DLB can be more challenging to treat than in PD, Dr. Okun notes, because certain medications can make symptoms worse. Persons with Lewy bodies often have what is called cognitive fluctuations, he explains. They can be very sensitive to many medicines.

Individuals with DLB and PD may also develop a sensitivity to dopamine and dopamine blockers, he adds. Thats more common with Lewy body dementia than it is with Parkinsons disease psychosis, and thats another thing you have to watch out for.

What Happens In Pdd

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People with PDD may have trouble focusing, remembering things or making sound judgments. They may develop depression, anxiety or irritability. They may also hallucinate and see people, objects or animals that are not there. Sleep disturbances are common in PDD and can include difficulties with sleep/wake cycle or REM behavior disorder, which involves acting out dreams.

PDD is a disease that changes with time. A person with PDD can live many years with the disease. Research suggests that a person with PDD may live an average of 57 years with the disease, although this can vary from person to person.

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What Happens If I Miss A Dose

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

If you miss several doses in a row, call your doctor before taking any more of rivastigmine.

Get your prescription refilled before you run out of medicine completely.

Common Dementia Drug Could Improve Parkinson’s Symptoms

Scientists have discovered that a commonly prescribed dementia drug could hold the key to preventing debilitating falls for people with Parkinson’s and improving their quality of life.

The research showed that people with Parkinson’s who were given the oral drug rivastigmine were 45% less likely to fall and were considerably steadier when walking, compared to those that took a pill with no active treatment.

The results were published today in The Lancet Neurology. The study was part-funded by Parkinson’s UK.

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Examples Of Delusions In Pd

  • Jealousy
  • Belief: Your partner is being unfaithful.
  • Behavior: Paranoia, agitation, suspiciousness, aggression.
  • Persecutory
  • Belief: You are being attacked, harassed, cheated or conspired against.
  • Behavior: Paranoia, suspiciousness, agitation, aggression, defiance, social withdrawal.
  • Somatic
  • Belief: Your body functions in an abnormal manner. You develop an unusual obsession with your body or health.
  • Behavior: Anxiety, agitation, reports of abnormal or unusual symptoms, extreme concern regarding symptoms, frequent visits with the clinician.
  • Causes And Risk Factors

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    PD is idiopathic, meaning that a doctor does not know why a person has the condition. However, according to Johns Hopkins Medicine, early-onset Parkinsons disease has links to genetic inheritance from a parent.

    Researchers have identified several risk factors that may make a person with Parkinsons disease more likely to experience dementia.

    These risk factors include:

    • advanced age at time of diagnosis
    • experiencing excessive daytime sleepiness
    • hallucinations before the onset of other dementia symptoms
    • having a specific Parkinsons symptom that causes a person to have difficulty starting to take a step or to halt mid-step while walking
    • a history of mild thought impairment
    • more severe movement impairment symptoms than most people with Parkinsons disease

    However, researchers do not know why some people with Parkinsons disease develop cognitive difficulties as well as movement problems.

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    What Causes Parkinson Disease

    Parkinson disease arises from decreased dopamine production in the brain. The absence of dopamine makes it hard for the brain to coordinate muscle movements. Low dopamine also contributes to mood and cognitive problems later in the course of the disease. Experts don’t know what triggers the development of Parkinson disease most of the time. Early onset Parkinson disease is often inherited and is the result of certain gene defects.

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    Parkinsons Disease Dementia Follow

    A person with Parkinsons disease and dementia requires regular checkups with his or her health care professional.

    • These checkups allow the health care professional to see how well treatment is working and make adjustments as necessary.
    • They allow detection of new problems of cognition, mood, or behavior that could benefit from treatment.
    • These visits also give the family caregiver an opportunity to discuss problems in the individuals care.

    Eventually, the person with Parkinsons disease and dementia will likely become unable to care for himself or herself or even to make decisions about his or her care if the patient lives long enough with Parkinsons disease and dementia.

    • It is best for the person to discuss future care arrangements with family members as early as possible, so that his or her wishes can be clarified and documented for the future.
    • A health care professional can advise patients and caregivers about legal arrangements that should be made to ensure that these wishes are observed.

    Parkinsons disease dementia prevention

    There is no known way of preventing dementia in Parkinsons disease. However, patients with Parkinsons disease are urged to continue to exercise and live a healthy lifestyle as this may delay or reduce the onset of dementia, although there is no good data to indicate this will occur.

    Parkinsons disease dementia prognosis

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