What To Look For When Buying Mushroom Products
Some mushroom supplements and products contain fillers and other ingredients you need to avoid in order to find the best quality product. “When purchasing a mushroom supplement, make sure starch is listed. Some supplements can be filled with ‘filler’ so make sure only 5% of the recipe includes starch,” says Kessler. Another tip from Kessler is to choose a concentrated extract over powder form. She says to look for “hot water extracted” on the label or company website.
“Avoid supplements that say mycelium — this means the supplements are void of the beta-glucan which gives it much of its medicinal quality. Look for labels that say triterpenoid compounds and active polysaccharides,” says Kessler.
Finally, keep in mind that taking medicinal mushrooms requires patience and you won’t see immediate benefits. “It takes at least two weeks to notice the effects of functional mushrooms, and it is recommended to take a week off every four to six months,” says Kessler.
The information contained in this article is for educational and informational purposes only and is not intended as health or medical advice. Always consult a physician or other qualified health provider regarding any questions you may have about a medical condition or health objectives.
How Much Lion’s Mane Should I Take Daily
When considering, how much lions mane should I take, its important to know your personal dosage will depend largely on your age, health, size, sensitivity and also – your reasons for wanting to try lions mane in the first place. The more severe the issue you are trying to treat, the more lions mane you may need for it to make a noticeable difference.
To give you a rough idea, for general improved immunity and cognitive functioning, a typical lions mane dosage is roughly 1000mg per day. Much like other supplements, always consumed alongside a good meal. This also helps to eradicate any feelings of potential nausea. Lions mane can be taken up to three times per day, though it is not recommended to exceed this limit. Daily dosages of 250mg to 750mg have also been shown to be effective. We recommend mixing one scoop of lions mane powdered mix into your tea or coffee, once a day for a two week period. Be aware of how you feel after two weeks, and you can always increase your dosage to one-two scoops per day.
Side Effects Of Lions Mane Mushroom
Side effects are a big nuisance on this earth.
Lions mane poses some serious side effects if taken by an asthmatic patient. Lions mane can exacerbate the asthmatic attack as they increase the levels of leukotrienes in the body. The leukotrienes are responsible for bronchoconstriction and inflammation of airways.
So, the lions mane is a no-go zone for someone with asthma.
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Reishi Balances The Immune System
Reishi mushrooms have a well-known ability to beneficially modulate the immune system.11,65-67 The mushrooms ability to boost immunity is the source of their advanced cancer- and infection-fighting properties. But it is equally important to keep your immune system from overreacting and turning on itself, as is the case with autoimmune diseases such as allergies. Reishi mushrooms have demonstrated the ability to modulate the delicate balance necessary for a healthy immune system. Studies have shown that Reishi mushrooms can reduce the overactive immune response that occurs in conditions such as allergies, asthma, and autoimmune diseases.
The polysaccharides and triterpenes found in Reishi mushrooms act at multiple targets in the cascade of events leading to inflammation and excessive immune response.17,67,68
Reishi extracts inhibit the release of histamine from specialized immune cells called “mast cells.”65 They have the ability to reduce the activity in nerves that transmit the itch sensation to the brain after a mosquito bite or similar itchy stimulus.69,70
In animal models, Reishi extracts were able to sharply reduce the symptoms associated with allergies, such as rhinitis and mosquito bites.9 Studies also show that Reishi extracts can reduce airway hyper-responsiveness, the twitchy smooth muscle responses in the lung bronchi that trigger an asthma attack.8
Medications That Slow Blood Clotting Interacts With Reishi Mushroom
High doses of reishi mushroom might slow blood clotting. Taking reishi mushroom along with medications that also slow clotting might increase the chances of bruising and bleeding.Some medications that slow blood clotting include aspirin, clopidogrel , diclofenac , ibuprofen , naproxen , dalteparin , enoxaparin , heparin, warfarin , and others.
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Screening The Main G Lucidum Active Extracts For Anti
The fur of animals treated with G. lucidum extracts was much smoother than that of those in the model group. The average weight of animals did not differ significantly between the treated and model groups male animals weighed approximately 320 g at the beginning and 500 g at the end of the experiment , while female rats weighed approximately 240 g at the beginning and 290 g at the end of the experiment .
-galactose + AEG high-dose AEG group, D-galactose + AEG , polysaccharide , alcohol , and oil extracts from G. lucidum by gavage. Every group consisted of eight animals and the procedure duration was 8 weeks. Male animals weighed While female rats weighed Morris water maze tests Brain tissue HE staining. p< 0.01.
The swimming time of the control group in the NW quadrant was significantly longer than that in the other three quadrants . The swimming time in the NW quadrant of the model group was 25.23 ± 2.66 s, which was significantly shorter than that of the control group , suggesting that the rats remembered the location of the placement of the platform. The swimming durations of the low- and high-dose AEG groups were 57.55 ± 1.39 s and 49.16 ± 1.87 s, respectively, which were significantly longer than the model group. Compared with the model group, the differences were significant . The other extracts treated groups do not improved so much .
Measurement Of Ad Parameters
The spatial learning and memory abilities of rats and mice were tested using a Morris water maze . MWM tests included three periods, initial spatial training, spatial reversal training, and the probe test, and were conducted as described previously . Animal weights were measured every 3 days during the drug administration period. Following water maze testing, blood and serum were acquired. Routine indices and cytokines were measured and the brains of the animals dissected. Four brains from each group were fixed in 4% paraformaldehyde solution and prepared as paraffin sections.
Sections were stained with hematoxylineosin or by immunohistochemistry and observed by light microscopy . Immunostaining for A1-42, Histone H3, DNMT3A, and DNMT3B was performed using paraffin-embedded 4 m sections with the two-step peroxidase conjugated polymer technique , and primary antibodies against A1-42 , Histone H3 , DNMT3A , and DNMT3B .
An Overview Of Edible Medicinal Mushrooms
Maitake: “Can be sautéed, cooked into dishes, or eaten cooked on its own ,” says Kessler. Maitake mushroom is an adaptogen, which means it can help the body adapt to stress and stay in balance. It also has potential anti-cancer benefits, in addition to helping improve cholesterol and type 2 diabetes.
Shiitake: ” cooked into any types of dishes, can be eaten raw, but typically cooked,” says Kessler. Shiitake mushrooms may help fight cancer and inflammation, and they contain beta glucans, which may help lower cholesterol.
Lion’s mane: “Not typically eaten raw, and can be substituted in recipes as crab meat. support mood health and memory,” says Kessler.
Oyster mushrooms: “Not typically eaten raw, can sauté, or use in stir fry,” says Kessler. Research has shown that oyster mushrooms contain antioxidants and may help decrease risk of certain diseases like cancer, heart disease, obesity and diabetes.
Lion’s mane is known for helping improve focus and brain health.
Can Help Prevent Neurological Degeneration
Reishi can also heal or even prevent the onset of Alzheimers disease by reducing the oxidative stress that proteins like Abeta can cause. This is achieved through triterpenes and polysaccharides, which research has shown are among the most powerful ingredients Reishi mushrooms have. Theyre also capable of combating tumor growth, strengthening the immune system and reducing blood pressure.
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Yuen-Shan Ho, Kwok-Fai So, Raymond Chuen-Chung Chang . Anti-aging herbal medicineHow and why can they be used in aging-associated neurodegenerative diseases? Ageing Research Reviews 9 354-362. Retrieved from
Jerome Sarris, Alexander Panossian, Isaac Schweitzer, Con Stough, Andrew Scholey . Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. European Neuropsychopharmacology 21 841-860. Retrieved from
Rebecca Erwin Wells, Russell S. Phillips, Steven C. Schachter, Ellen P. McCarthy . Complementary and alternative medicine use among US adults with common neurological conditions. Journal of Neurology 257 1822-1831. Retrieved from
Jianyou Guo, ChangYu Li, Jie Wang, Yongmei Liu, Jiahui Zhang . Vanadium-Enriched Cordyceps sinensis, a Contemporary Treatment Approach to Both Diabetes and Depression in Rats. Evidence-Based Complementary and Alternative Medicine Retrieved from
Wang Jun-Ming, Wang Shuai, Cui Ying . Antidepressant Activities of Extracts from Gynostemma pentaphyllum Makino. Lishizhen Medicine and Materia Medica Research Retrieved from
Reviewtherapeutic Applications Of Mushrooms And Their Biomolecules Along With A Glimpse Of In Silico Approach In Neurodegenerative Diseases
Edible mushrooms show very potent Anti-oxidative and Anti-inflammatory activity.
Biomolecules of mushrooms show a prominent therapeutic response against lifestyle-related diseases.
Mushrooms also widely utilize to manage neurodegenerative diseases like Parkinsons and Alzheimers disease.
The biomolecules of mushrooms also exhibit strong therapeutic properties.
Insilco approach is utilized to investigate the characterizes the important bioactive constituent in mushrooms.
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Cordyceps Mushroom: The Caterpillar Fungus
Species name: Cordyceps Militaris
Primary Cordyceps Mushroom Medicinal Benefits: Improves lung capacity and increases energy*
The Cordyceps mushroom is an incredible energy-boosting fungi because of its ability to increase ATP production through pre-cursor compounds like adenosine and cordycepin. ATP is the compound that gives our cells energy. This is why Cordyceps is recommended when it comes to physical performance*. In TCM, Cordyceps is also used for lung-related issues like asthma or even seasonal allergies*.
Historical Use of Cordyceps Medicinal Mushrooms
Cordyceps has been described as a treasure in old Chinese medical books and Tibetan medicine. With hundreds of different species, it is a parasitic fungi that prey on insects. Traditional healers have recommended the medicinal fungus as a powerful tonic because it improves energy, appetite, stamina and endurance . The most well known species of cordyceps is Cordyceps sinensis the most expensive mushroom in the world costing over $20,000 per kilogram, sold almost exclusively in Asia. It is a rare combination of a caterpillar and a mushroom and found at high altitudes in the Himilayan Plateau.
Luckily, there is one type of Cordyceps species that can be cultivated commercially to produce a mushroom , and that is Cordyceps militaris. If you would like to dive deeper into the realm of this fungi, we have written an engaging and helpful guide about cordyceps supplements to help you be informed.
Stress Anxiety And Mild Depression
The most common neurological disorders truly start out small. These consist of garden-variety stress, anxiety, and mild depression issues basically, the fallout our bodies feel on a nervous level when we push ourselves too hard mentally and emotionally. That, or when we experience something negative or devastating.
But while these issues are so common for so much of the population, its a huge wonder that there arent more formal cures for these mild neurological disturbances, despite the big impact they can have on our lives from time to time: interfering with our work lives, routines, confidence, and even our energy levels.
They can even have an unwanted domino effect on other aspects of our health: such as reducing our energy levels, interfering with memory, and even causing us to lose cognitive function and focus. We may even find ourselves building distance between ourselves and loved ones.
Its only when these issues become perceptible on a physical level that mainstream health practitioners will take action: usually by prescribing antidepressants, therapy, and other changes. Though in many cases, these still dont handle the source of the problem.
This is why herbs and mushrooms of various kinds are becoming of increasing interest to scientists. Not only may they help alleviate symptoms, but they hold hope in some ways of resetting the body and even healing the neurological damage that is caused byor is causingthe imbalance in the first place.
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Cognitive Supplement Spotlight: Lions Mane
What is Lions Mane? Lions Mane is also known as Hericium erinaceus, found in North America, Europe and Asia. It is an edible fungus that has been used for a very long time in Traditional Chinese Medicine. This mushroom is rich in many bioactive compounds such as beta-glucan polysaccharides, hericenones and erinacine terpenoids, isoindolinoes, sterols and myconutrients. These are all neuroprotective. Lions Mane also has the ability to stimulate the production of nerve growth factor, which helps repair and renew neurons and supports myelination. It is used in cases of Alzheimers, Parkinsons, MS and other conditions.
Benefits of Lions Mane? There are many different benefits of Lions Mane. It is used to support the heart and circulatory system, protects against cancer, can improve digestive health and reduces inflammation. One of the main benefits of Lions Mane is that it enhances brain function. It impacts brain cells and brain function that can help with neurodegenerative diseases. Lions Mane also enhances neuron outgrowth meaning that the axons and dendrites from the neurons grow. Increasing their growth can potentially slow or reverse cell degeneration in conditions like Alzheimers and Parkinsons disease.
How Much Should I Take? For cognitive support and nerve injury, I recommend one capsule twice a day of the 500 mg dose.
Reishi Mushrooms As An Anti
New discoveries are constantly being made about Reishis multi-faceted anti-cancer effects.
Probably the most important anti-cancer property of the Ganoderma lucidum mushroom is its ability to boost the immune system enhancing monocyte, macrophage, and T-lymphocyte activity thereby boosting tumor immune surveillance.
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Other Benefits Of Reishi Mushrooms
This amazing mushroom has also been effective for protecting and improving cardiovascular function. 102
Regular use of Ganoderma lucidum lowers levels of LDL and VLDL cholesterol and triglycerides, inhibits clumping of platelets, lowers blood pressure, and in clinical studies, has been shown to reduce cardiac pain and arrhythmia and to help prevent arteriosclerosis.
Reishi can be of benet for people with asthma 108, 109, chronic obstructive pulmonary disorder, pulmonary fibrosis82, Lupus ,88 chronic pancreatitis,91 Crohns disease,101 and hepatitis B and C111 due to its anti-inammatory activity.
The Reishi mushrooms adaptogenic effects are mild and cumulative, but research shows it improves adrenocortial function and relieves stress.
One randomized, double-blind and placebo-controlled study with 132 patients diagnosed with neurasthenia , mild depression, and chronic fatigue and immune dysfunction syndrome took part in a study of Reishis effects on those conditions.
The group given a polysaccharide extract made from the mushroom reported signicantly higher reductions in fatigue and an improved sense of well-being compared with patients who were given a placebo. 81
Another interesting use for Reishi is to prevent and treat altitude sickness. It can be combined with Jiaogulan, Cordyceps, Ginger, and Rhodiola and should be taken for four to six weeks before visiting high-altitude locations.
What Aremedicinal Mushrooms
There are approximately 38,000 known species of mushrooms, at least 270 of which are known to possess therapeutic or medicinal properties. The use of medicinal mushrooms in the treatment of human illness dates back thousands of years notably, Li Shizhen included numerous fungi as effective treatments in his 1578 Compendium of Materia Medica, regarded by many as the most comprehensive medical work ever completed in the history of traditional Chinese medicine. Within the past several decades, foresters, pharmacologists, ecologists, and researchers in both the Eastern and Western world have dedicated much clinical research to the effectiveness of medicinal mushrooms and their numerous immunological, antioxidant, anti-metastatic, cardioprotective, and obesity management properties.
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Rna Isolation And Real
Total RNA was extracted from primary microglial cells using RNAprep Kit according to the manufacturer’s specifications. RNA was primed with random 9-mers and converted into cDNA by reverse transcription using AMV reverse transcriptase by following the manufacturer’s recommended protocol . The resulting cDNA was then subjected to real-time PCR with SYBR Premix Ex Taq containing a final concentration of 1× SYBR Green and 0.2M of the primer set of interest in a 20-l reaction. The PCR mixture was run in the DNA engine Opticon 2 . After an initial 10s 95°C denaturation step, the reaction was run through 35 cycles at 95°C for 5s, 60°C for 30s and 80°C for 1s. Melting curve analysis was executed to ensure the resulting products from the reaction had equivalent and appropriate melting temperatures. The specific primers used are listed in . The quantification of target transcripts was based on a calibration curve. The housekeeping gene -actin was targeted for an internal control gene. The test gene data were normalized by corresponding -actin data.
Multiple Components Target Aging Mechanisms
Reishi mushrooms have been used for medicinal purposes for at least 2,000 years.37 The mushrooms were known to the ancients as the mushroom of immortality37and for good reason. They had the reputation of promoting health and longevity, boosting the immune system, and reducing the risk of life-shortening conditions such as cardiovascular disease and cancer.38-41 Science has finally validated this traditional wisdom.
Originally, Reishi mushrooms were rare and expensive,38,42 but now advances in cultivation techniques have made these medicinal mushrooms more available which has led to an explosion of research on their properties and components.38,42
Studies have shown that Reishi mushrooms can contribute to longer life spans.1,2 They can help manage some of todays most troubling age-related conditions, including autoimmune diseases, neurodegenerative disorders, diabetes, liver disease, cancer, and more.
How is it that this simple mushroom can have such wide-ranging health effects? Keep in mind that there isnt one single cause of aging and disease. Numerous factors contribute to these conditionsmeaning that in order to combat them, you need to fight them from a multi-targeted approach. Thats exactly what makes Reishi mushrooms so powerful. The mushroom itself contains hundreds of biologically active moleculesall of which work together to have such broad-reaching health benefits.37
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