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Parkinsons Disease Pipeline Offers Promising New Options For Treatment

Trial of new treatment for Parkinson’s disease | 7.30

DelveInsights Parkinsons Disease Pipeline Insight report provides comprehensive insights about 150+ companies and 150+ pipeline drugs in the Parkinsons Disease pipeline landscapes.

Los Angeles, USA, Jan. 17, 2022 Parkinsons Disease Pipeline Offers Promising New Options for Treatment | DelveInsight

DelveInsights Parkinsons Disease Pipeline Insight report provides comprehensive insights about 150+ companies and 150+ pipeline drugs in the Parkinsons Disease pipeline landscapes.

The report comprises Parkinsons Disease pipeline drug profiles, including clinical and non-clinical stage products. It also includes the Parkinsons Disease therapeutics assessment by product type, stage, route of administration, and molecule type and further highlights the inactive Parkinsons Disease pipeline products.

Get an overview of pipeline landscape @ Parkinsons Disease Clinical Trials Analysis

Parkinsons Disease is a progressive disorder caused by degeneration of nerve cells in the part of the brain called the substantia nigra, which controls movement.

· Combination· Mono/Combination

Key Questions regarding Current Parkinsons Disease Treatment Landscape and Emerging Therapies Answered in the Pipeline Report

Important Points About The New Medications

With multiple new medications available for the treatment of PD, there is more hope than ever that Parkinsons symptoms can be successfully managed for many years. A few things to consider:

  • For people whose symptoms are difficult to control, these new treatments are welcome additions to what was previously available and many people with PD have been using these new medications with significant benefit.
  • On the other hand, many of the newly-approved medications have the same mechanisms of action as older medications so they are not breaking new ground in treating symptoms.
  • In addition, for some people, the effect on symptoms may be mild or not substantial.

These caveats may mean that your physician has not suggested a medication change for you. It is also important to note that despite all the new medications, carbidopa/levodopa remains the most potent medication to treat the motor symptoms of PD.

If your doctor does choose to try one of the new options, there may be multiple paths that your doctor can take when contemplating a medication adjustment. Often trial and error is the only way to determine the best medication regimen for you, so you may need to practice some patience as you work together with your doctor to determine what works or doesnt work.

Why Scientists Believe Theyve Made New Breakthrough In Parkinsons Disease Treatment By Building On Gdnf Research

The Finnish researchers are now working to improve the properties of BT13 to make it more effective as a potential treatment that could benefit many people living with the disease.

The study, which was published online yesterday in the journal Movement Disorders, builds on previous research on another molecule that targets the same receptors in the brain.

GDNF or glial cell line-derived neurotrophic factor is an experimental treatment for Parkinsons discovered in 1993 that has been shown to bring dying brain cells back to life and particularly effective in dopamine neurons.

It was the subject of a BBC documentary in February 2019 that followed a phase two trial in Bristol involving 42 patients. While the results werent clear cut, GDNF has shown promise to restore damaged cells in people with Parkinsons.

However, the GDNF protein requires complex robot-assisted surgery to deliver the treatment to the brain because its a large molecule that cant cross the blood-brain barrier a protective wall that prevents some drugs from getting into the brain.

BT13 is a smaller molecule that is able to cross the blood-brain barrier and therefore could be more easily administered as a treatment if shown to be beneficial in further clinical trials.

Dr Yulia Sidorova, lead researcher on the study, said: We are constantly working on improving the effectiveness of BT13.

Our ultimate goal is to progress these compounds to clinical trials in a few coming years.

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Strategies For The Treatment Of Parkinsons Disease: Beyond Dopamine

  • 1Laboratorio de Neurobiología, Facultad de Ciencias de la Salud, Universidad San Sebastián, Concepción, Chile
  • 2Department of Biological Sciences, University of Limerick, Limerick, Ireland
  • 3Health Research Institute, University of Limerick, Limerick, Ireland
  • 4Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO, United States
  • 5Research & Development Service, Bay Pines VA Healthcare System, Bay Pines, FL, United States

Parkinsons disease is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of intraneuronal -synuclein-positive inclusions. Therapies to date have been directed to the restoration of the dopaminergic system, and the prevention of dopaminergic neuronal cell death in the midbrain. This review discusses the physiological mechanisms involved in PD as well as new and prospective therapies for the disease. The current data suggest that prevention or early treatment of PD may be the most effective therapeutic strategy. New advances in the understanding of the underlying mechanisms of PD predict the development of more personalized and integral therapies in the years to come. Thus, the development of more reliable biomarkers at asymptomatic stages of the disease, and the use of genetic profiling of patients will surely permit a more effective treatment of PD.

Updates On Currently Approved Pd Treatments

Promising New Therapy For Parkinsons Disease  Southwest Florida

Table 1 Approved dopaminergic drugs

Later, DA receptor agonists, such as those shown in Table , were developed either as monotherapies or combination therapies with L-DOPA for the treatment of PD. Five types of DA receptors, D1D5, exist in the brain. The D1 and D5 receptors are grouped together as D1-like receptors based on their stimulatory effects on adenylyl cyclase , and the D2, D3, and D4 receptors are classified as D2-like receptors due to their inhibition of cAMP activity. Many synthetic DA agonists, including pramipexole and apomorphine, activate D2-like receptors, and have a lower incidence of motor fluctuations and dyskinesia .

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Glucocerbrosidase Enhancing The Cells Lysosomal System

GBAis a gene that increases the risk of developing PD. The GBA protein works in the lysosome, the garbage disposal system of the cell, breaking down cellular products that can be harmful to the cell. Having two abnormal GBA genes causes Gauchers disease, which is characterized by the buildup of these cellular products. This results in fatigue, bone pain, easy bleeding and an enlarged spleen and liver. When a person inherits only one abnormal gene, he or she does not develop Gauchers disease however, they do incur a small increased risk of PD. Most people with one mutated GBA gene do not develop PD.

Enzyme replacement therapy, in which the GBA protein is given intravenously, is available as a treatment for Gauchers disease. This protein is too big to cross the blood-brain-barrier however, and so it does not enter the brain and does not treat any symptoms caused by the abnormal buildup of cellular components in the brain. The following strategies were developed in an attempt to compensate for the effects of the GBA mutation in the brain:

  • Ambroxol, approved in Europe for respiratory illnesses, improves the function of GBA in neurons NCT02941822 and NCT02914366
  • These small molecules can cross the blood-brain-barrier and help decrease the amount of accumulated cellular products in the brain:
  • A gene therapy trial of PR001A which introduces the un-mutated GBA gene into the brain is also underway NCT04127578
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    New Treatment Offers Improved Quality Of Life

    Duopa has proven capable of addressing those problems.

    A gel form of levodopa and carbidopa developed by AbbVie Inc., Duopa is delivered by an external pump directly into the small intestine through a surgically placed tube. The Parkinsons patient wears a small pouch that holds the pump and a drug cartridge. The Duopa is delivered continuously at a consistent level for up to 16 hours according to a schedule programmed into the pump.

    Siddiqui said he monitored the efficacy of the drug and delivery system in Europe, where it has been in use under the name Duodopa since 2004. He directed the clinical trial of Duopa at Wake Forest Baptist as part of the multi-center study which led to its approval by the federal Food and Drug Administration in 2015.

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    How Is Parkinson’s Disease Treated

    No treatment can stop or reverse the breakdown of nerve cells that causes Parkinson’s disease. But there are many treatments that can help your symptoms and improve your quality of life.

    Your age, work status, family, and living situation can all affect decisions about when to start treatment, what types of treatment to use, and when to make changes in treatment. As your medical condition changes, you may need regular changes in your treatment to balance quality-of-life issues, side effects of treatment, and treatment costs.

    You’ll need to see members of your health care team regularly to adjust your treatment as your condition changes.

    Treatments for Parkinson’s include:

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    ‘Miracle’ Parkinson’s treatment to be trialled in Australia | 7NEWS

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    Current Parkinsons Treatments Cant Slow Down Onset Of Disease

    Parkinsons is a long-term degenerative disorder of the central nervous system, which mainly the area of the brain that controls movement leading to a slow onset of symptoms including tremors, rigidity and slow movement.

    More than 10 million people worldwide are estimated to be living with Parkinsons disease, according to the US-based Parkinsons Foundation, with the Parkinsons News Today website saying it affects 1,900 per 100,000 among those aged over 80,

    Typically, by the time people are diagnosed with the condition, they have already lost between 70% and 80% of their dopamine-producing cells, which are involved in co-ordinating movement.

    While current treatments mask the symptoms, there is nothing that can slow down its progression or prevent more brain cells from being lost.

    As dopamine levels continue to fall, symptoms get worse and new symptoms can appear.

    The Latest Treatment For Parkinsons Disease

    Inbrija is the latest treatment for Parkinsons disease. It was approved by the Food and Drug Administration in late 2018 after two decades of research and development. Inbrija is a new form of levodopa that allows systemic delivery of the medication through inhalation, allowing higher doses of medication to enter the bloodstream.

    This new drug from Acorda Therapeutics will treat the intermittent symptoms of OFF episodes on demand and comes in the form of a powder capsule and inhaler. Inbrija is the first and only inhaled levodopa medication to be approved for Parkinsons disease by the FDA. It is available by prescription through your doctor.

    The Michael J. Fox Foundation helped to fund the early development of this new treatment for Parkinsons disease due to the impact OFF periods have on patients lives.

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    Parkinsons Disease Market Size Will Achieve Usd 6705 Million By 2030 Growing At 115% Cagr

    Acumen Research and Consulting recently published report titled Parkinsons Disease Market Share, Analysis Report and Region Forecast, 2022 – 2030

    LOS ANGELES, Sept. 05, 2022 — LOS ANGELES, September 05, 2022 The Global Parkinsons Disease Market is expected to grow at a CAGR of around 11.5% from 2022 to 2030 and expected to reach the market value of around USD 6,705 Million by 2030.

    Parkinsons Disease Market Report Key Highlights

    Global Parkinsons disease market size was USD 2,540 million in 2021 and is expected to grow at CAGR of 11.5% from 2022 to 2030

    North America Parkinsons disease market is expected to lead with more than 35% market share

    According to the National Institute of Health estimates, there will be over 1.2 million people suffering from Parkinsons in the US by 2030

    Asia-Pacific Parkinsons disease market is expected to grow with fastest CAGR during the forecast period from 2022 to 2030

    Among drug classes, carbidopa/levodopa occupied more than 30% of the total market share

    Parkinsons Disease Market Regional Scope

    North America, Europe, Asia Pacific, Latin America, and Middle East & Africa

    Key Companies Profiled

    Teva, Novartis AG, GSK, AbbVie, Merck, Boehringer Ingelheim, Impax Laboratories, Lundbeck, UCB, Valeant Pharmaceuticals, Acadia, and among others.

    Report Coverage

    COVID-19 Impact on the Global Parkinsons Disease Market Revenue

    Parkinsons Disease Market Dynamics and Opportunities

    Parkinsons Disease Market Segmentation

    Researchers From Johns Hopkins Create A Nanobody Capable Of Penetrating Brain Cells And Preventing Misshapen Proteins From Spreading Halting The Progression Of Neurocognitive Diseases

    New immunotherapy could stop progression of Parkinsons disease

    Image caption: The structure of alpha-synuclein clumps was disrupted by the nanobody PFFNB2. The debris from the disrupted clump is shown on the right.

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    Researchers from the Johns Hopkins University School of Medicine have helped develop a nanobody capable of getting through the tough exterior of brain cells and untangling misshapen proteins that lead to Parkinson’s disease, Lewy body dementia, and other neurocognitive disorders.

    The research, published last month in Nature Communications, was led by Xiaobo Mao, an associate professor of neurology at the School of Medicine, and included scientists at the University of Michigan, Ann Arbor. Their aim was to find a new type of treatment that could specifically target the misshapen proteins, called alpha-synuclein, which tend to clump together and gum up the inner workings of brain cells. Emerging evidence has shown that the alpha-synuclein clumps can spread from the gut or nose to the brain, driving the disease progression.

    The researchers had to shore up the nanobodies to help them keep stable within a brain cell. To do this, they genetically engineered them to rid them of chemical bonds that typically degrade inside a cell. Tests showed that without the bonds, the nanobody remained stable and was still able to bind to misshapen alpha-synuclein.

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    Multifunctional Agents With D2/d3 Receptor Agonist Antioxidant Or Iron Chelating Activities

    Compared with ropinirole, D512 exhibits superior peak-dose efficacy and longer duration effects in improving the rotational activity in the 6-OHDA-induced unilaterally lesioned rat model despite having similar side effects, including drug-induced dyskinesia. In addition, D512 protects dopaminergic MN9D cells from MPP+- and 6-OHDA-induced toxicity, inhibits lipid peroxidation and caspase 3/7 activity, and rescues 6-OHDA-induced changes in nuclear morphology. Moreover, D512 protects rat adrenal pheochromocytoma PC12 cells from 6-OHDA-induced apoptotic cell death and rescues dopaminergic neurons in the MPTP mouse model of PD. Furthermore, D512 displays neuroprotective effects against oxidative insult produced by buthionine sulfoximine, an inhibitor of glutathione synthesis, and 6-OHDA in PC12 cells.

    The Shift From Research On Symptomatic Therapy To The Search For Parkinsons Disease

    Based on these findings, the majority of cases with PD were assumed to present an alpha-synucleinopathy. Drug development shifted its focus from transmitters, transmitter-related receptor agonists and antagonists, and transmitter-synthesizing and -degrading enzymes to the protein chemistry, synthesis, transport, aggregation, and degradation of alpha-synuclein and other proteins related to neurodegenerative disorders, such as MAP-Tau or beta-amyloid. A now-20-year-long effort in neuroscience and drug development appears to provide the first results.

    This article summarizes the recent achievements to further improve symptomatic therapy of motor PD symptoms, the still-limited attempts to provide symptomatic therapy for NMSs in PD, and the advances in the development and clinical testing of compounds, which promise to offer disease modification in already-manifest PD. However, prevention is still a dream and one reason for this is that we have no consensus on primary endpoints for clinical trials, which reflect the progression in prodromal stages of PD, such as in rapid eye movement sleep behavior disorder , the most specific prodromal stage of PD a methodological challenge to be met in the future.

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    Component #3 Some Form Of Restorative Therapy

    Once the condition has been slowed/halted and a neuroprotective/nurturing environment is in place to protect the remaining cells , a curative treatment for Parkinsons will require replacing some of the cells that have been lost.

    And until we have developed methods that can identify Parkinsons long before the motor features appear , some form of cell replacement therapy is required to introduce new cells to take up lost function.Cell transplantation currently represents the most straight forward method of cell replacement therapy.

    Cell Transplantation

    Traditionally, the cell transplantation procedure for Parkinsons has involved multiple injections of developing dopamine neurons being made into an area of the brain called the putamen . These multiple sites allow for the transplanted cells to produce dopamine in the entire extent of the putamen. And ideally, the cells should remain localised to the putamen, so that they are not producing dopamine in areas of the brain where it is not desired .

    Targeting transplants into the putamen. Source: Intechopen

    Transplanted dopamine neurons. Source: Sciencedirect

    The transplanted cells take several years to develop into mature neurons after the transplantation surgery. This means that the actually benefits of the transplantation technique will not be apparent for some time . Once mature, however, it has also been demonstrated that these transplanted cells can produce dopamine.

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