Thursday, July 18, 2024

Focused Ultrasound Therapy For Parkinson’s

What Is The Success Rate Of Fus Treatment

Using Focused Ultrasound to Treat Parkinson’s Disease

While there is still no cure for Parkinsons or Essential tremor, FUS represents an excellent method of controlling the tremor in these disorders. Out of the patients treated thus far at Sheba, 92% have shown improvement of tremor on a clinical disability scale. This includes such dramatic effects as being able to write effectively after treatment.

If you or a loved one is suffering from the significant tremor caused by Essential tremor or Parkinsons disease, contact Sheba right away to learn more about FUS treatment.

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What Are The Benefits And Advantages Of Mr

Using this procedure:

  • No holes are made in the skull
  • No hardware/device are implanted
  • No general anesthesia is used
  • Theres no risk of infection or bleeding that would be present with incision-based procedures
  • Physicians can determine if treatment is working in real time during the procedure as well as stop if adverse effects occur

Three Advantages Of Mrgfus For Pd Tremor

MRgFUS is a noninvasive outpatient procedure. No scalpel is needed to cut skin, no drill is needed to bore a hole in the skull, and nothing is implanted in the brain. Its three main advantages for PD-related tremor are:

  • No infection risk associated with surgical thalamotomy or surgical implants
  • Test sonications to confirm precise targeting prior to full ablation
  • When successful, the results are immediately evident.
  • A few words of caution: MRgFUS is not effective in every case. As with MRgFUS for ET, treatment will be directed to the hand in which tremor is worse, since treating both hands increases the risk of side effects. Clinical studies show that some patients have short term side effect such as headaches, dizziness or nausea but these quickly resolve. However, the effect may not be durable. Patients who have suffered with significant tremor for years may experience less effective tremor control, or gradual recurrence of tremor. Finally, MRgFUS does not cure PD, nor will it have an effect on other PD-related problems.

    However, the consensus among researchers is that MRgFUS is a very promising treatment for PD-related tremor, especially as an alternative to invasive surgical procedures. If you or a loved one suffers from severe PD tremors, contact the Sperling Medical Group for more information about MRgFUS.


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    What Happens During Mri

    Before your procedure you will have an MRI, which your care team will use to pinpoint the area of your brain to be treated.

    During the treatment, you will lie in an MRI scanner with your head fitted into a water-filled helmet. The helmet circulates cool water around your head to prevent overheating during the ultrasound. The energy is first applied at a low level and your doctor will ask you to provide feedback on the effect it has on your hand tremor.

    You will be engaged throughout the process and may be asked to report the sensations you feel and to perform tasks such as writing or tracing lines to monitor improvement of your tremor. Your doctor will then adjust the focused ultrasound treatment in response to your input, increasing the energy level to perform the amount of ablation needed.

    The focused ultrasound energy waves pass through the helmet to meet at the identified point in your brain. The energy makes a small lesion in the brain, targeting the tissue where the tremors originate.

    After treatment, youll be moved to a recovery room for monitoring. Most patients go home the same day. Many return to work and other activities within a couple of days. You will receive specific discharge instructions from your doctor.

    Patient Story: Focused Ultrasound And Parkinsons Disease

    Pin on Focused Ultrasound for OCD and Depression

    It all started with a tiny tingle and I worried it was a sign of something bigger.

    I was at a chili taste-testing contest when I reached to pick up a glass of hot apple cider and my baby finger tingled.

    In that moment, I was concerned it was Parkinsons disease.

    I had a feeling because my dad had had Parkinsons.

    Over time I began noticing changes. My hand and arms started to tremor and my handwriting got progressively worse.

    When my neurologist first gave me my diagnosis, I didnt want to believe it was Parkinsons. I wanted to fight it and beat it.

    I still do.

    Right now, there is no cure for Parkinsons disease. Its a progressive disease and its symptoms such as stiffness and tremor worsen over time. Each person with Parkinsons disease, experiences it differently.

    For me, living with Parkinsons is a challenge. My main symptom is dyskinesia, which can include fidgeting or body swaying. My body isnt always doing exactly what I want it to do. Each day is different and depends on how my body is reacting to the medication that Im taking to help ease my symptoms.

    I ended up retiring early from my job as a private school secretary. Day-to-day tasks take a bit longer to do, but I want to do things myself and I just take breaks when I need to.

    The first participant of a world-first clinical trial

    While some parts of my life are different, what hasnt changed for me is how determined I am to help in the search for a treatment or cure for Parkinsons disease.

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    A New Era For Parkinson’s Disease Treatment

    “A diagnosis of Parkinson’s disease no longer automatically portends a future of extremely limited physical capabilities. Thanks to the commitment of researchers like Dr. Eisenberg and Dr. Fishmanand clinical trial participants like Steve Squirestreatment has expanded to include non-invasive options that significantly reduce certain symptoms within minutes and transform the lives of people who had been living with debilitating symptoms,” said Bert W. O’Malley, MD, President and CEO of the University of Maryland Medical Center.

    “Our school of medicine researchers have established themselves as world leaders in pioneering MRI-guided focused ultrasound for many devastating brain diseases, including Parkinson’s and essential tremors,” said E. Albert Reece, MD, PhD, MBA, Executive Vice President for Medical Affairs, UM Baltimore, and the John Z. and Akiko K. Bowers Distinguished Professor and Dean, University of Maryland School of Medicine. “The stellar work of Dr. Eisenberg and Dr. Fishman has led to a new era in which this breakthrough modality has now become the standard of care for patients looking for less invasive treatments for their symptoms.”

    Are There Patients Who Are Not Candidates For Mr

    This procedure may not be suitable if you:

    • Have any type of metal implant, such as pacemakers, neurostimulator, spine or bone fixation devices, total joint replacements that are not MRI compatible.
    • Have extensive scarring on your scalp.
    • Have tumors inside the skull.
    • Are on dialysis.
    • Have an active infection or severe blood, brain, or other uncontrolled disease.
    • Cannot tolerate lying still on a table for up to 4 hours.
    • Are not able to stop antiplatelet or anticoagulation therapy.

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    A New Tool To Manage Tremor

    Claire Bale, Head of Research Communications and Engagement, comments:

    “Tremor is one of the main symptoms of Parkinson’s, a condition which affects around 127,000* people in the UK.

    “Current Parkinson’s drugs can help to manage tremor and a surgical approach called deep brain stimulation can also be effective.

    “However, these treatments do not work for everybody and there is an urgent need to improve the range of therapeutic options available to help people manage this debilitating symptom.

    “The development of focused ultrasound techniques offers a new and promising tool for treating tremor.

    “It is particularly attractive because this therapy could provide similar benefits to deep brain stimulation but without the need for invasive brain surgery.”

    How Does The Focused Ultrasound Reduce Tremor

    Focused Ultrasound for Parkinson’s Disease: A Conversation with the Experts

    For essential tremor and Parkinsons disease, over 1,000 highly focused beams of ultrasound are concentrated on a specific area in the brains thalamus. The thalamus in the brain is a relay station of motor and sensory signals. Essential tremor and Parkinsons disease cause the thalamic circuitry to become abnormal, which results in tremors. The heat from the ultrasound causes a tiny burn or lesion on the targeted spot on the thalamus. Creating the tiny burn or lesion interrupts the abnormal activity, which relieves the tremors associated with these diseases.

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    Focused Ultrasound For Essential Tremor And Parkinsons

    OHSU is the only Oregon hospital to offer focused ultrasound for essential tremor and tremor-dominant Parkinsons disease. This life-changing treatment improves tremor symptoms for most patients right away. Benefits include:

    Advanced technology thats safer for you. This treatment combines ultrasound with MRI. This means we can do surgery without an incision while youre awake. No cutting means no risk of problems like infection. Being awake means no anesthesia and you can see results in real time.

    Improves your quality of life. Most patients have reduced tremor symptoms on one side right away. For more than 75% of patients, improvements were still there three years later.

    Outpatient procedure. Most patients return to daily activities within a day. Temporary side effects of the treatment stop within a week.

    To schedule an evaluation for focused ultrasound treatment for essential tremor or tremor-dominant Parkinsons disease, call our clinic at , or email us at .

    How Does Fus Work

    The procedure uses focused ultrasound waves to precisely destroy targeted brain tissue that is abnormal in patients with tremor due to Parkinsons disease or Essential Tremor.FUS carries no risk of infection and is guided by MRI allowing extremely high spatial accuracy as well as excellent control of heating of the target brain tissue.To allow the safe transmission of ultrasound energy the head needs to be completely shaven. To allow the accurate treatment a frame is used to fixate the patients head to the special ultrasound helmet and treatment system.

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    Why Choose Us For Mri

    The University of Kansas Health System is the only medical center in the region that provides MRI-guided focused ultrasound to treat essential tremor and Parkinsons disease with hand tremor as the primary symptom. Our health system is 1 of only 47 medical centers around the world that the Parkinsons Foundation has designated a Center of Excellence for Parkinsons disease care.

    When you choose The University of Kansas Health System for MRI-guided focused ultrasound, you will be cared for by a team of neurologists who are specialists in their fields. A dedicated nurse navigator will help you as you go through the processes needed leading up to your treatment. Our neurology and neurosurgery program is nationally ranked by U.S. News and World Report.

    Focused Ultrasound Shows Promise For Parkinsons Disease

    Ultrasound is poised to revolutionize treatment for ...

    Jeff Elias, MD, pioneered the use of focused ultrasound for the treatment of essential tremor and Parkinsons disease.

    A scalpel-free alternative to brain surgery has the potential to benefit people with Parkinsons disease symptoms that are much more severe on one side of the body, new research suggests.

    More testing is needed, but the approach, which uses a technology called focused ultrasound, could offer a new option for patients whose symptoms are poorly controlled by medications and those who cannot or do not wish to undergo traditional brain surgery.

    This small brain region, the subthalamic nucleus, had a very strong and potent effect on Parkinsonian symptoms when we targeted it with precise, focused ultrasound energy, said researcher Jeff Elias, MD, a neurosurgeon at UVA Health and a pioneer in the field of focused ultrasound. The key for the ultimate adoption of this new procedure will be further refinements of the technology to ensure reliability and safety.

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    How Does Focused Ultrasound Work

    We use ultrasound to ablate the part of your brain that causes tremor. Using ultrasound means:

    • No incisions. This technology lets us perform brain surgery without any cutting. This means no risk of bruising, bleeding or infection.
    • Precision and accuracy. This technology lets us create a small lesion in the exact right place. Thousands of ultrasound waves come together in one place smaller than a millimeter. This creates enough heat to cause a lesion.
    • Immediate feedback. Throughout the procedure, we test for improvement of your tremor symptoms so we know exactly when the procedure is complete.

    How Do I Know If I Am Eligible For Treatment

    Your doctor is the best person to ask about this. He or she will be able to tell you if you are a suitable candidate. In general, people who cannot go into an MRI will not be able to go through the treatment this includes patients with metallic implants, patients who are claustrophobic and patients who are allergic to contrast agents a dye used during MR imaging, patients who are over 300 lbs and patients who are under 22 years of age.

    • If you have any kind of metallic implants, such as pacemakers, neurostimulators, spine or bone fixation devices, total joints, metal clips, screws, etc., you may not be a candidate. Any metallic implants must be non-magnetic to prevent injury to the patient from the MRs strong magnetic field.
    • If you are not generally healthy enough to withstand the treatment and lie still in the same position for approximately 3 hours, you may not be a suitable candidate for this treatment.
    • If you have had a recent myocardial infarction or have congestive heart failure , unstable angina pectoris , or spinal conditions, are you should discuss these issues with your doctor.
    • If you have extensive scarring on the scalp, you may not be a good candidate.
    • If you have any tumors inside the skull, you may not be a good candidate.
    • If you are on dialysis, you may not be a good candidate.
    • If you have an active infection or severe hematological, neurological or other uncontrolled disease, you may not be a good candidate.

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    What Neurologic Conditions Can Be Treated With Mr

    The U.S. Food and Drug Administration has approved focused ultrasound for the following conditions:

    • Essential tremor. MR-guided focused ultrasound is approved for the treatment of essential tremor that cannot be controlled with medication. Approval is for treatment of one side of the brain only. Patients must be at least 22 years of age.
    • Tremor-dominant Parkinsons disease. MR-guided focused ultrasound is approved to treat patients with Parkinsons disease whose main symptom is tremor. Patients must be at least 30 years of age.

    Use of MR-guided focused ultrasound is being explored for other neurologic conditions including the tremors associated with multiple sclerosis, epileptic seizures that cannot be controlled by other treatment approaches, other movement disorders, stroke, brain tumors and neuropathic pain. Treating these other conditions is considered experimental at this time.

    Mr Guided Focused Ultrasound

    Focused Ultrasound for Essential Tremor and Parkinsons

    An Incisionless Treatment for Essential TremorMR Guided Focused Ultrasound is a treatment for essential tremor or tremor-dominant Parkinsons disease patients who have not responded to medication. Requiring no incisions, permanent implants, or radiation exposure, it uses focused sound waves guided by MRI to pass through skin, muscle, fat, and bone to treat deep in the brain.

    How Does the Procedure Work?During the procedure, ultrasound waves are focused on a small point in the brain–passing safely through the skull without the need for an incision. The temperature at the target rises high enough to create a microscopic ablation or burn, providing a therapeutic effect.

    Where Does the Procedure Take Place?The whole procedure is conducted inside of an MRI scanner at Mount Sinai West. Serving as the eyes of the treatment, the MRI enables your physician to plan, guide, and precisely target the area for treatment. It also acts like a thermometer, providing continuous temperature monitoring to verify that only the targeted tissue is destroyed.

    Will My Tremors Go Away?Based on the current scientific literature, most patients get a 50 to 80 percent reduction in tremor maintained for up to three years.

    Is This Treatment Right for Me?To determine if MR Guided Focused Ultrasound treatment is right for you, please make an appointment with the Center for Neuromodulation for a consultation.

    For more information, please reach out to Tiffany Arnold, or 212-523-8130.

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    Rapid Reversal Of Symptoms

    Focused ultrasound is a completely incisionless procedure, performed without the need for anesthesia or an in-patient stay in the hospital. Patients, who are fully alert, lie in a magnetic resonance imaging scanner, wearing a specialized energy conversion helmet for the procedure. Ultrasonic energy is targeted through the skull to the globus pallidus, a structure deep in the brain that helps regulate voluntary movement. MRI images provide doctors with a real-time temperature map of the area under treatment.

    Often before the procedure is even completed, patients experience relief from severe symptoms such as tremors, rigidity in the legs and arms, and side effects from medications that cause involuntary, erratic movements called “dyskinesia.”

    About one million Americans have Parkinson’s disease, a neurodegenerative disorder that affects brain cells or neurons in a specific area of the brain that produce the brain chemical dopamine. Other current treatments for Parkinson’s include medications and deep brain stimulation from surgically implanted electrodes.

    Fus: Principles Of Operation

    Similar to light waves, ultrasound waves can be focused using either single element concave transducers or electronically controlled phased arrays, comprised of large numbers of much smaller piezoelectric transducers. By doing so, their energy can be concentrated up to 3 orders or magnitude in to a small ellipsoid volume at the focus, resulting in a high-intensity field. As a result, energy levels typically used in physical therapy with nonfocused transducers are capable of raising the temperature of the tissues within seconds to 60 °C or greater, when focused, to induce denaturation of cell proteins and, ultimately, coagulative necrosis. However, in the intervening tissues the width of the beam is much broader, and so corresponding intensities are lower. As a result, energy absorption is also lower and the deleterious effects of the exposures do not occur .

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