Sunday, March 3, 2024

Cialis And Parkinson’s Disease

Activity Should Not Matter

Sexual Dysfunction in Parkinson’s Disease

Sexual desire and sexual activity remain an essential part of life for both older men and women. Sexual dysfunction for the general population and for persons with PD can be frustrating and very disabling. Sexual dysfunction contributes to a lower quality of life. Indeed, an active sexual life can be considered a surrogate for general health. In the PRIAMO study, men with PD who had better sexual activity had fewer problems with their motor symptoms, less issues from depression, and an overall better quality of life.

New Study Shows Cialis Assists Men With Problems Ejaculating And Achieving An Orgasm Despite The Severity Of Their Ed

NEW YORK New data suggests the erectile dysfunction drug Cialis may also be beneficial in helping men who have problems with ejaculation and orgasm, report researchers from NewYork-Presbyterian Hospital/Weill Cornell Medical Center in the February issue of the British Journal of Urology International. Cialis is currently approved for the treatment of ED, benign prostate hypertrophy and for treatment of men with both conditions.

Their study, a meta-analysis of 17 double-blind, placebo-controlled clinical trials of men with ED, is the first to analyze the benefit an agent like Cialis offers for common issues of sexual dysfunction that may have little to do with ED. Their study concluded that approximately 70 percent of men who used Cialis during sexual activity for 12 weeks were able to ejaculate most of the time and to reach orgasm, compared to 30 percent in the placebo group. Also, these benefits from the drug were seen despite the level of a man’s ED severity.

“There are many men who have, at most, very mild problems achieving an erection but who cannot easily ejaculate,” says the study’s lead author, Dr. Darius Paduch, a urologist and male sexual medicine specialist at NewYork-Presbyterian/Weill Cornell and director of Sexual Health and Medicine at Weill Cornell Medical College. “Our study shows Cialis works very well for these men with problems ejaculating.”

Psychological Issue: Depression And Sex

With diagnosis and decreased physical capacity, a persons sense of self is disrupted with Parkinsons. Parkinsons itself can cause changes in the brains chemicals that impact ones mood and well-being. Depression can affect up to 40 percent of those with Parkinsons. This is important to realize since sexual disorders may be due to the depression that can come with Parkinsons diagnosis more than by the actual disease itself. The antidepressant medications that may be administered can also result in sexual dysfunction.

Other emotional issues for those who have Parkinsons, which may result in sexual difficulties, include: anger, stress, grief, and mental fatigue. An individual grappling with Parkinsons may experience reduced self-esteem, which can inhibit ones sexuality. Such is made even more difficult by the body image problems that can arise, due to issues like changes in skin texture or the body smell that results from consuming Parkinsons drugs.

The partner of a person with Parkinsons can also have trouble coping with the situation. Issues that may arise include:

  • Fatigue and resentment in taking on more responsibility.
  • Dealing with their own feelings related to a partners diagnosis, like fear, anxiety, and depression.
  • Loss of attraction and sexual interest due to the symptoms of PD, e.g., involuntary movements or changes in appearance, like the lack of facial expression.

Also Check: Drugs Prescribed For Parkinson’s Disease

In The Name Of Jest: Ron Lal Takes On Cervantes With Cervantina

The Madrid-based theatre ensemble Ron Lalá arrives to these shores to perform four nights at Teatro Colón with a lyrical take of Miguel de Cervantes texts.

From April 26 to 29, Cervantina, blends literature with humour, music, poetry, under the direction of Yago Cáceres and with five actors interpreting short pieces by Miguel de Cervantes Saavedra, author of the canonical Don Quixote. For Cáceres the challenge is to share with the audience, through the permanent play of theater, the bitter joy, the sharp smile, the beauty of the language unleashed.

As an initiative to promote reading during the week in which Bogotá hosts the 30th edition of its International Book Fair , the Teatro Colón invited the award-winning actor and director Yayo Cáceres to host a workshop for actors from April 26 to 29 in the Mallarino hall of this iconic venue.

With striking choreography, period music and plenty of tongue-twisting riddles, Cervantina will delight spectators who may not be familiar with the Cervantes lesser known works, such as El Celoso Extremeño , La Galatea, Persiles and Segismunda.

While Cervantes is considered the father of the modern novel, he was also a prolific playwright and poet. His life was also as colourful as the gentleman and squire of his celebrated work, who set out from their village on the arid plains of La Mancha to discover the world.

Teatro Colón Calle 10 No.5-32

Male Sexual Disorders In Patients With Parkinson Disease: Treatment With Natural Remedies

Use Of Cialis With Parkinsonism : Parkinsons and Sex

Kameni Poumeni Mireille,

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Department of Animal Biology and Physiology, University of Yaounde I, Cameroon

Correspondence: Kameni Poumeni Mireille, University of Yaounde I, PO BOX 812, Yaounde, Cameroon, Tel 237 699 288 365

Citation: Mireille KP, Desire DDP, Pierre K. Male sexual disorders in patients with parkinson disease: treatment with natural remedies. Adv Tissue Eng Regen Med Open Access. 2017 3:355360. DOI: 10.15406/atroa.2017.03.00061

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Cialis: Not Always Suitable

Cialis, like all other PDE5 inhibitors, affects blood vessels and smooth muscle in other parts of the body, not just the penis which is why it is important to talk to a doctor BEFORE you take Cialis.

An erection is a complex process that depends on the well coordinated interaction of your brain, nerves, hormones and blood vessels to be successful. Erectile dysfunction can be an early warning sign for serious conditions such as diabetes or coronary heart disease.

It may also be a sign of stress or anxiety, a side effect of certain pills, or an early symptom of a neurological disorder such as Multiple Sclerosis or Parkinson’s Disease. Smoking, being overweight and excessive alcohol intake can all negatively impact on sexual function as well. Which is why an initial assessment by a doctor is so important. Your doctor will conduct a physical exam and possibly run a few tests to attempt to find a cause for your ED. For most men, the cause is usually found to be a combination of medical and psychological issues.

There are other effective treatment options for ED if your doctor subsequently advises you not to take Cialis or any other PDE5 inhibitor. Ask your doctor about alternative ED treatments or visit a men’s health clinic for more specialized advice.

Erectile Dysfunction And Problems With Ejaculation

Are your PD motor symptoms well controlled? Poorly controlled motor symptoms negatively affect sexual function, both physically and psychologically.

Do you take any medications that can negatively impact your sexual function? Review the list of medications with your doctor and determine if some may be causing the problem and if they can be replaced or stopped.

Discuss medication treatments by mouth. Medications called phosphodiesterase inhibitors can improve erection in most people with PD. It is crucial to discuss if you qualify to use these medications. They should not be used if you have low blood pressure or low blood pressure when standing up a common problem in PD.

Discuss injectible medication treatments. A medication to treat erectile dysfunction can be injected directly into the shaft of the penis . The effect lasts from 2 to 4 hours and is safe in people with low blood pressure. It requires hand dexterity to inject, which can be a problem for some people, though the bed partner can inject it.

Discuss mechanical devices. These include vacuum devices and constriction bands. Please take into account that these devices require varying levels of hand dexterity for use.

Discuss penile prosthesis. In some cases, following a urological specialist consultation, you might consider a penile prosthesis implantation . This approach can provide controlled erections without the use of repetitive injections. Surgical intervention is required.

Read Also: Parkinson’s Disease Research Paper

The Heart Of The Matter: Cardiovascular Effects Of Parkinsons Disease

It has long been understood that Parkinsons disease does not just cause movement symptoms, but also causes a litany of non-motor symptoms with effects throughout the body. One of the organ systems that is affected is the cardiac system, encompassing the heart, as well as the major and minor blood vessels. I received this topic as a suggestion from a blog reader and we will be discussing this important issue today. Please feel free to suggest your own blog topic.

Oncotelic To Acquire Late

Dr. David Samadi – Vitamin D Deficiency & Sexual Dysfunction

AGOURA HILLS, Calif., Sept. 01, 2021 — Oncotelic Therapeutics, Inc. , executed a binding term sheet with Autotelic Inc. to license AL-101 . Oncotelic intends to develop AL-101 via fast-to-market 5052 regulatory pathway for Parkinson Disease and Erectile Dysfunction , especially phosphodiesterase 5 non-responders. AL-101 will also be developed as a new drug against Female Sexual Dysfunction , including Hypoactive Sexual Desire Disorder . AL-101 has a favorable safety and efficacy profile and is phase 3 ready with six clinical trials completed and over 200 patients treated.

“The acquisition of AL-101, expands Oncotelics product portfolio to the fast to market 5052 regulatory pathway. AL-101 has many of the same properties necessary to replicate the successes I had with the 5052 route for Abraxane at Abraxis and Cynviloq at Igdrasol. I am impressed with its marked improvement on quality of life for PD patients and look forward to working with pts and healthcare professionals in PD. said Dr. Vuong Trieu, CEO and Chairman of Oncotelic.

About Parkinson Disease :

Over 60,000 new patients being diagnosed with PD in the United States and currently there are over 1 million patients in the US and expected to increase to over 1.2 million by 2030. In addition, approximately 10 million suffer from this disease globally. .

About Erectile Dysfunction

About Female Sexual Dysfunction :

About Oncotelic Therapeutics

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Mixing Nitrates And Cialis Can Be Dangerous

Cialis should not be taken with nitrates such as nitroglycerin , isosorbide dinitrate or isosorbide mononitrate.

Nitrates dilate blood vessels around the heart and are used in conditions such as angina and coronary artery disease. Combining Cialis, or any other pill for erectile dysfunction, with a nitrate could cause a massive and potentially fatal drop in blood pressure. Recreational drugs such as amyl or butyl nitrate may also have this effect when mixed with Cialis.

Men with other kinds of heart problems, liver or kidney problems, eye diseases, stomach ulcers, a deformed penis, or blood disorders may also not be candidates for Cialis. Anybody who experiences an allergic-type reaction after taking Cialis , or who develops symptoms such as chest pain, dizziness, or nausea during sex should seek urgent medical advice.

Understanding The Neurologic Control Of The Cardiac System

Before we explore this issue, lets first learn a bit about the autonomic nervous system and about the cardiac systems place within it. The ANS is part of the peripheral nervous system, a network of nerves throughout the body. The ANS exerts control over functions that are not under conscious direction such as respiration, heart function, blood pressure, digestion, urination, sexual function, pupillary response, and much more. The ANS is further subdivided into the parasympathetic nervous system and the sympathetic nervous system. Both the parasympathetic and sympathetic nervous systems regulate most major organs. Often, they have opposite effects, with the sympathetic nervous system activating a system and the parasympathetic system calming it down.

One of the systems controlled by the ANS is cardiac regulation. Blood pressure sensors, known as baroreceptors, reside in the heart as well as in the carotid artery, the major artery in the neck. If the baroreceptors sense a change in the blood pressure, a signal is sent to particular areas in the brain. From there, the autonomic nervous system sends signals to the heart to control heart rate and cardiac output. Signals are also sent to the blood vessels to change the size of their diameter, thereby regulating blood pressure.

Also Check: How To Test Yourself For Parkinson’s

Cialis For Managing Sex Problems Caused Due To Parkinsons Disease

Cialis for managing sex problems caused due to Parkinsons disease

The number one problem arising out of Parkinsons disease is erectile dysfunction. Sufferers of this disease will have to face the sexual problems at some point in their life. Aside from sexual problems like ED, Parkinsons disease is also known to trigger tremors and rigidity which also contribute to not being able to have sex properly. Unlike the previous times, people are more open to discussing this topic thus paving way for healthy and affordable solutions to ED. People afflicted with ED have improved their sexual life by treatment with Cialis. Purchasing and taking Cialis from authentic Canadian pharmacies has benefited a larger group of people to come out of their sexual problems.

Cialis and ED

The dosage and timing can be double checked with a doctor so the ED med works well and does not interfere with the Parkinsons disease. If the disease is associated with autonomic nerve dysfunction then Cialis or any other PDE5 inhibitors must be taken with great caution because there is a risk of a decrease in blood pressure. So, it is always best to just consult a doctor before using Cialis. You will have adequate protection when you suffer from dizziness or a headache if you take the first dose under the supervision of a doctor. There is no need to be embarrassed about your situation because ED is the most common sexual problems in the current time.

Does Cialis work for both genders?

How Does Parkinsons Disease Play A Part In Erectile Dysfunction In Men

What Causes Erectile Dysfunction (E.D)?
  • Male impotence, otherwise known as erectile dysfunction , refers to difficulty with achieving and maintaining an adequate erection.
  • Many men have benefited from the release and widespread use of ED treatments.
  • While these medications are contraindicated in certain heart conditions, they are generally safe to use in combination with antiparkinsons medicines and more effective in younger age groups.
  • As with other non-motor symptoms, the doctor or other healthcare provider should consider other causes of impotence and decreased libido, including poor circulation to the genitals that commonly occurs in diabetes and peripheral vascular disease, enlarged prostate, depression and other medical conditions.
  • Erectile dysfunction warrants a thorough evaluation so the physician or other healthcare provider can look for all possible causes, especially diabetes and other disorders listed above.
  • The general physician and urologist should conduct a complete physical examination.
  • The list of drugs available to treat ED has been upgraded in the last decade from those that must be injected into the penis to oral preparations.

Recommended Reading: How Is Parkinson’s Disease Associated With Headaches

Physical Issues Of Your Sex Drive

Parkinsons affects ones autonomic nervous system, which controls sexual response and functioning. Parkinsons acts upon neurons in the brains substantia nigra, causing dopamine-producing nerve cells to die. Since dopamine is a chemical that transmits signals between parts of the brain that usually coordinate smooth muscle movement, this is critical to sexual function on two fronts.

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First, this dopamine drop may result in a decreased sex drive and sexual interest. Second, the lower levels of dopamine that result are believed to cause ones loss of balance, changes in walking pattern and posture, muscle rigidity, Bradykinesia , and tremors when resting. The symptoms of Parkinsons can also be seen in:

Treatment Modalities For Sexual Dysfunction In Parkinsons Disease

Given the high prevalence of SD in patients with PD, physicians and other healthcare providers should discuss and treat sexual health issues as an integral part of treating the disease. In all instances, drug regimens should be reviewed for possible effects on sexual function. Sexual education, counselling and specific suggestions about therapeutic methods are important, and should be provided by the treating physician.

In a newly diagnosed patient with PD the possible enhancing influence of dopaminergic treatment on sexuality should be discussed with both partners. The improved libido in the male PD patient may be unwelcome, as the elderly spouse has already settled in a situation of not being bothered. The emergence of hypersexuality in the treated PD patient is, as a rule, drug induced, and modification of treatment is helpful. Profound loss of libido in the well-treated PD patient may call for an endocrinological consultation if it causes distress.

In a newly diagnosed PD patient who present with SD, the dopaminergic drugs should be introduced first, and their effect followed up. Occasionally, the SD will also improve. Difficulties with the motor aspects of the sexual activity may be overcome by counselling and appropriate timing of dopaminergic treatment. Poor lubrication in the female patient with PD may be helped by lubricants urge incontinence during coitus by previously emptying the bladder and treating the overactive bladder.

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Cilais: Third In The Line Of Erectile Dysfunction Treatments

In 2003, Cialis became the third phosphodiesterase-5 inhibitor to come onto the market, after Viagra and Levitra.

PDE5 inhibitors improve symptoms of erectile dysfunction by preventing the breakdown of a substance called cyclic GMP . cGMP acts as a vasodilator, which means it relaxes smooth muscle and widens blood vessels allowing more blood flow into tissue. This also increases blood flow into the corpus cavernosum these are the sponge-like chambers of erectile tissue inside the penis that fill with blood during an erection.

Like all PDE5 inhibitors, Cialis will not produce an erection in the absence of sexual stimulation. This is because the initial release of cGMP depends on nitric oxide release from penile nerves and endothelial cells which only happens with sexual stimulation, allowing men to still retain full control over their bodies.

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