Who Gets Parkinson’s Disease
About 1 million people in the United States have Parkinson’s disease, and both men and women can get it. Symptoms usually appear when someone is older than 50 and it becomes more common as people get older.
Many people wonder if you’re more likely to get Parkinson’s disease if you have a relative who has it. Although the role that heredity plays isn’t completely understood, we do know that if a close relative like a parent, brother, or sister has Parkinson’s, there is a greater chance of developing the disease. But Parkinson’s disease is not contagious. You can’t get it by simply being around someone who has it.
Support For People Living With Parkinsons Disease
While the progression of Parkinsons is usually slow, eventually a persons daily routines may be affected. Activities such as working, taking care of a home, and participating in social activities with friends may become challenging. Experiencing these changes can be difficult, but support groups can help people cope. These groups can provide information, advice, and connections to resources for those living with Parkinsons disease, their families, and caregivers. The organizations listed below can help people find local support groups and other resources in their communities.
Medications For People With Parkinsons Disease
Symptoms of Parkinsons disease result from the progressive degeneration of nerve cells in the brain and other organs such as the gut, which produce a neurotransmitter called dopamine. This causes a deficiency in the availability of dopamine, which is necessary for smooth and controlled movements. Medication therapy focuses on maximising the availability of dopamine in the brain. Medication regimes are individually tailored to your specific need. Parkinsons medications fit into one of the following broad categories:
- levodopa dopamine replacement therapy
- dopamine agonists mimic the action of dopamine
- COMT inhibitors used along with levodopa. This medication blocks an enzyme known as COMT to prevent levodopa breaking down in the intestine, allowing more of it to reach the brain
- anticholinergics block the effect of another brain chemical to rebalance its levels with dopamine
- amantadine has anticholinergic properties and improves dopamine transmission
- MAO type B inhibitors prevent the metabolism of dopamine within the brain.
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What Medications And Treatments Are Used
Medication treatments for Parkinsons disease fall into two categories: Direct treatments and symptom treatments. Direct treatments target Parkinsons itself. Symptom treatments only treat certain effects of the disease.
Medications
Medications that treat Parkinsons disease do so in multiple ways. Because of that, drugs that do one or more of the following are most likely:
Several medications treat specific symptoms of Parkinson’s disease. Symptoms treated often include the following:
- Erectile and sexual dysfunction.
- Hallucinations and other psychosis symptoms.
Deep brain stimulation
In years past, surgery was an option to intentionally damage and scar a part of your brain that was malfunctioning because of Parkinsons disease. Today, that same effect is possible using deep-brain stimulation, which uses an implanted device to deliver a mild electrical current to those same areas.
The major advantage is that deep-brain stimulation is reversible, while intentional scarring damage is not. This treatment approach is almost always an option in later stages of Parkinson’s disease when levodopa therapy becomes less effective, and in people who have tremor that doesnt seem to respond to the usual medications.
Experimental treatments
Researchers are exploring other possible treatments that could help with Parkinsons disease. While these arent widely available, they do offer hope to people with this condition. Some of the experimental treatment approaches include:
Is There A Cure For Parkinsons
Theres currently no cure for Parkinsons, a disease that is chronic and worsens over time. More than 50,000 new cases are reported in the United States each year. But there may be even more, since Parkinsons is often misdiagnosed.
Its reported that Parkinsons complications was the
Complications from Parkinsons can greatly reduce quality of life and prognosis. For example, individuals with Parkinsons can experience dangerous falls, as well as blood clots in the lungs and legs. These complications can be fatal.
Proper treatment improves your prognosis, and it increases life expectancy.
It may not be possible to slow the progression of Parkinsons, but you can work to overcome the obstacles and complications to have a better quality of life for as long as possible.
Parkinsons disease is not fatal. However, Parkinsons-related complications can shorten the lifespan of people diagnosed with the disease.
Having Parkinsons increases a persons risk for potentially life threatening complications, like experiencing:
Parkinsons often causes problems with daily activities. But very simple exercises and stretches may help you move around and walk more safely.
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Causes Of Parkinsons Disease
At present, we do not know the cause of Parkinsons disease. In most people there is no family history of Parkinsons Researchers worldwide are investigating possible causes, including:
- environmental triggers, pesticides, toxins, chemicals
- genetic factors
- combinations of environment and genetic factors
What About The Later Stages Of The Disease
Support from a physical therapist is important if symptoms start to affect your quality of life. So is continuing a regular exercise program.
Parkinson disease can make it hard to take care of your everyday needs. It also can cause balance problems that increase your risk for a fall. In the later stages, a physical therapist can help you:
- Minimize a further decline.
- Reduce your risk of falling.
- Learn to move and change positions more easily .
- Adapt to new or changing symptoms.
- Maintain your strength so you can stay as physically active as possible.
Whether you are in the early or later stages of the disease, your physical therapist will adjust your treatment plan as needed. They also may recommend assistive devices for your safety and mobility.
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Diagnosis And Management Of Parkinsons Disease
There are no diagnostic tests for Parkinsons. X-rays, scans and blood tests may be used to rule out other conditions. For this reason, getting a diagnosis of Parkinsons may take some time.
No two people with Parkinsons disease will have exactly the same symptoms or treatment. Your doctor or neurologist can help you decide which treatments to use.
People can manage their Parkinsons disease symptoms through:
- seeing a Doctor who specialises in Parkinsons
- multidisciplinary therapy provided for example, by nurses, allied health professionals and counsellors
- deep brain stimulation surgery .
Causes Of Parkinson Disease
In Parkinson disease, synuclein forms clumps called Lewy bodies in nerve cells. Lewy bodies consist of misfolded synuclein. Synuclein can accumulate in several regions of the brain, particularly in the substantia nigra and interfere with brain function. Lewy bodies often accumulate in other parts of the brain and nervous system, suggesting that they may be involved in other disorders. In Lewy body dementia Dementia With Lewy Bodies and Parkinson Disease Dementia Dementia with Lewy bodies is progressive loss of mental function characterized by the development of Lewy bodies in nerve cells. Parkinson disease dementia is loss of mental function characterized… read more , Lewy bodies form throughout the outer layer of the brain . Lewy bodies may also be involved in Alzheimer disease Alzheimer Disease Alzheimer disease is a progressive loss of mental function, characterized by degeneration of brain tissue, including loss of nerve cells, the accumulation of an abnormal protein called beta-amyloid… read more , possibly explaining why about one third of people with Parkinson disease have symptoms of Alzheimer disease and why some people with Alzheimer disease develop parkinsonian symptoms.
About 10% of people with Parkinson disease have relatives who have or have had the disease. Also, several gene mutations that can cause Parkinson disease have been identified.
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What Causes Parkinson’s
Doctors aren’t sure why all those brain cells start dying. They think it’s a mix of your genes and something in the environment, but the reason is not straightforward.
Someone could have a change in a gene tied to Parkinson’s, but never get the disease. That happens a lot. And a bunch of people could work side by side in a place with chemicals linked to Parkinson’s, but only a few of them end up with it.
It’s a complex puzzle, and scientists are still trying to put all the pieces together.
Who Gets Parkinsons
Parkinson’s disease affects both males and women. Men are 1.5 times more likely to be affected. It is also more common in the elderly. Parkinson’s disease is uncommon among young adults. It generally manifests itself in middle or late life, and the risk increases with age. Only roughly 4 out of every 100 instances involve adults under the age of 50.
Every year, roughly 60,000 people in the United States realize they have Parkinson’s disease. It is undeniable that this condition affects around 1 million people in the United States and 10 million people worldwide. If you have Parkinson’s disease in your family, you are more likely to develop it.
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How Is It Diagnosed
Diagnosing Parkinson’s disease is mostly a clinical process, meaning it relies heavily on a healthcare provider examining your symptoms, asking you questions and reviewing your medical history. Some diagnostic and lab tests are possible, but these are usually needed to rule out other conditions or certain causes. However, most lab tests aren’t necessary unless you don’t respond to treatment for Parkinson’s disease, which can indicate you have another condition.
What Is The On/off Phenomenon In Parkinsons
The ON/OFF phenomenon in PD happens when someone experiences flares of symptoms between regularly scheduled doses of levodopa.
During an ON episode, the levodopa is working well and symptoms improve. During an OFF episode, the levodopa isnt working and symptoms return or get worse.
A 2018 review found that 25 to 50 percent of people with PD developed OFF episodes within 2 years of beginning treatment with levodopa. Within 10 years of starting treatment, most people with PD had OFF episodes.
OFF episodes can affect different people in different ways. They may follow a predictable pattern or occur unpredictably. They may set in suddenly or gradually.
The researchers behind a
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Other Causes Of Parkinsonism
“Parkinsonism” is the umbrella term used to describe the symptoms of tremors, muscle rigidity and slowness of movement.
Parkinson’s disease is the most common type of parkinsonism, but there are also some rarer types where a specific cause can be identified.
These include parkinsonism caused by:
- medication where symptoms develop after taking certain medications, such as some types of antipsychotic medication, and usually improve once the medication is stopped
- other progressive brain conditions such as progressive supranuclear palsy, multiple system atrophy and corticobasal degeneration
- cerebrovascular disease where a series of small strokes cause several parts of the brain to die
You can read more about parkinsonism on the Parkinson’s UK website.
Page last reviewed: 03 November 2022 Next review due: 03 November 2025
What Is The Difference Between Parkinsons Disease And Parkinsonism
Parkinsons disease is a neurodegenerative disorder that leads to movement symptoms and non-movement symptoms. It is sometimes called idiopathic , but the cause is believed to be a combination of genetic and environmental factors.
Parkinsonism is a more general term that encompasses the symptoms of Parkinsons disease. A variety of disorders or syndromes can lead to Parkinsonism, and these syndromes can lead to faster progression of symptoms, increased falling, presence of hallucinations, and can be non-responsive to levodopa .
The majority of people with the symptoms of Parkinsons disease will be diagnosed with idiopathic Parkinsons disease. Between 10% to 15% of these people will be diagnosed with Parkinsonism that is caused by something else.
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Occupational Relaxation And Physical Therapy
A physical therapist may help people with tremors to improve their strength and muscle control with balancing, coordination, and relaxation exercises.
There are various types of Parkinsonism. The most common is idiopathic Parkinsons, or Parkinsons disease.
Other types, which are atypical Parkinsonism, include vascular and drug-induced Parkinsonism. Less common types include MSA, PSP, and normal pressure hydrocephalus.
Causes of Parkinsons disease are unclear, but risk factors include age, sex, environment, and genetics.
There is no diagnostic test for Parkinsons, but doctors use various methods to assess for the disease. Methods include MRI and PET scans, analyzing a persons symptoms, and physical and neurological exams.
Parkinsons disease has no cure, but medication, DBS, and physical, occupational, and relaxation therapy can treat the symptoms.
Behaviors Seen In Parkinsons Disease Dementia
As dementia progresses, managing disorientation, confusion, agitation, and impulsivity can be a key component of care.
Some patients experience hallucinations or delusions as a complication of Parkinsons disease. These may be frightening and debilitating. Approximately 50 percent of those with the disease may experience them.
The best thing to do when giving care to someone experiencing hallucinations or delusions from Parkinsons disease dementia is to keep them calm and reduce their stress.
Take note of their symptoms and what they were doing before they exhibited signs of hallucinating and then let their doctor know.
This element of the disease can be particularly challenging for caregivers. Patients may become unable to care for themselves or be left alone.
Some ways to make caregiving easier include:
- sticking to a normal routine whenever possible
- being extra comforting after any medical procedures
- limiting distractions
- using curtains, nightlights, and clocks to help stick to a regular sleep schedule
- remembering that the behaviors are a factor of the disease and not the person
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Symptoms Of Parkinsons Disease
Parkinsons has four main symptoms:
- Tremor in hands, arms, legs, jaw, or head
- Muscle stiffness, where muscle remains contracted for a long time
- Slowness of movement
- Impaired balance and coordination, sometimes leading to falls
Other symptoms may include:
The symptoms of Parkinsons and the rate of progression differ among individuals. Early symptoms of this disease are subtle and occur gradually. For example, people may feel mild tremors or have difficulty getting out of a chair. They may notice that they speak too softly, or that their handwriting is slow and looks cramped or small. Friends or family members may be the first to notice changes in someone with early Parkinsons. They may see that the persons face lacks expression and animation, or that the person does not move an arm or leg normally.
People with Parkinson’s disease often develop a parkinsonian gait that includes a tendency to lean forward take small, quick steps and reduce swinging their arms. They also may have trouble initiating or continuing movement.
Symptoms often begin on one side of the body or even in one limb on one side of the body. As the disease progresses, it eventually affects both sides. However, the symptoms may still be more severe on one side than on the other.
Deep Brain Stimulation For Parkinson’s: Am I A Candidate
Deep brain stimulation is not a cure, but it can relieve your symptoms from Parkinson’s disease when medications are not an option. Only you and your doctor can decide if this surgical procedure is right for you. You may be a candidate for deep brain stimulation if:
- You have idiopathic Parkinson’s disease. Patients with atypical parkinsonism are not candidates.
- You have good motor function and independence during your best “on” state when taking the drug Sinemet.
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What Causes Parkinsons Movement Symptoms
Dopamine is a chemical messenger that is primarily responsible for controlling movement, emotional responses and the ability to feel pleasure and pain. In people with Parkinsons, the cells that make dopamine are impaired. As Parkinsons progresses, more dopamine-producing brain cells die. Your brain eventually reaches a point where it stops producing dopamine in any significant amount. This causes increasing problems with movement.
What Are The Risk Factors For Parkinsons Disease
Risk factors for Parkinsons disease include:
Genetics
People with a first-degree relative with Parkinsons are at an increased risk for the disease possibly as much as 9 percent greater.
Fifteen percent of people with Parkinsons have a known relative with the disease, but a condition called familial Parkinsons, which has a known genetic link, is relatively rare.
The average age of onset is 60 years, and the incidence rises with advancing age. About 4 percent of people have early-onset or young-onset disease, which begins before age 50.
Gender
Parkinsons affects about 50 percent more men than women, for unknown reasons.
Pesticide Exposure
Exposure to some pesticides has been shown to raise the risk of developing Parkinsons.
Problematic chemicals include organochlorine pesticides like DDT, dieldrin, and chlordane. Rotenone and permethrin have also been implicated.
Fungicide and Herbicide Exposure
Exposure to the fungicide maneb or the herbicides 2,4-dichlorophenoxyacetic acid , paraquat, or Agent Orange may raise the risk of Parkinsons.
The U.S. Veterans Health Administration considers Parkinsons to be a possible service-related illness if the person was exposed to significant amounts of Agent Orange.
Head Injuries
Head injuries may contribute to the development of Parkinsons in some people.
Coffee and Smoking
People who drink coffee or smoke tobacco have been found to have a lower risk of Parkinsons disease, for reasons that remain unclear.
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What Is Parkinsonism And What Causes It
Some people may develop Parkinson’s-like symptoms, including slow movement, muscle stiffness, or tremors, without having true Parkinson’s disease. Causes of parkinsonism include:
Medication. Certain medications, mainly antipsychotic prescriptions, induce symptoms similar to Parkinson’s disease. Luckily, the symptoms usually stop once you stop taking the medication.
Ministrokes. People with cerebrovascular disease may experience a series of ministrokes. The strokes cause multiple areas of the brain to become inactive, leading to the symptoms.
Progressive supranuclear palsy. Also called Steele-Richardson-Olszewski syndrome, this condition mainly causes balance and vision issues but also has other symptoms similar to Parkinson’s.
Multiple system atrophy. This condition also has similar symptoms but also causes bladder issues and low blood pressure.
Corticobasal degeneration. This condition happens when a protein called tau doesn’t break down properly in the brain. It builds up and causes damage and neurological degeneration.