Wednesday, February 21, 2024

Can You Diagnose Parkinson’s With A Blood Test

What Are My Next Steps

Ask the MD: Parkinson’s Diagnosis and Biomarkers

If your doctor doesnt diagnose Parkinsons, they can help you find out what the best next step is depending on what condition they suspect. In some cases, treatment may be as simple as changing the dosage of a medication that may be leading to Parkinsons-like symptoms.

Receiving a Parkinsons diagnosis can be overwhelming. If your diagnosis is confirmed, contact a movement disorder specialist as soon as possible. A specialist can help you develop a strategy to delay the onset of more severe disease and manage symptoms youre already experiencing.

Physical And Neurological Examination

Your doctor will conduct a physical and neurological examination. This can involve observing your behavior, movements, and mental state and conducting tests or asking you to perform certain exercises.

These are some of the symptoms of Parkinsons your doctor can determine visually:

  • Fewer spontaneous movements or hand gestures
  • Reduced frequency of blinking
  • Tremors in your hands while they are at rest, often only in one hand
  • Hunched posture or forward lean while walking
  • Stiff movements

These are some of the exercises your doctor may ask you to do to evaluate your movements, balance, and coordination:

  • Opening and closing your fist
  • Tapping your fingers, toes, and heels
  • Holding your arms out in front of you
  • Moving your finger from one point to another
  • Rotating your wrists or ankles
  • Standing from a chair

What Tests Diagnose Parkinson’s Disease

There currently are no tests that can definitively diagnose Parkinsons Disease. A diagnosis is based on the clinical findings of your physician in combination with your report on the symptoms you are experiencing.

In situations where an older person presents with the typical features of Parkinsons and they are responsive to dopamine replacement therapy, there is unlikely to be any benefit to further investigation or imaging.

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Brain Imaging And Other Tools To Aid Diagnosis Of Parkinsons

In addition to taking a history and performing a detailed neurologic examination, physicians sometimes use brain imaging to help support a particular diagnosis. However, these studies have their limitations in the diagnosis of Parkinsons disease and are typically used only in select patients. Brain imaging is not routinely performed by neurologists or movement disorder specialists when they are considering a diagnosis, especially if the persons symptoms strongly suggest to the physician that idiopathic Parkinsons disease is the correct diagnosis.

Helping diagnose Parkinsons with DaTscan and other tests

Rather, use of imaging is most helpful when the diagnosis is uncertain, or when physicians are looking for changes in the brain that are more typical of one of several Parkinsonian syndromes and other conditions that can mimic Parkinsons. Imaging studies to evaluate Parkinsons disease and Parkinsonian syndromes include magnetic resonance imaging , which examines the structure of the brain, and DaTscan, an imaging test approved by the Food and Drug Administration to detect the dopamine function in the brain. A DaTscan may help differentiate idiopathic Parkinsons disease from certain other neurologic disorders. Most physicians offices will have access to MRI however, DaTscan imaging may only be available at larger hospitals or medical centers.

How Can I Try To Get An Early Diagnosis

Parkinson

By the time Parkinsons causes noticeable motor symptoms, usually about 50 percent of the cells that produce dopamine in your substantia nigra have already died off. Non-motor symptoms, such as constipation, loss of smell, or restless sleep, often appear before motor symptoms.

Theres still debate among medical professionals on how long non-motor symptoms may appear before an individual has noticeable changes in their movement. Its thought that they could appear years to decades beforehand.

But a formal Parkinsons diagnosis requires the symptom slowness of movement. In the time before this symptom appears, your doctor cant make a Parkinsons diagnosis, but they may alert you that youre at a high risk of developing Parkinsons in the future if these or other symptoms appear at any point.

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How To Spot Symptoms In Yourself Or Someone You Love

Most diagnoses of Parkinsons disease come after age 60, but about 4 percent of diagnoses come before age 50. What signs of Parkinsons should you watch out for in yourself or someone you love?

Diagnosing Parkinsons SomeParkinsons diseases symptomsare well known, like the tremors that boxing great Muhammad Ali experienced. But Parkinsons is often difficult to diagnose when its in its early stages, and no blood or imaging test can confirm if someone has the disease.

So how is Parkinsons diagnosed? A healthcare provider will take a medical history and look for signs. In addition to slow movementcalled bradykinesiaeither stiffness or tremors must also be present. The HCP may also use a SPECT test that tracks the chemical dopamine in the brain. But your HCP needs to know to look for Parkinsons, and thats where you come in. Tell your HCP if youve noticed any of these early warning signs.

Early warning signs of Parkinsons disease 1. Tremors. If one of your fingers, a foot, or part of the jaw or face shakes while youre at rest, that could be an early sign of Parkinsons. Tremors usually start on one side of the body, and eventually progress to the whole body as the disease progresses.

3. Rigid limbs.Stiffness in the arms or legs is another hallmark sign of Parkinson’s. Like tremors, rigidity often starts on one side of the body before it progresses to the other. Take note if you notice that you’re starting to shuffle, or not swinging one of your arms as you walk.

Blood Test May Help Differentiate Parkinsons From Similar Diseases

The American Academy of Neurology is the world’s largest association of neurologists and neuroscience professionals, with 36,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, concussion, Parkinson’s disease and epilepsy.

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Measuring A Particular Blood Protein Might Help Doctors Easily Distinguish Parkinson’s Disease From Some Similar Disorders A New Study Suggests

WEDNESDAY, Feb. 8, 2017 Measuring a particular blood protein might help doctors easily distinguish Parkinson’s disease from some similar disorders, a new study suggests.

The potential blood test is “not ready for prime time,” Parkinson’s disease experts said. But, it marks progress in the quest for an objective way to diagnose Parkinson’s and similar conditions known as atypical parkinsonian disorders, they noted.

Parkinson’s disease is a movement disorder that affects nearly 1 million people in the United States alone, according to the Parkinson’s Disease Foundation.

The root cause is unclear, but as the disease progresses, the brain loses cells that produce dopaminea chemical that regulates movement. As a result, people suffer symptoms such as tremors, stiff limbs, and balance and coordination problems that gradually worsen over time.

Right now, there is no blood test, brain scan or other objective measure that can definitively diagnose Parkinson’s, said James Beck, vice president of scientific affairs for the Parkinson’s Disease Foundation.

“In general, Parkinson’s disease is diagnosed with a clinical exam,” Beck explained.

The best person to make that call is a neurologist with expertise in movement disorders, according to Beck.

“But,” he said, “even highly trained doctors initially get it wrong about 10 percent of the time.”

There is no cure for Parkinson’s or APDs, or any way to halt their progression.

How Did My Dad Get Diagnosed With Parkinsons

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Dad and I began our care journey closer to the beginning of his Parkinson diagnosis when I was so naive to believe all that was involved were shaky hands. Some of my Chinese patients living in the Dallas-Fort Worth area couldnt understand the English materials. I decided to translate the library contents into Chinese.

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Blood Test Would Detect Parkinsons In Early Stages

A group of researchers developed a blood test that would allow neurologists detect Parkinsons disease and track the illness as it progresses.

If successful, we expect our findings will translate into a valuable diagnostic tool for Parkinsons disease, said study co-author Judith Potashkin, professor of cellular and molecular pharmacology at Chicago Medical School, Rosalind Franklin University of Medicine and Science.

According to the Parkinsons Disease Foundation, it is estimated that 60,000 people in the United States are diagnosed with Parkinsons disease each year. Data from 2013, by the University Center for Health Sciences at the University of Guadalajara, reported more than 500,000 cases of this neurodegenerative condition in Mexico. The same year, an economic model of Parkinsons disease forecasted that cases in the worlds population will double by 2040.

Now days, this disease is still incurable. It can cause tremors and severely hamper movement. Although medications allow controlling the condition, it gets worse over the years and medications do not stop its progression.

The traditional method to diagnose Parkinsons is by analyzing symptoms. Currently, brain scans are available, allowing the analysis of imaging studies to detect the disease however, the information obtained from these devices may still be somewhat imprecise, Potashkin said.

The study was published in the Feb. 3 online issue of the Proceedings of the National Academy of Sciences.

Blood Test May Distinguish Parkinsons From Multiple System Atrophy

A highly sensitive and specific blood test has been developed that can distinguish Parkinsons disease from multiple system atrophy , a team at the University of California, Los Angeles Health reported.

The test examines the levels of a protein called alpha-synuclein in exosomes tiny vesicles released by cells that end up in the blood. In Parkinsons, alpha-synuclein comes from neuron-derived exosomes, while in MSA it comes from exosomes released by oligodendrocytes, another type of brain cell.

Based on the content and origin of the exosomes, this test can help discriminate between Parkinsons disease and MSA.

This is a major breakthrough, because it allows us to analyze whats going on in the brain using a blood test, Gal Bitan, PhD, the studys senior author and a professor of neurology at the David Geffen School of Medicine at UCLA, said in a university press release.

The study, -Synuclein in blood exosomes immunoprecipitated using neuronal and oligodendroglial markers distinguishes Parkinsons disease from multiple system atrophy, was published in Acta Neuropathologica.

Parkinsons and neurodegenerative diseases such as MSA have several symptoms in common, including muscle rigidity and tremors. Because of this overlap in symptoms, many cases are misdiagnosed.

Incorrect diagnoses can also affect clinical trial results, as potential treatments would be tested in people without the disorder under evaluation.

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Can A Blood Test Tell You If You Have Parkinsons Disease

This test cant tell you for sure that you have Parkinsons disease, but it can give your doctor more information to work with. It can take a long time for some people to get a diagnosis. You may need to see your neurologist regularly so she can keep an eye on your symptoms and eventually figure out whats behind them.

New Diagnostic Standards For Parkinsons

Parkinson

Until recently, the gold-standard checklist for diagnosis came from the U.K.s Parkinsons Disease Society Brain Bank. It was a checklist that doctors followed to determine if the symptoms they saw fit the disease. But thats now considered outdated. Recently, new criteria from the International Parkinson and Movement Disorder Society have come into use. This list reflects the most current understanding of the condition. It allows doctors to reach a more accurate diagnosis so patients can begin treatment at earlier stages.

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How Is The Diagnosis Of Parkinsons Disease Made

Making an accurate diagnosis of Parkinsons disease can be complicated. Doctors must carefully weigh symptoms, family history and other factors to come to a conclusion. The standard diagnosis of Parkinsons disease right now is clinical, explain experts at the Johns Hopkins Parkinsons Disease and Movement Disorders Center.

How Is Parkinson’s Disease Diagnosed

Your doctor will ask questions about your symptoms and your past health and will do a neurological exam. This exam includes questions and tests that show how well your nerves are working. For example, your doctor will watch how you move. He or she will check your muscle strength and reflexes and will check your vision.

Your doctor also may check your sense of smell and ask you questions about your mood.

In some cases, your doctor will have you try a medicine for Parkinson’s disease. If that medicine helps your symptoms, it may help the doctor find out if you have the disease.

Tests

There are no lab or blood tests that can help your doctor know whether you have Parkinson’s. But you may have tests to help your doctor rule out other diseases that could be causing your symptoms. For example:

  • An MRI or CT scan is used to look for signs of a stroke or brain tumor.
  • Blood tests check for abnormal thyroid hormone levels or liver damage.

Another type of imaging test, called PET, sometimes may detect low levels of dopamine in the brain. These low levels are a key feature of Parkinson’s. But PET scanning isn’t commonly used to evaluate Parkinson’s. That’s because it’s very expensive, not available in many hospitals, and only used experimentally.

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Further Testing In Parkinson’s

In other situations, where perhaps the diagnosis is not as clear, younger individuals are affected, or there are atypical symptoms such as tremor affecting both hands or perhaps no tremor at all, further testing may help. For example, imaging can play a role in differentiating between essential tremor and Parkinsons. It can also be important to confirm what is initially a clinical diagnosis of Parkinsons prior to an invasive treatment procedure such as surgical DBS

What Doctors Look For When Diagnosing Parkinsons

Diagnosing Parkinsons Disease

Certain physical signs and symptoms noticed by the patient or his or her loved ones are usually what prompt a person to see the doctor. These are the symptoms most often noticed by patients or their families:

  • Shaking or tremor: Called resting tremor, a trembling of a hand or foot that happens when the patient is at rest and typically stops when he or she is active or moving

  • Bradykinesia: Slowness of movement in the limbs, face, walking or overall body

  • Rigidity: Stiffness in the arms, legs or trunk

  • Posture instability: Trouble with balance and possible falls

Once the patient is at the doctors office, the physician:

  • Takes a medical history and does a physical examination.

  • Asks about current and past medications. Some medications may cause symptoms that mimic Parkinsons disease.

  • Performs a neurological examination, testing agility, muscle tone, gait and balance.

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How Is Parkinsons Disease Tested And Diagnosed

At Banner Health, our neurologists have years of experience in testing and diagnosing Parkinson’s disease. Our team of compassionate experts knows that each patient is different, so we work with you to quickly find the right diagnosis to begin building your treatment plan.

Parkinsons is not simple to diagnose. No test exists to diagnose Parkinsons disease. Doctors test and diagnose Parkinsons based on your medical history, symptoms and neurological and physical exams.

Many times a primary care provider is the first to suspect a Parkinsons diagnosis. If youre experiencing symptoms such as tremors, shaking, slow movement, stiffness and/or trouble with balance, talk to your doctor or seek the opinion of a neurologist. Banner Health neurologists are movement disorder specialists, who have experience and specific training to assess and treat Parkinsons.

Urgent Need For A Simple Test For Parkinson’s

Claire Bale, Head of Research Communications at Parkinson’s UK, comments:

“Parkinson’s has no definitive diagnostic test, leaving an urgent need for a simple and accurate way of detecting the condition, particularly in its early stages.

“It’s encouraging to see that something as simple as a blood test could be a significant step forward for diagnosing Parkinson’s.

“We know the process of diagnosis can take time and waiting for a diagnosis can by very stressful.

“Our recent survey findings, released this week to mark Parkinson’s Awareness Week, show that people will often experience negative emotions in the year following their diagnosis, with the news having the hardest emotional impact on younger people with Parkinson’s.

“We hope this research will pave the way for larger studies to find out how accurately, and at what stage, a blood test can diagnose Parkinson’s providing a major breakthrough for Parkinson’s research and opening up new avenues to test treatments earlier to eventually stop this condition in its tracks.”

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Medical History And Physical Exam

The process of diagnosing Parkinsons usually begins with the neurologist evaluating your medical history and performing a physical exam. For a formal diagnosis to be made, you need to have a general slowness of movement with either a resting tremor or rigidity.

During the physical exam, your doctor will have you perform a series of tests to monitor your movement. An example of a test they might use is a finger tap, where they measure how many times you can tap your finger in 10 to 15 seconds.

They will also look for signs that you may have another condition. A group of movement disorders collectively called parkinsonisms can produce symptoms that are indistinguishable from those of Parkinsons but are not the same. Usually, additional tests are needed to rule out these conditions as well.

Is Early Diagnosis Possible

Testing the level of caffeine in the blood can help ...

Experts are becoming more aware of symptoms of Parkinsons that precede physical manifestations. Clues to the disease that sometimes show up before motor symptoms and before a formal diagnosis are called prodromal symptoms. These include the loss of sense of smell, a sleep disturbance called REM behavior disorder, ongoing constipation thats not otherwise explained and mood disorders, such as anxiety and depression.

Research into these and other early symptoms holds promise for even more sensitive testing and diagnosis.

For example, biomarker research is trying to answer the question of who gets Parkinsons disease. Researchers hope that once doctors can predict that a person with very early symptoms will eventually get Parkinsons disease, those patients can be appropriately treated. At the very least, these advances could greatly delay progression.

Parkinson’s Disease and Movement Disorders Center

Our center provides compassionate and timely treatment to patients with movement disorders, such as dystonia, ataxia, essential tremor and similar conditions. But our mission goes beyond patient care excellence. By offering educational events and support groups, we empower patients and caregivers to become better partners in their health.

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