Wednesday, July 20, 2022

Mushrooms And Parkinson’s Disease

Are Mushrooms The Best Brain Food

Can Microdosing Psilocybin Magic Mushrooms help with Parkinson’s disease?

Penn State professor emeritus of food science and director of the Center for Plant and Mushroom Foods for Health Robert B. Beelman, Ph.D., has spent much of his career paying attention to mushrooms in particular, how eating them might protect the human brain from dementia and other forms of cognitive decline. It may be possible to decrease the incidence of neurological diseases by increasing mushroom consumption, he wrote last year in The Conversation. His latest paper, published earlier this year inNutrition Today, further highlights the connection.

Beelman is careful to say there is no proven causative link between mushroom consumption and protection against dementia and other chronic neurodegenerative diseases, although a 2017 study showed that frequent mushroom consumption is significantly associated with a lower risk of incident dementia, and earlier this year another study found that participants who consumed mushrooms had reduced odds of having mild cognitive impairment. The week of our interview, an additional study found that eating mushrooms may reduce the risk of memory problems, as the New York Times coverage put it.

I spoke with Beelman, 75, who is now retired but still doing research through collaborations, about what the latest research means and whether mushroom coffee is worth considering.

But the big micronutrient they contain, and what especially interests me regarding neurological benefits, is this antioxidant called ergothioneine.

Pharma Company Also Plans To Investigate Psychedelic Therapies For Multiple Sclerosis

In 2006, Johns Hopkins researchers published a groundbreaking study on the effects of a single dose of psilocybin, a naturally occurring psychedelic compound found in more than 200 species of mushrooms. The team had to set up unusually rigorous scientific conditions and measures amid highly restrictive regulatory policies, which were partially due to unfavorable media coverage from the recreational use of shrooms in the 1960s and 70s that had resulted in misperceptions of risk.

The landmark study provided a scientific framework to better understand how hallucinogenic drugs target the brains serotonin receptors, and the researchers announced future plans to investigate how psilocybin might be used to treat conditions like cancer-related anxiety and depression, and other mental health conditions. Since then, more than 60 peer-reviewed articles in scientific journals further validated the safety and enduring positive effects of a unique class of pharmacological compounds known as psychedelics.

The US Food and Drug Administration has since granted breakthrough therapy designation for psilocybin to determine its viability for treating major depressive disorder, opening enrollment to patients for clinical studies in 2019.

in Neuropsychiatric Disorders Laboratory is studying why people with mental illnesses have trouble with social connection.

For Weisblum, working in this industry has been particularly personal.

Find Out More About This Capital Raise

Welcome to the Market Herald Deal Room for this Friday, where we review the week in capital raising.

Emyria shares soared more than 60 per cent on news Andrew Twiggy Forrests private investment group Tattarang had invested $5 million.

It could be viewed as a controversial move for Tattarang, in that Emyria is not only trialling cannabinoid treatments for mental health conditions, epilepsy and Parkinsons disease, but also MDMA and magic mushrooms.

Emyrias Managing Director Dr Michael Winlo said thered been a resurgence in research into the effectiveness of these drugs.

Conservative medicines cautious about these treatments, in the same way theyre cautious about medicinal cannabis, he said.

But the reality is, for many patients, standard treatments arent effective, have unwanted side effects or are just not available yet.

Tattarang sees the size of the problem. This is a global, massive issue that were trying to address and obviously theres clear commercial value to that.

Emryias market cap has increased since the announcement to $135 million, with shares opening at 50 cents today. Tattarang has already doubled its investment after securing its shares at 25 cents.

Pharmaxis this week launched a $2 million share purchase plan to help fund phase two trials of its treatment for liver and bone cancer, as well as trials of a topical drug with the potential to improve scarring.

It was a nice entrance onto the ASX, he said.

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The Antioxidants In Mushrooms

Mushrooms contain high amounts of two antioxidants thought to be key to preventing the aging of neurons in the brain: ergothioneine and glutathione. In fact, Dr. Robert Beelman, professor emeritus at Penn State, found that the porcini mushrooms of northern Italy may help keep older Italians free of dementia. He observed that Italians who ate more of these mushrooms had less neurodegenerative diseases, such as Alzheimers and Parkinsons Disease.

Dr. Beelman and his colleagues also found that the ergothioneine content of mushrooms varies by the species. The good news: most mushrooms contain both neuroprotective ergothioneine and glutathione.

These antioxidants remain active whether the mushrooms are consumed raw or cooked.

Bdnf Staat Voor Brain

Can Microdosing Psilocybin Magic Mushrooms help with ...

Brain-derived neurotrophic factor, BDNF, is een neurotrofine. Neurotrofines zijn belangrijk voor het overleven, herstellen en laten groeien van neuronen. Neuronen zijn zenuwcellen die informatie verwerken, doorsturen of verwerken in het brein of zenuwstelsel. Neuronen kunnen worden gezien als de datakabels tussen delen van de hersenen en het lichaam. Een gemiddeld lichaam heeft zo’n ongeveer 100.000.000.000 neuronen .

Read Also: Parkinson’s And Violent Behavior

Cognitive Supplement Spotlight: Lions Mane

What is Lions Mane? Lions Mane is also known as Hericium erinaceus, found in North America, Europe and Asia. It is an edible fungus that has been used for a very long time in Traditional Chinese Medicine. This mushroom is rich in many bioactive compounds such as beta-glucan polysaccharides, hericenones and erinacine terpenoids, isoindolinoes, sterols and myconutrients. These are all neuroprotective. Lions Mane also has the ability to stimulate the production of nerve growth factor, which helps repair and renew neurons and supports myelination. It is used in cases of Alzheimers, Parkinsons, MS and other conditions.

Benefits of Lions Mane? There are many different benefits of Lions Mane. It is used to support the heart and circulatory system, protects against cancer, can improve digestive health and reduces inflammation. One of the main benefits of Lions Mane is that it enhances brain function. It impacts brain cells and brain function that can help with neurodegenerative diseases. Lions Mane also enhances neuron outgrowth meaning that the axons and dendrites from the neurons grow. Increasing their growth can potentially slow or reverse cell degeneration in conditions like Alzheimers and Parkinsons disease.

How Much Should I Take? For cognitive support and nerve injury, I recommend one capsule twice a day of the 500 mg dose.

Parkinsons Disease And How It Works

Parkinsons disease is a neurological disorder more specifically, a neurodegenerative disease.

Its unclear what causes it. Scientists state it most likely involves inflammation targeting certain neurons in the brain, thus causing them to degenerate and malfunction.

At first, effects may be unnoticeable but then slowly increase over the years.

Symptoms are different in every person and can emerge differently. But the most prominent symptoms tend to include:

  • Tremors
  • Sleep disorders

Recommended Reading: Parkinson’s Short Term Memory Loss

News And Commentary From The World Of Neurology And Neuroscience

Your brain on psilocybin: an MRI study looked at brain connectivity 20 minutes, 40 minutes, and 70 minutes after people received either psilocybin or placebo.

New research about the role of microglia is shifting the brain-body paradigm and may make inflammation an important target for Alzheimer’s and other neurological diseases, an essayist argued.

A common probiotic, Bacillus subtilis, inhibited alpha-synuclein aggregation and cleared pre-formed aggregates in a roundworm synucleinopathy model, which may have implications for Parkinson’s disease.

Roche announced plans to aggressively price its oral spinal muscular atrophy drug risdiplam to challenge two of the world’s most expensive medicines — nusinersen and the gene therapy onasemnogene abeparvovec — if the drug is approved in May.

Is norepinephrine signaling a missing piece of the Alzheimer’s disease puzzle?

An investigational drug that may lead to a vaccine for Parkinson’s disease by triggering alpha-synuclein antibodies is starting a phase II trial, Affiris announced.

RimabotulinumtoxinB injections significantly reduced saliva production and drooling in older adults with Parkinson’s disease and other disorders.

Are patients in persistent vegetative states — who are conscious, but sealed off from the rest of the world — in a limbo of torture?

Nerve ultrasound coupled with standard nerve conduction studies improved detection of treatment-responsive chronic inflammatory neuropathies.

Studies On Ibogaine And Parkinsons Disease

Parkinson’s Disease – Music Magic

One experiment showed that ibogaine increased the production of two neurotrophins. These are the glial-derived neurotrophic factor and brain-derived neurotrophic factor in the neural circuits affected by PD.

Research has shown that GDNF administration can recover dopamine-producing cells lost in PD. These pieces of evidence have led researchers to use GDNF in clinical trials of Parkinsons disease. In one study using human patients, direct brain injection of GDNF in PD patients improved the patients motor symptoms and daily living and increased their brain levels of dopamine.

Increasing neurotrophins by administering ibogaine could help reverse some of the cell death and symptoms associated with PD.

Evidence has suggested problems with BDNF may be linked to PD. A study in mice showed that removing the BDNF receptor caused increased alpha-synuclein aggregation and increased the death of dopamine-producing nerve cells.

The experimental evidence for GDNF and BDNF in PD suggest increasing these neurotrophins by administering ibogaine could help reverse some of the cell death and symptoms associated with PD.

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Can Herbs And Mushrooms Help Parkinsons

Once Parkinsons disease develops, it cannot be remediednot by mainstream medicine, nor by alternative medicine.

Luckily, the condition is not fatal. However, the more it develops, the more complicated and serious symptoms can get.

Thats why early detection, risk reduction, and treatment are important.

Together, both medical treatments and natural remedieslike herbs and mushroomscan provide supplemental support as well as risk reduction of Parkinsons symptoms getting worse, studies show.

According to science, here are some of the best natural remedy candidates for Parkinsons.

Mushroom For Parkinsons Disease To Stimulate The Brain

Mushrooms for patients with Parkinsons disease are vegetables that were tackled in many studies regarding the best foods to stimulate the brain functions. One of these studies showed that consuming mushrooms significantly reduces the risk of dementia, while another showed that the deterioration in cognitive abilities was less among people who eat mushrooms. A third study indicated that mushrooms have a role in improving memory.

The researchers believe that mushrooms help activate different brain functions because it contains a compound called ergothioneine. After extensive research, it was found that this compound levels are decreased in people with PD. That is why eating mushrooms can help stimulate brain functions.

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Where To Find Lions Mane

  • In the Woods: This mushroom typically grows from late summer throughout fall on living hardwood trees. It often grows high up on trees, so keep an eye to the sky when hunting for it!
  • At The Market: Due to its growing popularity, commercially grown Lions Mane can often be found at local farmers markets. Ive even heard reports of it being sold at Whole Foods.
  • Grow Your Own: Of course, you can take matters into your own hands and easily grow some Lions Mane at home.

I picked up a few grow kits from Myc Tyson which produced over a pound of Lions Mane for my first flush. Hazzah!

Research: Mushrooms Are Disease

Pin on Meds

By Robert Beelman, PhD, Professor of Food Science, Pennsylvania State University

Mushrooms are often considered only for their culinary use because they are packed with flavor-enhancers and have gourmet appeal. That is probably why they are the second most popular pizza topping, next to pepperoni.

In the past, food scientists like me often praised mushrooms as healthy because of what they dont contribute to the diet they contain no cholesterol and gluten and are low in fat, sugars, sodium and calories. But that was selling mushrooms short. They are very healthy foods and could have medicinal properties, because they are good sources of protein, B-vitamins, fiber, immune-enhancing sugars found in the cell walls called beta-glucans, and other bioactive compounds.

Mushrooms have been used as food and sometimes as medicine for centuries. In the past, most of the medicinal use of mushrooms was in Asian cultures, while most Americans have been skeptical of this concept. However, due to changing consumer attitudes rejecting the pharmaceutical approach as the only answer to healing, that seems to be changing.

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Pharmather Announces Fda Approval Of Ketamine Ind In The Treatment Of Parkinsons Disease

TORONTO, May 17, 2021 PharmaTher Holdings Ltd. , a psychedelics biotech company, is pleased to announce that the U.S. Food and Drug Administration has approved the Companys Investigational New Drug application to proceed with a Phase 2 clinical trial to evaluate the safety, efficacy and pharmacokinetics of ketamine in the treatment of levodopa-induced dyskinesia in patients with Parkinsons disease . PharmaTher expects to begin enrolling patients in the Phase 2 clinical trial in Q3-2021. Assuming the Phase 2 clinical trial is positive, the Company will request a meeting with the FDA to discuss its plan and obtain an agreement to move to a Phase 3 clinical study under the 505 regulatory pathway next year.

Parkinsons disease is a debilitating disorder that affects over 1 million people in the U.S. and more than 7 million people worldwide. There is currently no cure for Parkinsons disease, although some drug combinations are used to treat the disease symptoms. The global Parkinsons disease market is expected to grow from USD $5 billion in 2019 to USD $7.5 billion by the end of 2025 and it is estimated that the potential market opportunity for LID-PD to be over USD $3 billion in the U.S. alone.

About the Phase 2 Clinical Trial

For more information about PharmaTher, please contact:Fabio ChianelliWebsite: www.pharmather.com

Cautionary Statement

Lions Mane Mushroom Crab Cakes

Posted on

This easy Lions Mane mushroom recipe creates a delicious meatless and gluten-free entrée that tastes just like crab. Its Paleo, Keto, and can be made Vegan with a few simple substitutions.

The diverse textures and flavors of our fungi never ceases to amaze me.

If you thought that a mushroom that tastes like chicken was something, be prepared to be blown away over by one that looks and tastes like crab!

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Onze Triptherapie En Bdnf

Wij gebruiken bij onze triptherapie psilocybine houdende paddenstoelen of magic truffels. Psilocybine zorgt na omzetting van het lichaam naar psilocine voor een zeer hoge stimulatie van de 5HT-2a receptor. Door deze stimulatie en het vrijkomen van BDNF door de stimulatie van de 5HT2a receptor gaat het brein in staat van hyperconnectiviteit .

Tijdens deze staat van hyperconnectiviteit vindt er neurogenese plaats en maakt het bewuste brein connectie met het onderbewuste. Hierdoor kunnen problemen in het onderbewuste worden verholpen waardoor er minder stress is, wat BDNF juist afremt.Tevens worden er ook nieuwe permanente verbindingen worden gemaakt en vinden er herstelwerkzaamheden plaats om de schade van depressie te verhelpen. Zelfs neurodegeneratieve ziekten kunnen worden bestreden door de activiteit van BDNF, omdat er weer nieuwe neuronen en dus verbindingen ontstaan.

Is Lions Mane Effective In Treating Ms

Magic mushrooms effective in treating depression, study finds

Lions mane may be effective in treating MS in the future, however more research is needed, especially on humans.

As previously mentioned, MS causes damage to myelin. Current treatments for MS can reduce the severity of the disease, and slow its progression. However, they do not directly repair damaged myelin.

Researchers and doctors are now trying to form treatment strategies for MS that include neurotrophins, such as NGF, for myelin repair. NGF also regulates key structural proteins that can compromise myelin. NGF also promotes the production of another neurotrophin involved in myelination, called brain-derived neurotrophic factor.

Researchers view NGF as a possible therapeutic candidate in treating white matter disorders such as MS.

Researchers previously demonstrated that lions mane may induce NGF. However, these studies have so far mostly involved animals.

found that rats who received lions mane extract daily experienced faster nerve regeneration.

Another preclinical study has shown promising results as well. Researchers supplied rats with H. erinaceus mycelia enriched with erinacines in daily meals.

Following this, the areas of their brain that correlate with certain brain diseases were damaged. The rats that researchers had pretreated with the substance, had a delay in brain damage. This could lead to improvements in ischemic stroke, Parkinsons disease, Alzheimers disease, and depression.

  • Cannabis:

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Voeding En Lager Bdnf

De onderstaande voeding staat erom bekend om ontstekingsreacties uit te lokken en de serotonine te verlagen waardoor BDNF ook omlaag gaat.

Suiker: Het eten van suiker en met name fructose remt rechtstreeks de productie van BDNF en zorgt voor cognitieve achteruitgang. Fructose samen met glucose in een molecuul is wat wij tafelsuiker noemen. Vermijdt toegevoegd suiker zo veel mogelijk. Tevens zorgt suiker voor ontstekingsreacties in het lichaam waardoor er minder serotonine vrijkomt.

Slechte vetten: Slechte vetten zorgen voor ontstekingsreacties in het het lichaam en dat zorgt via ontstekingsfactoren een verlaging van de vrijlating van serotonine. De slechte vetten zijn doorgaans plantaardige omega 6 vetten die worden gebruikt om te bakken zoals zonnebloem-, soja- en pindaolie. Geharde vetten zijn ook slechte vetten.

Zuivel: Zuivel kan bij hoge inname ook ontstekingsbevorderend werken. Het beste kan er geen gezoete of niet aangezuurde zuivel worden genuttigd. Ongezoete kefir of yoghurt kan dus wel met mate worden gegeten.

Gluten: Eet zo min mogelijk producten op basis van granen. Gluten kunnen ook ontstekingen veroorzaken, vooral bij allergische reacties. Haver en dus havermout kunnen wel worden gegeten.

Alcohol: Alcohol is vergist suiker en kan het beste geheel worden vermeden. Indien er toch alcohol wordt gedronken dan kan een half tot een heel glas wijn per dag worden gedronken worden zonder al te veel schade. Daarboven wordt alcohol al een een ontstekingsbevorderaar.

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