Can A Glutathione Deficiency Cause Anemia
Remember earlier when I said that Janice had a glutathione deficiency? High homocysteine is a sign of glutathione deficiency and so is high levels of potassium in the serum. I love it when various markers on blood tests agree!
Interestingly enough, glutathione is the main protector of red blood cells . Red blood cells contain hemoglobin which carries oxygen. Oxygen is negatively charged which means that it can cause free radical damage.
Red blood cells live 120 days. After they die, they are broken down and recycled by the liver. While they are alive, they carry oxygen throughout the entire body.
A glutathione deficiency can cause free radical damage to the red blood cells and cause them to die early.
When red blood cells die too early, it can cause a condition where people can have immature red blood cells circulating in the blood instead of mature red blood cells that are capable of carrying higher levels of oxygen.
Doesnt this sound like anemia? Anemia is when you dont have enough oxygen carrying components in the blood. Premature destruction of red blood cells can cause hemolytic anemia .
So yes, a glutathione deficiency can cause anemia!
Guess what? Type 2 Diabetes and Insulin Resistance can also cause high potassium levels. Potassium follows sugar into the cells. When someone is a Type 2 Diabetic , sugar wont go into the cells properly and stay in the blood. Therefore, potassium wont be able to get into the cells and can go high in the blood serum.
Angel Martn De Pablos
1Laboratory of Neurophysiology and Molecular Neurology , Department of Medical Physiology and Biophysics, Faculty of Medicine, University of Seville, Seville, Spain.
3Department of Surgery, University of Seville, Seville, Spain.
Dr. Emilio FernándezLaboratorio de Neurofisiología y Neurología Molecular Departamento de Fisiología Médica y BiofísicaFacultad de MedicinaUniversidad de SevillaAv. Sanchez Pizjuan 4Sevilla E-41009
Can High Potassium Cause Nerve Problems
Potassium is a very important electrolyte. You dont want too much and you dont want too little. Nerves conduct electrical signals through pumping sodium ions out of the cells and potassium ions into the cells.
We actually have sodium potassium pumps in every cell in our body but nerves can only work through sodium and potassium exchange. That is why it is critically important to have the correct amount of these electrolytes in your blood.
The adrenal glands and kidneys regulate sodium and potassium levels in the blood. When someone is in a chronic state of inflammation, has chronic blood sugar levels that fluctuate, or immune dysregulation, the adrenal glands can become fatigued and unable to help regulate electrolytes in a healthy way.
High levels of potassium can cause muscle cramps, irritability, nerve problems, heart problems, diarrhea, and spasms.
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It Was Not Parkinsons But What Was It
Rather than self-diagnosing, I saw my primary care physician. She ordered a complete blood work-up. The results were within the normal range with one exception my thyroid hormone levels. They were trending upward so my doctor said we would repeat the test in a few months. My immediate reaction was: Oh no! I am getting older and it is menopause!
As suspected, my hormone levels continued to climb, indicating my thyroid was underactive. I was diagnosed with hypothyroidism and started levothyroxine to replace the hormones my body needed. Follow-up bloodwork indicated within the normal range. However, my ANA marker was positive which meant I had an antibody and possibly an autoimmune disorder. Articles have referred to Parkinsons as an autoimmune disease. So, could Parkinsons take the blame for my current health issue? It was still a puzzle.
Western Blotting And Albumin Removal
For removing albumin from serum and better understanding the signal of studying the presence of serum -synuclein, a low denaturalizing method was used based on filtration with Amicon Ultra 50K , based on our previous study . We have observed that one-step filtration allows obtaining a filtrate with molecules lower than 60kDa, and hence, albumin is depleted without the need of magnetic beads or immunoprecipitation. The serum samples were lysated in 10% glycerol, 137mM NaCl, and 20mM Tris HCl, pH 7.5, containing peptidase inhibitors . Protein levels were quantified by using the Bradford method. Samples were boiled, and aliquots containing 15g of protein each were subjected to SDS/polyacrylamide gel electrophoresis. Proteins were transferred electrophoretically to PVDF membranes. Immunolabeling was conducted with primary antibodies for nitrosylated -synuclein at tyrosine 125/136 residues , nitrosylated -synuclein at tyrosine 39 residue , and -synuclein . Primary antibodies were detected with peroxidase-linked secondary antibodies , with enhanced chemiluminescence , and autoradiography. Band densities of resulting autoradiograms were quantified by using the Scion Image program for PC . Values are given as intensity of bands in arbitrary Scion Units.
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Hypothyroidism And Parkinsons Disease
Although it is commonly recognised that diseases of the thyroids can simulate extrapyramidal disorders, a review of the causes of Parkinsonism in the neurology literature shows that they are not usually mentioned or, if so, only very briefly. The development of hypothyroidism in a patient with Parkinson s disease can go undetected, since the course of both diseases can involve similar clinical features. Generally speaking there is always an insistence on the need to conduct a thyroidal hormone study in any patient with symptoms of Parkinson, but no emphasis is put on the need to continue to rule out dysthyroidism throughout the natural course of the disease, in spite of the fact that the concurrence of both pathological conditions can be high and that, in the same way hypothyroidism can simulate Parkinson s disease, the latter can also conceal hypothyroidism.
We report the case of a female patient who had been suffering from Parkinson s disease for 17 years and started to present on off fluctuations that did not respond to therapy. Hypothyroidism was observed and the hormone replacement therapy used to resolve the problem allowed the Parkinsonian fluctuations to be controlled.
What Is The Difference Between Hdl And Ldl Cholesterol
LDL cholesterol is short for Low Density Lipoprotein. Most people are aware that HDL cholesterol is considered the good cholesterol and that LDL is the bad cholesterol.
Consider this: LDL cholesterol is considered bad because it has a higher content of fat than HDL cholesterol. Both, HDL and LDL cholesterol are antioxidants though. They help heal and protect tissues.
Even the bad LDL cholesterol helps repair damaged tissues. The problem with LDL cholesterol is that it repairs the damaged tissues with cholesterol that has more fat in it than what is considered healthy.
However, it is still repairing tissue. This is another example of the body healing itself. Ideally, LDL cholesterol levels will be low and HDL cholesterol levels will be high so that if a part of your body gets inflamed, it will repair with the good HDL cholesterol.
This is especially important for someone with high levels of homocysteine like Janice. Homocysteine damages the inner lining of the arteries . When this damage occurs, LDL will create foam cells or fibrous plaques in the arteries.
This creation of plaques is what can lead to arteriosclerosis and atherosclerosis and that is exactly how high levels of homocysteine is considered a significant risk factor for a stroke or heart attack.
Im especially proud of Janice. I call her my rock star. She took ownership of her health and through my guidance, got herself healthy and has stayed that way.
Health is Happiness,
Dr. Keith Currie
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Thyroid Status And Cognitive Function In Euthyroid Patients With Early Parkinson’s Disease
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Serum Collection And Elisa Measures
Five milliliters of blood was collected, after cephalic vein puncture, in gel-coated tubes to induce blood coagulation and to obtain serum . Serum was centrifuged at 2500rpm for 10min, and then, it was aliquoted, coded, and frozen at 80°C. For measuring 3-nitrotyrosine proteins, a commercial kit was used , following the manufacturer’s instructions. For measuring myeloperoxidase and thyroperoxidase, commercial kits were also used . Serum was not diluted for ELISA.
What Is Parkinsons Disease
Parkinsons disease is a nervous system disorder where a part of the brain degenerates over time. Tremors, slow speech and movement, and an altered or festinating gate are common symptoms.
I have worked with many patients who had resting tremors and also patients who truly had Parkinsons disease. Resting tremors are when your hands shake without doing anything.
Some people who have resting tremors will be told that they might have Parkinsons disease. Of course, many of them do but some of them dont.
I have seen a strong correlation with over activation of the Sympathetic Autonomic Nervous System and tremors.
The Parasympathetic Autonomic Nervous System is the Rest and Digest side of the nervous system. It is what keeps us calm. When you eat a large meal, it is what gets activated and causes you to want to rest.
When the two sides of the Autonomic Nervous System are out of balance, it can create health problems.
The best way that I can explain it is when you have a car accident, a physical altercation or a really bad argument, what tends to happen? Your blood pressure will rise and for about 10-20 minutes or so, your hands shake.
Some people can get stuck in a chronic Sympathetic state where the Sympathetic nervous system overpowers the Parasympathetic.
For some people, this can cause them to have resting tremors or the shakes while others will experience anxiety, depression, night sweats, excessive sweating during the day, poor digestion, hot flashes, etc
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Association Between Thyroid Diseases And Parkinsons Disease: A Nested Case
Article type: Research Article
Affiliations: Department of Neurosurgery, Hallym University College of Medicine, Anyang, Korea | Department of Otorhinolaryngology, Hallym University College of Medicine, Anyang, Korea | Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang, Korea | Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang, Korea
Correspondence: Correspondence to: Hyo Geun Choi, MD, PhD, Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, 14068, Republic of Korea. Tel.: +82 31 380 3849 Fax: +82 31 386 3860 E-mail: .
Keywords: Hyperthyroidism, hypothyroidism, neurodegenerative disorder, Parkinsons disease, pathophysiology, thyroid disease, thyroid dysfunction
Journal: Journal of Parkinson’s Disease, vol. 11, no. 1, pp. 211-220, 2021
What Can Cause A High Mcv On A Blood Test
Anemia, hypothyroidism, vitamin C deficiency, autoimmune disease, and intestinal dysbiosis are common causes of high MCV.
It is important to note that even subclinical hypothyroidism can cause a high MCV. Red blood cells need proper functioning levels of thyroid hormones to mature. Without enough thyroid hormones circulating in the bloodstream, red blood cell development can be decreased.
MCH is the acronym for Mean Corpuscular Hemoglobin. It is the amount of weight of hemoglobin in each red blood cell. A high MCH can be a sign of B12 or Folate deficiency, low stomach acid , and possible parasitic infection.
A high MCH can also be caused by chronic antibiotic usage which could create an imbalance of intestinal microflora. Altered microflora could be the cause of B12 or folate absorption associated with high levels of homocysteine.
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Statistical Analysis And Ethics
We enrolled 35 control subjects, six thyroidectomized subjects, and 50 patients, comprising early disease patients and advanced PD patients . The early period corresponds to HoehnYahr 1 and 2 stages. The advanced period corresponds to HoehnYahr 3 and 4 stages. Differences in nitrosylation markers and clinical characteristics between the PD and control groups were analyzed by the 2 test or Student’s t-test . Immunoblot band signals of different groups were analyzed by one-way ANOVA, followed by Tukey’s test. When two factors were analyzed, two-way ANOVA was employed , followed by the NewmanKeuls test. Two groups were compared with Student’s t-test. If needed, normalization was verified with the ShapiroWilk test. Correlations were studied with Pearson’s test. Informed consent forms, under a protocol approved by the University of Seville and the Macarena Hospital internal ethics and scientific boards, were obtained from all the subjects, and the subjects’ consent was obtained according to the Declaration of Helsinki .
Parkinsons Disease Hypothyroidism And Tremors Thyroid And Gut Health
I dont make it a common practice to write about particular patients and their results under my care. However, a patient named Janice T. has a story that must be told. Janice gave me permission to write about her so that others like her could possibly get help the same way that she did.
Im also going to do things a little differently when it comes to telling Janices story. Im going to tell you the ending first. Then Ill explain how we got there.
I remember how she shook uncontrollably. It was non-stop and she was absolutely miserable. She didnt know if she had a condition called Parkinsons disease or not. Her symptoms had been going on for a long time and she was miserable.
She then told me how before she came to me that she thought she was going to die. She explained how she had made funeral arrangements. She also shared that she arranged for the care of her daughter and put my affairs in order.
Ive known Janice for 4 years. She has sent me other patients and we have told each other many times how much we appreciate each other.
Even though I knew that Janice has done great over the last 4 years, I didnt know truly how much her condition had affected her until she told me that she had made arrangements for her death and burial.
She took ownership of her health and through my guidance, improved her immune system function, nervous system function, and endocrine system function and in doing so, was able to reclaim her life.
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How Are Lymphocytes Associated With Autoimmune Disease
Another important finding on Janices blood test was an elevated lymphocyte count. Lymphocytes are a type of white blood cell that is involved in the humoral immune response .
Lymphocytes will often go up and can stay up for many years with a chronic viral infection. Viral infections are notorious for causing chronic fatigue and when Janice first came to me, she had a chief complaint of fatigue.
Another important cause lymphocytosis is chronic inflammation. It is obvious that Janice had systemic inflammation with high blood glucose, and especially elevated homocysteine .
We have already seen that Janice had inflammation and high levels of lymphocytes associated with a possible autoimmune response. Another important finding is that she had clinically high levels of thyroid peroxidase antibodies.
How Are Thyroid Peroxidase Antibodies Linked To Hashimotos And Graves Disease
High thyroid peroxidase antibodies are associated with thyroiditis and an autoimmune response. When the lymphocytes see something that they dont recognize, they bring in inflammatory armies and work to destroy the foreign substance.
Alone, elevated thyroid peroxidase antibodies arent enough to diagnose Hashimotos thyroiditis but they are a sure sign of heightened autoimmune activity and a possible sign of autoimmune thyroiditis or future thyroid disease.
Often, Graves disease can cause tremors and a Sympathetic Nervous System response where someone can literally be bouncing off of the walls and be all over the place.
Graves disease also has a symptom of unexplained weight loss and people can have a skin on bones appearance. This is caused by the excessive amount of thyroid hormones produced in Graves disease.
People with Graves disease almost seem like they want to crawl out of their own skin. Janices other thyroid hormones were all normal, so there wasnt enough evidence to diagnose her with Graves disease.
Her total cholesterol, LDL cholesterol, and triglycerides were all high. As I wrote about in one of my articles, high triglycerides is a hallmark sign of insulin resistance. Insulin resistance can be another cause of high blood sugar, and chronic fatigue.
Hypothyroidism causes a slow metabolism. In hypothyroidism, the liver continues making cholesterol and since the metabolism is slow , the cholesterol doesnt get broken down and will go high.
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