Wednesday, August 3, 2022

Survival Rate For Parkinson’s Disease

How Is Parkinsons Disease Diagnosed

Parkinson’s Disease – Types, Prevalence, and Prognosis

Diagnosing Parkinsons disease is sometimes difficult, since early symptoms can mimic other disorders and there are no specific blood or other laboratory tests to diagnose the disease. Imaging tests, such as CT or MRI scans, may be used to rule out other disorders that cause similar symptoms.

To diagnose Parkinsons disease, you will be asked about your medical history and family history of neurologic disorders as well as your current symptoms, medications and possible exposure to toxins. Your doctor will look for signs of tremor and muscle rigidity, watch you walk, check your posture and coordination and look for slowness of movement.

If you think you may have Parkinsons disease, you should probably see a neurologist, preferably a movement disorders-trained neurologist. The treatment decisions made early in the illness can affect the long-term success of the treatment.

Reported Standardised Mortality Ratios From 1935 To 2001

The SMRs or mortality ratios comparing PD cases and controls from 39 studies from 1935 to 2006 are reported in table 1. The SMRs ranged from 1, indicating no differences compared with the general population, to 3.4, indicating more than threefold higher mortality in PD. The time trend of estimates is inconsistent, although there appears to be a decrease in the 1970s, corresponding to the introduction of levodopa trials during that time period .). A geographical trend is not apparent, as the SMRs within each geographical region are as variable as between regions .

Table 1Summary of studies that have reported a standardised mortality ratio, comparing Parkinson’s disease patients with a general population

Reference/date

Figure 1Standardised mortality ratios for Parkinson’s disease from 39 studies by publication date.

Curability Of Parkinson’s Disease

Not all doctors are comfortable in saying that Parkinson’s disease is curable. This is because of the fact that there are a lot of factors that could cause the disease, which makes it really tough for doctors do determine the right treatment for Parkinson’s.

However, recovery is possible. It is the rate of recovery from Parkinson’s Disease that is tough to find out. There are a lot of people who have received Parkinson’s treatment for a total of three months and have recovered. There are people who have undergone treatment for Parkinson’s for ten years, to no avail. The rate of recovery from Parkinson’s depends on a lot of factors and there are equal chances that a person would be able to become better, given that all the other conditions are kept normal.

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Can A Patients Ability To Make Decisions In The Last Days Of Life Be Impaired And How Is This Managed

In a North American study of 47 carers of idiopathic PD patients in the last months of life most described the goal of care as comfort, and almost half of the patients were described as unable to make any decisions in the last month of life. 10

When presenting, the patient may already be unable to communicate their symptoms and care preferences due to cognitive impairment and confusion. Also, there might be a physical difficulty in communication from severe rigidity. Care should be taken in considering the presence and consequent treatment of an intercurrent illness, and whether dopaminergic medication is exacerbating confusion due to hallucinations and/or psychosis.27

Continued attempts at verbal and non-verbal communication should be made throughout given the often fluctuating symptoms associated with PD and possible improvement in the intercurrent illness. In the absence of a next of kin or other person who is able to inform the clinical team, decisions should be made on a best interest basis as recommended in end of life care guidance.30

Antioxidants In Red Wine Berries May Slow Progression Of Parkinson’s

Parkinson Disease Survival: A Population

Red wine may be a guilty pleasure, but new research shows it might also be a powerful weapon against the ravages of Parkinson’s disease.

Why? The antioxidants in red wine, and fruit such as berries for that matter, might slow progression of the movement disorder, a new study suggests.

According to researchers, people with Parkinson’s who eat three or more servings per week of foods high in antioxidants called flavonoids may reduce their odds of dying early compared with people who do not eat as many flavonoid-rich foods.

“Flavonoids are naturally occurring, plant-based dietary components, rich in fruit and vegetables. They give various colors in these plants,” said senior researcher Dr. Xiang Gao. He is director of the nutritional epidemiology lab at Pennsylvania State University, in University Park.

“Adapting a healthy dietary pattern, high in colorful fruits and veggies, even after Parkinson diagnosis, could slow disease progression and improve survival rate,” he added.

Still, the study can’t prove that flavonoids prolonged the lives of Parkinson’s patients, only that there may be an association, Gao said.

“In our previous study, published in Neurology in 2012, we found that flavonoids could prevent against Parkinson risk in the future among those who did not have Parkinson at the beginning of follow-up,” Gao said. “The current study provides further evidence regarding neuro-protective effects of fruit and vegetables.”

More information

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Survival In Incident Idiopathic Parkinsonism

Clinical characteristics at baseline for the patients with idiopathic parkinsonism are shown in . Survival data from first evaluation to death or end of the study were obtained for all participants . Of the 178 patients with idiopathic parkinsonism, 109 died during follow-up. Seventy-seven of the deaths occurred in the PD group, 12 in the MSA group, and 16 in the PSP group. The 4 patients with unclassifiable parkinsonism likely represent cases of late-onset PD but were excluded from further analyses, as they did not fulfill specific diagnostic criteria. The overall mean age at death was 82.0 years. Deep brain stimulation or pumps for intestinal delivery of levodopa were used or had been used by 12 of the 143 patients with PD.

    Kaplan-Meier plots of survival in patients with Parkinson disease in relation to clinical and neurobiological phenotype at baseline . Severe hyposmia is defined by a B-SIT score < 4. All variables were significantly related to survival at the p< 0.001 level except the tremor or PIGD/intermediate variable , which was significant at the p = 0.004 level . B-SIT = Brief Smell Identification Test PIGD = postural imbalance and gait disorder.

    How Do I Prevent Falls From Common Hazards

    • Floors: Remove all loose wires, cords, and throw rugs. Minimize clutter. Make sure rugs are anchored and smooth. Keep furniture in its usual place.
    • Bathroom: Install grab bars and non-skid tape in the tub or shower. Use non-skid bath mats on the floor or install wall-to-wall carpeting.
    • Lighting: Make sure halls, stairways, and entrances are well-lit. Install a night light in your bathroom or hallway and staircase. Turn lights on if you get up in the middle of the night. Make sure lamps or light switches are within reach of the bed if you have to get up during the night.
    • Kitchen: Install non-skid rubber mats near the sink and stove. Clean spills immediately.
    • Stairs: Make sure treads, rails, and rugs are secure. Install a rail on both sides of the stairs. If stairs are a threat, it might be helpful to arrange most of your activities on the lower level to reduce the number of times you must climb the stairs.
    • Entrances and doorways: Install metal handles on the walls adjacent to the doorknobs of all doors to make it more secure as you travel through the doorway.

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    How Can Hospice Help Your Loved One In The Final Stages Of Parkinsons Disease

    Hospice care is an extra layer of support to help you care for your loved one with end-stage Parkinsons disease. It is a special kind of care that provides comfort, support, and dignity at the end of life.

    The comprehensive program focuses on physical, emotional, and spiritual quality of life through the help of a team of experts. The team includes a board-certified physician, nurse, social worker, certified home health aide , spiritual support counselor, and volunteer.

    The nurse will explain the prognosis and what to expect in the upcoming days or weeks. They will also monitor pain and other symptoms. The CHHA helps with personal care needs like bathing and changing bed linens. The social worker helps address social, emotional and practical challenges including complex and inter-related needs. The spiritual support counselor helps explore spiritual concerns.

    Most importantly, the hospice team will be there for you during this difficult time, bringing you peace of mind. The team is on call 24 hours a day even at 2:00 am.

    Hospice is about making your final months and weeks as good as possible. This means focusing on what really matters to you.

    New Clues On Why Some People With Parkinsons Die Sooner

    Parkinson’s Disease- Prognosis and Clinical Symptoms

    The American Academy of Neurology, an association of more than 22,000 neurologists and neuroscience professionals, is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as epilepsy, dystonia, migraine, Huntingtons disease, and dementia.For more information about the American Academy of Neurology, visit http://www.aan.com.

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    Causes Of Parkinson’s Disease

    Parkinson’s disease is caused by a loss of nerve cells in part of the brain called the substantia nigra. This leads to a reduction in a chemical called dopamine in the brain.

    Dopamine plays a vital role in regulating the movement of the body. A reduction in dopamine is responsible for many of the symptoms of Parkinson’s disease.

    Exactly what causes the loss of nerve cells is unclear. Most experts think that a combination of genetic and environmental factors is responsible.

    Myth : Parkinsons Disease Is Fatal

    Fact: Although a diagnosis of Parkinsons is devastating, it is not as some people may still believe a death sentence. Parkinsons disease is not a direct killer, like stroke or heart attack. That said, much depends on the quality of your care, both from your medical team and yourself.

    As the disease progresses, you may become more vulnerable to falls, which can be dangerous. Thats why exercise and physical therapy are so important.

    Infection is another problem. In later stages of Parkinsons, people often miss those signals and may not notice somethings up until its too late. That can be, literally, a killer so be sure to stay up to date with checkups.

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    The Importance Of Establishing Parkinsons Prevalence Numbers

    Parkinsons Prevalence estimates will help the Parkinsons Foundation attract the attention of federal and state government as well as the pharmaceutical industry to the growing need and urgency in addressing PD. This is an important first step to better understanding who develops PD and why.

    The next phase of this study will be to determine the rate of PD diagnosis or incidence, how that has changed over time and what is the rate of mortality among those affected by PD. Determining the prevalence and incidence will allow the PD community to effectively advocate for additional money and resources necessary to support Parkinsons research.

    Parkinsons Foundation Prevalence Project numbers highlight the growing importance of optimizing expert Parkinsons care and treatment for people with Parkinsons, which would help future caregivers and ease the strain on health and elder care systems.

    By supporting this study, the Foundation works to better understand Parkinsons with the goal of solving this disease. Establishing these numbers and using them to educate PD communities and influence legislation will help the foundation provide tailored resources, outreach and advocacy to the underserved PD populations across the nation. The entire published study is available in the Parkinsons Foundation scientific journal, npj Parkinsons Disease.

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    Stages Of Parkinsons Disease

    Parkinsons disease death rates in the United States

    Experts have identified a general Parkinsons progression and created a set of Parkinsons stages, which can help determine where you are at in the disease and what your prognosis might be. However, not everybody progresses through Parkinsons disease in the same way or on the same time frame. Some people skip stages or rapidly progress to later stages. Others live for many years with mild or moderate Parkinsons and never reach the more advanced stage of the illness.

    Here are five commonly recognized stages of Parkinsons, including what symptoms you might expect. Treatment also can occur during these stages to help prevent or delay later stages of the illness. This can include medication, , and lifestyle changes, such as a healthy diet and exercise program.

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    Demographic And Clinical Data

    Medicare Beneficiary Annual Summary Files contain individual level demographic, health service utilization, and survival data, as well as clinical data on 21 common conditions, identified using ICD-9 based algorithms.22We used the clinical data from these files to calculate an age-weighted modified Charlson comorbidity index for each PD case.23These data were also used to determine whether a PD case had been diagnosed with Alzheimer dementia/ Senile dementia or related disorders according to the Centers for Medicare and Medicaid services Chronic Condition Warehouse algorithm22 between 1997 and 2008.

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    At a five-year follow-up, the mortality ratio the ratio between the number of PDD/DLB patients deaths over the number of deaths in the general population was 3.02, and at 10 years, it was 3.44, indicating that PDD and DLB patients have mortality rates more than three times higher than the general population.

    Researchers also found that survival was worse if the patients were diagnosed at a younger age, were female, and showed lower scores on the cognitive test.

    A more detailed analysis revealed higher mortality in DLB patients who were positive for the APOE test, but not in PDD patients who tested positive in APOE.

    This retrospective study demonstrated a higher mortality rate in patients with PDD and DLB compared with the general population 10 years after the diagnosis of the disease.

    Also, younger patients, females, and those who tested positive for APOE are linked to excess mortality.

    In conclusion, mortality in patients diagnosed with Lewy bodies and Parkinsons disease dementia is over three times higher in patients during a ten-year follow-up, compared to persons in the general population unaffected by the disease, the researchers wrote.

    Excess mortality is found primarily in younger patients, females and carriers of APOE. Further research is required regarding survival and possible interventions, including disease-modifying treatments, to improve care and prognosis for these patients, they added.

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    What Is The Impact Of Levodopa Treatment On The Prognosis And Mortality Rate Of Parkinson Disease

    Before the introduction of levodopa, Parkinson disease caused severe disability or death in 25% of patients within 5 years of onset, 65% within 10 years, and 89% within 15 years. The mortality rate from Parkinson disease was 3 times that of the general population matched for age, sex, and racial origin. With the introduction of levodopa, the mortality rate dropped approximately 50%, and longevity was extended by many years. This is thought to be due to the symptomatic effects of levodopa, as no clear evidence suggests that levodopa stems the progressive nature of the disease.

    Myth : Parkinsons Is Only A Motor Condition

    Zoltan_Mari – Pimavanserin and Parkinson√Ęs Disease Psychosis

    Fact: While its true that Parkinsons disease symptoms include shaking and tremor, rigid muscles, slowness of movement, and a frozen or flat expression, its a lot more than that.

    Nonmotor symptoms deserve and are getting more attention from doctors and researchers. These symptoms include cognitive impairment or dementia , anxiety and depression, fatigue, sleep problems and more.

    For some patients, nonmotor symptoms are more disabling than motor symptoms, which are the focus of treatment. Be sure to talk to your doctor about other issues so you can get all of your symptoms addressed.

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    Parkinson’s Disease Diet And Nutrition

    Maintaining Your Weight With Parkinson’s Disease

    Malnutrition and weight maintenance is often an issue for people with Parkinson’s disease. Here are some tips to help you maintain a healthy weight.

    • Weigh yourself once or twice a week, unless your doctor recommends weighing yourself often. If you are taking diuretics or steroids, such as prednisone, you should weigh yourself daily.
    • If you have an unexplained weight gain or loss , contact your doctor. He or she may want to modify your food or fluid intake to help manage your condition.
    • Avoid low-fat or low-calorie products. . Use whole milk, whole milk cheese, and yogurt.

    Death Rate From Parkinsons Disease Rising In The Us

    Over the last two decades, the death rate from Parkinson’s disease has risen about 63% in the US, according to research published in Neurology, the medical journal of the American Academy of Neurology. The study also reported that the death rate was twice as high in men as in women, and there was a higher death rate in white people than other racial/ethnic groups.

    “We know that people are living longer and the general population is getting older, but that doesn’t fully explain the increase we saw in the death rate in people with Parkinson’s,” study author Wei Bao, MD, PhD, who conducted the research at the University of Iowa in Iowa City. “Understanding why more people are dying from this disease is critical if we are going to reverse the trend.”

    The study looked at a national death registry that included 479,059 people who died of Parkinson’s between 1999 and 2019.

    After adjusting for age, researchers found that the number of people who died from the disease increased from 5.4 per 100,000 people in 1999 to 8.8 per 100,000 people in 2019. The average annual increase was 2.4%.

    It’s important to continue to evaluate long-term trends in Parkinson’s death rates, said Dr. Bao. This can inform future research that may help pinpoint why more people are dying of the disease. Also, updating vital statistics about Parkinson’s death rates may be used for priority setting and financing of health care and policy.”

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