Wednesday, September 21, 2022

Parkinson’s Disease And Cough Medicine

What Are Some Side Effects That I Need To Call My Doctor About Right Away

Vlog #159 – Ambroxol For Parkinson’s Disease

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash hives itching red, swollen, blistered, or peeling skin with or without fever wheezing tightness in the chest or throat trouble breathing, swallowing, or talking unusual hoarseness or swelling of the mouth, face, lips, tongue, or throat.

What Do I Need To Tell My Doctor Before I Take This Drug

  • If you are allergic to this drug any part of this drug or any other drugs, foods, or substances. Tell your doctor about the allergy and what signs you had.
  • If you have taken certain drugs for depression or Parkinsons disease in the last 14 days. This includes isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Very high blood pressure may happen.
  • If you have a cough with a lot of mucus, a long-term cough caused by smoking or being around smoke, or lung problems like asthma or emphysema.

This is not a list of all drugs or health problems that interact with this drug.

Tell your doctor and pharmacist about all of your drugs and health problems. You must check to make sure that it is safe for you to take this drug with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What Are Some Things I Need To Know Or Do While I Take This Drug

  • Tell all of your health care providers that you take this drug. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
  • Do not take this drug for longer than you were told by your doctor.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this drug affects you.
  • Talk with your doctor before you use marijuana, other forms of cannabis, or prescription or OTC drugs that may slow your actions.
  • If the patient is a child, use this drug with care. The risk of feeling excitable may be higher in children.
  • Different brands of this drug may be for use in different ages of children. Talk with the doctor before giving this drug to a child.
  • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

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Ucl Researchers Test Cough Syrup Drug For Parkinsons

A research team at University College London has secured funding to evaluate the use of cough syrup drug ambroxol to treat Parkinsons disease patients in clinical trials.

A research team at University College London has secured funding to evaluate the use of cough syrup drug ambroxol to treat Parkinsons disease patients in clinical trials.

Ambroxol was originally intended to clear phlegm and ease coughing in patients with respiratory diseases.

In a recent study conducted by the universitys researchers, the drug was observed to be safe and well-tolerated in 17 Parkinsons patients.

The drug was found to have effectively crossed the blood-brain barrier and elevated the glucocerebrosidase protein levels in the brain cells of the subjects.

GCase protein enables the effective removal of waste by cells. This function is known to be deficient in some patients with Parkinsons.

It is expected that increasing levels of the protein may help in keeping cells healthier for longer and, in turn, slow disease progression in this patient population. These study findings were published in the JAMA Neurology journal.

Based on the results, the Cure Parkinsons Trust , the Van Andel Institute , and the John Black Charitable Foundation agreed to provide £522,126 in funding to advance the drug into further clinical trials.

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How Is This Drug Best Taken

Parkinsons Disease: Symptoms, Treatment &  Support

Use this drug as ordered by your doctor. Read all information given to you. Follow all instructions closely.

All products:

  • Take with or without food. Take with food if it causes an upset stomach.
  • Drink lots of noncaffeine liquids unless told to drink less liquid by your doctor.

Liquid:

  • Measure liquid doses carefully. Use the measuring device that comes with this drug. If there is none, ask the pharmacist for a device to measure this drug.

Extended-release tablets:

  • Swallow whole. Do not chew, break, or crush.
  • Take with a full glass of water.

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What Does This Have To Do With Parkinsons Disease

In fact, ambroxol increases the level of an enzyme that breaks down waste products from the cells. Interestingly, the level of this enzyme is regulated by a gene called GBA. It turns out that mutations in this gene are also associated with Parkinsons disease. In fact, it is one of the genetic mutations that causes the most cases of Parkinsons disease . Interestingly, even people living with Parkinsons disease who do not have this genetic mutation have lower enzyme levels, which leads to accumulations of toxic chemicals in the neurons.

In recent years, studies on mice or primates have shown that ambroxol increases the level of this cleansing enzyme but also reduces the level of alpha-synuclein, a protein that is partially responsible for Parkinsons disease.

In 2018, ambroxol was being evaluated in Phase II in 17 patients. Not only is this drug safe for people living with Parkinsons disease, but it has the ability to reach the brain, which is a big issue with most drugs. Once it reaches the dopaminergic neurons, it increases the concentration of this cleansing enzyme.

What Happens If I Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of rasagiline can be fatal.

Overdose symptoms may include drowsiness, dizziness, severe headache, rapid pulse, feeling agitated or irritable, muscle spasms in your neck or jaw, sweating, cold or clammy skin, shallow breathing, fainting, or seizure . These symptoms may be delayed for 12 to 24 hours after an overdose.

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Tips For People With Parkinsons Who Want To Take Over The Counter Medications During Flu Season

People with PD often tell us that when they get sick with cold and flu-like symptoms, their pharmacist and healthcare professionals warn them to stay away from the medication aisle of the pharmacy. They are told that any over-the-counter medication has the potential to worsen Parkinsons symptoms. Unfortunately, many people interpret this potential worsening as a recommendation to never use these medications.

Also contributing to this issue is a series of reports that medications such as anticholinergics may cause acute confusion and even contribute to long-term cognitive changes. It is important to keep in mind when selecting a cough or flu medication that the intent is not to treat long-term issues.

This flu season we wanted to provide the PD community with some tips to help you navigate Parkinsons while simultaneously addressing cold and flu symptoms:

In 2014, Kim Painter wrote a great article in the USA Today to help individuals and families stay safe in the cold and flu aisle.

Here are some of Kims tips:

  • Treat only symptoms you have and be wary of multi-symptom products.
  • Know your dose and dont overdose.
  • Know your health risks .
  • Don’t double up and accidentally take two medicines with similar ingredients.
  • Consider trying alternatives .

How Do I Store And/or Throw Out This Drug

Cold Medicine Warning â ï¸?ð (Parkinsonâs)
  • Store at room temperature in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

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Changes In Sleeping Patterns

As Parkinsons progresses, you can also develop problems with sleep patterns. These may not happen in the early stages, but can be noticeable later. You might wake up often in the middle of the night or sleep more during the day than you do at night.

Another common sleep disturbance for people with Parkinsons is rapid eye movement sleep behavior disorder. This is when you start acting out your dreams in your sleep, such as verbally and physically, which can get uncomfortable if someone is sharing your bed. Dr. Rundle-Gonzalez says many times a bed partner will be the one to notice sleep problems.

REM sleep behavior disorder can also happen in people who dont have Parkinsons. However, if this isnt something youve dealt with before, its likely related to your disease. There are medications your doctor can prescribe to help you sleep comfortably through the night.

What Do I Do If I Miss A Dose

  • If you take this drug on a regular basis, take a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not take 2 doses at the same time or extra doses.
  • Many times this drug is taken on an as needed basis. Do not take more often than told by the doctor.

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Identifying Newly Diagnosed Pd Patients And Matched Controls For Each Pd Patient

The study population comprised newly diagnosed patients with PD and their matched controls. First, we identified PD patients using the registration code for PD in the program for rare, intractable disease from January 1, 2004, to December 31, 2006, and we defined the index date as the date of the earliest claim with the V124 code. To remove any prevalent cases, we excluded patients who had PD diagnostic codes or PD registration codes before January 1, 2004. As the V124 registration criteria did not exclude atypical Parkinsonian syndromes, we excluded patients diagnosed with atypical parkinsonism during the entire study period, from 2002 to 2017. Moreover, we excluded patients under 40 years of age. Lastly, we excluded patients whose total number of days of antiparkinsonian medications was less than 180 days. The list of the antiparkinsonian medications used in this study is given in Supplementary Table .

Then, we selected up to four controls for each PD patient matched by sex and age at the index date. Previous studies reported that matching 4 controls to 1 patient can minimize the bias in measuring treatment effect in the maximum number of matched controls,. Individuals who had the registration code for rare, intractable disease for PD , had any diagnostic code for Parkinsonism , or had been prescribed an antiparkinsonian drug during the study period were not recruited as controls.

Cough Syrup Drug Being Trialled As Parkinsons Treatment

drugs of Parkinson

14 February 2020

After finding that a drug found in cough syrups may have use as a treatment for Parkinsons disease, UCL researchers have received funding for the next stage in clinical trials.

Ambroxol, a medication originally designed to clear phlegm and ease coughing for people with respiratory diseases such as bronchitis, is being tested to see if it can slow down the progression of Parkinsons disease by keeping cells healthier for longer.

A research team led by Professor Tony Schapira reported in January that ambroxol was safe and well-tolerated in 17 study participants with Parkinsons disease.

According to the findings published in JAMA Neurology, the drug also effectively crossed the blood-brain barrier and increased levels of the glucocerebrosidase protein in the participants brain cells. This protein allows cells to remove waste more effectively, a function which evidence suggests is deficient in some people with Parkinsons. Increasing levels of the protein may have the potential to keep cells healthier for longer and, therefore, slow Parkinsons progression.

By increasing levels of GCase, ambroxol allows cells to remove waste, which would ideally keep cells healthier for longer and could slow down the progression of Parkinsons, explained Professor Schapira.

The iLCT committee had prioritised ambroxol in 2014.

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Standard Protocol Approval Registration And Patient Consent

The study protocol was assessed and determined to be exempt from review by the Institutional Review Board of Seoul National University Hospital . Furthermore, the NHIS approved the use of its database and provided data after excluding all possible patient identification information . The requirement for informed consent was waived by the Institutional Review Board of the Seoul National University, because the database was anonymized. All methods were carried out in accordance with relevant guidelines and regulations.

Memory Or Thinking Problems

Having issues with thinking and processing things could mean your disease is progressing. Parkinsons is more than a movement disorder. The disease has a cognitive part as well, which means it can cause changes in the way your brain works.

During the final stage of the disease, some people may develop dementia or have hallucinations. However, hallucinations can also be a side effect of certain medications.

If you or your loved ones notice that youre getting unusually forgetful or easily confused, it might be a sign of advanced-stage Parkinsons.

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How To Use Nasal Decongestant Pd Capsule Extended Release

Take this medication by mouth as directed by your doctor. If you are self-treating, follow all directions on the product package. If you have any questions, ask your doctor or pharmacist.

This medication may be taken with food if stomach upset occurs. Drink plenty of fluids unless otherwise directed by your doctor.

If you are using the liquid form of this medication, carefully measure the dose using a special measuring device/spoon. Do not use a household spoon because you may not get the correct dose. If your liquid form is a suspension, shake the bottle well before each dose.

Do not crush or chew extended-release tablets or capsules. Doing so can release all of the drug at once, increasing the risk of side effects. Also, do not split extended-release tablets unless they have a score line and your doctor or pharmacist tells you to do so. Swallow the whole or split tablet without crushing or chewing.

If you are using chewable tablets, chew each tablet thoroughly before swallowing.

If you are using a product made to dissolve in the mouth , dry your hands before handling the medication. Place each dose on the tongue and allow to dissolve completely, then swallow it with saliva or with water.

Dosage is based on the product you are taking and your age, medical condition, and response to treatment. Do not increase your dose or take this medication more often than directed without your doctor’s approval. Improper use of this medication may result in serious harm .

Before Taking This Medicine

Swallowing Problems in Parkinson’s Disease

You should not take Azilect if you are allergic to rasagiline.

Do not use Azilect if you have used any other MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, selegiline, tranylcypromine, and others.

Many drugs can interact and cause dangerous effects. Some drugs should not be used together with Azilect. Your doctor may change your treatment plan if you also use:

People with Parkinson’s disease may have a higher risk of skin cancer . Ask your doctor about skin symptoms to watch for.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.

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Make Simple Changes To Your Home

If you have trouble moving around or become tired easily, it also may help to make a few changes in your home.

  • Change the location of furniture so that you can hold on to something as you move around the house.
  • Use specially modified chairs that make it easier to sit down and stand up.
  • Group the items you use most often in one easy-to-reach place.
  • Tack down rugs to prevent tripping.
  • Put no-slip tape in the bathtub and install handrails to prevent falls.

An occupational therapist can assist in making these and other changes to your home, including helping you to find ways to make dressing, bathing, and eating easier.

What Are Some Other Side Effects Of This Drug

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling nervous and excitable.
  • Trouble sleeping.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to your national health agency.

You may report side effects to the FDA at 1-. You may also report side effects at .

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Definition Of Demographics And Confounders

We defined age, sex, residential region, and household income in reference to the index date. We also defined the presence of comorbidities according to previous diagnoses up to two years before the index date. The defined comorbidities included diabetes mellitus, hypertension, ischemic heart disease, congestive heart failure, cancer, tuberculosis, peripheral arterial disease, atrial fibrillation, chronic kidney disease, dyslipidemia, cerebrovascular disease, dementia, chronic obstructive pulmonary disease, and seizure disorder,. Information on medications, including anticoagulants, antihypertensive agents, oral hypoglycemic agents, insulin, benzodiazepines, and antipsychotics was collected from the prescription records within two years from the index date. The list of co-medications is provided in Supplementary Table . Modified Charlson comorbidity index scores were calculated from the previous diagnosis within a year before the index date. These diagnoses include diagnoses of myocardial infection, congestive heart failure, peripheral vascular disease, cerebrovascular disease, dementia, chronic pulmonary disease, rheumatologic disease, peptic ulcer disease, diabetes without chronic complications, diabetes with chronic complications, hemiplegia, renal disease, any malignancy including leukemia and lymphoma, mild liver disease, moderate or severe liver disease, metastatic solid tumor, and AIDS.

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