Tuesday, December 6, 2022

Does Parkinson’s Cause High Blood Pressure

Tips: Avoiding Neurogenic Orthostatic Hypotension

Understanding Blood Pressure Fluctuations in Parkinson’s Disease
  • Drink lots of water and other fluids, at least one cup with meals and two more at other times of the day.
  • Regularly practice gentle exercise and avoid long periods of inactivity.
  • Eat small, frequent meals. Reduce alcohol intake and avoid hot drinks and hot foods.
  • After consulting your doctor, increase your salt intake by eating prepared soups or pretzels. Note: for people with heart disease, this should be avoided.
  • If you expect to be standing for a long period of time, quickly drinking two eight-ounce glasses of cold water will increase blood volume and causes blood pressure to go up for several hours.
  • Try wearing compression garments such as anti-gravity stockings.
  • Do isometric exercises, like marching your legs slowly in place, before getting up.
  • Shift slowly from lying to sitting and then standing.

Printing made possible with a grant from Theravance. Content created independently by the Parkinsons Foundation.

For more insights on this topic, listen to our podcast episode Understanding Neurogenic Orthostatic Hypotension.

Understanding The Neurologic Control Of The Cardiac System

Before we explore this issue, lets first learn a bit about the autonomic nervous system and about the cardiac systems place within it. The ANS is part of the peripheral nervous system, a network of nerves throughout the body. The ANS exerts control over functions that are not under conscious direction such as respiration, heart function, blood pressure, digestion, urination, sexual function, pupillary response, and much more. The ANS is further subdivided into the parasympathetic nervous system and the sympathetic nervous system. Both the parasympathetic and sympathetic nervous systems regulate most major organs. Often, they have opposite effects, with the sympathetic nervous system activating a system and the parasympathetic system calming it down.

One of the systems controlled by the ANS is cardiac regulation. Blood pressure sensors, known as baroreceptors, reside in the heart as well as in the carotid artery, the major artery in the neck. If the baroreceptors sense a change in the blood pressure, a signal is sent to particular areas in the brain. From there, the autonomic nervous system sends signals to the heart to control heart rate and cardiac output. Signals are also sent to the blood vessels to change the size of their diameter, thereby regulating blood pressure.

Blood Pressure And Parkinsons: Whats The Connection

This 60-minute audio with slides is an interview of two neurologists and a person with Parkinsons discussing the symptoms, causes, and how to mitigate episodes of low blood pressure, as well as high blood pressure and recent Phase III trial testing of the high blood pressure medication, isradipine, to slow Parkinsons disease progression without lowering blood pressure too much.

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High Blood Pressure In Autonomic Failure May Pose A Risk To Health

Autonomic failure is a condition that develops when the nerves that control the heart and circulation become damaged. It is most often found in adults with neurodegenerative diseases that affect the brainstem or peripheral nerves, like Parkinson disease, Lewy body dementia, and multiple system atrophy. As a result, these patients have problems with blood pressure control, which is why they are followed in autonomic clinics.

One of the most challenging aspects for any doctor encountering a patient with autonomic failure is how to manage their blood pressure. When a patient with Parkinsonism stands up, their blood pressure can plummet to very low levels. But, when they lie down it often enters the hypertensive range. Treating the lows, often worsens the highs, and vice versa, which means you have to be vigilant about both. More recently, there has been a shift in the attention to high blood pressure in Parkinsons and multiple system atrophy. We recently took part in writing new international guidelines for the diagnosis and management of supine hypertension. But until now, it wasnt quite clear what were the consequences of high blood pressure in patients with autonomic failure on the organs.

Read more here:

Learn more about how to measure your blood pressure at home: here

Learn the non-pharmacological remedies that can help lower supine blood pressure in patients with autonomic failure:here.

Literature Search And Study Characteristics

In Parkinsons disease, managing orthostatic hypotension improves ...

The search strategy identified 1,141 articles from PubMed, 212 articles from Web of Science, 2,800 articles from EMBASE, 64 articles from China National Knowledge Infrastructure, 407 articles from Wan fang, 83 articles from VIP and 260 articles from CBM. After duplicates being removed, 3,205 articles were excluded on screening of titles and/or abstract. After reading full text, 102 articles were excluded for the following reasons: duplicated reports from the same study population lacking OR, RR or HR and 95% CI inverse exposure and outcome review . Finally, 26 articles were included in this meta-analysis. The detailed literature search for article inclusion is shown in Figure 1.

Fig. 1.

Selection of studies for inclusion in this meta-analysis. RR, risk ratio HR, hazard ratio.

Table 1.

Characteristics of studies on hypertension and the risk of PD

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What Research Is Being Done

The NINDS supports research on disorders of the autonomic nervous system, including multiple system atrophy with orthostatic hypotension. This research is aimed at developing techniques to diagnose, treat, and prevent these disorders. Currently there are ongoing treatment trials of drugs to treat MSA.

National Institutes of Health National Institute of Neurological Disorders and Stroke

Last reviewed by a Cleveland Clinic medical professional on 02/07/2018.

Cleveland Clinic is a non-profit academic medical center. Advertising on our site helps support our mission. We do not endorse non-Cleveland Clinic products or services.Policy

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Grounds For Cautious Optimism

The scientists used genetically altered mice and zebrafish for their study. The mice had gene alterations that induced them to develop either Huntingtons disease or a type of Parkinsons disease. The zebrafish had gene alterations that induced changes that model a form of dementia.

Treatment with felodipine reduced the buildup of toxic, incorrectly folded proteins and signs of disease in the mouse models of Huntingtons disease and Parkinsons disease, as well as in the zebrafish model of dementia.

When scientists study the effects of drugs in mice, they typically use higher levels than the doses that are safe in humans. In this study, however, the team showed that the blood levels of felodipine necessary for triggering autophagy were similar to those in humans.

They inserted minipumps under the mices skin to enable drug concentrations at levels similar to those of humans and to keep the levels steady without wild fluctuations.

Our data with this minipump administration suggest that at human-like plasma concentrations, felodipine can induce autophagy in the brains of mice and clear aggregate-prone disease-causing proteins, conclude the study authors.

These results are just the beginning, says Prof. Rubinsztein. We need to be cautious, he adds, but I would like to say we can be cautiously optimistic.

The drug will need to be tested in patients to see if it has the same effects in humans as it does in mice.

Prof. David C. Rubinsztein

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Stay Informed On Your Parkinsons Journey

Would you like to learn more about nOH and living well with Parkinsons?

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Dr. Jose-Alberto Palma is Assistant Professor of Neurology and Assistant Director of the Dysautonomia Center at New York University. His work over the past years has been focused on the diagnosis, management and understanding on autonomic disorders in patients with autonomic synucleinopathies, such as Parkinson disease and multiple system atrophy, as well as in the search for biomarkers for early diagnosis of these disorders. He has been involved in several studies and clinical trials to develop new treatments for autonomic dysfunction, and to describe the premotor phase of Parkinson disease.

Stay Away From Hot Stuff

Anyone who’s suffered from low blood pressure for a while knows that its symptoms tend to get worse during hot summer weather. That is because higher temperatures relax your blood vessels, reducing your blood pressure. You’ll want to stay away from hot baths and saunas, consider turning the thermostat down when relevant, and avoid exercising in hot weather.

When it’s already hot out, you’re also more likely to become dehydrated so keep drinking water!

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The Cause Of Parkinsons Delusions And Hallucinations

Some risk factors associated with the development of psychosis in Parkinsons disease include:

  • Age: Parkinsons disease usually occurs in people over age 60.
  • Duration and severity of Parkinsons disease: Psychosis is more common in advanced or late-stage Parkinsons disease.
  • Later onset: Occurring later in life
  • Hyposmia: A decreased sense of smell
  • Cognitive impairment: Problems with thinking, including trouble remembering, difficulty learning new things, difficulty concentrating, problems making decisions that affect everyday life
  • Depression: People who have both depression and Parkinsons disease are at a greater risk of developing psychosis.
  • Diurnal somnolence: Daytime sleepiness
  • REM sleep behavior disorder: A sleep disorder in which you physically act out dreams involves making vocal sounds and sudden, often extreme, arm and leg movements during REM sleep
  • Visual disorders: Impaired vision
  • Severe axial impairment: Speech, swallowing, balance, freezing of gait
  • Autonomic dysfunction: Impairment of the autonomic nervous system , which controls involuntary or unconscious actions such as heart rate, breathing, body temperature, blood pressure, digestion, and sexual function
  • High medical comorbidity: The existence of more than one condition or illness in the same person at the same time with Parkinsons disease, may include conditions such as dementia, depression, and sleep disorders

Hypertension And Risk Of Subsequent Motor Pd

Low blood pressure could be a culprit in dementia, studies suggest

Seven cohort studies published between 2007 and 2015 included 3,170 persons who met the criteria for PD diagnosis and 339,517 participants who had not met the criteria for PD diagnosis during follow-up. Among them, four studies reported that hypertension is associated with an increased risk of PD , whereas the other three studies indicated that there was no significant association .

Figure 2. Meta-analysis of the association between hypertension and Parkinsons disease risk.

Figure 3. Meta-analysis of the association between hypertension and Parkinsons disease risk after adjustment for the potential confounding vascular factors.

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Fluctuations In Blood Pressure

I know it has been well established that Parkinsons patients often experience fluctuations in BP.

Does anyone know:

Is the cause Parkinsons disease or the medications?

Thanks

My guess is, Who knows!!

It could be one or both.

Just take good care of yoursself.

Love, Eva G.

I believe it can be caused by both.

My vote for the cause of blood pressure changes in PD patients is the disease.

After developing rather serious heart problems some years ago, involving high blood pressure, a cabbage , numerous stints and a rather gloomy prognosis, I was prescribed two different medications to lower blood pressure. . Then, in November, 2010, I was diagnosed with PD and have been taking Sinemet ever since. As the Parkinsons progressed, the symptoms of heart problems lessened. including the high blood pressure. I was able to discontinue the two medications I had been taking for it. My neuro was pleased and agreed that the disease does sometimes improve heart problems and hypertension. I am not overjoyed to have Parkinsons but, in this case the trade-off has left me, , to the good.

Well my husband, has come off his BP meds,

Since he had these problems, with his blood pressure,

Ok sitting down . But plummets when hes standing..

But does vary with Parkimsons

Its the disease not the meds. I collapsed before I had my diagnosis and the neuro said it was due to low blood pressure.

my neuro has never asked me about my blodpressure.

Isnt this strange?

Impaired Ans Response To Standing In Noh

In patients with PD and nOH, autonomic dysfunction causes blood pressure to fall upon standing, due to an inappropriate NE response to postural change. Orthostatic hypotension has been defined as a drop in SBP of at least 20 mmHg or a drop in diastolic blood pressure of at least 10 mmHg after 3 minutes of standing. There is often a loss of the cardioacceleratory response too. Non-neurogenic causes of orthostatic hypotension are also common in patients with PD, and contribute to blood pressure drop. These non-neurogenic causes of orthostatic hypotension should be identified first, and include dehydration, medications, and cardiac pump failure. A clinical diagnosis of nOH can be made when these non-neurogenic causes of persistent orthostatic hypotension are excluded, and can be confirmed through autonomic testing and plasma NE levels.

In PD, autonomic dysfunction is mainly a result of cardiac sympathetic denervation with inadequate activation of NE pathways, and also baroreflex failure. This can emerge during the course of PD or can occur early in its course. Parkinsonism due to multiple system atrophy is also accompanied by prominent autonomic dysfunction, but nOH results from failure of central NE pathways.,

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How Is Noh Diagnosed

Diagnosis of nOH requires blood pressure readings taken while lying flat as well as while standing up. At least a 20 mmHg drop in your systolic blood pressure and a 10 mmHg drop in your diastolic blood pressure when you stand up is required to make the diagnosis.

Some people with Parkinsons dont experience a drop in blood pressure every time they stand up. In these cases, a doctor may use a monitor to measure the persons blood pressure every 30 minutes for an entire day to assist in diagnosis and subsequent management of nOH.

To learn more about the impact of nOH on people with Parkinsons and their care partners, read results from the Harris Poll Survey here.

How Is Wpw Syndrome Diagnosed

Understanding blood pressure fluctuations – HeartGuide

People experiencing a fluttering or racing heartbeat usually tell their doctors. The same applies to those experiencing chest pain of difficulty breathing. However, if you dont have symptoms, the condition may go unnoticed for years.

If you have a racing heartbeat, your doctor will likely perform a physical exam and conduct tests that measure your heart rate over time to check for tachycardia and diagnose WPW syndrome. These heart tests may include:

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Limitations And Future Perspectives

Further well-designed studies with consideration of different levels of hypertension are still required to verify and clarify the association between hypertension and motor stage PD/PD diagnosis. In addition, the possible relation between ethnicity, PD diagnosis, and hypertension may warrant further investigation due to the different conclusions derived from the subgroup analysis by ethnicity. Furthermore, experimental studies are also needed to explore the biological mechanisms linking hypertensive status to PD.

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