Thursday, November 24, 2022

Possible Treatment For Parkinson’s Disease

Complementary And Alternative Medicine

Researchers look to cycling as possible treatment option for Parkinson’s disease

There isn’t strong evidence that massage is beneficial for Parkinson’s disease, but it might help reduce muscle tension and can help you relax.

Acupuncture and dietary supplements have not been found to be effective in controlling the symptoms of Parkinson’s disease. In particular, research has shown coenzyme Q-10 and creatine had no effects beyond that of placebos. Vitamin E supplements raised concerns that they could be harmful in Parkinson’s disease.

Some patients find that medical marijuana or CBD oil helps with symptoms of pain and may help improve sleep, but there is no specific evidence supporting benefits.

Treatment Of Parkinsons Disease

Conventional Treatment to Parkinsons Disease

In conventional treatment for Parkinsons Disease anticholinergic drugs are used for tremors. The drugs used include benztropine, procyclidine, and orphenadrine. Regular ingestion of these drugs may produce many side effects such as dryness of the mouth, urine retention, constipation, and blurred vision. People feel confused and may experience hallucinations.

Another common drug used in combination with anticholinergic drugs is Amantadine. This drug can also produce a myriad of side effects such as restlessness, edema, irregular heartbeat, and skin rashes.

Doctors also prescribe Levodopa in combination with carbidopa for people suffering from PD. The common side effects produced by these drugs include nausea, vomiting, hypotension, and irregular heartbeat.

Another group of drugs used for PD treatment includes Dopamine agonist which includes bromocriptine, pergolide, pramipexole, and ropinirol. These drugs also produce many side effects.

Other treatments include speech therapy, yoga, nutrition supplements, exercises, and diet modifications that may help in improving the function of nerve cells in some individuals.

Natural Treatment to Parkinsons Disease

Homeopathic remedies

Homeopathy is an alternative system that includes the use of bioenergetic impressions of intended organs, tissues, and secretions that work on the principle of like cures like to help the body and specific organs function optimally.

Herbs

Macuna pruriens

Research And Statistics: Who Has Parkinsons Disease

According to the Parkinsons Foundation, nearly 1 million people in the United States are living with the disease. More than 10 million people worldwide have Parkinsons.

About 4 percent of people with Parkinsons are diagnosed before age 50.

Men are 1.5 times more likely to develop the disease than women.

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Green Tea And Coffee To Reduce The Risk Of Developing Pd

Green tea is prepared from the leaves of the Camellia Sinensis plant and contains phenolic compounds such as -Epigallocatechin-3-gallate a potent antioxidant and neuroprotective compound. Preclinical clinical and self-report studies suggest that green tea may prevent PD . However, the therapeutic mechanism of green teas potential protective actions in PD is unclear. It is feasible that green teas phenolic compounds are modulating critical neuroprotective signaling pathways in the brain . On the other hand, green tea could exert its effects via caffeine-induced inactivation of the adenosine receptor.

Diet And Lifestyle Changes

Treatment and Management of Parkinsons Disease

Additional therapies for Parkinsons disease treatment include eating a healthy diet and engaging in regular exercise.

Some individuals may benefit from participating in physical and occupational therapy. These therapies often focus on balance, improving your gait, or tactics to allow you to complete your work.

Other alternative options center on promoting holistic well-being while living with Parkinsons disease. These are not shown to stop the diseases progression but can help you manage symptoms and stay hopeful:

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How Do You Know You Have Parkinsons Disease

There is no definitive way to diagnose Parkinsons disease. Your doctor will ask questions about the onset of your symptoms and assess your movement to make referrals to specialists who can make a formal diagnosis.

You can expect to see a neurologist who can complete a neurologic examination. This may include brain imaging, an MRI, or a PET scan to see activity in the area of the brain typically affected by Parkinsons disease.

Your doctor may also refer you to a movement disorder specialist. Seeing subspecialists is very important to avoid being misdiagnosed. Highly trained specialists can provide their expertise in specific areas of medicine where a precise diagnosis isnt possible from blood work or another definitive test.

Stages Of Parkinsons Disease

Parkinsons disease symptoms progress slowly and may worsen over time. The symptoms are divided into five stages.

Stage 1

It is a very mild stage and symptoms are not noticeable. The symptoms will not interfere with daily living activities.

Stage 2

It may take months or years to progress to the second stage. Each person may experience different symptoms. The symptoms experienced at this stage include:

  • Stiffness of muscles
  • Changes in facial expressions

Stage 3

It is a middle stage and symptoms become more noticeable. Symptoms start interfering with the daily activities of the patient. Movements slow down and balance issues may occur. But, at this stage patients may not need assistance.

Stage 4

In stage 4, significant changes occur. The patient may experience difficulty standing without using support. Muscle movements slow down. Living alone becomes unsafe for the patient.

Stage 5

It is an advanced stage. Symptoms become critical, and the patient needs full-time assistance. It is not possible to stand alone, and a wheelchair may be needed. At this stage, patients become confused, experience delusions, and hallucinations.

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Is Medical Marijuana An Option For Me

What’s next for a person with PD who wants to know if medical marijuana is an option? “Marijuana should never be thought of as a replacement for dopaminergic and other approved therapies for PD,” said Dr. Michael S. Okun, the Parkinson’s Foundation National Medical Advisor.

Research is still needed to determine how medical marijuana should be administered and how its long-term use can affect symptoms of PD. To keep patients safe, states that legalize medical marijuana will eventually need to develop training programs for doctors and medical teams that prescribe medical marijuana. Consult your doctor to see if medical marijuana is an option for you.

The Parkinsons Foundation is designed to help guide the PD community in making informed decisions about using cannabis for Parkinsons. The statement is based on the input from 46 experts who attended the Foundations first-ever medical marijuana convening. Read it now.

Page reviewed by Dr. Bhavana Patel, Movement Disorders Fellow at the University of Florida, a Parkinsons Foundation Center of Excellence.

How Soon After Treatment Will I Feel Better And How Long Will It Take To Recover

Understanding Parkinsons Disease, Causes, Symptoms and Treatment | Dr. Kamal Nagar

The time it takes to recover and see the effects of Parkinson’s disease treatments depends strongly on the type of treatments, the severity of the condition and other factors. Your healthcare provider is the best person to offer more information about what you can expect from treatment. The information they give you can consider any unique factors that might affect what you experience.

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What Are Surgery Options For Parkinson’s Disease

Depending upon your needs, medical history, health, and symptoms, one of the following procedures may be considered for Parkinson’s disease:

There are many other procedures being researched. One of the most promising involves the transplantation of fetal dopamine neurons into the brains of people with Parkinson’s disease. The hope is that these cells will be able to re-grow the damaged dopamine-producing nerve cells.

Assembling Your Care Team

Assembling a team that will provide you with physical and emotional support and adapt to your needs over time is one of the best ways to remain healthy. Parkinsons disease is complex and requires an interdisciplinary approach to care. The care team may include, but is not limited to:

  • Movement disorder specialist
  • Rehabilitation specialists including physical, occupational, and speech therapists
  • Nurse

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Who Can Get It

While anyone can develop Parkinsons disease, age is the greatest factor in receiving a diagnosis. The average age of developing this disease is 60, and men are more likely to receive a diagnosis than women. Having a close relative, like a parent or sibling, who has Parkinsons disease doubles your risk factor.

A New Era For Parkinsons Disease Treatment

Treatment and Management of Parkinsons Disease

March 2, 2022 | By

A non-invasive ultrasound treatment for Parkinsons disease that was tested in a pivotal trial led by University of Maryland School of Medicine researchers is now broadly available at the University of Maryland Medical Center .

Howard Eisenberg, MD, Dheeraj Gandhi, MD, MBBS, Paul Fishman, MD, PhD, Bert W. OMalley, MD.

The device, called Exablate Neuro, was approved in November by the U.S. Food and Drug Administration to treat advanced Parkinsons disease on one side of the brain. The approval was based on findings from the UMSOM clinical trial and effectively expands access to focused ultrasound beyond clinical trial participation.

Rapid Reversal of Symptoms

Focused ultrasound is an incisionless procedure, performed without the need for anesthesia or an in-patient stay in the hospital. Patients, who are fully alert, lie in a magnetic resonance imaging scanner, wearing a transducer helmet. Ultrasonic energy is targeted through the skull to the globus pallidus, a structure deep in the brain that helps control regular voluntary movement. MRI images provide doctors with a real-time temperature map of the area being treated. During the procedure, the patient is awake and providing feedback, which allows doctors to monitor the immediate effects of the tissue ablation and make adjustments as needed.

Patient: Focused Ultrasound Changed My Life

A New Era for Parkinsons Disease Treatment

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Progress In The Treatment Of Parkinsons Disease

Despite the fact that 200 years passed since the discovery of PD, it was not until later in the 20th century that progress in the treatment of PD was achieved, predominantly due to the limited understanding of PD pathophysiology. Given Carlssons discoveries of DAs involvement in the 1950s, it became clear that PD development involved dopaminergic cell death and a decrease of DA in the striatum and other structures of the forebrain. The first steps towards treatment were made by Carlsson , who proposed targeting this DA deficiency to facilitate symptom reduction.

Strategies For The Treatment Of Parkinsons Disease: Beyond Dopamine

  • 1Laboratorio de Neurobiología, Facultad de Ciencias de la Salud, Universidad San Sebastián, Concepción, Chile
  • 2Department of Biological Sciences, University of Limerick, Limerick, Ireland
  • 3Health Research Institute, University of Limerick, Limerick, Ireland
  • 4Department of Psychology and Neuroscience, Center for Neuroscience, University of Colorado, Boulder, CO, United States
  • 5Research & Development Service, Bay Pines VA Healthcare System, Bay Pines, FL, United States

Parkinsons disease is the second-leading cause of dementia and is characterized by a progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of intraneuronal -synuclein-positive inclusions. Therapies to date have been directed to the restoration of the dopaminergic system, and the prevention of dopaminergic neuronal cell death in the midbrain. This review discusses the physiological mechanisms involved in PD as well as new and prospective therapies for the disease. The current data suggest that prevention or early treatment of PD may be the most effective therapeutic strategy. New advances in the understanding of the underlying mechanisms of PD predict the development of more personalized and integral therapies in the years to come. Thus, the development of more reliable biomarkers at asymptomatic stages of the disease, and the use of genetic profiling of patients will surely permit a more effective treatment of PD.

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Prevention Of Parkinsons Disease

Researchers dont know of any proven ways to prevent Parkinsons disease, but avoiding certain risk factors and adopting a healthy lifestyle may reduce your risk.

Some studies have shown a diet high in antioxidants along with regular exercise may play a role in preventing Parkinsons. Other findings have suggested that compounds like caffeine, niacin, and nicotine may have a protective effect against Parkinsons disease.

Researchers have studied various formulations of nicotine including intranasal, transdermal, and chewing gum to see whether they could help with Parkinsons symptoms, but so far none has been found effective at slowing the progression of Parkinsons.

Exploring Seven Recently Approved Parkinsons Treatments

Early Parkinson’s Disease

Remarkably, in the last five years, seven new medications have been approved for the treatment of the motor symptoms of Parkinsons disease , with two approved in 2020. Thats exciting progress! And while it is great to have so many choices, the various options can be confusing so today I will describe these new medications and their uses.

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Treatment And Medication Options For Parkinsons Disease

For decades, doctors couldnt treat Parkinsons disease effectively and thought it was a terminal illness. In the late 19th century, arsenic, morphine, hemlock, and cannabis were used to treat tremors.

The biggest advance in Parkinsons treatment came in the 1960s. Researchers identified differences in the brains of people with Parkinsons associated with low levels of the chemical dopamine, which plays a role in coordinated movement.

Theres no cure for Parkinsons, but a number of treatments can help manage the diseases symptoms.

Who Does It Affect

The risk of developing Parkinsons disease naturally increases with age, and the average age at which it starts is 60 years old. Its slightly more common in men or people designated male at birth than in women or people designated female at birth .

While Parkinsons disease is usually age-related, it can happen in adults as young as 20 .

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Treating Parkinsons With Complementary Medicine

Complementary medicine incorporates many different practices that can be used alongside conventional medicine to try to ease PD symptoms. There is typically not as much rigorous data to support the use of complementary medicine techniques, as compared to conventional medicine, but many patients find them helpful. These include yoga and massage.

Medical Marijuana And Legislation By State

What is Parkinson

Thirty-five states and Washington, DC have passed legislation allowing the use of marijuana-based products.

In some states where medical marijuana is legalized, consumers must register to possess and use cannabis. Other states require consumers to acquire a document from a physician stating that the patient has an approved condition. Under federal law doctors cannot prescribe cannabis, but many states authorize them to issue certifications that allow patients to obtain medical marijuana.

PD is listed as a qualifying condition for medical marijuana in Connecticut, Florida, Illinois, Louisiana, Massachusetts, Michigan, Mississippi, Missouri, New Hampshire, New Mexico, New York, Ohio, Pennsylvania and West Virginia.

Medical marijuana is legal in Alaska, Arizona, Arkansas, California, Colorado, Connecticut, Delaware, Florida, Hawaii, Illinois, Louisiana, Maine, Maryland, Massachusetts, Michigan, Minnesota, Mississippi, Missouri, Montana, Nevada, New Hampshire, New Jersey, New Mexico, New York, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Dakota, Utah, Vermont, Washington, West Virginia and Washington, DC.

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Symptoms Of Parkinsons Disease

Parkinsons has four main symptoms:

  • Tremor in hands, arms, legs, jaw, or head
  • Muscle stiffness, where muscle remains contracted for a long time
  • Slowness of movement
  • Impaired balance and coordination, sometimes leading to falls

Other symptoms may include:

The symptoms of Parkinsons and the rate of progression differ among individuals. Early symptoms of this disease are subtle and occur gradually. For example, people may feel mild tremors or have difficulty getting out of a chair. They may notice that they speak too softly, or that their handwriting is slow and looks cramped or small. Friends or family members may be the first to notice changes in someone with early Parkinsons. They may see that the persons face lacks expression and animation, or that the person does not move an arm or leg normally.

People with Parkinson’s disease often develop a parkinsonian gait that includes a tendency to lean forward take small, quick steps and reduce swinging their arms. They also may have trouble initiating or continuing movement.

Symptoms often begin on one side of the body or even in one limb on one side of the body. As the disease progresses, it eventually affects both sides. However, the symptoms may still be more severe on one side than on the other.

What Is My Parkinsons Disease Prognosis

The outcome of Parkinsons disease varies from person to person, though women with the disorder tend to live longer than men. If you or a loved one has recently been diagnosed with Parkinsons, you may be wondering about the course of your illness and your life expectancy. While there is no definitive prognosis for Parkinsons, most doctors agree that the disease itself is not fatal. Health complications such as deep vein thrombosis and arterial blockage in the lungs can, however, shorten your lifespan with the condition, regardless of your age or gender.

These possible health complications may sound scary, but as long as you seek treatment, your life expectancy with Parkinsons disease shouldnt differ much from that of the general population.

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The Promise And Potential Of Stem Cells In Parkinsons Disease

Neurosurgeon Viviane Tabar is co-leading a trial to inject stem cells into the brains of people with Parkinsons disease to restore dopamine levels.Credit: Courtesy of Memorial Sloan Kettering Cancer Center

Neurosurgeon Viviane Tabar has scrubbed in. In front of her is the first participant in a clinical trial to determine whether stem cells can be safely injected into the brains of people with Parkinsons disease. The cells had been frozen, but they are now thawed and sitting on ice, waiting for their moment.

Tabar, a physician-scientist at Memorial Sloan Kettering Cancer Center in New York City, makes an incision in her patients scalp and drills a small hole in their skull. She then uses a brain scan almost like a GPS, she says, to guide her to the putamen a part of the brain in which levels of the neurotransmitter dopamine are unusually low in people with Parkinsons. Once she has confirmed that shes reached the right spot, she injects the stem cells, then repeats the process on the other side of the brain. She hopes these cells will take hold and eventually begin to produce dopamine where otherwise there would be little or none. The surgery itself is minor enough that the patient can go home the next day.

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