Friday, September 22, 2023

Parkinson’s And Magnesium Supplements

Vitamins For Parkinson’s Disease

My Parkinson’s Supplements.

Verywell / Michela Buttignol

Apart from traditional pharmaceutical treatments, if you have Parkinsons disease, your doctor may recommend vitamins with antioxidant properties. While it is best to get these from food sources as part of a healthy, balanced diet, some people need to take supplements. These vitamins include:

Naturaltreatment For Parkinsons #9 Exercise And Other Alternative Therapies:

Regular exercise has been shown to help Parkinsonssufferers by reducing muscle stiffness, increasing mobility, and enhancing postureand balance. Exercise also increases oxygen levels and neurotransmitters, alongwith releasing potent mood elevating chemicals called endorphins.

The type of exercise performed for PD is crucial. Aqua orwater aerobics can be particularly useful as traditional exercise is usuallyquite difficult for many Parkinsons sufferers. Muscle decline, loss of strength,stiffness and loss of balance can make conventional exercises difficult toperform. The great thing about aqua aerobics is it still has the same benefits as other exercise regimens,but the risk of falling is eliminated.

Other types of exercises that can be beneficial for PDsufferers include Tai Chi, Yoga, dancing, walking, aerobic/jazzercise classes,and general stretching.

For more information on the different exercise programsavailable for Parkinsons patients, you can check out this website Exercise and Physical Therapy for ParkinsonsDisease

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Metalloproteins And Differential Expression

Next, the metal-bound protein search was executed in Protein Data Bank by applying the search filters that include: Organism type: Experimental method: XRD Molecule type: Protein Sequence feature: Wild-type protein and X-ray resolution: > 3A°. Overall, we retrieved 6,367 proteins that bound with 60 different metals. Each metalloprotein was named using its official gene symbol. Among 6,367 metalloprotein-encoding genes, we only took DEGs that are commonly overexpressed and downregulated in both blood and brain of PD. This exercise yielded 280 DEGs, which served input for metalloprotein network construction.

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Dataset Selection For Meta

Gene expression dataset searches were executed in NCBI Gene Expression Omnibus 1 and Array Express database2 by inception of database records between January 1990 and November 2018 using the keywords related to Parkinsons disease. Two independent groups tested the procedure of dataset search and retrieval following the inclusion and exclusion criteria as described. Inclusion criteria: case-control study , comparative studies between PD and other neurological diseases, brain or whole blood as study specimens, datasets include raw or processed data. Whereas the exclusion criteria include animal model and in vivo studies, secondary gene expression studies, microarray dataset with less than two replicate samples in a group, and studies other than microarray experiments.

Figure 1. Study design: Systematic workflow describing the major steps adopted in this study: collection, curation, and meta-analysis of datasets identification of differential genes and selecting the genes that encode metalloproteins genes that encode metalloproteins showing a common trend in the blood and brain were selected and subjected to metalloprotein network identification of the linker protein that connects the hubs extracted from the metalloprotein network recruitment of research participants to determine the gene expression linker protein in peripheral blood mononuclear cell and the serum metal concentration of proteins in the hubs.

Best Form Of Magnesium Supplement


Interested in folks opinions on this. Looking to start taking Mg Supplement but confused about the relative positive/negatives for each type. L-threonate being talked up as it crosses the BBB and has slowed neural decline in mice – but quite pricey compared to say Malate or Glycimate.

Aged 50, diagnosed 18 months ago. Still very active. Toes cramp sometimes on runs – hoping Mg can help with this.

Also aiming to use as a ‘platform’ for finding ‘sweet spot’ dose of B1 therapy.

Any feedback appreciated!

Ive noticed a marked improvement in leg cramps using magnesium glycinate.

At what dosage? How bad are your cramps? Toe cramps that make walking difficult? Did you try other MG types?

I take 300mg usually before bed. Its a powder form. Ive tried several types but this one seems to help me. My cramps would get pretty bad. Very painful. So far since Ive been using this MG its been going ok.

Which brand or brands have you used and seem to work the best?

My husband has noticed a marked decline in restless legs using clean magnesium from British Supplements worth reading the reviews.

Try Mercola’s L-threonate. We’ve been taking it for years. You can read about it on his website. My husband also takes magnesium oxide to help with constipation. And Pure’s magnesium glycinate which was recommended on HU.

I wrote this 5 years ago, but you may find it helpful regarding magnesium :

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Foods Containing Nutrients That People May Be Deficient In

Some research suggests that people with Parkinsons often have certain nutrient deficiencies, including deficiencies in iron, vitamin B1, vitamin C, zinc, and vitamin D.

The above study points out that some of these deficiencies may be associated with neuroinflammation and neurodegeneration, which are key factors in Parkinsons.

Therefore, people with Parkinsons may wish to consume more of the following foods.

Foods containing iron

The following foods are good sources of iron:

  • certain fortified foods

How Much Magnesium Do You Need

Studies on supplementing magnesium levels indicate that 300 mg/day is enough to impact blood pressure significantly. However, there are also indications that increasing magnesium above normal levels is not advisable.

The positive impact of magnesium supplementation is primarily because you are correcting a deficiency. If you already have adequate magnesium levels, supplementing with magnesium is not helpful.

Talk to your doctor or your nutritionist before taking a magnesium supplement.

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Foods High In Saturated Fat

Although the specific role of saturated fat in Parkinsons is still being studied, research suggests that a high dietary fat intake may increase your risk of this disease .

Generally speaking, diets high in saturated fat have been linked to chronic conditions like heart disease. As such, you may wish to keep these foods in moderation (

  • some baked and fried foods

Conversely, a very small study notes that the keto diet which is high in fat is beneficial for some people with Parkinsons. However, a low fat diet also showed benefits. Overall, more research is needed .

How To Choose A Magnesium Supplement

Vitamins, supplements, & other drugs for Parkinson’s disease – 2017 Parkinson Symposium

People may wish to consider the following factors when choosing a magnesium supplement:

  • Third-party lab tests. People may wish to purchase products that have testing from a third-party lab. These labs check to ensure the products do not contain any ingredients that may be harmful to health and verifies that the products contain the ingredients on their labels.
  • Dosage. People should ensure that the amount of magnesium in the supplement is enough for their requirements.
  • Type of magnesium. Some types of magnesium are easier for the body to absorb, such as magnesium aspartate, chloride, lactate, and citrate.

per day for people aged 9 and over.

Studies show that higher doses are safe to consume. For example, 500 mg of magnesium may help improve sleep quality and reduce insomnia.

The NIH also says that consuming too much magnesium through food does not pose a health risk to most people as the kidney filters the excess mineral in the urine.

However, the main side effects of having too much magnesium supplementation include diarrhea, nausea, and abdominal cramping.

Very high doses of magnesium, often in the form of antacids, can cause magnesium toxicity. This is more common in people who consume around 5000 mg of magnesium with antacids. Symptoms of magnesium toxicity include:

Below are some common questions about magnesium.

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Best Magnesium For Anxiety

What is the best magnesium for anxiety? The best type of magnesium for anxiety, panic and depression is a Full Spectrum Magnesium, which is a blend of all natural forms of magnesium in the exact dosage to balance mental and emotional health. It can help you prevent panic attacks, mood swings, irritability and is particularly good for social anxiety. It works where harmful medicines make your anxiety worse. It is safe and non-addicting too.

You can simply take a good full spectrum magnesium supplement before you go out and your mood is even and you just feel good naturally, without any drugged up feeling. It improves your blood flow, helps your heart pump in a natural cycle and helps your brain and nervous system stay calm and balanced.

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Vitamin E Vitamin C And Natural Foods

Scientists have also examined Vitamin E, Vitamin C and health foods to evaluate oxidative properties. Vitamin E can fight damage in the brain caused by free radicals and has been suggested to lower the risk of PD. However, researchers conducted an extensive and thorough study more than 10 years ago and failed to find any evidence that Vitamin E slows the progression of PD or manages symptoms.

However, a recent study published in Neurology, revealed that those with high Vitamin E and C consumption might be associated to a lower risk of PD. Additional research is still needed to better understand this association. Vitamin E has few side effects, and many people with PD continue to take it in high doses of 400 IU or more.

Researchers are also examining if health foods, such as fermented papaya and blueberries, play a role in slowing nerve cell death. Scientists are optimistic about the research, but do not have conclusive data at this time to recommend these supplements to treat PD.

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As A Blocker Of The Glutamatergic Nmda Receptor

Mg controls cytochrome c release in mito- chondria , and decreases the activity of N-methyl-D-aspartate receptors in excitotoxicity . Mg treatment has also been shown to decrease cerebral infarct volume in rats in vivo . The mechanism responsible for the neuroprotective effect of Mg has been considered to be reduced presynaptic release of the neurotrans-mitter glutamate , and blockade of the glutamatergic NMDA receptor . A relationship between decreased Mg concentration in serum and migraine has been reported in humans, and it has been suggested that migraine might be caused by hypersensitivity of the NMDA receptor to glutamic acid and certain other neuro-excitatory amino acids due to Mg depletion . A decrease of cytosolic free Mg in the occipital lobe of PD patients has also been demonstrated by phosphorus magnetic response spectroscopy .

Metallic elements and neuron conduction.

Diet Nutrition And Parkinsons Disease

Parkinson Care Pack

In the past, it was thought that a special diet was unnecessary in the early stages of Parkinsons disease and that all was needed was eating a healthy, well-balanced diet. As we learn more about the mechanisms in the brain involved with Parkinsons disease and the role certain nutrients may play, it becomes apparent that taking a good look at your diet may be a good idea even early on after diagnosis.

Studies have shown some eating habits may help slow the progression of your disease, at least in theory Since the role of food in disease has only recently been looked at systematically, its likely we will be learning much more in the coming years.

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Caution With Mucuna For Parkinsons

Mucuna pruriens is a natural source of levodopa . A recent study in a major journal suggested that labels for Mucuna pruriens supplements were highly misleading however, we analyzed their data and came to a different conclusion. Learn more in our updated CL Answer about Supplements for Parkinson’s Disease.

Clinical Update


Vitamins That Might Help With Parkinsons Tremors

Parkinsons is a brain disorder that leads to tremors, stiffness, and adds difficulty to walking, balance, and coordination.

Parkinson’s occurs when nerve cells, or neurons, that are in the area of the brain that controls movement become impaired, and scientists still do not know what causes the nerve cells to die.

Although there is no cure for Parkinsons, there are some solutions that can often help to reduce some of the symptoms. Other supportive therapies include a healthy diet and exercise to strengthen muscles and improve balance along with many vitamins that are considered essential to reduce tremors.

The best way to get vitamins and minerals is in the healthy food you consume on a daily basis. Still, vitamins and mineral supplements need to be taken following your doctors guidelines, because the type of tremors and effective vitamins varies. You can also read The Most Common Questions About Essential Tremor.

Taking a daily multivitamin is good for your health. However, it wont stop the symptoms of essential tremor . Tremors and other movement disorders are usually associated with vitamin deficiency, most vitamins are B1, B6, and especially B12.

The most well-studied vitamins are the B vitamins. Deficiency in B1 , B6 , B9 , or B12 in particular have been linked to numerous neurological conditions including postural and internal tremors.

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Vitamin C And Vitamin E

Vitamin C is found in fruit, vegetables, and the livers of animals. Vitamin E is an antioxidant found in vegetable oils, nuts, seeds, leafy greens, bell peppers, and avocados.

An 18-year study followed 41,058 subjects in Sweden. Within that population, there were 465 cases of Parkinson’s disease. Researchers evaluated vitamin C and E to determine whether antioxidants and total non-enzymatic antioxidant capacity were linked to a lower risk of Parkinsons disease.

Search Strategies And Selection Of Studies

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The review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement and was registered in PROSPERO . We searched relevant literature from PubMed, Web of Science, China National Knowledge Infrastructure , and WANGFANG, selecting studies from 1991 to 2021. The search terms were magnesium,Alzheimers disease,serum,plasma, or CSF. Both English and Chinese languages were used. The Supplementary Materials present the PRISMA checklist and detailed search strategy . The inclusion criteria were: case-control study design human subjects both AD and control groups described in terms of sample size and Mg concentration in serum, blood, plasma, or CSF. The exclusion criteria were: letter, review, or case reports duplicated studies with repeated data in vitro or laboratory studies animal studies studies lacking quantitative data on Mg concentrations.

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Benefits Of Magnesium Supplements

What are the health benefits of magnesium supplements? This is the most important natural mineral duo you need to be adding to your daily diet. It will keep you healthy, strong and flexible for years to come. Here is a simple list of magnesium benefits youâll get by using the best type of magnesium :

  • Naturally Relieves Anxiety and Panic
  • Helpful for Depression and Seasonal Affective Disorder
  • Relieves Constipation
  • Helps Prevent Cancers
  • You Just Feel Better!

The best type of magnesium supplement is probably the #1 essential mineral that you should have in your health cabinet because it helps you with so many things.

What The Research Is Saying

According to a recent 2021 study published in the Journal of Hepatology it was found that both patients and mice that had non-alcoholic steatohepatitis also had high amounts of cyclin M4 protein. This protein has a job of transporting magnesium out of the liver. It is the responsible party behind the imbalance of magnesium levels that can lead to liver disease development.

These patients have an altered magnesium export machinery that increases the vulnerability of their liver to suffer inflammatory processes, development of fibrosis and fat deposition, Malu Martinez Chantar, first author in the publication, told NYU in an interview . This study also presents a novel therapeutic approach based on GalNAc-siRNA technology that specifically targets the liver by modulating CNNM4 levels. The CNNM4 molecule developed from Silence Therapeutics proprietary mRNAi GOLD Platform effectively protects from liver pathology in preclinical models of steatohepatitis.

To make things a little less complicated, basically siRNA is a drug that has shown potential to treat various diseases including cancer and Parkinsons disease. N-acetylgalactosamine siRNA was developed specifically for liver delivery.

With this treatment targeting CNNM4 and decreasing its quantity steatosis, inflammation, and fibrosis are all alleviated in NASH models. Not only that, but it helps magnesium accumulate back into the liver and reduces stress on the endoplasmic reticulum .

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Rpl: A Key Molecule Regulating Zinc

  • 1Drug Discovery and Multi-omics Laboratory, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, India
  • 2School of Engineering and Sciences, Centre of Bioengineering, Tecnologico de Monterrey, Queretaro, Mexico
  • 3Department of Neurology, School of Medicine, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM, United States
  • 4Department of Medical Laboratory Technology, Manipal College of Health Professions, Manipal, Manipal Academy of Higher Education, Manipal, India
  • 5Department of Pharmacology, Saveetha Dental College , Saveetha Institute of Medical and Technical Sciences, Chennai, India

Vitamins For Parkinsons Disease


Verywell / Michela Buttignol

Apart from traditional pharmaceutical treatments, if you have Parkinsons disease, your doctor may recommend vitamins with antioxidant properties. While it is best to get these from food sources as part of a healthy, balanced diet, some people need to take supplements. These vitamins include:

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Magnesium The Most Imperative Mineral

Magnesium is the most abundant element that is involved in a wide range of biochemical processes in the body including energy generation, DNA, RNA, and protein synthesis, and cell growth. It is essential for the proper functions of the brain, heart, and muscle. It is also crucial for your bone development.

Mg is abundant in plant and animal foods. It can be found in green leafy vegetables, nuts, whole grains, cereals, legumes, potatoes, rice, milk, fruits, chicken, beef, and salmon.

Green Tea Polyphenols Or Gtps

GTPs have antioxidant properties along with free radical scavenging activities. There are current studies being conducted, which suggest that GTPs have a neuroprotective impact with the potential of treating Parkinsonâs disease. Ongoing studies are being conducted by the Chinese Ministry of Health along with the Michael J. Fox Foundation whether GTPs can slow down the progression of Parkinsonâs disease.

Magnesium in Parkinsons disease: an update in clinical and basic aspects

Kiyomitsu Oyanagi and Tomoyo Hashimoto.


Magnesium is essential for cell functions such as transport of calcium and potassium ions, and modulates signal transduction, energy metabolism, and cell proliferation. Several studies elucidated a reduced concentration of Mg in patients with Parkinsons disease , and experimentally, severe loss of dopaminergic neurons exclusively in the substantia nigra in 1-year-old rats that had been subjected to continuously low Mg intake over generations. A study conducted by the authors revealed a significant and striking effect of Mg to prevent neurite and neuron pathology, and also to ameliorate neurite pathology in a rat Parkinson disease model involving culture of ventral mesencephalic-striatal cells with 1-methyl-4-phenylpyridinium . Mg is expected to prevent and ameliorate Parkinsons disease in cases where it would be able to cross into the brain in a suitable way.

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