What Might Cbd Do For Parkies
CBD has shown potential in early studies for reducing dyskinetic activity in people with PD and treating motor symptoms in various neurodegenerative conditions.
According to a 2018 review study published by the journal Frontiers in Pharmacology, Cannabidiol is a non-psychotomimetic compound from Cannabis sativa that presents antipsychotic, anxiolytic, anti-inflammatory, and neuroprotective effects. Data also suggest that CBD could potentially play a protective role in the treatment of certain movement disorders. Results are promising, but further studies are needed to clarify the efficacy of CBD.
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Garlic Provides Several Effects To Protect Brain Cells
The research evidence is clear that garlic contains a host of compounds that work synergistically to protect and even prevent the brain cell damage that results in the devastation of Parkinsons disease. Weve discussed several compounds in garlic in this article, including S-methyl-L-cysteine, S-allyl-cysteine, deoxy-D-fructos-1-yl)-L-arginine and thiacremonone.
Other medicinal garlic compounds include alliin , allicin and various other sulfur compounds like thiosulfinates and ajoenes, S-allylmercaptocysteine, L-cysteine sulfoxides, -glutamyl-L-cysteine, S-trityl-l-cysteine, terpenoids, steroids, flavonoids and phenols. Garlic is a complex plant with many medicinal properties.
All these constituents work together to produce a combination of healing effects on the body. These include reducing free radical damage and oxidative stress.
Effects of garlic also include inhibiting brain cells from developing Lewy bodies. Effects include boosting levels of thiols and glutathione. And garlics effects also include boosting levels of hydrogen sulfide within the body and brain tissues.
This synergy of effects from garlic results in what may become one of the biggest breakthroughs in the treatment of Parkinsons disease. No, there has yet to be any large-scale clinical studies treating Parkinsons patients with garlic. But this is likely the result of the fact that garlic or aged garlic is easily purchased at any supermarket or health food store.
Surgery For People With Parkinsons Disease
Deep brain stimulation surgery is an option to treat Parkinsons disease symptoms, but it is not suitable for everyone. There are strict criteria and guidelines on who can be a candidate for surgery, and this is something that only your doctor and you can decide. Surgery may be considered early or late in the progression of Parkinsons. When performing deep-brain stimulation surgery, the surgeon places an electrode in the part of the brain most effected by Parkinsons disease. Electrical impulses are introduced to the brain, which has the effect of normalising the brains electrical activity reducing the symptoms of Parkinsons disease. The electrical impulse is introduced using a pacemaker-like device called a stimulator. Thalamotomy and pallidotomy are operations where the surgeon makes an incision on part of the brain. These surgeries aim to alleviate some forms of tremor or unusual movement, but they are rarely performed now.
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Other Therapies To Consider
Trained therapists across a number of disciplines can work with you to develop exercises and lifestyle strategies to improve specific challenges youre having as a result of Parkinsons disease. You dont have to wait until youre struggling to seek out a therapist its important to intervene early. These lifestyle changes will hopefully benefit you now and down the road.37
Physical Therapy
A physical therapist can help you do exercises to improve your balance, gait, coordination and dealing with symptoms like freezing. For example, a physical therapist can teach you to cope with freezing episodes by using a laser which projects a line on the ground, stepping over such lines on the ground to cue your brain to start moving again, and walking assisted by rhythmic musical cues.13
One specific type of physical therapy for Parkinsons is LSVT BIG, which utilizes overexaggerated movements to retrain your bodys smaller, slower movements caused by Parkinsons. For example, buttoning a button with more purposeful, forceful movements, like youre angry at the buttons, can help you button faster.22 Some research found LSVT BIG to be more effective at improving your movement abilities than general exercise.24
Occupational Therapy
Occupational therapists teach you how to do everyday activities that have become difficult for you. For example, how to do daily tasks when you have a tremor and how to keep track of when your food has gone bad after you lose your sense of smell.13
Is It Safe Safety Of Commercial Stem Cell Clinic Work
Safety data is also limited, although there have been some publicized lawsuits claiming that these treatments resulted in harm. Stem cell researchers in general question whether cells harvested in such a way contain sufficient amounts of adult-derived stem cells to be meaningful. It is also unclear how this type of procedure would target the stem cells to the correct location. If stem cells are introduced in the nose for example, it is unclear how they would find their way to the basal ganglia and make the correct connection in order to help a person with Parkinsons disease.
In order for the medical community to accept this type of treatment as safe and beneficial, it would need to be shown to work in a placebo-controlled clinical trial for which participants do not pay, are aware of the known risks and benefits, and are carefully monitored throughout the trial. In addition, the trial would need to track adverse events, as well as record and share the outcomes of trial participants as they compare to the group of patients receiving a placebo treatment. So far this has not happened. The FDA is in fact studying mesenchymal stem cells in the laboratory in order to determine the best way to use them to help people, but these studies have not yet led to approved treatments. Most recently, the FDA filed federal complaints against two clinics that are marketing stem cell products without regulatory approval.
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What To Look For Cbd Oil
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Can A Daily Dose Of Cbd Help With Parkinsons Disease
- CBD may have therapeutic effects on Parkinsons disease , especially on the non-motor symptoms associated with the neurodegenerative disease.
- A study in 2009 has found that CBD improved psychosis and decreased delusions, hallucinations, and sleep disturbances in Parkinsons disease patients.
- A study published in The International Journal of Neuroscience reported CBDs positive effects on motor symptoms, such as tremors, of the test subjects with Parkinsons disease.
- A study published in the journal Frontiers in Pharmacology suggests that CBD may be a useful preventive therapy for Parkinsons disease. However, the researchers acknowledge that it is challenging to diagnose PD in its early stages.
- Current research shows that CBD has great potential in the treatment of Parkinsons disease. However, further studies need to be done to establish CBDs benefits for Parkinsons disease.
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Does It Work Efficacy Of Commercial Stem Cell Clinics
Commercial clinics do not as a rule publish their results in peer-reviewed journals to demonstrate to the scientific community that the treatments work. Rather, they usually rely on anecdotes from patients as proof of efficacy. Some clinics are tracking their results by measuring variables such as quality of life before or after the procedure. However, without comparing the patients to a similar group who does not receive the treatment, it is hard to know whether any improvement is due to placebo effect or to the treatment itself.
Adding Treatments To Your Medication Regimen
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Garlic Tested In Other Studies
The use of garlic for nerve-related damage comes not only from the Blackfeet Nation. Garlic has been used for thousands of years for a variety of conditions. The Egyptians, the Greeks, and healers from many other traditional medicines have used garlic for nerve-related disorders of different kinds.
But now we find the emergence of studies that confirm, at least from a laboratory basis, that garlic may be able to provide a valid treatment for Parkinsons.
The first are findings that garlic significantly increases the bodys levels of hydrogen sulfide and thiol levels. In 2007, University of Alabama researchers discovered that it was garlics ability to boost hydrogen sulfide levels that was responsible for its ability to reduce blood pressure.
Boosting levels of glutathione is but one of the many effects of fresh or aged garlic consumption.
In a 2016 study, researchers from South Koreas Pusan National University tested a compound extracted from garlic called thiacremonone. This compound was found to significantly halt the progression of damage to substantia nigra cells in Parkinsons nerve cell degeneration.
A 2012 study from Indias SASTRA University found a similar result when they tested S-allylcysteine against Parkinsons disease symptoms caused by haloperidol. They found that S-allylcysteine from garlic blocked the nerve cell damage and progressive motor symptoms of Parkinsons.
Stages Of Parkinsons Disease
Neurologists usually describe the progression of Parkinsons symptoms in stages, using the system known as the Hoehn and Yahr scale. These stages are:
- Stage I Symptoms are seen on one side of the body only.
- Stage II Symptoms are seen on both sides of the body. Theres no impairment of balance.
- Stage III Balance impairment has begun. In this mild- to moderate stage of the disease, the person is still physically independent.
- Stage IV This stage is marked by severe disability, but the person is still able to walk or stand unassisted.
- Stage V The person is wheelchair-bound or bedridden unless assisted.
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Research And Statistics: Who Has Parkinsons Disease
According to the Parkinsons Foundation, nearly 1 million people in the United States are living with the disease. More than 10 million people worldwide have Parkinsons.
About 4 percent of people with Parkinsons are diagnosed before age 50.
Men are 1.5 times more likely to develop the disease than women.
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Does Cbd Help Parkinsons
CBD hasnt been used in Parkinsons Disease patients long term, and there are few studies to rely on for treatment guidance. Recently, a Phase II clinical trial was completed on CBDs role in the treatment of Parkinsons Disease. Treatment outcomes were positive for sleep, depression, behavior and emotion, anxiety, and cognition. Improvements in psychotic features were seen as well. About 20-40% of PD patients experience psychotic symptoms. And, treatment with antipsychotics may bring out Parkinson-like symptoms. Taking CBD may relieve pain associated with PD, although researchfavors THC for this effect.
CBD oil for Parkinsons symptom treatment can be in the form of edibles, oils, tinctures, ointments, vape cartridges, and creams. Topical CBD can be used for the muscle spasms so common in patients with PD, and oils can be used to relieve symptoms faster. However, data is lacking regarding this mode of delivery. Tinctures also offer speedy effects as a way to take CBD. The only FDA approved way of taking CBD, however, is through the drug Epidiolex although its benefits have been shown from other CBD oils.
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Diagnosis And Management Of Parkinsons Disease
There are no diagnostic tests for Parkinsons. X-rays, scans and blood tests may be used to rule out other conditions. For this reason, getting a diagnosis of Parkinsons may take some time.
No two people with Parkinsons disease will have exactly the same symptoms or treatment. Your doctor or neurologist can help you decide which treatments to use.
People can manage their Parkinsons disease symptoms through:
- seeing a Doctor who specialises in Parkinsons
- medication
- multidisciplinary therapy provided for example, by nurses, allied health professionals and counsellors
- deep brain stimulation surgery .
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How Do I Prevent Falls From Common Hazards
- Floors: Remove all loose wires, cords, and throw rugs. Minimize clutter. Make sure rugs are anchored and smooth. Keep furniture in its usual place.
- Bathroom: Install grab bars and non-skid tape in the tub or shower. Use non-skid bath mats on the floor or install wall-to-wall carpeting.
- Lighting: Make sure halls, stairways, and entrances are well-lit. Install a night light in your bathroom or hallway and staircase. Turn lights on if you get up in the middle of the night. Make sure lamps or light switches are within reach of the bed if you have to get up during the night.
- Kitchen: Install non-skid rubber mats near the sink and stove. Clean spills immediately.
- Stairs: Make sure treads, rails, and rugs are secure. Install a rail on both sides of the stairs. If stairs are a threat, it might be helpful to arrange most of your activities on the lower level to reduce the number of times you must climb the stairs.
- Entrances and doorways: Install metal handles on the walls adjacent to the doorknobs of all doors to make it more secure as you travel through the doorway.
How Is Parkinson Disease Diagnosed
Parkinson disease can be hard to diagnose. No single test can identify it. Parkinson can be easily mistaken for another health condition. A healthcare provider will usually take a medical history, including a family history to find out if anyone else in your family has Parkinson’s disease. He or she will also do a neurological exam. Sometimes, an MRI or CT scan, or some other imaging scan of the brain can identify other problems or rule out other diseases.
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Treating Parkinsons With Complementary Medicine
Complementary medicine incorporates many different practices that can be used alongside conventional medicine to try to ease PD symptoms. There is typically not as much rigorous data to support the use of complementary medicine techniques, as compared to conventional medicine, but many patients find them helpful. These include yoga and massage.
Is There A Dose
It seems plausible, based on different observational approaches, that higher doses of dopaminergic medications and combined therapies could also increase the chances of manifesting OH. Also some works have suggested that the main effect of medications could be at the beginning of the therapy developing some tolerance thereafter .
Based on all these evidence, the possibility of OH should be especially considered, when starting/adding a new drug or increasing its dose as the probability of symptoms could increase.
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Dopaminergic Features And Their Treatment
Patients with PD usually present with features indicative of degeneration of nigrostriatal pathways. A useful clinical definition for PD is asymmetric onset of an akinetic rigid syndrome with resting tremor and a good response to levodopa. When applied by neurologists with an interest in movement disorders, this definition has a pathological correlation exceeding 98%. When treatment is considered appropriate, and this is a topic discussed in detail below, a variety of options is available. The use of dopaminergic drugs improves motor function, significantly reduces both the morbidity and mortality of PD, and improves quality of life.
Levodopa remains the drug most commonly used in PD. It is very effective in improving bradykinesia and rigidity, and in practice remains the gold standard against which other drugs are judged. Some studies, predominantly in vitro, have suggested that levodopa may be toxic. However, such data are conflicting, and some laboratory studies have suggested a growth factor-like effect for levodopa. Overall, the pre-clinical evidence for levodopa toxicity is not convincing and there are no data to indicate that any toxic action is of clinical relevance.
Table 1
Percentage of patients remaining on dopamine agonist monotherapy at years 14 and years 15 during treatment trials