What Other Information Should I Know
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body’s response to risperidone.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
What Are The Possible Side Effects Of Risperidone
Get emergency medical help if you have signs of an allergic reaction: hives difficult breathing swelling of your face, lips, tongue, or throat.
- uncontrolled muscle movements in your face
- breast swelling or tenderness , nipple discharge, impotence, lack of interest in sex, missed menstrual periods
- severe nervous system reaction –very stiff muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out
- high blood sugar –increased thirst, increased urination, dry mouth, fruity breath odor
- low blood cell counts –fever, mouth sores, skin sores, sore throat, cough, easy bruising, unusual bleeding, trouble breathing, feeling light-headed or
- penis erection that is painful or lasts 4 hours or longer.
Serious side effects may be more likely in older adults.
Common side effects may include:
- tremors, twitching or uncontrollable muscle movements
- depressed mood, agitation, anxiety, restless feeling
- muscle or joint pain
- dry mouth, upset stomach, constipation
- weight gain or
- pain in your arms or legs.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Risperidone 1 Mg/ml Oral Solution
This information is intended for use by health professionals
Risperidone 1 mg/ml oral solution
Each 1 ml of oral solution contains 1 mg of Risperidone.
For the full list of excipients, see section 6.1.
The solution is clear and colourless.
Risperidone is indicated for the treatment of schizophrenia.
Risperidone is indicated for the treatment of moderate to severe manic episodes associated with bipolar disorders.
Risperidone is indicated for the short-term treatment of persistent aggression in patients with moderate to severe Alzheimer’s dementia unresponsive to non-pharmacological approaches and when there is a risk of harm to self or others.
Risperidone is indicated for the short-term symptomatic treatment of persistent aggression in conduct disorder in children from the age of 5 years and adolescents with subaverage intellectual functioning or mental retardation diagnosed according to DSM-IV criteria, in whom the severity of aggressive or other disruptive behaviours require pharmacologic treatment. Pharmacological treatment should be an integral part of a more comprehensive treatment programme, including psychosocial and educational intervention. It is recommended that risperidone be prescribed by a specialist in child neurology and child and adolescent psychiatry or physicians well familiar with the treatment of conduct disorder of children and adolescents.
Risperidone may be given once daily or twice daily.
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Antipsychotics Used For Parkinson’s Despite Warnings
Doctors Still Prescribe Antipsychotics Despite Risks for Some Parkinson’s Patients
July 11, 2011 — Doctors continue to prescribe antipsychotic drugs to their patients with Parkinson’s disease and psychosis, despite “black box” warnings from the FDA linking them to increased risk of death among patients with dementia, a study shows.
A black box warning is the strongest drug warning issued by the FDA.
“My sense is that the black box warnings don’t factor into decision making,” says study researcher Daniel Weintraub, MD, an associate professor of psychiatry at the University of Pennsylvania.
The study is published in the Archives of Neurology.
The black box warning for antipsychotics says the drugs are associated with an increased risk of death for those with dementia, which is common among people diagnosed with Parkinson’s. Some commonly prescribed antipsychotics also worsen symptoms of Parkinson’s.
Clozaril , the only drug known to be both effective and well-tolerated for treating psychosis in Parkinson’s patients, is prescribed to less than 2% of those with the disease.
“Quetiapine is the No. 1 choice without clear evidence that it’s effective,” says Weintraub.
How Should I Use This Medication
The dose of risperidone varies according to needs and the condition being treated.
For adults with schizophrenia, the dose is usually started at 1 mg to 2 mg per day and increased slowly over several days to 4 mg to 6 mg per day. Lower doses are often used for people with low blood pressure, kidney problems, or liver disease. The safety of risperidone has not been established beyond a maximum dose of 16 mg per day .
For seniors with schizophrenia, the dose is usually 0.25 mg given twice daily to a maximum daily dose of 3 mg.
For behavioural problems in people with severe Alzheimer type dementia, the usual starting dose is 0.25 mg twice a day. This dose is slowly increased every 2 to 4 days to a usual dose of 1 mg per day . This dose may be increased to a maximum of 2 mg per day .
For adults with mania associated with bipolar disorder, risperidone should be taken once daily, starting with 2 mg or 3 mg daily. This dose may be increased to a maximum of 6 mg daily.
Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.
Risperidone can be taken with or without meals. Swallow the tablets with some water or other fluid.
Store risperidone at room temperature in a dry place , protect it from light, and keep it out of the reach of children.
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Risperidone May Cause Side Effects Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:
- difficulty falling asleep or staying asleep
- breast enlargement or discharge
- late or missed menstrual periods
- difficulty breathing or swallowing
- painful erection of the penis that lasts for hours
Risperidone may cause children to gain more weight than expected and for boys and male teenagers to have an increase in the size of their breasts. Talk to your doctor about the risks of giving this medication to your child.
Risperidone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration’s MedWatch Adverse Event Reporting program online or by phone .
Motor And Nonmotor Symptoms Of Pd
At its core, PD is characterized by four cardinal symptoms: bradykinesia, rigidity, resting tremor, and postural instability.4 Along with these typical motor symptoms come many nonmotor symptoms with significant associated morbidity and mortality. These include autonomic dysfunction, disorders of sleep and wakefulness, cognitive dysfunction and dementia, mood disorders, and psychosis.5 These nonmotor symptoms of PD are responsible for a significant proportion of hospitalizations, with psychosis reportedly accounting for 24% of hospital admissions in patients with PD.6 This fact signifies the importance of properly managing patients with PD psychosis on both an inpatient and an outpatient basis.6
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What Other Drugs Could Interact With This Medication
There may be an interaction between risperidone and any of the following:
- abiraterone acetate
- alpha blockers
- alpha agonists
- angiotensin converting enzyme inhibitors
- angiotensin receptor blockers
- antiparkinson medications
- “azole” antifungals
- beta-adrenergic blockers
- botulinum toxin
- calcium channel blockers
- diabetes medications
- ergot alkaloids
- general anesthetics
- hepatitis C antivirals
- certain HIV protease inhibitors
- macrolide antibiotics
- monoamine oxidase inhibitors
- muscle relaxants
- narcotic pain relievers
- opioid pain relievers
- protein kinase inhibitors
- quinolone antibiotics
- seizure medications
- selective serotonin reuptake inhibitors
- serotonin/norepinephrine reuptake inhibitors
- tricyclic antidepressants
How Does This Medication Work What Will It Do For Me
Risperidone belongs to the group of medications known as antipsychotic agents. These medications are used to treat mental and emotional disorders such as schizophrenia and bipolar disorder. Schizophrenia can cause symptoms such as hallucinations , delusions, unusual suspiciousness, and emotional withdrawal. People with this condition may also feel depressed, anxious, or tense. Bipolar disorder was previously referred to as manic depressive illness it causes alternating episodes of mania and depression. Risperidone is used for short-term treatment of manic symptoms.
Risperidone is also used for the short-term treatment of behavioural problems for people with severe Alzheimer-type dementia that has not responded to non-medication approaches and when there is a risk of harm to themselves or others.
Medications like risperidone are thought to work by correcting the function of nerve pathways in certain areas of the brain.
This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.
Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.
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Lack Of Treatment Alternatives
The researchers examined Department of Veterans Affairs patient records from fiscal year 2008, comparing the rates of antipsychotic drug prescriptions among two groups: 2,597 patients with Parkinson’s disease and psychosis with and without dementia and 6,907 patients with dementia and psychosis but without Parkinson’s disease 97.3% of the patients studied were men.
“More men are diagnosed with Parkinson’s, and men are more likely to develop dementia,” says Weintraub.
An estimated 60% of Parkinson’s patients will experience some form of psychosis during their illness, according to the study. Weintraub and colleagues found that half of all patients with Parkinson’s and psychosis were treated with antipsychotic medications.
Perhaps their most striking finding was that overall prescription rates had not decreased compared to 2002, despite the black box warning that was issued in 2005. To Fernandez, the reason is simple: doctors have few options to offer.
“This study is very important because it highlights the problem that clinicians face,” says Fernandez. “The problem is it’s not very easy to treat, and few patients will be completely treated.”
Weintraub agrees that treatment choices are quite limited, but he hopes that his study will encourage doctors to make greater use of clozapine and to be more conservative in prescribing other antipsychotics.
Biological Basis Of Iatrogenic Movement Disorders
The biological basis of the movement disorders is complex. However, those listed above as secondary to medication are characterised by the action of drugs on central nuclei and in particular pathways and nuclei associated with the basal ganglia, a functional unit located at the base of the forebrain.
The basal ganglia have principal connections to the cortices and thalamus. Although involved in multiple functions including cognition and emotional function, it is their role in the control of involuntary movements that is relevant to this chapter. The other functions, though, are clinically important and discussed elsewhere in this book. At rest, the structures of the basal ganglia can be considered to provide a tonic inhibition of motor activity. This inhibition is released through conscious activity via an increased release of dopamine from the substantia nigra, thereby allowing voluntary control of motor activity in the necessary area.
However, cholinergic pathways elsewhere are involved in cognition, vigilance and emotional modulation and degenerate in Parkinsons disease while anticholinergic medication may therefore be associated with an improvement in movements, it is at the expense of deterioration in cognition in this disease, as well as in patients with psychosis, where anticholinergic medication may additionally mediate confusion and psychotic symptoms.
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Overview Of Pdp Management
Physical Versus Emotional Control:The intertwining pathophysiology of psychosis and PD through dopaminergic pathways presents healthcare professionals and patients with the unfortunate choice between physical and emotional stability. Dopaminergic agents that treat the symptoms of PD and maintain physical control are predominately associated with the triggering of psychosis symptoms through D2-receptor activation.9,11 This swing to emotional instability could be broadly treated in one of two ways. One option is to stop the anti-PD agent however, this is not feasible for most patients because physical instability and motor symptoms would return. Alternatively, an antipsychotic could be added, but nearly all typical and atypical antipsychotics work via D2-receptor antagonism, potentially tipping the scale toward physical instability. Accordingly, methods used in practice involve dose reduction of offending agents, as tolerated, or the use of an atypical antipsychotic with low D2-receptor affinity.9,11
What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture . Always store the orally disintegrating tablets in their sealed package, and use them immediately after opening the package.
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
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Are There Any Other Precautions Or Warnings For This Medication
Before you begin taking a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should take this medication.
Blood clots: This medication may increase the chance of blood clot formation, causing reduction of blood flow to organs or the extremities.
If you have a history of clotting you may be at increased risk of experiencing blood clot-related problems such as heart attack, stroke, or clots in the deep veins of your leg. If you experience symptoms such as sharp pain and swelling in the leg, difficulty breathing, chest pain, blurred vision or difficulty speaking, contact your doctor immediately.
Body temperature regulation: Risperidone can cause body temperature changes. If you are taking this medication you should take precautions when there is a risk of exposure to extreme heat or cold, strenuous exercise, or dehydration, or if you are also taking anticholinergic medication. Discuss with your doctor about how to prevent body temperature issues.
Cataract surgery: During eye surgery for cataracts, people who take or have taken risperidone are at risk for developing a condition called Intraoperative Floppy Iris Syndrome . This condition can lead to eye damage. If you are planning to have an operation on your eye, inform your doctor if you are taking or have taken risperidone.
Drugs Associated With Parkinsonism And Other Abnormal Involuntary Movements
There are numerous drugs and drug classes that are associated with the development of parkinsonism and other abnormal involuntary movements. Drug-induced parkinsonism is often not recognised, especially in the non-psychiatric patient , The side effect often develops within 1 month of the start of treatment, with 60% of patients developing it by this time point and 90% within 3 months .The potency of antipsychotics is defined by their ability to block the D2 receptors. Therefore, high-potency neuroleptics tend to have a greater propensity to cause extra-pyramidal side effects. However, some high-potency neuroleptics that also have anticholinergic properties are associated with fewer motor side effects. Atypical antipsychotics tend to have broader pharmacodynamic effects, and it is thought that their activity at 5HT2a receptors mediate efficacy with less need for blocking of the D2 receptors in the mesolimbic pathways and therefore in the substantia nigra.
The evidence surrounding iatrogenic dystonias is less well developed. Conventional neuroleptics are clearly implicated as are calcium channel blockers. Additionally, there are several case reports noting an association with olanzapine, carbamzaepine, lithium, imipramine, gabapentin and ziprasidone. Other dystonias are less clearly associated with iatrogenic causes.
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How Is Risperidone Given
If you already use other antipsychotic medication, you may need to keep using it for a short time. Do not change your dose or dosing schedule without your doctor’s advice.
You may need to take risperidone by mouth before you start receiving risperidone injections. Follow your doctor’s dosing instructions very carefully.
Risperidone is injected under the skin or into a muscle.
A healthcare provider will give you this injection.
Risperdal Consta is usually given once every 2 weeks. Perseris is usually given once every month.
If you use risperidone injections long-term, your doctor will need to check your progress on a regular basis.