Naturaltreatment For Parkinsons #9 Exercise And Other Alternative Therapies:
Regular exercise has been shown to help Parkinsonssufferers by reducing muscle stiffness, increasing mobility, and enhancing postureand balance. Exercise also increases oxygen levels and neurotransmitters, alongwith releasing potent mood elevating chemicals called endorphins.
The type of exercise performed for PD is crucial. Aqua orwater aerobics can be particularly useful as traditional exercise is usuallyquite difficult for many Parkinsons sufferers. Muscle decline, loss of strength,stiffness and loss of balance can make conventional exercises difficult toperform. The great thing about aqua aerobics is it still has the same benefits as other exercise regimens,but the risk of falling is eliminated.
Other types of exercises that can be beneficial for PDsufferers include Tai Chi, Yoga, dancing, walking, aerobic/jazzercise classes,and general stretching.
For more information on the different exercise programsavailable for Parkinsons patients, you can check out this website Exercise and Physical Therapy for ParkinsonsDisease
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Vitamins For Parkinsons Disease
Verywell / Michela Buttignol
Apart from traditional pharmaceutical treatments, if you have Parkinsons disease, your doctor may recommend vitamins with antioxidant properties. While it is best to get these from food sources as part of a healthy, balanced diet, some people need to take supplements. These vitamins include:
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How About For Parkinsons
Researchers have been trying to find a connection between Mg intake and the risk of developing Parkinsons disease. The evidence collected so far suggests that there is a possible involvement of Mg in Parkinsons disease.
A study conducted in Japan showed that those who consume less Mg are at high risk of developing Parkinsons. In this study, 249 Parkinsons patients and 368 controls without brain diseases were examined for their consumption of different metals. The study found that those who were consuming high Mg in their diet were less likely to develop Parkinsons compared to those who were consuming less. The study further concluded that a higher intake of Mg may be protective against Parkinsons.
There is also evidence indicating that Mg could play a role in Parkinsons progression. A study involving 91 Parkinsons patients and 18 controls found that Mg concentration in cerebrospinal fluid decreased with the duration and severity of the disease. Its abnormal levels were also observed in otherstudies.
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How Much Magnesium Do You Need
Studies on supplementing magnesium levels indicate that 300 mg/day is enough to impact blood pressure significantly. However, there are also indications that increasing magnesium above normal levels is not advisable.
The positive impact of magnesium supplementation is primarily because you are correcting a deficiency. If you already have adequate magnesium levels, supplementing with magnesium is not helpful.
Talk to your doctor or your nutritionist before taking a magnesium supplement.
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Magnesium For Pain Or Cognition
Magnesium malate, glycinate, and threonate forms of magnesium for maximum neurological and systemic benefits for the body.
Malate: energizing, metabolism, reduces muscle pain
Glycinate: relaxing, gut friendly, good for nerve pain
Citrate: relaxing, reduce muscle pain, good for kidneys
Taurate and orotate: cardiovascular health
Chloride: detoxifying and good for kidneys
L-Threonate: The best for brain injuries, depression, anxiety, memory, learning, neurodegenerative disorders, and etc.
Once ingested magnesium oxide is poorly absorbed by the body .
Magnesium glycinate is much more effective than magnesium oxide, and absorbed in different areas of the gut compared to traditional magnesium supplementation . It appears to be very effective, but not the best
Magnesium glycinate is the current best form to take due to high absorption and no digestive side effects. Magnesium citrate is also very well absorbed by the body but some people experience diarrhea when taking it. Others, welcome it as a relief for constipation. Avoid taking magnesium oxide as it is not well absorbed by the body research shows it is no different than taking a placebo.
Beware of combination type products. First form listed is most prevalent by rule, but could be 90% of product.
The Mayo Clinic has similar, yet slightly lower, recommended guidelines teenaged and adult men should ingest 270 to 400 milligrams of magnesium each day.
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Benefits Of Magnesium Supplements
What are the health benefits of magnesium supplements? This is the most important natural mineral duo you need to be adding to your daily diet. It will keep you healthy, strong and flexible for years to come. Here is a simple list of magnesium benefits youâll get by using the best type of magnesium :
- Naturally Relieves Anxiety and Panic
- Helpful for Depression and Seasonal Affective Disorder
- Relieves Constipation
- Helps Prevent Cancers
- You Just Feel Better!
The best type of magnesium supplement is probably the #1 essential mineral that you should have in your health cabinet because it helps you with so many things.
Determination Of The Phosphorylation Status Of Wt And Pa350v Variant
The PhosphoProtein Purification Kit was used according to the manufacturerâs instructions. 1.5Ã107 cells of the stably transfected HEK293 cell lines expressing strep- or flag-tagged wt or strep-tagged variant p.A350V were used as starting material. 2.5 mg of total protein was used for the affinity purification of phosphorylated proteins. Flow through and elution fractions were precipitated with 8% trichloroacetic acid and washed once with acetone. The pellets were dissolved in 0.1 M Tris.HCl buffer containing 2 M urea. Proteins were separated on a 10% SDS-polyacrylamide gel, transferred to a PVDF membrane and immunostained with a primary anti-strep antibody and a secondary HRP-coupled mouse antibody. For the flag-tagged cell line M2 antibody was used. To detect the phosphorylated form of Akt, the phospho-akt primary antibody and the secondary mouse antibody were used. Images were acquired with the BioRad ChemiDoc MP System .
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Green Tea Polyphenols Or Gtps
GTPs have antioxidant properties along with free radical scavenging activities. There are current studies being conducted, which suggest that GTPs have a neuroprotective impact with the potential of treating Parkinsonâs disease. Ongoing studies are being conducted by the Chinese Ministry of Health along with the Michael J. Fox Foundation whether GTPs can slow down the progression of Parkinsonâs disease.
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Magnesium In Parkinsons Disease
Magnesium in Parkinsons disease: an update in clinical and basic aspects
Kiyomitsu Oyanagi and Tomoyo Hashimoto.
Abstract
Magnesium is essential for cell functions such as transport of calcium and potassium ions, and modulates signal transduction, energy metabolism, and cell proliferation. Several studies elucidated a reduced concentration of Mg in patients with Parkinsons disease , and experimentally, severe loss of dopaminergic neurons exclusively in the substantia nigra in 1-year-old rats that had been subjected to continuously low Mg intake over generations. A study conducted by the authors revealed a significant and striking effect of Mg to prevent neurite and neuron pathology, and also to ameliorate neurite pathology in a rat Parkinson disease model involving culture of ventral mesencephalic-striatal cells with 1-methyl-4-phenylpyridinium . Mg is expected to prevent and ameliorate Parkinsons disease in cases where it would be able to cross into the brain in a suitable way.
For the rest of this article please go to source link below.
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Metalloproteins And Differential Expression
Next, the metal-bound protein search was executed in Protein Data Bank by applying the search filters that include: Organism type: Experimental method: XRD Molecule type: Protein Sequence feature: Wild-type protein and X-ray resolution: > 3A°. Overall, we retrieved 6,367 proteins that bound with 60 different metals. Each metalloprotein was named using its official gene symbol. Among 6,367 metalloprotein-encoding genes, we only took DEGs that are commonly overexpressed and downregulated in both blood and brain of PD. This exercise yielded 280 DEGs, which served input for metalloprotein network construction.
Mg In Parkinsons Disease And Related Diseases
analysed four brain regions for concentrations of 24 metals by atomic absorption and atomic emission spectroscopy in brains of 9 patients with PD, 15 patients with other chronic neurological diseases and 12 subjects of controls. The results were that brains of PD and parkinsonism secondary to neurofibrillary tangle disease showed lower concentrations of Mg in the caudate nucleus and copper in the substantia nigra than control brains. Barbiloni et al., performed in vivo phosphorus magnetic resonance spectroscopy on the occipital lobes of 13 patients with PD, 15 patients with multiple system atrophy and 16 age-matched healthy subjects. They reported that patients with PD showed significantly increased contents of inorganic phosphate , decreased cytosolic free , and unchanged phosphocreatine and pH. examined concentrations of Ca, Cu, Fe, Mg, Si and Zn by inductively coupled plasma atomic emission spectrometry in blood, urine and cerebrospinal fluid of 91 PD patients and 18 controls. They concluded that Mg concentration in CSF of PD patients decreased with the duration and severity of the disease.
It has been proposed that Mg deficiency is involved in the pathogenesis of parkinsonism- dementia complex and amyotrophic lateral sclerosis in the Chamorro population on Guam, which is a member of the Mariana Islands in the western Pacific Ocean, as well as in the Kii peninsula of Japan and in West New Guinea . PDC is a disease entity that was established by
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Transdermal Magnesium Application In Parkinson’s Disease
Quality of Life Improvement for People Affected by Parkinson’s Disease
One of the early wins I had when starting Out-Thinking Parkinsons was the discovery of Magnesium Oil Spray. For me this has been highly beneficial and really helped me to re-open the pathways to movement we have since developed.
Back then, I had been describing to Deb Helfrich, Co-Founder of Out-Thinking Parkinsons, how when the Parkinsons stiffness and rigidity of muscles took hold , the very worst part was the pain in my shoulders. To help her understand what it felt like, I described it to her like this:
Imagine tensing the muscles of the shoulders up as hard as possible and then holding it like that for several minutes but then being unable to release the muscles by one millimeter again afterwards. Now imagine being stuck like that for hours!
Deb then made the intuitive leap between what I had described and muscle cramp. She herself had suffered in the past from something she calls Charlie Horses intense cramping of the calf muscles. She had researched the problem and discovered Magnesium, and that this provided quick and consistent relief for her.
Her second major insight however was that PD comes with all sorts of gut and digestive issues. She was worried that taking Magnesium orally might not result in good absorption in to the blood stream due to this. She had the very bright idea of topical application through the skin.
Search Strategies And Selection Of Studies
The review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement and was registered in PROSPERO . We searched relevant literature from PubMed, Web of Science, China National Knowledge Infrastructure , and WANGFANG, selecting studies from 1991 to 2021. The search terms were magnesium,Alzheimer’s disease,serum,plasma, or CSF. Both English and Chinese languages were used. The Supplementary Materials present the PRISMA checklist and detailed search strategy . The inclusion criteria were: case-control study design human subjects both AD and control groups described in terms of sample size and Mg concentration in serum, blood, plasma, or CSF. The exclusion criteria were: letter, review, or case reports duplicated studies with repeated data in vitro or laboratory studies animal studies studies lacking quantitative data on Mg concentrations.
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Determination Of Free Intracellular Mg2+ By Mag
The -tet and +tet wt and p.A350V cells were rinsed twice with ice-cold, completely divalent-free, Dulbeccoâs phosphate-buffered saline , detached by HyQtase, centrifuged, washed twice in completely Ca2+- and Mg2+-free Hankâs balanced solution supplemented with 10 mM HEPES and 1.36 mM L-glutamine , and finally resuspended in the same solution. Then, the cells were loaded with 7.5 µM mag-fura 2-AM in the presence of the loading-facilitator Pluronic F-127 . After being washed in CMF-HBS+, cells were incubated for a further 30 min at 37°C to allow for the complete de-esterification of the fluorescence probe, washed twice in CMF-HBS+ to remove extracellular mag-fura 2 and stored in CMF-HBS supplemented with 10 mM HEPES, 5 mM glucose, and 0.4 mM Mg2+ until the start of the experiments. Directly before measurements, all cells were Mg2+-loaded by a 20-min pre-incubation in CMF-HBS+ supplemented with 10 mM Mg2+ . Then, after the remaining extracellular Mg2+ had been washed out by rinses in CMF-HBS+, the i of cells was continuously determined for 10 min in CMF-HBS+ CMF-HBS+ supplemented with 5 mM Mg2+ or CMF-HBS+ supplemented with 10 mM Mg2+. Differentiation of NME from other transport components was performed by means of the NME inhibitor imipramine or the NME stimulator dB-cAMP , .
Serum Metal And Peripheral Blood Mononuclear Cell Gene Expression
The levels of Mg and Zn were assessed in the blood serum of PD and control using AAS. The normality test was conducted, which showed normal distribution of data. Further, Students test was executed that demonstrated that Mg was significantly increased, whereas Zn was significantly decreased in PD compared to control. Similarly, the gene expression of RPL6 was decreased significantly in PD . Furthermore, the interdependency between metal concentrations and gene expression shows RPL6 was negatively correlated with Mg and positively correlated with Zn based on R > 0.90.
Figure 6. Relative expression: Gene expression analysis of 60S ribosomal protein L6 in peripheral blood mononuclear cells of control and PD . The columns represent the average gene expression with standard deviation error bar, and asterisk denotes statistical significance with p-value 0.05.
Table 3. Pearsons correlation between serum metal concentrations with the RPL6 gene expression showing interdependency in Parkinsons disease.
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Unfolded Protein Retention And Endoplasmic Reticulum Stress
Alpha-synuclein was found as a main component of the Lewy bodies and the gene was found to be a causative gene of a rare autosomal dominant PD . It has been reported that multiplication of the gene was to be the cause of the disease . It has been suggested that aggregates of alpha-synuclein cause potentiation of oxidative stress, possibly with interaction with iron.
Synuclein was considered to be degraded in the proteasome. Knockout of the 26S proteasome in the dopaminergic neurons induced pale bodies, which is reported to be a prodrome of the Lewy bodies .
Parkin and UCHL-1 are considered essential for ubiquitination of the unfolded proteins, and the gene mutations were found in some familial PD. It is considered that oxidative stress may lead a combination of Parkin and DJ-1, and the combination suffocates unfolded protein degrad- ation . Mg has also been reported to inhibit spontaneous and iron-induced aggregation of alpha-synuclein .
Scheme of possible pathomechanisms of dopaminergic neuron death in Parkinsons disease.
Coq10 Not Helpful In Parkinson Disease
A study among people with early Parkinson Disease found that high-dose CoQ10 was not effective in slowing progression of the disease. For details about the study, information about other uses of CoQ10, as well as our tests of supplements, see the updated CoQ10 and Ubiquinol Supplements Review > >
Clinical Update
2/17/2015
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But How Does Magnesium Cause Such A Protective Effect
In Parkinsons disease, the brain becomes unable to sufficiently produce the neurotransmitter dopamine, which is responsible for controlled movement. This is due to the death of certain cells called the dopaminergic neurons.
Researchers think that Mg might act to protect the death of these dopaminergic neurons in the brain. This neuroprotective effect is attributed to its ability to inhibit the generation of oxidative stress, a process that caused the loss of dopaminergic neurons in the brain.
In a study performed on rats, Mg was found protective against the oxidative stress-dependent loss of brain cells. In this study, when brain cells from 1-year old rats were exposed to a neurotoxin, called MPP+, that caused oxidative stress damage to the brain, a significant loss of dopaminergic neurons was observed. But when the same brain cells were treated with high concentration of Mg before exposing to MPP, the loss of dopaminergic neurons was rescued .
What The Research Is Saying
According to a recent 2021 study published in the Journal of Hepatology it was found that both patients and mice that had non-alcoholic steatohepatitis also had high amounts of cyclin M4 protein. This protein has a job of transporting magnesium out of the liver. It is the responsible party behind the imbalance of magnesium levels that can lead to liver disease development.
These patients have an altered magnesium export machinery that increases the vulnerability of their liver to suffer inflammatory processes, development of fibrosis and fat deposition, Malu Martinez Chantar, first author in the publication, told NYU in an interview . This study also presents a novel therapeutic approach based on GalNAc-siRNA technology that specifically targets the liver by modulating CNNM4 levels. The CNNM4 molecule developed from Silence Therapeutics proprietary mRNAi GOLD Platform effectively protects from liver pathology in preclinical models of steatohepatitis.
To make things a little less complicated, basically siRNA is a drug that has shown potential to treat various diseases including cancer and Parkinsons disease. N-acetylgalactosamine siRNA was developed specifically for liver delivery.
With this treatment targeting CNNM4 and decreasing its quantity steatosis, inflammation, and fibrosis are all alleviated in NASH models. Not only that, but it helps magnesium accumulate back into the liver and reduces stress on the endoplasmic reticulum .
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Natural Remedy For Parkinsons #4 Chlorella And Borax:
If you have a neurological disease such as Parkinsons orAlzheimers, the importance of removing heavy metals from the body â especiallyfrom the brain and nervous system â cannot be overstated. Heavy metalsaccumulate in the brain and nervous system at a rapid rate and cause damage tothe neurological pathways and brain inflammation. Fluoride is one ofthe worst, however, mercury, lead, aluminium and cadmium are also extremely dangerous.Chlorella and borax not only remove these heavy metals completely, theycontinue to prevent further toxic build-ups.
Chlorella is a miracle blue-green algae and one of themost powerful detoxifiers and chelators yet discovered. Whenits combined with cilantro, its benefits are enhancedsignificantly. A Russian study found that chlorella, combined with cilantro,was able to remove all heavy metals from the body, including fluoride and mercury,with no adverse or harmful side effects. You can purchase chlorellain powdered form online or from most health food stores. Just make sure you buythe Broken Cell Wall Chlorella as this is the strongest and most bio-available.For dosage recommendations, simply follow the directions on the container.