Optimise Your Diet Reduce Your Toxic Load
While the cause of Parkinsons is not known, environmental toxins such as pesticides and herbicides are implicated. Researchers have found levels of these chemicals to be higher in the brains of Parkinsons sufferers and incidence of Parkinsons is higher in areas with greater use of these chemicals. It makes sense to avoid any environmental toxins that you can. Also, consider your intake of dietary toxins such as alcohol and caffeine avoiding or reducing these may reduce the load on your bodys detoxification pathways.
Can Dietary Magnesium Control The Symptoms Of Parkinsons Disease
While the dietary intake of Mg has been shown to reduce the risk of developing Parkinsons disease, whether it relieves the symptoms of the disease is still uncertain. There are some anecdotal evidence suggests that high consumption of Mg could help with relieving some symptoms of the disease. For some people that have tried it are convinced that it works. They got improvement in their tremor and movement . On the contrary, there are people who reported that their symptoms become worse due to high intake of Mg. Therefore, one must be cautious and should take the advice of his doctor before using it.
Cannabis & Parkinsons Disease
It has only recently been observed that some cannabinoids are potent antioxidants that can protect neurons from death even without cannabinoid receptor activation. It seems that cannabinoids can delay or even stop progressive degeneration of brain dopaminergic systems, a process for which there is presently no prevention. In combination with magnesium, cannabinoids represent, qualitatively, a new approach to the treatment of Parkinsons disease.
Dr. Evzin Ruzicka, an attending neurologist at Charles University in Prague in the Czech Republic said, To our knowledge, this is the first study to assess the effect of cannabis on Parkinsons disease, and our findings suggest it may alleviate some symptoms.
The investigators had asked all patients who were treated for Parkinsons disease at a centre in Prague to complete a questionnaire that asked about cannabis use and about several Parkinsons disease symptoms. Of 630 questionnaires sent out 339 were returned
Among the responders, 25% reported that they had used cannabis. Most had used it orally, either as fresh or dried leaves.
Within this group, thirty-nine patients reported that their Parkinsons disease symptoms in general were relieved after they started using cannabis. In terms of specific symptoms, 26 reported an improvement in tremor while at rest, and 38 experienced a relief of bradykinesia. Relief of muscle rigidity was reported by 32 , and 12 said they had an improvement in levodopa-induced dyskinesias.
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How About For Parkinsons
Researchers have been trying to find a connection between Mg intake and the risk of developing Parkinsons disease. The evidence collected so far suggests that there is a possible involvement of Mg in Parkinsons disease.
A study conducted in Japan showed that those who consume less Mg are at high risk of developing Parkinsons. In this study, 249 Parkinsons patients and 368 controls without brain diseases were examined for their consumption of different metals. The study found that those who were consuming high Mg in their diet were less likely to develop Parkinsons compared to those who were consuming less. The study further concluded that a higher intake of Mg may be protective against Parkinsons.
There is also evidence indicating that Mg could play a role in Parkinsons progression. A study involving 91 Parkinsons patients and 18 controls found that Mg concentration in cerebrospinal fluid decreased with the duration and severity of the disease. Its abnormal levels were also observed in otherstudies.
Does Magnesium Protect Against Parkinsons Disease
Dietary intake of magnesium has been shown to improve many clinical conditions like cancer, depression, asthma, and neurodegenerative diseases. Several lines of research evidence show a possible therapeutic role of magnesium for Parkinsons disease. There are studies showing that low level of magnesium in the brain increases the risk of developing Parkinsons disease.
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What The Research Is Saying
According to a recent 2021 study published in the Journal of Hepatology it was found that both patients and mice that had non-alcoholic steatohepatitis also had high amounts of cyclin M4 protein. This protein has a job of transporting magnesium out of the liver. It is the responsible party behind the imbalance of magnesium levels that can lead to liver disease development.
These patients have an altered magnesium export machinery that increases the vulnerability of their liver to suffer inflammatory processes, development of fibrosis and fat deposition, Malu Martinez Chantar, first author in the publication, told NYU in an interview . This study also presents a novel therapeutic approach based on GalNAc-siRNA technology that specifically targets the liver by modulating CNNM4 levels. The CNNM4 molecule developed from Silence Therapeutics proprietary mRNAi GOLD Platform effectively protects from liver pathology in preclinical models of steatohepatitis.
To make things a little less complicated, basically siRNA is a drug that has shown potential to treat various diseases including cancer and Parkinsons disease. N-acetylgalactosamine siRNA was developed specifically for liver delivery.
With this treatment targeting CNNM4 and decreasing its quantity steatosis, inflammation, and fibrosis are all alleviated in NASH models. Not only that, but it helps magnesium accumulate back into the liver and reduces stress on the endoplasmic reticulum .
Quantitative Real Time Pcr
To determine the transcription activity of both transgenic variants of SLC41A1, namely wt and c.1049C> T, by the quantitative real time PCR method in induced and non-induced cells, we used the following primers: hSLC41A1fw, 5-TTGGACGCTCGCCTTGCCTG-3 and hSLC41A1rev, 5-TGGTGTGGAACACCTGCGCC-3. Expression activities of SLC41A2 and SLC41A3 were determined with following primer pairs: hSLC41A2fw, 5-TGGTTATAAGTAGCATTGGGGGCCT-3 and hSLC41A2rev, 5-TCCTGCTAGCCTGAATGGCCA -3 hSLC41A3fw, 5-CACAAAGATAGTCGGTATCTGACG-3and hSLC41A3rev, 5-GACCATGGCCAGGATGATT-3. Total RNA isolation, the determination of its integrity, purity, and quantity, cDNA synthesis, and q-RT-PCR were performed as described by Kolisek and colleagues . Data were evaluated with software application FK-Wolf-01, developed by Katharina Wolf . Statistical evaluation was performed with data sets acquired from three biological preparations for each condition loaded in triplicate.
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Determination Of The Phosphorylation Status Of Wt And Pa350v Variant
The PhosphoProtein Purification Kit was used according to the manufacturer’s instructions. 1.5×107 cells of the stably transfected HEK293 cell lines expressing strep- or flag-tagged wt or strep-tagged variant p.A350V were used as starting material. 2.5 mg of total protein was used for the affinity purification of phosphorylated proteins. Flow through and elution fractions were precipitated with 8% trichloroacetic acid and washed once with acetone. The pellets were dissolved in 0.1 M Tris.HCl buffer containing 2 M urea. Proteins were separated on a 10% SDS-polyacrylamide gel, transferred to a PVDF membrane and immunostained with a primary anti-strep antibody and a secondary HRP-coupled mouse antibody. For the flag-tagged cell line M2 antibody was used. To detect the phosphorylated form of Akt, the phospho-akt primary antibody and the secondary mouse antibody were used. Images were acquired with the BioRad ChemiDoc MP System .
Serum Metal And Peripheral Blood Mononuclear Cell Gene Expression
The levels of Mg and Zn were assessed in the blood serum of PD and control using AAS. The normality test was conducted, which showed normal distribution of data. Further, Students test was executed that demonstrated that Mg was significantly increased, whereas Zn was significantly decreased in PD compared to control. Similarly, the gene expression of RPL6 was decreased significantly in PD . Furthermore, the interdependency between metal concentrations and gene expression shows RPL6 was negatively correlated with Mg and positively correlated with Zn based on R > 0.90.
Figure 6. Relative expression: Gene expression analysis of 60S ribosomal protein L6 in peripheral blood mononuclear cells of control and PD . The columns represent the average gene expression with standard deviation error bar, and asterisk denotes statistical significance with p-value 0.05.
Table 3. Pearsons correlation between serum metal concentrations with the RPL6 gene expression showing interdependency in Parkinsons disease.
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Parkinsons And Nutrition: Food For Thought
Scientific and Medical Senior Director
A healthy lifestyle and balanced nutrition are essential pillars of good health for all people.A balanced diet is even more critical for people with a neurodegenerative condition, such as Parkinson’s disease .
PD influences many systems in the body, making those living with PD susceptible to malnutrition. Involuntary movements associated with PD result in increased energy expenditure. Constipation caused by slowed gastrointestinal transit, disease symptoms , and medication side effects can all limit food consumption. In addition, one of the most used medications, levodopa, competes with proteins for absorption from the small intestine.Although no single specific diet is recommended for everyone with PD, there has been growing research on the potential health benefits for PD patients of a balanced diet that includes high quality and nutritional food. Nutrition may affect PD patients wellbeing in several ways, from neuroprotection to symptom relief. This article provides a taste of the latest research in the field.
Magnesium For Pain Or Cognition
Magnesium malate, glycinate, and threonate forms of magnesium for maximum neurological and systemic benefits for the body.
Malate: energizing, metabolism, reduces muscle pain
Glycinate: relaxing, gut friendly, good for nerve pain
Citrate: relaxing, reduce muscle pain, good for kidneys
Taurate and orotate: cardiovascular health
Chloride: detoxifying and good for kidneys
L-Threonate: The best for brain injuries, depression, anxiety, memory, learning, neurodegenerative disorders, and etc.
Once ingested magnesium oxide is poorly absorbed by the body .
Magnesium glycinate is much more effective than magnesium oxide, and absorbed in different areas of the gut compared to traditional magnesium supplementation . It appears to be very effective, but not the best
Magnesium glycinate is the current best form to take due to high absorption and no digestive side effects. Magnesium citrate is also very well absorbed by the body but some people experience diarrhea when taking it. Others, welcome it as a relief for constipation. Avoid taking magnesium oxide as it is not well absorbed by the body research shows it is no different than taking a placebo.
Beware of combination type products. First form listed is most prevalent by rule, but could be 90% of product.
The Mayo Clinic has similar, yet slightly lower, recommended guidelines teenaged and adult men should ingest 270 to 400 milligrams of magnesium each day.
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The Relationship Between Magnesium And Your Liver
Magnesium is an important nutrient for our health. It is a part of many different processes, such as:
- Regulating muscle and nerve function
- Regulating blood sugar levels
- Regulating blood pressure
- Making protein, bone, and DNA
The liver is also an important organ where its involved in metabolism, immune response, and regulating the transportation and distribution of many trace elements including magnesium.
Many people who have liver disease are also deficient in magnesium, which can make the condition become worse. According to a 2019 article , every 100 milligram increase in magnesium intake results in a 49% decrease in the mortality from all liver diseases.
- Viral hepatitis
Magnesium The Most Imperative Mineral
Magnesium is the most abundant element that is involved in a wide range of biochemical processes in the body including energy generation, DNA, RNA, and protein synthesis, and cell growth. It is essential for the proper functions of the brain, heart, and muscle. It is also crucial for your bone development.
Mg is abundant in plant and animal foods. It can be found in green leafy vegetables, nuts, whole grains, cereals, legumes, potatoes, rice, milk, fruits, chicken, beef, and salmon.
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Natural Remedy For Parkinsons #4 Chlorella And Borax:
If you have a neurological disease such as Parkinsons orAlzheimers, the importance of removing heavy metals from the body – especiallyfrom the brain and nervous system – cannot be overstated. Heavy metalsaccumulate in the brain and nervous system at a rapid rate and cause damage tothe neurological pathways and brain inflammation. Fluoride is one ofthe worst, however, mercury, lead, aluminium and cadmium are also extremely dangerous.Chlorella and borax not only remove these heavy metals completely, theycontinue to prevent further toxic build-ups.
Chlorella is a miracle blue-green algae and one of themost powerful detoxifiers and chelators yet discovered. Whenits combined with cilantro, its benefits are enhancedsignificantly. A Russian study found that chlorella, combined with cilantro,was able to remove all heavy metals from the body, including fluoride and mercury,with no adverse or harmful side effects. You can purchase chlorellain powdered form online or from most health food stores. Just make sure you buythe Broken Cell Wall Chlorella as this is the strongest and most bio-available.For dosage recommendations, simply follow the directions on the container.
Green Tea Polyphenols Or Gtps
GTPs have antioxidant properties along with free radical scavenging activities. There are current studies being conducted, which suggest that GTPs have a neuroprotective impact with the potential of treating Parkinson’s disease. Ongoing studies are being conducted by the Chinese Ministry of Health along with the Michael J. Fox Foundation whether GTPs can slow down the progression of Parkinson’s disease.
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Rpl: A Key Molecule Regulating Zinc
- 1Drug Discovery and Multi-omics Laboratory, Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Kelambakkam, India
- 2School of Engineering and Sciences, Centre of Bioengineering, Tecnologico de Monterrey, Queretaro, Mexico
- 3Department of Neurology, School of Medicine, University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, NM, United States
- 4Department of Medical Laboratory Technology, Manipal College of Health Professions, Manipal, Manipal Academy of Higher Education, Manipal, India
- 5Department of Pharmacology, Saveetha Dental College , Saveetha Institute of Medical and Technical Sciences, Chennai, India
So What Does Nutrition Have To Do With Parkinsons
1. The neurotransmitter dopamine is made in the body from amino acids which are the building blocks of protein. Every time we eat a protein rich food we take in protein, which the body breaks down into its component amino acids. Two amino acids are converted in the body into L-Dopa, which is then converted into dopamine in the brain.
2. Nutrient co-factors are required for each stage of this conversion process, so deficiencies of these may reduce dopamine production.
3. L-dopa medication competes for absorption with dietary amino acids, therefore the timing of taking L-dopa and the eating of protein needs to be managed for optimal absorption and effectiveness of the drug and the reduction of side-effects.
Therefore, the nutritional therapy approach to Parkinsons includes:
1. Supporting dopamine production by ensuring adequate precursors and co-factors
2. Considering drug-nutrient interactions to enhance effectiveness and reduce side-effects
3. Optimising nutritional status and addressing co-morbidities . These co-morbidities include constipation, depression, fatigue, and insomnia.
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Determination Of Free Intracellular Mg2+ By Mag
The -tet and +tet wt and p.A350V cells were rinsed twice with ice-cold, completely divalent-free, Dulbecco’s phosphate-buffered saline , detached by HyQtase, centrifuged, washed twice in completely Ca2+- and Mg2+-free Hank’s balanced solution supplemented with 10 mM HEPES and 1.36 mM L-glutamine , and finally resuspended in the same solution. Then, the cells were loaded with 7.5 µM mag-fura 2-AM in the presence of the loading-facilitator Pluronic F-127 . After being washed in CMF-HBS+, cells were incubated for a further 30 min at 37°C to allow for the complete de-esterification of the fluorescence probe, washed twice in CMF-HBS+ to remove extracellular mag-fura 2 and stored in CMF-HBS supplemented with 10 mM HEPES, 5 mM glucose, and 0.4 mM Mg2+ until the start of the experiments. Directly before measurements, all cells were Mg2+-loaded by a 20-min pre-incubation in CMF-HBS+ supplemented with 10 mM Mg2+ . Then, after the remaining extracellular Mg2+ had been washed out by rinses in CMF-HBS+, the i of cells was continuously determined for 10 min in CMF-HBS+ CMF-HBS+ supplemented with 5 mM Mg2+ or CMF-HBS+ supplemented with 10 mM Mg2+. Differentiation of NME from other transport components was performed by means of the NME inhibitor imipramine or the NME stimulator dB-cAMP , .
Metalloproteins And Differential Expression
Next, the metal-bound protein search was executed in Protein Data Bank by applying the search filters that include: Organism type: Homo sapiens Experimental method: XRD Molecule type: Protein Sequence feature: Wild-type protein and X-ray resolution: > 3A°. Overall, we retrieved 6,367 proteins that bound with 60 different metals. Each metalloprotein was named using its official gene symbol. Among 6,367 metalloprotein-encoding genes, we only took DEGs that are commonly overexpressed and downregulated in both blood and brain of PD. This exercise yielded 280 DEGs, which served input for metalloprotein network construction.
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Substitution Pa350v In Na+/mg2+ Exchanger Slc41a1 Potentially Associated With Parkinson’s Disease Is A Gain
Affiliation Institute of Veterinary-Physiology, Free University Berlin, Berlin, Germany
Affiliation Institute of Veterinary-Physiology, Free University Berlin, Berlin, Germany
Affiliation Institute of Veterinary-Physiology, Free University Berlin, Berlin, Germany
Affiliation Institute of Physiology, Pathophysiology and Biophysics, University of Veterinary Medicine, Vienna, Austria
Affiliation INSERM, U699, Paris, France
Affiliation Institute of Prevention and Nutrition, Ismaning, Germany
Affiliation Institute for Nutritional Physiology Oskar Kellner, Leibniz Institute for Farm Animal Biology, Dummerstorf, Germany
Naturaltreatment For Parkinsons #9 Exercise And Other Alternative Therapies:
Regular exercise has been shown to help Parkinsonssufferers by reducing muscle stiffness, increasing mobility, and enhancing postureand balance. Exercise also increases oxygen levels and neurotransmitters, alongwith releasing potent mood elevating chemicals called endorphins.
The type of exercise performed for PD is crucial. Aqua orwater aerobics can be particularly useful as traditional exercise is usuallyquite difficult for many Parkinsons sufferers. Muscle decline, loss of strength,stiffness and loss of balance can make conventional exercises difficult toperform. The great thing about aqua aerobics is it still has the same benefits as other exercise regimens,but the risk of falling is eliminated.
Other types of exercises that can be beneficial for PDsufferers include Tai Chi, Yoga, dancing, walking, aerobic/jazzercise classes,and general stretching.
For more information on the different exercise programsavailable for Parkinsons patients, you can check out this website Exercise and Physical Therapy for ParkinsonsDisease
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