Can Lions Mane Help Anxiety And Depression
Depression and Anxiety are two of the most common mental illnesses. Do any of these words ring a bell? They are some of the most frequent modern diseases that exist today. The high-speed, high-stress life is causing us more harm than we realize, and we often fail to recognize it until it has serious ramifications for our health and well-being. One out of every three persons in developed countries suffers from symptoms of sadness or anxiety, according to the latest statistics. This is why it is so critical to fighting against it even before we are aware that we may be facing a crisis.
The anti-inflammatory properties of this fungus have been demonstrated in fresh research conducted on mice, which suggests that the extract of this mushroom can help to alleviate the symptoms of depression and anxiety.
Anxiety and sadness are believed to be reduced in their effects by enhancing the functions of the hippocampus . So, what is the connection between this and our topic? Other animal research has demonstrated that Lions Mane extract can aid in the regeneration of brand cells and, as a result, can improve the function of the hippocampus.
We can further add that CBD has the same benefits for anxiety and depression and mixed with Lions Mane can further enhance the results of treating these conditions.
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Current And Future Developments
Current pharmacotherapies for PD do not provide the much desired permanent curative benefits to patients. Scientists in the field of nutrition have identified natural products as potential adjuvant treatments to conventional drug therapy to attenuate the PD symptoms and reduce the dose of anti-Parkinson drugs and the incidence of associated adverse events. There is a high rate of dyskinesia and relapse of Parkinsonian symptoms following long-term treatment with levodopa . Combination therapy with natural herbal products has demonstrated substantial benefits in lowering levodopa- related complications . However, the long term effect of combination therapy has not been investigated, and potential interactions with drugs that are currently used in the PD treatment remain unclear. The dosage regimen for anti-parkinsons drug is of major clinical importance of anti-parkinsons drug due to its lifelong requirement. Adjunct therapy with natural products may ultimately prove useful for reducing the dose of levodopa for managing PD symptoms.
Cordyceps Mushroom: The Caterpillar Fungus
Species name: Cordyceps Militaris
Primary Cordyceps Mushroom Medicinal Benefits: Improves lung capacity and increases energy*
The Cordyceps mushroom is an incredible energy-boosting fungi because of its ability to increase ATP production through pre-cursor compounds like adenosine and cordycepin. ATP is the compound that gives our cells energy. This is why Cordyceps is recommended when it comes to physical performance*. In TCM, Cordyceps is also used for lung-related issues like asthma or even seasonal allergies*.
Historical Use of Cordyceps Medicinal Mushrooms
Cordyceps has been described as a treasure in old Chinese medical books and Tibetan medicine. With hundreds of different species, it is a parasitic fungi that prey on insects. Traditional healers have recommended the medicinal fungus as a powerful tonic because it improves energy, appetite, stamina and endurance . The most well known species of cordyceps is Cordyceps sinensis the most expensive mushroom in the world costing over $20,000 per kilogram, sold almost exclusively in Asia. It is a rare combination of a caterpillar and a mushroom and found at high altitudes in the Himilayan Plateau.
Luckily, there is one type of Cordyceps species that can be cultivated commercially to produce a mushroom , and that is Cordyceps militaris. If you would like to dive deeper into the realm of this fungi, we have written an engaging and helpful guide about cordyceps supplements to help you be informed.
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An Overview Of Edible Medicinal Mushrooms
Maitake:Can be sautéed, cooked into dishes, or eaten cooked on its own , says Kessler. Maitake mushroom is an adaptogen, which means it can help the body adapt to stress and stay in balance. It also has potential anti-cancer benefits, in addition to helping improve cholesterol and type 2 diabetes.
Shiitake: cooked into any types of dishes, can be eaten raw, but typically cooked, says Kessler. Shiitake mushrooms may help fight cancer and inflammation, and they contain beta glucans, which may help lower cholesterol.
Lions mane: Not typically eaten raw, and can be substituted in recipes as crab meat. support mood health and memory, says Kessler.
Oyster mushrooms: Not typically eaten raw, can sauté, or use in stir fry, says Kessler. Research has shown that oyster mushrooms contain antioxidants and may help decrease risk of certain diseases like cancer, heart disease, obesity and diabetes.
Lions mane is known for helping improve focus and brain health.
Reviewtherapeutic Applications Of Mushrooms And Their Biomolecules Along With A Glimpse Of In Silico Approach In Neurodegenerative Diseases
Edible mushrooms show very potent Anti-oxidative and Anti-inflammatory activity.
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Biomolecules of mushrooms show a prominent therapeutic response against lifestyle-related diseases.
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Mushrooms also widely utilize to manage neurodegenerative diseases like Parkinsons and Alzheimers disease.
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The biomolecules of mushrooms also exhibit strong therapeutic properties.
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Insilco approach is utilized to investigate the characterizes the important bioactive constituent in mushrooms.
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Promotes Neurogenesis: Lion’s Mane Promotes Nerve Growth Factor Production
One of the most extraordinary properties of Lions mane mushroom is its ability to stimulate the growth of nerve cells or neurons and reduce nerve damage. This means that lion’s mane supplements can be potentially utilized in the treatment of Parkinsons as the major cause behind its symptoms is neuron degeneration.
In addition to providing lion’s mane Parkinson’s benefits, the mushroom’s aqueous extract’s ability to stimulate nerve growth can help with a variety of other mental health-related conditions, including dementia and Alzheimer’s disease.
The best mushroom for Parkinson’s disease, Hericium Erinaceus intake increases the production of Nerve Growth Factor , a protein that regulates the growth, development, proliferation, and survival of neurons. The nerve growth factor supports memory, learning, and the ability of the nerve cells to rewire. Often listed among the best mushrooms for brain health, lions mane Parkinson’s benefits go beyond the production of the Nerve Growth Factor.
When it comes to Parkinson’s mushroom treatment, Lion’s mane mushroom extract also increases the expression of the Brain-Derived Neurotropic Factor , another protein that plays an important role in the growth and survival of neuronsjust like the nerve growth factor.
However, when using lion’s mane mushroom for Parkinson’s, elderly adults do not just benefit from the mushroom’s ability to stimulate nerve growththe mushroom also combats oxidative stress.
What Tests Might I Have
Your doctor may want to start by testing your blood or doing a brain scan to rule out other conditions.
People who have Parkinsonâs disease donât make enough of a brain chemical called dopamine, which helps you move. If those first tests donât show a reason for your symptoms, your doctor may ask you to try a medication called carbidopa-levodopa, which your brain can turn into dopamine. If your symptoms get much better after you start the drug, your doctor probably will tell you that you have Parkinsonâs disease.
If the medication doesnât work for you and thereâs no other explanation for your issues, your doctor might suggest an imaging test called a DaTscan. This uses a small amount of a radioactive drug and a special scanner, called a single photon emission computed tomography scanner, to see how much dopamine is in your brain. This test can’t tell you for sure that you have Parkinson’s disease, but it can give your doctor more information to work with.
It can take a long time for some people to get a diagnosis. You may need to see your neurologist regularly so they can keep an eye on your symptoms and eventually figure out whatâs behind them.
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Pharmather Announces Fda Approval Of Ketamine Ind In The Treatment Of Parkinsons Disease
- Post published:May 17, 2021
- Post category:Press Release
TORONTO, May 17, 2021 PharmaTher Holdings Ltd. , a psychedelics biotech company, is pleased to announce that the U.S. Food and Drug Administration has approved the Companys Investigational New Drug application to proceed with a Phase 2 clinical trial to evaluate the safety, efficacy and pharmacokinetics of ketamine in the treatment of levodopa-induced dyskinesia in patients with Parkinsons disease . PharmaTher expects to begin enrolling patients in the Phase 2 clinical trial in Q3-2021. Assuming the Phase 2 clinical trial is positive, the Company will request a meeting with the FDA to discuss its plan and obtain an agreement to move to a Phase 3 clinical study under the 505 regulatory pathway next year.
Parkinsons disease is a debilitating disorder that affects over 1 million people in the U.S. and more than 7 million people worldwide. There is currently no cure for Parkinsons disease, although some drug combinations are used to treat the disease symptoms. The global Parkinsons disease market is expected to grow from USD $5 billion in 2019 to USD $7.5 billion by the end of 2025 and it is estimated that the potential market opportunity for LID-PD to be over USD $3 billion in the U.S. alone.
About the Phase 2 Clinical Trial
For more information about PharmaTher, please contact:Fabio ChianelliWebsite: www.pharmather.com
Cautionary Statement
What To Look For When Buying Lion’s Mane
Watch out for products claiming proven health benefits in humans the majority of research has been limited to animal studies. Some lion’s mane supplements have been marketed with unsupported claims, such as the promotion of weight loss, brain health, and the prevention of heart disease.
For example, in 2019, the Food and Drug Administration sent a warning letter to Pure Nootropics, LLC, for making unsubstantiated claims about a variety of their products, including for their lion’s mane powder. The company was marketing the supplement as “great for brain injury recovery” and to “reduce symptoms of anxiety and depression.” Since then, the company has removed these specific claims from their marketing but continue to claim that the product “supports overall cognitive health.”
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Lions Mane And Neurogenesis
Lions Mane has taken center stage as the number one natural supplement to support cognitive function due to its abundance of brain boosting compounds called hericenones and erinacines.
In the early nineties, organic chemist Hirokazu Kawagishi made a fascinating discovery while studying lions mane mushrooms. He discovered two unique organic compounds that he named hericenones and erinacines after the mushrooms scientific name, Hericium erinaceus.
In study after study since the 1990s, hericenones and erinacines have been reported to stimulate neurogenesis, stimulate neuron regeneration, and rebuild neurons protective myelin sheaths .
The research has also shown potential success with treating cognitive disorders like Alzheimers and Parkinsons disease .
Personally, I used lions mane mushroom extract to treat neurological Lyme disease that plagued my life for over four years. After only two weeks of steady use, my migraines, insomnia, and brain fog were virtually nonexistent. Its that powerful.
A wild lions mane mushroom I foraged.
Other Benefits Of Reishi Mushrooms
This amazing mushroom has also been effective for protecting and improving cardiovascular function. 102
Regular use of Ganoderma lucidum lowers levels of LDL and VLDL cholesterol and triglycerides, inhibits clumping of platelets, lowers blood pressure, and in clinical studies, has been shown to reduce cardiac pain and arrhythmia and to help prevent arteriosclerosis.
Reishi can be of benet for people with asthma 108, 109, chronic obstructive pulmonary disorder, pulmonary fibrosis82, Lupus ,88 chronic pancreatitis,91 Crohns disease,101 and hepatitis B and C111 due to its anti-inammatory activity.
The Reishi mushrooms adaptogenic effects are mild and cumulative, but research shows it improves adrenocortial function and relieves stress.
One randomized, double-blind and placebo-controlled study with 132 patients diagnosed with neurasthenia , mild depression, and chronic fatigue and immune dysfunction syndrome took part in a study of Reishis effects on those conditions.
The group given a polysaccharide extract made from the mushroom reported signicantly higher reductions in fatigue and an improved sense of well-being compared with patients who were given a placebo. 81
Another interesting use for Reishi is to prevent and treat altitude sickness. It can be combined with Jiaogulan, Cordyceps, Ginger, and Rhodiola and should be taken for four to six weeks before visiting high-altitude locations.
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Lions Mane Mushrooms For Brain Health
It is evident that brain functions naturally slow down over time. The symptoms associated with aging such as cognitive decline, memory loss, and lack of focus have been linked to factors like shrinking neurons and damaged brain cells.
Research shows that Lions mane mushroom has the potential to promote brain health by stimulating the creation of Nerve growth factor and Brain-derived neurotrophic factor .
NGF and BDNF are proteins that stimulate the production of new cells and strengthen existing ones. NGF is also important in the formation of myelin, the covering around nerve cells that helps transmit impulses stimulating brain cells to do their job. BDNF increases brain pliability, helping the brain cells to maintain their integrity.
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Are Mushrooms The Best Brain Food
Penn State professor emeritus of food science and director of the Center for Plant and Mushroom Foods for HealthRobert B. Beelman, Ph.D., has spent much of his career paying attention to mushrooms in particular, how eating them might protect the human brain from dementia and other forms of cognitive decline. It may be possible to decrease the incidence of neurological diseases by increasing mushroom consumption, he wrote last year inThe Conversation. His latest paper, published earlier this year inNutrition Today, further highlights the connection.
Beelman is careful to say there is no proven causative link between mushroom consumption and protection against dementia and other chronic neurodegenerative diseases, although a 2017 study showed that frequent mushroom consumption is significantly associated with a lower risk of incident dementia, and earlier this year another study found that participants who consumed mushrooms had reduced odds of having mild cognitive impairment. The week of our interview, an additional study found that eating mushrooms may reduce the risk of memory problems, as the New York Times coverage put it.
I spoke with Beelman, 75, who is now retired but still doing research through collaborations, about what the latest research means and whether mushroom coffee is worth considering.
But the big micronutrient they contain, and what especially interests me regarding neurological benefits, is this antioxidant called ergothioneine.
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The Antioxidants In Mushrooms
Mushrooms contain high amounts of two antioxidants thought to be key to preventing the aging of neurons in the brain: ergothioneine and glutathione. In fact, Dr. Robert Beelman, professor emeritus at Penn State, found that the porcini mushrooms of northern Italy may help keep older Italians free of dementia. He observed that Italians who ate more of these mushrooms had less neurodegenerative diseases, such as Alzheimers and Parkinsons Disease.
Dr. Beelman and his colleagues also found that the ergothioneine content of mushrooms varies by the species. The good news: most mushrooms contain both neuroprotective ergothioneine and glutathione.
These antioxidants remain active whether the mushrooms are consumed raw or cooked.
Mushrooms For Brain Health
Mushrooms are an excellent source of B vitamins. They contain niacin, riboflavin, and pantothenic acid, which are important for regulating the nervous system. Vitamin D is essential for brain function. It plays a major role in the part of the brain that regulates cognitive function.
They are great for your brain health because theyre rich in vitamin B12. Vitamin B12 is essential for keeping your mood, memory, and cognition in check. In fact, a deficiency in this important vitamin can lead to dementia.
One study found that people with Alzheimers disease were more likely to have low vitamin B12. Another study found that taking a vitamin B complex supplement improved memory, cognition, and other mental processes in patients with Alzheimers.
Our bodies become less efficient at absorbing vitamin B12 from food as we age. Its recommended that adults get 2.4 mcg of vitamin B12 a day, but some experts believe this amount is too low.
In addition to increasing your intake of foods rich in Vitamin B12 , you might consider taking a supplement or finding a multivitamin product that offers 100% of the recommended daily value for Vitamin B12 or more.
Mushrooms are rich in antioxidants, and they can help protect your body from oxidative stress, which can lead to premature aging of cells and disease. Antioxidants help remove free radicals from the body by binding them with oxygen, so they become harmless molecules that dont.
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Can Herbs And Mushrooms Help Parkinsons
Once Parkinsons disease develops, it cannot be remediednot by mainstream medicine, nor by alternative medicine.
Luckily, the condition is not fatal. However, the more it develops, the more complicated and serious symptoms can get.
Thats why early detection, risk reduction, and treatment are important.
Together, both medical treatments and natural remedieslike herbs and mushroomscan provide supplemental support as well as risk reduction of Parkinsons symptoms getting worse, studies show.
According to science, here are some of the best natural remedy candidates for Parkinsons.
What Are The Benefits Of Lions Mane Mushrooms
Research on the health benefits of lions mane indicates the mushroom has significant potential to promote neurogenesis, prevent nerve damage, as well as alleviate dementia, depressive disorders symptoms, and neuropathic pain, among other neuro health properties. Hericium erinaceus seems to aid in:
- anxiety and depression symptom relief
- cognitive functions improvement
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