How To Use Cbd Oil For Parkinsons Disease
Pay attention to your dosage in your use of CBD. It is recommended that you ask your health professional for medical advice, diagnosis, or treatment. Read the label on the bottle for dosage guidance or ask your health care professional for medical advice. It is always good to start with low doses and go slow, paying close attention to how you feel and at what dose your symptoms may improve without making things worse. In no time, you may experience an increase in your quality of life for the long term.
Problem #1 Mitochondrial Dysfunction
A flurry of emergent research has linked mitochondrial dysfunction to the pathogenesis of Parkinsons disease. Mitochondrial dysfunction results in impaired ATP generation, loss of cellular repair mechanisms, and cellular inefficiency.
As mitochondria become dysfunctional they generate large quantities of free radicals, which contribute to oxidative stress that, in turn, causes further mitochondrial dysfunction. Concurrently, loss of mitochondria to oxidative damage means fewer mitochondria are available to meet the energy demands of the cell to repair damaged components. The cascade of mitochondrial dysfunction, oxidative stress, and loss of mitochondria form a continuity that ultimately leads to cell death .
Numerous studies have clearly identified mitochondrial dysfunction as a central pathological feature of both genetic and sporadic Parkinsons disease . Moreover, many of the genes that confer predisposition to familial Parkinsons are intimately related to mitochondrial function much of the neuronal death in Parkinsons of genetic origin is due to mitochondrial dysfunction, and impaired mitophagy . While several factors, including exposure to environmental toxins , also contribute to mitochondrial dysfunction in the substantia nigra, age-related mutations in mitochondrial DNA are thought to be a primary culprit . Alarmingly, dopamine itself, and L-DOPA, may contribute to mitochondrial toxicity in dopaminergic neurons .
Basics Of Parkinsons Disease
Parkinsons disease , or paralysis agitans, is a common neurodegenerative condition, which typically develops between the ages of 55 and 65 years. This disease was first named and described by James Parkinson in 1817. The progression of this disease is gradual and prolonged. It has a plausible familial incidence, although the estimates of these occurrences are low and usually sporadic. This disease is organized into two classifications: genetic and sporadic. Genetic PD follows Mendelian inheritance. Sporadic PD, which accounts for about 90% of all Parkinsons cases, is a more complex category in which the pathogenic mechanisms that underlie it are not yet fully understood. Nonetheless, it is known that the byzantine interactions of genetic and environmental influences play roles in the determination of sporadic PD. Several subtypes of PD exist. Each has its own set of causative factors and susceptibilities, pathology, and treatment courses. General risk factors, symptoms, and pathology will be discussed first, before addressing some of the subtypes.
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Surgical Therapies With Transplantation And Gene Therapy
Cell transplantation is regarded as a potential future PD treatment. There have been trials using autologous and non-autologous cells. Human embryonic stem cells and induced pluripotent stem cells are few of the cells that have been included in these transplantation studies. One of the concerns with cell transplantation using stem cells is the ethical bounds that must be considered.
Since the first clinical trial in 1987 involving the transplantation of dopaminergic- neuron-rich human fetal mesencephalic tissue into PD patients striatums, more research has aimed to explore whether the grafted dopaminergic neurons will live and form connections in the brain, if the patients brain can harmonize and make use of the grafted neurons, and if the grafts can generate significant clinical improvement. Clinical trials with cell therapy intend to discover if there are long-lasting improvements following restoration of striatal DA transmission by grafted dopaminergic neurons. Experimental data from rodents and nonhuman primates show that fetal ventral mesencephalon intrastriatal grafted DA neurons demonstrate many morphological and functional characteristics of normal DA neurons. Significant improvements of PD-like symptoms in animal models have been demonstrated after successful reinnervation by the grafts. Dopaminergic grafts can reinnervate the striatum in the brain, restore regulated release of DA in the striatum, and can become functionally integrated into neural circuitries.
Cbd Dosage For Parkinsons Disease
The recommended dosage for Epidiolex, an FDA-approved CBD drug, is to start at 2.5 mg/kg/d twice daily up to a maximum of 10- 20 mg/kg/d. This dose may be higher than what is used in many clinical trials on CBD. This means that an adult weighing 130 lbs., which is 59 kg , would make 20 x 59 kg = 1180 milligrams of CBD/day taken in divided doses. This is much higher than what we are seeing in current studies on CBD oil and PD. Doses in clinical trials using CBD oil are using 100-600 mg/day on people with Parkinsons and finding increased side-effects with dosages higher than 300 mg/day. The oil may precipitate unwanted effects at higher doses of CBD. More research is needed to come up with the number of milligrams of CBD to use and the dose of CBD to give per day.
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Parkinsons Sufferers Offer Tips For Those Struggling With Symptoms
Despite Parkinsons Disease affecting around 1 million people in the US alone, the degenerative disease can be difficult to live with. We Have Parkinsons, one of the growing support and research groups in the US dedicated to helping those live with the disease, has offered those who may feel isolated and struggling with daily tasks tips for living with their illness.
The first port of call for sufferers is to ask for help. Many feel that seeking help is a sign of weakness, but as Parkinsons becomes more well-known, many individuals are much more informed and educated on the topic, meaning theyre often more sympathetic to those suffering.
Speaking about the illness, Jon Sherman, CEO, from We Have Parkinsons, said, Not long ago, not an awful lot was known about Parkinsons, but as treatments have developed, and more people with Parkinsons have spoken about their experiences, there is a growing awareness of the disease. As a result, friends, family and colleagues increasingly will know how to help those struggling. Therefore, anyone who may be struggling with new symptoms, or those whose quality of life is gradually deteriorating, will often find that asking loved ones and even strangers for help can be a huge support.
To find out more about We Have Parkinsons, and read the reviews of Restore Gold, the groups innovative product that has been easing Parkinsons symptoms, visit the website: wehaveparkinsons.com
Problem #2 Lewy Bodies And Alpha
Damaged mitochondria are continually being cleared from within the cell through a process called mitophagy. Mitophagy, a type of autophagy, is a kind of cellular recycling system that clears damaged mitochondria before they can accumulate and cause cellular dysfunction. However, age-related mutations in mitochondrial DNA, which cause mitophagy to become less efficient, coupled with an ever-intensifying propensity for endogenous and environmentally mediated mitochondrial damage cause the neuronal mitophagic system to become overwhelmed . Over time, damaged mitochondria build up inside the neuron, leading to cell death. Not surprisingly, several of the genetic mutations linked to familial Parkinsons disease cause disturbances in mitophagy .
Lewy bodies share some characteristics with toxic proteins that develop in the brains of patients with Alzheimers disease and other neurodegenerative diseases, primarily in that they cannot be broken down and cleared from the cell by normal autophagic actions.
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What Are The Side Effects Of Total Restore
It wouldnt be a fair review of Total Restore if we didnt discuss potential side effects. Certain ingredients used may cause an allergic reaction and other health problems.
For example, N-Acetyl- D-Glucosamine, which is a primary ingredient, is often derived from shellfish shells. For those with shellfish allergies, this can lead to joint pain, hives, vomiting, and nausea.
As mentioned before, those with liver disease or kidney disease can experience adverse side effects.
L-Glutamine is also essential for cancer to grow. Without L-glutamine, cancer couldnt grow. If normal human cells didnt need it to function as well, we would have had a cure for cancer years ago.
Alternatively, there are many other ways to get the required amount of L-Glutamine in a non-concentrated form. By merely eating foods like beans that are high in L-Glutamine, you can get what you need.
Grapefruit is another problematic ingredient. It can react poorly with many common medications like certain calcium channel blockers, psychiatric drugs, immunosuppressants, and impotence drugs.
Check with your doctor to see if Total Restore is incompatible with any of your current medications.
The Losses And The Adjustments
I was starting to get very good at making adjustments when a PD symptom would impair me in some way. As an example, I find it difficult to put my coat on with my left sleeve first, so now I put my coat on with my right sleeve first. Or, since I can no longer feel where to put in my pierced earrings, I just make sure I have a mirror handy to see what I am doing. While waiting on a cashiers line to check out, I make sure I have my money ready so I am not fumbling around in my purse and holding up the line. Wearing satin pajamas makes it easier to move around in bed at night. Being mindful of all my movements is critical so I do not trip, walk into things, or let things fall through my hands.
If my PD does not progress any further, I feel I can deal with the losses it has thrust upon me thus far. However, at times when I wake up in the morning, I think to myself, What simple task will elude me today? PD is a disease of loss, the loss of some of the most, mundane things in life many of us take for granted. These include:
- Holding a purse or newspaper firmly under the arm
- Folding laundry
- Putting on a seat belt
- Zipping a jacket
- Opening a package
- Cutting a salad
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Eat Plenty Of Protein But Not With Levodopa Medications
If youre taking a levodopa medication, your doctor may tell you to avoid protein when taking your meds. Both animal and plant protein can interfere with the absorption of levodopa medications.
But you should still eat plenty of protein. Just be strategic with the timing. Dont take levodopa medications with meals, Dr. Gostkowski says. Its best to take it on an empty stomach either 30 minutes before your meal or an hour after eating.
If you get nauseous from the medication, eat a small amount of starchy food with it, such as crackers. Make sure whatever you eat with your medicine doesnt have protein. Its a misunderstanding that people with Parkinsons should avoid protein, Dr. Gostkowski says. You definitely need protein in your diet. Just dont eat it when youre taking your levodopa medication.
Doctor’s Articles On Parkinson’s Retracted
By Joe Carlson andBrooks Johnson Order Reprint
For more than 20 years, Dr. Martin C. Hinz has been an advocate and researcher in the use of nutritional products and urinalysis for people suffering from Parkinson’s disease, depression and other maladies.
The 67-year-old Duluth native claimed in his most recent paper that the costly amino-acid treatments he says he invented work better than gold-standard therapy prescribed by neurology specialists.
But questions about that work have surfaced in recent months after the owner of Dove Medical Press, an academic publisher of peer-reviewed scientific and medical journals, retracted all six of Hinz’s articles on Parkinson’s. The six were among 20 papers on various diseases and lab techniques retracted because Hinz and his co-authors failed to produce raw data and medical ethics paperwork after not fully disclosing his and his family’s business interests in sales of the costly pills.
It isn’t the first time Hinz’s theories and methods have drawn scrutiny and criticism.
In 2005 and 2011 he received warnings from the Food and Drug Administration for marketing untested nutrients as drugs. Last year, the Minnesota Board of Medical Practice reprimanded him for false advertising, unethical conduct and fee splitting. The board restored Hinz’s Minnesota medical license to full standing in November after he paid a $7,188 civil penalty.
“We treat nothing,” Hinz wrote in an e-mail. “We claim to treat nothing with nutrients.”
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What Has Happened To Me
My quality of life was deteriorating due to my neurological issues. Along with poor fine motor skills on my left side and slowness of movement, I was constantly fatigued. This was a fatigue that no amount of quality sleep could ever satisfy. Additionally, I had internal tremors . I thought for sure there must be some kind of natural solution to help cure what ailed me one that did not involve prescription drugs.
My initial approach was to go to physical and occupational therapy and to continue my exercise regimen . This plan did not seem to slow disease progression or alleviate my symptoms. My depression and lack of motivation were also hindering me.
To Target A Problem First Understand The Problem
Conventional medical approaches to treating Parkinsons disease aim to replace the lost dopamine, but fall short of addressing the ongoing destruction of dopaminergic neurons. As time progresses, the ability of medications to replenish dopamine levels becomes overwhelmed by further loss of dopaminergic cells. Moreover, the pharmaceutical drugs typically used to alleviate symptoms of Parkinsons disease are heavily loaded with debilitating side effects and often worsen affection over time. Thus, the prognosis for Parkinsons disease patients relying on conventional treatment remains limited.
The mainstream medical establishment has failed to recognize the urgent need to address the multiple, interrelated pathological features of Parkinsons disease in order to prevent further neuronal loss and slow disease progression.
Researchers now know that a primary root cause of Parkinsons is mitochondrial dysfunction. Secondary causes of Parkinsons are neural oxidation, neural inflammation, and alpha-synuclein aggregation.
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How I Reversed My Parkinsons Disease Symptoms
- SAVE
Being diagnosed with Parkinsons disease is a life-altering event. Youre presented with all these drugs to take to help ward off the unpleasant symptoms but these drugs cause unwanted side effects.
Its not a no-win situation. You can manage and possibly reverse Parkinsons disease and live a full life.
Its time to find out what you can do to help your body deal with this disease naturally and effectively. Just keep reading.
Is Gundry Md Total Restore Effective
As we mentioned, research into leaky gut syndrome is sparse. There isnt even a consensus over whether it exists, though evidence does point to at least that fact.
We know that the ingredients in Total Restore, like L-Glutamine and NAG can be effective treatments for bowel issues. That doesnt necessarily mean that it can help everyone.
Before trying supplements, doctors recommend across the board that you attempt to address the root cause of your bowel issues. Changing your diet or getting diagnosed with the underlying issue will always be the most effective way to treat leaky gut.
Of those who didnt have other options, many have reported that Total Restore alleviates symptoms like bloating, gassiness, and diarrhea. As a result, theyve seen marked improvements in their day-to-day lives.
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Problem #3 Neural Inflammation And Oxidation
Inflammatory responses contribute to the perpetuation of neurodegeneration in Parkinsonss disease. The brain contains immune cells called microglia, which are known to be activated in Parkinsons disease . Upon activation, microglia release inflammatory cytokines that can spread to nearby healthy neurons and cause degeneration. Dopaminergic neurons in the substantia nigra, the brain region most affected by Parkinsons disease, express receptors for an inflammatory cytokine called Tumor Necrosis Factor-alpha , which suggests that excess TNF-alpha released by nearby activated microglia may damage nigral dopaminergic cells.
Elevated cytokines in the brain of those with Parkinsons disease is a consequence of neurodegeneration . In experimental models, exposure to the neurotoxin MPTP leads to death of dopaminergic neurons. Interestingly, in monkeys, inflammation is increased even years after initial exposure to MPTP . This suggests that inflammation, once initiated, has long-term consequences in Parkinsons disease.
As dopaminergic cells succumb to either environmentally or genetically induced mitochondrial dysfunction, they release free radicals. These free radicals then activate nearby microglial cells, which in turn, excrete inflammatory cytokines that bind to and damage nearby dopaminergic neurons. This positive feedback loop may continue over years or even decades and slowly contribute to the loss of dopaminergic neurons that leads to Parkinson symptoms .
Stage Three Of Parkinsons Disease
Stage three is considered mid-stage and is characterized by loss of balance and slowness of movement.
Balance is compromised by the inability to make the rapid, automatic and involuntary adjustments necessary to prevent falling, and falls are common at this stage. All other symptoms of PD are also present at this stage, and generally diagnosis is not in doubt at stage three.
Often a physician will diagnose impairments in reflexes at this stage by standing behind the patient and gently pulling the shoulders to determine if the patient has trouble maintaining balance and falls backward . An important clarifying factor of stage three is that the patient is still fully independent in their daily living activities, such as dressing, hygiene, and eating.
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What Is Parkinsons Disease
Parkinsons disease is a neurological condition afflicting about one percent of men and women over the age of seventy years old.
Individuals with Parkinsons disease have tremor of the hands, rigidity, poor balance, and mild intellectual deterioration. The tremor is most apparent at rest and is less severe with movement. Shaking or tremors are an early symptom of Parkinsons disease. Progression leads to trembling in arms, legs, jaw, and rigidity or stiffness of the limbs.
Research has shown that Parkinsons disease occurs when a small region in the brain, called the substantia nigra, begins to deteriorate. The neurons of the substantia nigra use the brain chemical dopamine. Tremors begin to happen and movement slows when you have inhibited dopamine function.
Dopamine is broken down in the brain by an enzyme called monoamine oxidase . When the activity of MAO is inhibited, dopamine stays around longer, and this is beneficial to those with Parkinsons disease.