A New Study Found That Vitamin C And Vitamin E Could Successfully Reduce The Risk Of Parkinson’s Disease
The new researchpublished on Jan. 6, 2021 in the journal Neurologywas conducted with 41,058 adults, a mix of men and women ranging in age from 18 to 94 years old, who were studied for an average of 17.6 years. None of the participants were previously diagnosed with Parkinson’s disease. The participants were divided into three vitamin consumption groups for the study, those with the highest intake, those with moderate intake, and those with the lowest intake. Across the nearly 18-year timespan of the research, 465 peopleor 1.1 percent of participantswere diagnosed with Parkinson’s disease.
After looking at the results, the researchers concluded that vitamin C and vitamin E can reduce your risk of Parkinson’s disease. “Our large study found that vitamin C and vitamin E were each linked to a lower risk of Parkinson’s disease, and we found the association may be even stronger when intake of both vitamin C and E is high,” Essi Hantikainen, PhD, of one of the co-authors of the study, said in a statement.
Supplements For Reducing Parkinsons Risk
Many nutrients are associated with a lower risk of developing Parkinsons. But that does not mean they can prevent the disease. They have an association, not necessarily causation.
A Higher Consumption Of Vitamin E Also Reduced Patients’ Risk Of Parkinson’s By 32 Percent
The study’s results showed a higher intake of vitamin E and vitamin C yielded very similar results. “Researchers found a rate of 67 cases of Parkinson’s disease per 100,000 person-years in the group that consumed the highest amounts compared to a rate of 110 cases in the group that consumed the lowest amounts,” the study authors stated. “After adjusting for the same factors, people in the highest consumption group had a 32 percent lower risk of Parkinson’s disease than those in the lowest group.”
Meanwhile, a 2005 meta-analysis published in the journal Lancet Neurology also found that an increased amount of vitamin E reduces your risk of developing Parkinson’s by 19 percent.
Similar to vitamin C, vitamin E is also an antioxidant that’s used to boost your body’s immune system. The fat-soluble nutrient, which can be found in vegetable oils, nuts, and green vegetables, also protects your cells from free radical damage, according to NIH.
And to see if you’re lacking another common nutrient, here are 20 Symptoms of Vitamin D Deficiency, According to Medical Experts.
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Clinical Studies Regarding Vitamin D In Pd
Substantial epidemiological and clinical studies suggest that vitamin D has a positive effect on PD. In a cohort study, over 7000 Finnish’s serum samples were collected for measuring the 25-hydroxy vitamin D level, and meanwhile, the occurrence of PD was instigated over a 30-year follow-up period. The results showed that individuals with higher serum vitamin D concentrations had a lower risk of PD . Evatt et al. also noted consistent findings .
As mentioned above, vitamin D3 can be endogenously synthesized upon sunlight exposure in the skin. In a large case-control study of Danish men, involving 3819 PD patients and 19,282 controls, the scholars proposed that men working outdoors have a lower risk of PD . Another nationwide ecologic study in France also suggests that vitamin D levels are negatively correlated with the risk of PD, but this result needs taking ages into account . Wang et al. not only demonstrated a positive correlation between serum 25-hydroxy vitamin D and sunlight exposure but also noted that lower serum levels of 25-hydroxy vitamin D and sunlight exposure can increase the risk of PD .
Furthermore, PD patients with lower 25-hydroxy vitamin D levels may exhibit more severe symptoms compared with normal controls . Unsurprisingly, a randomized, double-blind, placebo-controlled trial found that vitamin D3 supplementation significantly prevented the deterioration of PD .
But Too Much Vitamin E Can Also Have Negative Side Effects
According to Hantikainen, more research is needed to truly know the exact amount of vitamins C and E that would best prevent Parkinson’s.ae0fcc31ae342fd3a1346ebb1f342fcb
But, she said in a statement, “the possibility of being able to reduce the risk of Parkinson’s disease simply with the foods we eat is encouraging news”emphasis on “foods we eat.” Hantikainen says people should exercise caution when it comes to taking supplements, particularly in the case of vitamin E. “While increasing the amounts of healthy foods in our diet is beneficial, it is important to note that excess intake of some vitamins may be harmful,” she said, adding that “too much vitamin E from supplements has been linked in other studies to a higher risk of certain cancers or stroke.”
Possible side effects from a higher dose of vitamin E include nausea, headache, blurred vision, fatigue, or intestinal cramps, the Mayo Clinic says. They note that vitamin E use can also increase the risk of prostate cancer, or worse, death in people with a “severe history of heart disease.” So, as always, it’s best to consult your doctor before you add any supplements to your routine.
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What The Researchers Found
Results, published in the journal Cell Metabolism, showed that nicotinamide riboside supplements boosted levels of a compound called NAD in the brain compared to the group who took the dummy medication.
The supplement also showed promising signs that it may improve metabolism and reduce inflammation in the brain, which could have protective effects in the brain. And the participants who showed the greatest increase in NAD levels also showed some mild improvements in their Parkinsons symptoms.
These early findings suggest that nicotinamide riboside may have beneficial properties for slowing down the progression of Parkinsons. The team are already taking these findings forward in a larger, phase 2, trial.
Dr Beckie Port, Head of Research Communications and Engagement at Parkinsons UK, comments:
This study builds on previous research that shows the important role vitamin B3 may play in keeping brain cells healthy and working properly.
While results are needed from larger, longer-term trials, it is exciting that the researchers may find that a relatively inexpensive dietary supplement could help manage some of the symptoms which impact the everyday lives of people with Parkinsons.
Interestingly, the team found that the supplement may not benefit everyone. But for some, there are promising signs that nicotinamide riboside may have protective effects that could help slow the progression of Parkinsons.
Supplement Intake Parkinsons Meds Ruled Out Eligibility
Patients were eligible for the study if they had not started treatment for Parkinsons and if they had not been taking a vitamin supplement of greater strength than a standard daily multivitamin , in the month before the start of the study. The study endpoint was disease progression to a degree indicating readiness for levodopa, standard Parkinsons therapy that over time becomes less effective.
After preliminary testing, patients were offered the option of taking a daily multivitamin. Close to 50 percent of participants were found to have higher B12 on subsequent testing, suggesting that many took the supplement or improved their diets. For those patients who remained in a lower B12 level suggesting they may not have started supplements their annualized average increase of disability was 14.4 on the Unified Parkinsons Disease Rating Scale , a test that assesses activities of daily life, motor skills, behavior and mood. In contrast, for the group whose B12 levels began low but improved during the study, their average increase in the UPDRS score was 10, showing less disability.
The study was supported by funding from the Michael J. Fox Foundation and from gifts from the Ko and Tsu family, and William and Mary Ann S. Margaretten.
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Possible Neuroprotective Mechanisms Of Vitamin B3 In Pd
Firstly, numerous studies have demonstrated that mitochondrial dysfunction and cellular energy failure are pathophysiological features of PD. Nicotinamide participates in the biosynthesis of nicotinamide adenine dinucleotide via various metabolic pathways . NADH is an essential cofactor assisting the tetrahydrobiopterin functioning in tyrosine hydroxylase, which can hydroxylate tyrosine and produce dopamine NADH deficiency is common in PD .
Secondly, NADH is indispensable for the physiological function of mitochondrial complex I in ATP synthesis, and the corresponding dysfunction is involved in PD patients and animal models . Nicotinamide mononucleotide constitutes one of the key precursors of NAD+. In previous in vitro studies, the scholars have established a cellular model of PD using rotenone-treated PC12 cells, and they found the NMN treatment was associated with a significantly higher survival rate in the rotenone-treated PC12 cells. NMN is assumed to enhance the intracellular levels of NAD+ and ATP in the cellular model of PD .
What The Researchers Did
The team in Norway have conducted the first small scale clinical trial of nicotinamide riboside for people with Parkinsons.
30 people took part in the study with 15 receiving 1000mg of nicotinamide riboside daily for 30 days. The other 15 people were given dummy pills known as a placebo. Importantly, neither the participants nor the researchers knew who was taking the supplement containing nicotinamide riboside.
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Parkinsons New Treatment :
Luckily, there are many natural alternative solutions which can help ease the symptoms of Parkinsons Disease. This is why we decided to look into the 3 best natural herbs and supplements which help treating Parkinsons Disease , listed from least to most effective.
Number 3:
Turmeric: The Super-Spice
Lately, this golden spice, widely used in curry and other oriental dishes, turned into a favorite amongst scientists and health enthusiasts. New health benefits of turmeric are discovered with every new research: its a natural remedy for infections, it contains antioxidants, it even seems to help with treating cancer! The component in turmeric which helps with all the above is curcumin, and as experts from Michigan State University recently found, it also helps with easing Parkinsons Disease. It does that by preventing proteins which lead to Parkinsons Disease from becoming aggressive.
How to Use Turmeric for PD:
If youd like to try using turmeric as a natural remedy for Parkinsons, just add some to your cooking.
Number 2:
/5healthy Diet Prevents Several Diseases
Vitamin C and Vitamin E are the two vital fat-soluble vitamins imperative for the body to function properly. Densely present in citrus fruits, veggies and whole grains, the two vitamins are known for their powerful antioxidant compound. Vitamin C helps in the absorption of iron, aids in healing wounds and keeps the eyes healthy, while Vitamin E plays a critical role in cell regeneration. Besides, both vitamins help to boost immunity and improve skin health. Now the scientists have found another reason to load up on these two vitamins: To reduce the risk of Parkinsons disease.
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Magnesium And Magnesium L
Magnesium is an essential dietary mineral and is the second most common electrolyte in the body. Magnesium deficiencies are common in the western diet, and magnesium deficiencies have been linked to a number of adverse health effects including weakness, cramps, anxiety, and high blood pressure.
Which Foods Are Rich In Vitamin E
Given the powerful effects Vit E has on brain and nerve health, one should include it in their regular diet.
Some common sources of vitamin E include almonds, spinach and sweet potato. The compound is also present in avocado and sunflower seeds.
Cooking using olive oil is another way of including Vit E in ones diet. Eating trout can provide the body with both proteins and Vit E.
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Foods Containing Nutrients That People May Be Deficient In
Some research suggests that people with Parkinsons often have certain nutrient deficiencies, including deficiencies in iron, vitamin B1, vitamin C, zinc, and vitamin D.
The above study points out that some of these deficiencies may be associated with neuroinflammation and neurodegeneration, which are key factors in Parkinsons.
Therefore, people with Parkinsons may wish to consume more of the following foods.
Foods containing iron
The following foods are good sources of iron:
- certain fortified foods
Vitamins For Parkinson’s Disease
Verywell / Michela Buttignol
Apart from traditional pharmaceutical treatments, if you have Parkinsons disease, your doctor may recommend vitamins with antioxidant properties. While it is best to get these from food sources as part of a healthy, balanced diet, some people need to take supplements. These vitamins include:
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With Parkinsons Disease How Can I Increase My Energy
The date is August 21,2015.
Vitamin E Prevents Neurodegeneration And Protects Dopaminergic Neurons In Preclinical Research
Parkinsons disease is a progressive neurodegenerative disorder. As the disease advances, neurons or brain cells in areas of the brain that are responsible for our movement are damaged or die.
Presence of higher levels of vitamin E can prevent such neurodegeneration.
Nor did the researchers observe any benefit of dietary Vit E or supplemental tocopherol in PD.
However recent studies have a different view.
Mucuna pruriens, a natural source of dopamine, is a proven effective natural aid for PD.
According to an animal study, Vitamin E is as effective as clinical drugs such as minocycline, and Sinemet in improving motor activity in PD. It helped improve motor function by regulating the activity of Parkinsons related genes and tyrosine hydrolase, an enzyme responsible for the synthesis of dopamine.
Estrogen, a female hormone, is said to offer protection against Parkinsons disease. Vitamin E interacts with estrogen receptors in our body to protect dopamine-producing brain cells in PD.
Gamma and delta tocotrienol bind to estrogen receptors to activate biochemical pathways that help boost antioxidant defences and protect brain cells.
This interaction with estrogen receptors helps prevent loss of dopaminergic neurons .
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Vitamin B12 Acetylcholine Homocysteine And The Transmethylation Cycle
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How Can Vitamins Help With Parkinson Disease
How Can Vitamins Help with Parkinson Disease?By: Dr. George Obikoya
Parkinson’s disease is a common neurodegenerative movement disorder that is associated with significant medical disability, reduction in quality of life, and, in advanced stages, caregiver burden. Approximately half a million to one million individuals in the United States have been diagnosed with PD, most falling within the age range of 55 to 60 years at time of diagnosis.
With the increase in the senior population of the United States, the prevalence of PD is expected to rise. In response to this anticipated increase in the prevalence of PD, the search for agents that may delay or arrest its pathologic progression has become a high priority among researchers.
Neuroprotection is defined as protecting neurons from cellular damage induced by various biochemical insults associated with the pathogenesis of PD. There is no known cure for Parkinson’s disease.
Parkinson’s disease is caused by deterioration of nerve cells in the basal ganglia, the part of the brain responsible for muscle movement. As less dopamine is produced, muscle function is lost. Symptoms of Parkinson’s include unstable balance, slow movement, difficulty walking, muscle stiffness or rigidity, difficulty initiating movement, muscle tremors, muscle ache, and speech changes.
Other supplements at earlier stages of investigation in the laboratory include nicotinamide, riboflavin, acetyl-l-carnitine and alpha lipoic acid.
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How Parkinsons Develops
In the following section, I will briefly explain how Parkinsons disease develops. The insight is meant to help you understand the prevailing thinking behind where, when, and why to intervene with supplements. However, if you prefer to skip this part, you can go to the section on Principles of Supplementation in Parkinsons Disease.
Neurons or nerve cells in a part of the brain, called substantia nigra produce a chemical called dopamine. It is a neurotransmitter that helps transmit messages between nerves that control body movements. It is also involved in the proper functioning of the brains reward and pleasure centres.
In normal people, with age, the nerve cells in the substantia nigra die, reducing the dopamine levels in the brain. So as we get older, our movements, behaviour, and emotions are affected for the worse. But this happens at a very, very slow rate in normal individuals. As a result, normal people almost never display Parkinsons symptoms.