Friday, August 5, 2022

Parkinson’s Sleep Disorder Treatment

Insomnia Complaints In Pd

Healthy Sleep & Sleep Disorders in Parkinson’s Disease

Studies examining insomnia prevalence in PD have found that as PD severity worsens, the frequency of insomnia complaints increases. For example, in a study using the PDSS in individuals with mild PD, Svensson and colleagues found that 25% of the cohort reported either sleep onset and/or maintenance insomnia. In moderate PD, Tandberg and colleagues found that individuals with PD had a higher prevalence of DMS , but not DIS , than non-PD sleepers. In the Parkinson’s and non-motor symptoms multicenter study, Barone and colleagues found that in patients with moderate PD, 36.9% reported insomnia symptoms using a single question on the Non-Motor Symptom questionnaire. Thus, among individuals with PD, DMS appears to be the most common complaint and prevalence increases with worsening PD severity.

Naturaltreatment For Parkinsons #9 Exercise And Other Alternative Therapies:

Regular exercise has been shown to help Parkinsonssufferers by reducing muscle stiffness, increasing mobility, and enhancing postureand balance. Exercise also increases oxygen levels and neurotransmitters, alongwith releasing potent mood elevating chemicals called endorphins.

The type of exercise performed for PD is crucial. Aqua orwater aerobics can be particularly useful as traditional exercise is usuallyquite difficult for many Parkinsons sufferers. Muscle decline, loss of strength,stiffness and loss of balance can make conventional exercises difficult toperform. The great thing about aqua aerobics is it still has the same benefits as other exercise regimens,but the risk of falling is eliminated.

Other types of exercises that can be beneficial for PDsufferers include Tai Chi, Yoga, dancing, walking, aerobic/jazzercise classes,and general stretching.

For more information on the different exercise programsavailable for Parkinsons patients, you can check out this website Exercise and Physical Therapy for ParkinsonsDisease

Classification Of Sleep Disorders In Parkinsons Disease

Sleep disorders in PD may occur during the day or at night. In PD, sleep disorders can be classified into three major categories such as abnormal behaviors and events during or around sleep , inability to sleep , and EDS . These three categories of sleep disorders can be seen separately or together .

Categories
NREM parasomnias
Inability to sleep/sleeping difficulty
  • Initial insomnia

  • Maintenance insomnia

  • Terminal insomnia

Recommended Reading: The American Parkinson Disease Association

Beating The Lockdown Blues

Did you knowBodily functions are heavily influenced by biological clocks which are distributed throughout your body . Your clocks primary role is timing and orchestrating your bodys everyday vital functions and aligning these to geophysical and social schedules. Disruptions to your daily routine derail your clock which reflects negatively on your mood, energy, sleep, digestion, heart and immune system, just to name a few!

With COVID-19-related lockdowns causing unanticipated disruptions to our routine, Researchers at the University of Queensland have developed some guidelines to stay on a schedule to improve sleep and support your health and wellbeing.

Deep Brain Stimulation In The Treatment Of Sleep Disorders In Pd

Parkinsons Disease &  Other Movement Disorders  Falcon ...

Studies investigating the effect of DBS in the treatment of sleep disorders in PD patients showed that DBS improved the sleep scales and quality . Baumann-Vogel et al. found that subthalamic nucleus DBS-enhanced subjective sleep quality, reduced sleepiness measured by the Epworth sleepiness scale, and reduced sleep fragmentation shown by actigraphy recordings. However, the authors observed that subthalamic DBS was not improved REM sleep features . Similarly, Cicolin et al. reported that RBD symptoms did not benefit from STN DBS. On the other hand, Chahine et al. reported that STN DBS improved significantly symptoms of RLS in PD patients. The effect of PPN DBS on sleep disorders in PD has been investigated in several studies . One study showed that PPN DBS improved sleep quality and reduced EDS however, it caused a reduction in REM latency and a relevant increase in REM sleep . In another study, it has been reported that PPN DBS improved the total duration and rate of REM sleep . As a result, DBS seems to be beneficial in the treatment of sleep disorders in PD because it seems to be useful in improving sleep quality. However, large-scale prospective studies are needed to understand the benefits of DBS in the treatment of sleep disorders in PD.

Recommended Reading: Is Dizziness A Symptom Of Parkinson’s

Parkinsons Disease And Sleep

Reviewed by David Rye, MD, and Mark Mahowald, MD. Published by the National Sleep Foundation

This web article offers a detailed description of Parkinsons disease and the challenges it presents to restorative rest and recuperation. Some suggestions are included for improving sleep and the environment around sleeping.

Sleep Disorders In Parkinson’s Disease By Amer G Aboukasm

Although the daytime clinical manifestation of Parkinson’s disease have been well recognized for almost two centuries, the nocturnal symptoms, which occur in as many as 75% of patients and the associated sleep disorders were not studied until the 1960s. A variety of psychological and physiological processes can lead to disruption of the normal rhythm of the sleep-wake cycle in patients with Parkinsonism. First, the degenerative process in Parkinson’s disease affects the neurophysiological and neurochemical systems responsible for sleep organization, thus results in disruption of sleep. Second, the motor, respiratory and behavioral phenomena accompanying the disease may produce nocturnal symptoms. Third, the medication used in its treatment may induce new symptoms, such as nightmares or nocturnal movements. All these effects on sleep have implications for treatment planning.

Also Check: Stem Cells For Parkinson’s Disease Therapy

Movement Disorder Society’s Evidence

As part of a comprehensive nonmotor symptom treatment review, the Movement Disorder Society examined the literature for the efficacy, safety, and practice implications of insomnia treatments in PD., The medications that were considered âpossibly usefulâ in clinical practice with acceptable risk safety profiles were rotigotine, eszopiclone, and low-dose melatonin 3 to 5 mg. The data for the use of carbidopaâlevodopa CR and high doses of melatonin to treat insomnia were judged insufficient in terms of efficacy and considered âinvestigationalâ for clinical use.

Nondopaminergic Medications For Insomnia In Pd

Sleep Disorders in Parkinson’s Disease: Dr. Andrew Berkowski

The following 3 sedativeâhypnotic treatments have been tested for insomnia in PD patients, with mixed results: eszopiclone, doxepin, and melatonin . Eszopiclone is Food and Drug Administrationâapproved for the treatment of DIS and DMS. In a single RCT including 30 PD patients, a dose of 2 to 3 mg significantly improved several sleep measures when compared with placebo. These included a reduction in nocturnal awakenings and improvement in sleep quality ratings. Eszopiclone side effects occurred in 13% of the treatment group and included daytime sleepiness and dizziness.

Doxepin is also Food and Drug Administrationâapproved for the treatment of DIS and DMS at doses of 3 and 6 mg. In a 3-arm parallel trial of 18 participants, doxepin 10 mg was compared to red light and the combination of cognitive behavioral therapy for insomnia and bright light therapy . Compared with the placebo condition, the doxepin group had significant improvements in ISI scores, SCOPA-S, and fatigue. Of the participants in the doxepin group, 50% reported side effects, including fatigue, orthostatic dizziness, and nausea.

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How Your Support Made This Research Project Possible

As an international student studying in Canada from Italy, receiving this award from Parkinson Canada was “very important,” says Cristini.

He hopes the award will also help his lab attract additional students.

He encourages donors to fund research like his which will provide study participants with feedback, alternatives, and guidance about how best to continue the improvements he believes exercise will bring to their lives after the study has ended.

Rem Sleep Behavioral Disorder

Rapid eye movement, or REM, sleep is a normal part of the sleep cycle when people dream. Usually the only part of the body that moves during REM is the eyes, thus the name.

  • People with rapid eye movement sleep behavior disorder do not have the normal relaxation of the muscles during their dreams. Therefore, they act out their dreams during REM sleep.
  • People with RBD may shout, kick their bed partner or grind their teeth. Sometimes, in moderate to severe RBD, people may have aggressive, violent behaviors, like getting out of bed and attacking their bed partner.
  • About half of people with PD suffer from RBD. It may develop after or along with the disease, but in most cases, it precedes the PD diagnosis by five to 10 years.

RBD Treatment

  • Consider making environmental adjustments to protect the person with RBD and bed partner from injury. This may include padding the floor, using bed rails or sleeping in separate rooms.
  • Clonazepam has been shown in large case series to improve RBD in 80 to 90 percent of cases. The dose of clonazepam required is low, usually from 0.5 mg to 1.0 mg. The adverse effects of clonazepam include nocturnal confusion, daytime sedation, and exacerbation of obstructive sleep apnea, if present. It is in generic form and not expensive.
  • Talk to your doctor about the over-the-counter sleep aid Melatonin. Doses up to 12 mg at night one hour before can improve RBD.

Recommended Reading: Can You Reverse Parkinson Disease

What Is Rem Sleep Behavior Disorder

It may seem like sleepwalking, but RBD is, by definition, not a sleepwalking disorder. RBD involves dream enactment behavior.

The difference between sleepwalking and RBD is subtle, but important: sleepwalking typically takes place in non-REM and transitional stages of sleep, whereas RBD takes place during REM sleep.

Naturalremedy For Parkinsons #10 Foods You Must Avoid

9 Tips for Getting Rest and Sleep With Parkinsons Disease ...

There are certain foods that are known to worsen thesymptoms of Parkinsons and certain foods that are known to help. Healthadvocate, Dr Joseph Mercola, says that Parkinsons disease is primarily relatedto poor lifestyle choices, particularly poor dietary habits. Increasing yourbodys natural dopamine levels is also extremely important in your fight againstPD.

The foods and liquids you should be eating and drinkingmore of to help you along include:

· Clean Filtered Water Clean filtered water helpsto flush toxins from the body and hydrate the cells .Try and aim to drink at least two liters of water every day, and under nocircumstances drink tap water! Tap water is laced with toxic fluoride and otherchemicals and heavy metals so NEVER drink it. Buy yourself a good quality waterfilter. Its worth the investment.

· Whole Foods and Raw Foods Eat plenty oforganic mixed berries, green leafy vegetables, liver , fish,eggs, nuts and seeds such as chia and flaxseeds, along with plenty of herbs andspices. When it comes to buying any of these remember fresh is alwaysbest.

· Consume Lots of Probiotics Good gutbacteria are needed for strong immunity and healthy digestive function, whichin turn produces healthy brain and nerve function. You can learn how to makeyour own probiotic rich foods such as kefir, sauerkraut, kombucha and yogurt hereCultures for Health.

The foods you should be avoiding or not eating at allinclude:

Read Also: When A Person Is Suffering With Parkinson’s Disease

Treatment Of Excessive Daytime Sleepiness In Pd

The first step in the treatment of EDS should be the correction of underlying conditions . For example, it may be useful to treat the conditions that disturb sleep quality at night or to arrange medications that cause daytime sleep episodes. After that, pharmacological treatment options for EDS should be considered. Nonpharmacological treatment approaches can be performed in the treatment of mild to moderate EDS cases . Modafinil is widely used for the symptomatic treatment of EDS, which appears to stimulate catecholamine production . Common side effects of modafinil are insomnia, headache, dry mouth, dizziness, nausea, nervousness, and depression . A review has reported that sodium oxybate and methylphenidate have inadequate evidence that they are effective in the treatment of EDS in PD . Amantadine and selegiline are reported to have an alerting effect . Thus, amantadine and selegiline may be preferentially used in PD patients with EDS.

Pathophysiology Of Excessive Daytime Sleepiness In Pd

It has been reported that there are three main causes of sleepiness in PD deterioration of night sleep quality, neurodegeneration of sleepwake-related brain regions, as a result of disease pathology, and the side effects of antiparkinsonian medications . However, many of the abovementioned causes may be related to EDS. For this reason, it is necessary to consider these causes in the diagnosis and treatment of EDS.

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The Relationship Between Parkinsons Disease And Sleep

Its unclear whether poor sleep causes parkinsonian symptoms to worsen or whether worsening parkinsonian symptoms cause poor sleep. In many cases its likely a case of bidirectionality, with each one exacerbating the other.

Fragmented sleep and sleep deprivation appear to leave the brain more vulnerable to oxidative stress, which has been tied to the development of Parkinsons disease. Parkinsons disease is not usually diagnosed until individuals have developed sufficient motor symptoms, by which time a significant portion of brain cells have already been damaged. If poor sleep quality or having sleep disorders foreshadows the development of parkinsonian symptoms, these could be useful in early diagnosis of the disease.

More research is needed to clarify the multifaceted relationship between Parkinsons disease and sleep. A better understanding of this connection may offer medical experts the unique opportunity to screen at-risk individuals and perhaps delay the onset of the disease.

Are You A Carer

REM Behavioral Sleep Disorder in Parkinson’s

Sleep and night-time problems are almost twice as common among carers of people with Parkinsons than in the general population.

If you are caring for someone with Parkinsons, these sleep disturbances may lead to an increased risk of depression and stress.

It may be difficult sometimes, but if youre a carer its important to have good sleeping habits. This will help improve your health, wellbeing and general quality of life.

Much of the advice on this page applies to you as a carer as well as the person you care for.

Also Check: Parkinson’s Disease Specialist In Florida

What Else Can I Do To Sleep Better With Parkinsons Disease

Practicing healthy sleep hygiene habits may also promote more restful sleep.

  • Get outside during the day. Bright light tells your body its time to be awake.
  • Keep your body moving during the day. Even if all you feel up to is a short walk or two, all physical activity offers benefits.
  • Try at-home remedies, such as massage or a warm bath. Relaxing your mind may help your body fall asleep.

Dont:

  • Take long naps during the day.
  • Use stimulants, such as caffeine, within six hours of bedtime.
  • Use your bedroom for activities other than sleeping. Go to another room to read, watch TV or work.

Diagnosis Of Insomnia In Pd

In the diagnosis of insomnia in PD, the clinical history including the stages of insomnia and its associated factors are essential. For example, the factors associated with initial insomnia should be learned from the clinical history because the identification of factors associated with insomnia is necessary for the treatment plan. Table 2 shows the factors associated with insomnia . For example, for the diagnosis of RLS, as a reason for the difficulty of falling into sleep, clinical assessment is sufficient. Thus, patients should be asked for the features in the definition mentioned below for the diagnosis of RLS . In contrast to idiopathic RLS, family history of RLS is less frequent in PD . Polysomnography and actigraphy can be used to detect the objective findings of the insomnia . It has been reported that insomnias PSG findings may be an increase in the number of brief EEG arousalsor arousal index, number of stage shifts to stage 1 or wake, wake time after sleep onset , and percentage of stage 1 sleep . The actigraphic findings of insomnia include the presence of irregularity in sleep onset and increased number of awakening times during the night . One review has been reported that studies comparing PSG to actigraphy in insomnia show that PSG and actigraphy have no significant difference in showing the measurements of WASO, total sleep time , and sleep efficacy .

Factors

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Natural Treatment For Parkinsons #1 Cannabis/medicalmarijuana:

Cannabis, aka medical marijuana, is an incredibletreatment for Parkinsons disease. You can have a Parkinsons patient shakingviolently and uncontrollably, and yet within 30-40 minutes of self-administering with some cannabis, their symptoms will almost completely disappear. Watch this short 2minute video from Parkinsons sufferer, Ian Frizell, who shows you what he waslike before self-medicating with cannabis and then again after. The change is truly astonishing!

Taylor French is another Parkinsons patient thatundergoes a remarkable transformation once he ingests what he calls nutritional vegetable extract . This guy has an advanced form ofParkinsons and is normally confined to a wheelchair with limited use of hisbody due to stiff and rigid muscles . But after ingestingsome cannabis hes able to walk, and incredibly, in his video he even getsinto his car and drives off down the road!

You can view it here

Elyse Del Francia also tells the story of her Parkinsonssuffering husband, and the time she decided to smother his morning pancakes withsome canabutter. She said

Within45 minutes of eating a pancake with marijuana on it, he stopped shaking. Thatwas my lightbulb moment. Thats when I knew that I was onto something thatwould relieve his pain and suffering, because its horrible, horrible, to haveParkinsons Disease and not have any relief. I feel that this is something thathelps so many people in so many ways with pain and suffering. 5

Sleep Matters: A Review Of Sleep Issues In Parkinson’s

Parkinson

Sleep disorders are present in 66-99% of people with Parkinson’s disease . In this 1-hour webinar Okeanis Vaou, MD, describes common sleep disorders in PD and how to treat them. Disorders described include REM sleep behavior disorder, daytime sleepiness, insomnia, nocturnal motor fluctuations, and restless leg syndrome. Dr. Vaou ends the webinar with tips on how to maintain good sleep hygiene.

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