Tuesday, October 4, 2022

Mortality Rate Of Parkinson’s Disease

The Death Rate From Parkinsons Disease Has Risen By 63% In The United States According To A New Study

Living with Parkinsons disease

Researchers looked at a national death registry of 479,059 people who died of Parkinsons between 1999-2019 and found that the death rate from the disease had risen by about 63% in the United States.

The results also showed that the death rate was twice as high in men and in white people.

We know that people are living longer and the general population is getting older, but that doesnt fully explain the increase we saw in the death rate in people with Parkinsons, study author Wei Bao, MD, PhD, who conducted the research at the University of Iowa in Iowa City. Understanding why more people are dying from this disease is critical if we are going to reverse the trend.

Mortality Of People With Parkinsons Disease In A Large Population

O. Okunoye, L. Horsfall, L. Marston, K. Walters, A. Schrag

Category:Epidemiology

Objective: To explore how PD mortality rates have changed over time and their relationship to disease progression, age, gender and social deprivation using a large UK-based cohort from The Health Improvement Network .

Background: Parkinsons disease is associated with increased mortality, but little is known on changes over time, and its relationship to disease progression and other sociodemographic variables.

Method: Individuals aged 50 years and over with a first recording of PD diagnosis code and at least two prescriptions of any antiparkinsonian drug actively registered within a general practice from 2006 to 2016 up to six randomly selected controls without PD, frequency-matched on age, gender, year and general practice. We estimated adjusted mortality rates using multivariable Poisson regression. We also explored the impact of disease duration and sociodemographic variables on PD mortality.

Whilst mortality in PD is only slightly increased overall, it gradually increases with advancing disease. There has been a slight decline in mortality in PD over the studied time period, but this decrease was less pronounced than that in the general population. These data highlight the impact of advancing disease on mortality, and emphasises the need for the development of treatments to slow the progression of PD.

To cite this abstract in AMA style:

Mov Disord.

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Its important to continue to evaluate long-term trends in Parkinsons death rates, Bao said, as these studies can help pinpoint why more people are dying of the disease and be used for priority setting and financing of health care and policy.

The study, Trends in Mortality From Parkinson Disease in the United States, 19992019, was published in the journal Neurology.

Parkinsons disease affects nearly 1 million Americans and more than 6 million people around the world.

According to the World Health Organization, Alzheimers disease and other dementias such as those related to Parkinsons were the second-most common cause of death in high-income countries in 2019, a sharp raise since 2000.

However, the death rate from Parkinsons itself and its long-term trends in the U.S. remain unknown.

To address this, Bao and his team, along with colleagues in China, analyzed 19992019 data from the National Vital Statistics System, a nationwide, population-based death registry.

The data showed that during that 20-year period, Parkinsons disease was reported as the cause of death of 479,059 people.

After adjusting for age , the researchers found that the death rate from Parkinsons increased from 5.4 deaths per 100,000 people in 1999 to 8.8 deaths per 100,000 people in 2019 reflecting a 2.4% annual raise and a total increase of 63%.

A notably higher mortality rate was also seen among white people compared with Hispanics and non-Hispanic Black people .

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Caring For Your Health With Parkinson’s Disease

In addition to caring for your Parkinson’s health, it is also important to care for your overall health. This means visiting your primary care physician periodically for preventive care like the annual flu shot and cancer screeningsfor example, a mammogram for breast cancer screening and a colonoscopy for colon cancer screening.

A primary care physician can also evaluate for risk factors related to heart attacks and strokes, and provide counseling on exercise, smoking, alcohol use, depression, or other mental health concerns. Regular visits to your primary care physician or neurologist will also allow them to catch bacterial infections like urinary tract infections before they get serious.

Incidence And Prevalence Of Pd In The Norwegian Population Between 2005 And 2016

Do you die from Parkinsons?

The crude incidence for PD between 2005 and 2016 was on average 23.1 for females and 29.6 for males, per 100,000 person-years. The prevalence for PD in the population was on average 0.2% of the females and 0.23% of the males in the general population, and 0.98% of the females and 1.35% of the males for the population > 65 years. For both sexes, the age-specific incidence and prevalence increased with age, peaking at the 7585 age group . However, while the male/female PD prevalence ratio remained ~1.5 across all age groups , the male/female incidence ratio changed with age, increasing by 1.2% for every year of life . Substantial variation in both incidence and prevalence was observed over the 20052016 observation period, for which the measures were calculated . There was no general time-trend in the incidence of PD during the observation period, though a significant decrease was observed among the 3059 age group . In contrast, PD prevalence significantly increased during the observation period in all age groups, with the exception of the 3059 group, for which only a trend for increased prevalence was observed . Interestingly, the yearly rise in PD prevalence increased with age, with the biggest differences observed for older populations .

Table 1 Age- and sex-adjusted PD incidence, prevalence, and mortality.

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Death Rate From Parkinson’s Rising In Us Study Finds

Date:
American Academy of Neurology
Summary:
A new study shows that in the last two decades the death rate from Parkinson’s disease has risen about 63 percent in the United States. The study also found that the death rate was twice as high in men as in women, and there was a higher death rate in white people than other racial/ethnic groups.

A new study shows that in the last two decades the death rate from Parkinson’s disease has risen about 63% in the United States. The research is published in the October 27, 2021, online issue of Neurology┬«, the medical journal of the American Academy of Neurology. The study also foundthat the death rate was twice as high in men as in women, and there was a higher death rate in white people than other racial/ethnic groups.

We know that people are living longer and the general population is getting older, but that doesn’t fully explain the increase we saw in the death rate in people with Parkinson’s,” study author Wei Bao, MD, PhD, who conducted the research at the University of Iowa in Iowa City. “Understanding why more people are dying from this disease is critical if we are going to reverse the trend.”

The study looked at a national death registry that included 479,059 people who died of Parkinson’s between 1999 and 2019.

After adjusting for age, researchers found that the number of people who died from the disease increased from 5.4 per 100,000 people in 1999 to 8.8 per 100,000 people in 2019. The average annual increase was 2.4%.

What Is Parkinsons Disease

Parkinsons disease is a progressive brain disorder that affects mobility and mental ability. If you or a loved one has been diagnosed with Parkinsons, you may be wondering about life expectancy.

According to some research, on average, people with Parkinsons can expect to live almost as long as those who dont have the condition.

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Death In Parkinsons Disease

This article was written at the request of a Parkinsons patient who wanted to know how patients die from PD.

Most patients die with Parkinsons Disease and not from it. The illnesses that kill most people are the same as those that kill people with PD. These are heart conditions, stroke and cancer. As we age we become increasingly aware that more than one bad thing can happen to our bodies.

How Did They Do This

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Dr. Backstrom works at Umea University, in Sweden. He and his colleagues work in an area in northern Sweden where approximately 142,000 people live. Umea University is the main medical center in this region, and most of the people who live there are referred to Umea University. In order to better understand the connection between PD and early death, Dr. Backstrom enrolled only people who had early PD and who were not yet taking medication for this. People were enrolled between January 1, 2004, and April 30, 2009, and were followed until August 31, 2017. Dr. Backstrom identified 182 people with symptoms of early PD.

In the study, many tests were done . All of the participants had neurologic examinations, filled out questionnaires, and had neuropsychological testing. Not everybody had the other tests . The first test was a detailed neurologic examination in order to confirm and firmly establish the diagnosis of PD. This is essential because there are several illnesses that are very similar to PD, and Dr. Backstrom wanted to be sure that the diagnosis was as precise as possible. Of the 182 patients, Dr. Backstrom found that 143 had classic PD, 13 had a similar disease called multiple system atrophy , and 18 had progressive supranuclear palsy . The other 8 had an unclear diagnosis or simply did not have PD.

Tests performed

The study was designed to look at the association of mortality with PD. During the study, 109 people died. For 98 of these , a cause of death was known.

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Baseline Characteristics Of Patients

In total, 25,620 patients were enrolled in the study: 2,562 in the PD cohort and 23,058 in the comparison cohort. Demographic and medical characteristics of both cohorts are presented in Supplementary Table 1. No significant differences in age, sex, year of diagnosis, residential area, or income level were noted between the two cohorts. As these variables were used for sample matching, this finding indicates that the matching was performed appropriately. Patients with PD had a higher prevalence of comorbidities such as stroke , hip fractures and vertebral fractures than the comparison cohort. However, hypertension, dyslipidemia and COPD were not as prevalent in the PD cohort as compared to the comparison cohort. The mean follow-up period for the patients in the PD and non-PD cohorts was 3.66 ┬▒ 2.75 and 4.06 ┬▒ 2.90 years, respectively. Patients with PD had a higher all-cause mortality rate than those in the comparison cohort.

Mortality Risk After Pd

During the 10-year follow-up period, the all-cause mortality rate was 29.66% in the PD cohort and 15.70% in the comparison cohort . displays the adjusted HR for mortality during the follow-up period using univariate and multivariate Cox proportional hazard regression models. Increased mortality risk was observed in the PD cohort compared with the comparison cohort in all models. After adjusting for comorbidities, the Cox proportional regression model showed an aHR of 2.479 for mortality in the PD cohort. According to sex, the aHR for mortality was 2.809 in male patients and 2.275 in female patients. The log-rank test revealed a significantly higher mortality rate in the PD cohort .

Table 1

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Inclusion And Exclusion Criteria

We excluded all people with a history of PD and those with restless leg syndrome without PD who were treated with dopamine agonists. In addition, individuals with diagnosis in the first 6months after registration with a practice were excluded because they could represent a recording of medical information which may be retrospective rather than a true new recording of PD. For the analysis on time trends and disease duration, we started the study period 1year from the index date only for those entering before and during 2007 to avoid follow-up time being too short for deaths to occur .

The PD Cohort consisted of all adults aged 50+years with first ever diagnosis Read code for PD and at least two prescriptions of any of five major classes of antiparkinsonian medications , in which there is an overlap with THIN in about 60% of patients. This same case definition has been used in a previous study. Read code lists to identify electronic recording of PD diagnosis and drug code lists to identify the five major classes of antiparkinsonian medications were created using published guidelines.

The General Population comprised a frequency-matched random sample of up to six people with no record of PD. The non-PD cohort was frequency-matched within each practice on age, gender, and calendar year using a randomly assigned index date.

Causes Of Parkinson’s Disease And Risk Factors

QuickStats: Age

Parkinsons disease is caused by low dopamine activity in certain areas of the brain. Its associated with degeneration of the substantia nigra, a small area of the brain that produces dopamine, a neurotransmitter that mediates motor movements and other body functions.

The underlying cause or trigger for these changes is not known, although some people have a family history of the condition.

Many potential risk factors have been examined as possible triggers, including exposure to chemicals, but no environmental or lifestyle factors have been confirmed as causing Parkinsons disease.

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At a five-year follow-up, the mortality ratio the ratio between the number of PDD/DLB patients deaths over the number of deaths in the general population was 3.02, and at 10 years, it was 3.44, indicating that PDD and DLB patients have mortality rates more than three times higher than the general population.

Researchers also found that survival was worse if the patients were diagnosed at a younger age, were female, and showed lower scores on the cognitive test.

A more detailed analysis revealed higher mortality in DLB patients who were positive for the APOE test, but not in PDD patients who tested positive in APOE.

This retrospective study demonstrated a higher mortality rate in patients with PDD and DLB compared with the general population 10 years after the diagnosis of the disease.

Also, younger patients, females, and those who tested positive for APOE are linked to excess mortality.

In conclusion, mortality in patients diagnosed with Lewy bodies and Parkinsons disease dementia is over three times higher in patients during a ten-year follow-up, compared to persons in the general population unaffected by the disease, the researchers wrote.

Excess mortality is found primarily in younger patients, females and carriers of APOE. Further research is required regarding survival and possible interventions, including disease-modifying treatments, to improve care and prognosis for these patients, they added.

Parkinson’s Disease By Age And Gender

Parkinsons disease generally affects people who are over 60 years old. Early-onset Parkinsons disease is defined as beginning before age 50. The prevalence of Parkinsons disease increases with increasing age, and it is estimated to affect 1 in 40 people who are 85 to 89 years old.

People who begin to have symptoms at an older age generally have more severe symptoms and also have more comorbid conditions , such as heart disease, lung disease, or diabetes.

Parkinsons disease is more common among males than females, affecting approximately twice as many males.

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Factors Associated With Mortality In Pd

shows the OR for mortality in the PD cohort based on multivariate logistic regression analyses. After adjusting for other variables, comorbidities such as ischaemic stroke , haemorrhagic stroke and COPD were significantly associated with mortality in the PD cohort . However, dyslipidemia was negatively correlated with mortality . With regard to sex, COPD significantly increased the mortality rate only in male patients and haemorrhagic stroke significantly increased the mortality rate in female patients only.

Table 3

ORs for all-cause mortality according to age group are presented in Supplementary Table 2. In all age groups, ischaemic stroke was significantly associated with increased mortality, whereas dyslipidemia was significantly associated with decreased mortality . Haemorrhagic stroke , COPD and hip fractures were associated with increased mortality only in groups aged 60-79 years. In the group aged under 59 years, vertebral fractures showed an increased OR for mortality.

How Common Is Parkinson’s Disease

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The incidence of Parkinsons disease has been increasing in most countries around the world. This is likely due to an increase in life expectancy in the general population, as the condition is seen more often with older age. In the United States, Parkinsons disease affects almost six per 1,000 people age 45 and over.

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Death Rate From Parkinsons Disease Rising In The Us

Over the last two decades, the death rate from Parkinson’s disease has risen about 63% in the US, according to research published in Neurology, the medical journal of the American Academy of Neurology. The study also reported that the death rate was twice as high in men as in women, and there was a higher death rate in white people than other racial/ethnic groups.

“We know that people are living longer and the general population is getting older, but that doesn’t fully explain the increase we saw in the death rate in people with Parkinson’s,” study author Wei Bao, MD, PhD, who conducted the research at the University of Iowa in Iowa City. “Understanding why more people are dying from this disease is critical if we are going to reverse the trend.”

The study looked at a national death registry that included 479,059 people who died of Parkinson’s between 1999 and 2019.

After adjusting for age, researchers found that the number of people who died from the disease increased from 5.4 per 100,000 people in 1999 to 8.8 per 100,000 people in 2019. The average annual increase was 2.4%.

It’s important to continue to evaluate long-term trends in Parkinson’s death rates, said Dr. Bao. This can inform future research that may help pinpoint why more people are dying of the disease. Also, updating vital statistics about Parkinson’s death rates may be used for priority setting and financing of health care and policy.”

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