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The Inhibition Of Abnormal Protein Aggregation
Currently, impaired degradation of misfolded and aggregated proteins has been proposed to play a key role in the pathogenesis of PD . The abnormal deposition of protein in brain tissue is characteristic of several age-related neurodegenerative diseases, such as PD. Although, the composition and position of protein aggregates are different from disease to disease, this common characteristic shows that protein deposition per se, or some related event, is toxic to neurons .
In a study, rotenone was used to stimulate PC12 cells to develop a cell model of PD with over expression of -syn. After treatment with bilobalide, the oligomer of -syn were effectively restrained, cell activity was intensified and apoptosis was decreased accordingly. Before that, some scholars found that the bilobalide could regulate the metabolism of the amyloid precursor protein , increase the proportion of soluble APP alpha, reduce the formation of -amyloid protein . The similar experimental results were presented that bilobalide could inhibit the formation of abnormal aggregation of different protein by some common mechanism and alleviate the toxic effects of abnormal proteins on cells. Therefore, it acts as a neuroprotective role in this kind of protein folding diseases .
The Inhibition Of Oxidative Stress
The etiology and pathogenesis of PD so far have not been completely elucidated, but it has been generally acknowledged that the improvement of oxidative stress is one of the most important pathophysiological mechanisms .
Oxidative stress is incurred by the increase of free radicals in the organism, while the eliminative ability of free radicals decreased at the same time. There will be excessive free radicals in the body, which will be damaging cell components eventually . PD patients are in a state of oxidative stress. In the substantia nigra of PD patients, the elevated concentration of ferric ion, weaken mitochondrial function and anomaly protection system of antioxidant and free radical scavenging enzyme SOD, GSH-Px) have contributed to the acceleration of oxidative stress and excessive generation of oxygen free radicals. Thereby, large amount of lipid peroxide, such as Malondialdehyde , hydroxyl, carbonyl, etc., will cause cell death, which leads to neuronal apoptosis ultimately .
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Introduction To Parkinsons Disease
PD is a neurodegenerative disease, most commonly seen among middle-aged and elderly people. There is neither any known treatment capable of halting the progression of PD, nor is there any known cure, treatment focuses primarily on decelerating disease progression and improving quality of life. Western medical treatment chiefly consists of oral medication and deep brain stimulation surgery, while TCM treatment consists mainly of herbal decoctions and acupuncture .
Clinically, the cardinal motor symptoms of PD are: resting tremor, bradykinesia, and rigidity. Common non-motor symptoms include abnormal sense of smell, constipation, rapid eye movement sleep behavior disorder , pain, fatigue, salivation, and so on .
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In pathological conditions, glutamate can produce the effects of excitotoxicity on nerve cells. The relationship between neurotoxicity of Glu and pathogenesis of PD has received elevating attention. At present, the treatment of PD with Glu release inhibitor has become one of the hottest spots in the research.
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Chinese Medicine Treatment Of Parkinson’s Disease
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Traditional Chinese medicine has a long history in the treatment of Parkinson’s disease. Traditional Chinese medicine classifies Parkinson’s disease as “shaking syndrome”, which is a disease syndrome characterized by shaking of the head or limbs and inability to control oneself as the main clinical manifestation. In mild cases, the head shakes or the hands and feet tremble slightly. In severe cases, the head shakes, the limbs vibrate continuously, and even the limbs are anxious and the ability to take care of themselves is lost. There is already a record of “Shaking Syndrome” in the classic work of traditional Chinese medicine “Huangdi Neijing”. Until now, the treatment of Parkinson’s disease with traditional Chinese medicine is still relatively common in Asian countries, but the experimental research on traditional Chinese medicine started relatively late. With the increase in research on active ingredients, traditional Chinese medicine has also received more and more attention. In addition, the therapeutic effects of traditional Chinese medicine acupuncture and taijiquan have been recognized internationally.
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The current accessible treatment approaches for neurological disorders target only a small portion of the individuals, hardly improve disease symptoms and fail to stop advancement. US Food and Drug Administration -approved drugs against PD, such as Rivastigmine and Donepezil, decrease the PD symptoms and slow down the advancement, but unsafe for long-term use. Treatment of L-DOPA improved the motor symptoms of PD in most patients but often caused motor complications, recognized as
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How To Treat Parkinsons Disease With Acupuncture And Tcm
Hand tremor or shaky hands, stiffness in limbs, trouble walking, or problems with balance? These may be signs of Parkinsons Disease . Parkinsons is a progressive neurological disorder that primarily affects the brain cells that produce dopamine. Integrative care with acupuncture treatment may help relieve symptoms of Parkinsons disease better than conventional treatments alone.
Parkinsons disease is a neurological disorder that causes damage and dysfunction in brain cells, so that communications between the brain and the body dont work the way they usually do. Sometimes a range of symptoms similar to those experienced by people with Parkinsons occurs due to small strokes that affect the blood supply to the brain. This condition is called vascular parkinsonism.
More than ten million people are currently living with Parkinsons disease worldwide. The chances of having PD increase with age, and men are more likely to have Parkinsons than women. Early onset Parkinsons can occur in people under 50. While it is often considered a movement disorder that causes hand tremors and other problems with mobility, Parkinsons disease can cause less obvious symptoms, too.
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A Buffer Against Anxiety
Reached for comment, Shaheen Lakhan, MD, a neurologist and researcher from Boston, Massachusetts, who was not involved in the study, said the finding that after 8 weeks that sham and real acupuncture produced an anti-anxiety effect in a 100% Chinese population with tremendous cultural expectation bias does not surprise him.
I cannot say the same with the follow-up period a full 8 weeks after treatment stopped anxiety was re-measured and there was a clear, significant clinical improvement between the real acupuncture and the sham groups, Lakhan told Medscape Medical News.
The sham groups anxiety returned to baseline levels before any intervention, while the real acupuncture group not only had sustained anti-anxiety response, but made even more gains after stopping treatment, he noted.
Lakhan said it is important to note that anxiety is fundamentally a disorder of cognition and autonomic function with a bidirectional relationship.
Patients with anxiety have cognitive inflexibility and autonomic dysregulation , and disturbance of either make the other worse.
In certain neurodegenerative disorders like PD, the autonomic nervous system is particularly and progressively impaired causing failures to adapt. Acupuncture, I postulate, actually trains that flight-and-fight nervous system so it can buffer against anxiety, Lakhan said.
JAMA Netw Open. Published online Sept. 21, 2022. Full text.
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Open Access License: This is an Open Access article licensed under the terms of the Creative Commons Attribution-NonCommercial 3.0 Unported license , applicable to the online version of the article only. Distribution permitted for non-commercial purposes only. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor. The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
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Pd Patients In The Middle And Severe Stages
Symptoms will become more complex for patients in the middle and severe stages, due to the development of the disease, the side effects of medication, and motor complications such as motor fluctuation and dyskinesia. The scope of treatment in these stages is to improve the movement disorders, motor complications, and non-motor symptoms.
Motor fluctuations such as end-of-dose deterioration, on-off phenomenon, and dyskinesia are common motor complications in the severe stages of PD. Changing the kind of medication as well as modifying the dose and dosing time may help to improve the complex symptoms. Insect TCM drugs such as stiff silkworm , earthworm , scorpio , and centipede , as well as tonifying Gan’ and Shen’ TCM herbs are helpful in modifying the doses and dosing times of Western medicine administered to these patients. TCM doctors not only use oral TCM decoction or patent medicine, but they also individually use TCM as external application to improve complex complications. Sometimes, DBS, Tai chi chuan, and acupuncture can be used as additional non-drug treatments.
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