Animal Models Of Parkinsons Disease
As noted in a recent review and evident upon inspection of the biomedical research enterprise, there are three commonly used animal groups for modeling human disease: Rodents, non-human primates and non-mammalian species . Each of these groups has distinct advantages and disadvantages as outlined below and as reviewed by Konnova and Swanberg .
Rodents, especially mice and rats, have been studied across biomedical fields and are convenient to care for, relatively inexpensive compared to non-human primates, well-characterized genetically and easily genetically modified. The majority of > 23,000 studies in animals over the last three decades or more have involved rodents in contrast, only approximately 10% of studies included non-human primates and 5% include non-mammalian species . These studies often model the genetics of PD by humanization of key loci and subsequent chemical or surgical lesion of distinct brain regions as in a recent study of the impact of -synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized -synuclein rat model of PD .
Effects Of An Aquatic Physical Exercise Program On Ventilatory Parameters In People With Parkinsons Disease
Problems in the respiratory system are the main cause of death in Parkinsons disease . Ventilatory limitations can also be part of a vicious cycle involving physical-functional limitations and the patients perception of fatigue. The objective of this study was to analyze the effects of an aquatic physical exercise intervention program on ventilatory parameters, perception of fatigue, and gait capacity in participants with PD. This quasi-experimental study had a single group with repeated measures in four assessments, proposing an aquatic physical exercise intervention program. The inclusion criteria encompassed being in levels 1 to 4 on the Hoehn and Yahr scale and having a medical certificate for the activities. Assessments took place at 3-month intervals between themthe first period was the control, the second following the intervention, and the third period was the follow-up. The intervention had 25 biweekly sessions over 3 months. A total of 13 people participated in the intervention, without significant differences in the control period. Between the intervention assessments, they had statistically significant differences in MIP, MEP, FVC, Tiffeneau index, MVV, and fatigue. The study demonstrated that the aquatic physical exercise intervention was effective for ventilatory outcomes and fatigue in people with PD.
Is Npj Parkinson’s Disease’s Impact Factor High Enough That I Should Try Publishing My Article There
To be honest, the answer is no. The impact factor is one of the many elements that determine the quality of a journal. Few of these factors include review board, rejection rates, frequency of inclusion in indexes, and Eigenfactor. You need to assess all these factors before you make your final call.
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What Is Sherpa Romeo Archiving Policy For Npj Parkinson’s Disease
We extracted this data from Sherpa Romeo to help researchers understand the access level of this journal in accordance with the Sherpa Romeo Archiving Policy for npj Parkinson’s Disease. The table below indicates the level of access a journal has as per Sherpa Romeo’s archiving policy.
| RoMEO Colour |
Npj Parkinson’s Disease Issn
The International Standard Serial Number of npj Parkinson’s Disease is/are as follows: 23738057.
The ISSN is a unique 8-digit identifier for a specific publication like Magazine or Journal. The ISSN is used in the postal system and in the publishing world to identify the articles that are published in journals, magazines, newsletters, etc. This is the number assigned to your article by the publisher, and it is the one you will use to reference your article within the library catalogues.
ISSN code can be expressed as follows: NNNN-NNNCHere, N is in the set , a digit character, and C is in
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Transcription Factors And Induced Neuron Replacement Strategies
Whether genetic factors have been identified or note, the main pathological hallmark of PD is the selective degeneration of midbrain dopamine neurons in the substantia nigra . Many studies have consequently focused on how these neurons are formed and how to increase their lifespan. Studies using mouse genetic and in vitro models have demonstrated that the development and maintenance of mDA neurons are delicately regulated by genetic and signaling networks, including several transcription factors . During the development of mouse mDA neurons, unique sets of TFs are activated, including Engrailed-1/Engrailed-2, Foxa1/2, Lmx1a/b, Nurr1, Otx2, and Pitx3 . Recent single-cell RNA-seq analysis on developing human brains has confirmed their induction in human mDA neurons as well . Functional interactions between pairs of these TFs have been identified to ensure proper development of mDA neurons. Specification of mDA neurons progenitors depends on the interaction of signal molecules , growth factors , and a series of key TFs including En1/2, Otx2, Lmx1a/b, and Foxa1/2 . The subsequent differentiation and maturation of mDA neurons requires the expression of Nurr1 and Pitx3, which control the expression of several marker genes for mature mDA neurons, such as TH , DAT and VMAT2 , AADC , DRD2 , or ALDH1A1 .
Npj Parkinson’s Disease Impact Score 2021
The impact score 2021 of npj Parkinson’s Disease is 9.01, which is computed in 2022 as per its definition.npj Parkinson’s Disease IS is increased by a factor of 1.09 and approximate percentage change is 13.76% when compared to preceding year 2020, whichshows a rising trend.The impact score , also denoted as Journal impact score , of an academic journal is a measure of the yearly average number of citations to recent articles published in that journal. It is based on Scopus data.
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Iii Other Science Influence Indicators
Any impact factor or scientometric indicator alone will not give you the full picture of a science journal. There are also other factors such as H-Index, Self-Citation Ratio, SJR, SNIP, etc. Researchers may also consider the practical aspect of a journal such as publication fees, acceptance rate, review speed.
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Npj Parkinson’s Disease Rank And Scimago Journal Rank
The overall rank of npj Parkinson’s Disease is 1025.According to SCImago Journal Rank , this journal is ranked 2.25. SCImago Journal Rank is an indicator, which measures the scientific influence of journals. It considers the number of citations received by a journal and the importance of the journals from where these citations come.
Npj Parkinson’s Disease H
npj Parkinson’s Disease has an h-index of 31. It means 31 articles of this journal have more than 31 number of citations.The h-index is a way of measuring the productivity and citation impact of the publications. The h-index is defined as the maximum value of h such that the given journal/author has published h papers that have each been cited at least h number of times.
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About Npj Parkinson’s Disease
npj Parkinson’s Disease is a journal covering the technologies/fields/categories related to Cellular and Molecular Neuroscience Neurology Neurology . It is published by Springer Nature. The overall rank of npj Parkinson’s Disease is 1025.According to SCImago Journal Rank , this journal is ranked 2.25. SCImago Journal Rank is an indicator, which measures the scientific influence of journals. It considers the number of citations received by a journal and the importance of the journals from where these citations come. SJR acts as an alternative to the Journal Impact Factor . This journal has an h-index of 31. The best quartile for this journal is Q1.
The ISSN of npj Parkinson’s Disease journal is 23738057.An International Standard Serial Number is a unique code of 8 digits. It is used for the recognition of journals, newspapers, periodicals, and magazines in all kind of forms, be it print-media or electronic. npj Parkinson’s Disease is cited by a total of 1034 articles during the last 3 years .
Direct Conversion Of Fibroblasts To Induced Neurons
Studies outlined above underline the role of TFs in development and also suggest the potential for use in cell replacement therapy for PD. Indeed, mDA-related TFs not only coordinate the development and survival of mDA neurons in vivo but are also able to guide in vitro cell fate conversion of various cell types into mDA neurons . Mouse and human fibroblasts can be efficiently directed to generate induced DA neurons by the combined action of the Ascl1, Nurr1, and Lmx1a TFs . Forced expression of Lmx1a or various combinations of TFs is also able to induce differentiation of human pluripotent stem cells into mDA neurons in vitro . In addition, several findings indicate that NURR1 alone or in combination with other TFs, such as FOXA2, NGN2, ASCL2, and PITX3, induces iDA neurons from hPSCs or human astrocytes or fibroblasts . More recently, several groups have reported direct cell fate conversion in vivo triggered by TFs with the overexpression of Ascl1, Lmx1a, Neurod1, and miRNA-218 in mouse brain directly converting astrocytes to mDA neurons that when transplanted, result in marked improvement in spontaneous motor behavior deficits in 6-OHDA-induced PD model mice .
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Article Of The Year 2021
Staging Parkinsons Disease Combining Motor and Nonmotor Symptoms Correlates with Disability and Quality of Life
Journal profile
Parkinsons Disease publishes research related to the epidemiology, etiology, pathogenesis, genetics, cellular, molecular and neurophysiology, as well as the diagnosis and treatment of Parkinsons disease.
Editor spotlight
Chief Editor Dr Cristine Alves da Costa is based at Centre National de la Research Scientifique, France. Her research is focuses on Parkinsons molecular and cell biology.
Special Issues
Npj Parkinson’s Disease Ranking And Scimago Journal Rank
The npj Parkinson’s Disease is ranked 1025 among 27339 Journals, Conferences, and Book Series.As per SJR, this journal is ranked 2.25.
SCImago Journal Rank is an indicator, which measures the scientific influence of journals. It considers the number of citations received by a journal and the importance of the journals from where these citations come.
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Aims & Scope Of The Journal
npj Parkinson’s Disease publishes scholarly documents studying novel essential contributions in the fields of Biological Sciences, Clinical Neurology and General Neuroscience. npj Parkinson’s Disease publishes original scholarly articles which undergo peer review by experts in the field. The journal welcomes submissions from the research community where the priority will be on the originality and the practical impact of the reported work.npj Parkinson’s Disease is covered by various abstracting/indexing services including Scopus, Journal Citation Reports and Research.com. Many prominent scholars considered this journal to publish their scholarly documents including K. Ray Chaudhuri, K. Ray Chaudhuri, Daniel Weintraub, Daniel Weintraub and Per Svenningsson.For additional details on the rules and submission requirements for authors, it is recommended to see the journal website for npj Parkinson’s Disease at .
Epigenetic Changes Linked To Parkinson’s Disease Differ In Men And Women
The epigenetic changes linked to Parkinson’s diseasea nervous system disorder that afflicts nearly 1 million Americansare different in men and women, according to a new Rutgers study published in npj Parkinson’s Disease.
In a postmortem analysis of brain neurons, researchers compared samples from 50 people who died with Parkinson’s and 50 who had no sign of the disease. They found more than 200 genes with different epigenetic marks in diseased and healthy brainsbut the affected genes were almost entirely different in men and women.
“You could illustrate the male-female divide with two circles depicting genes with different epigenetic markings in Parkinson’s disease, one for men and one for women, and the overlap between the circles would only contain five genes,” said Alison Bernstein, senior author and assistant professor of pharmacology and toxicology at Ernest Mario School of Pharmacy.
“And we’ve found this every time we’ve looked at males and females separately, regardless of whether we’ve been looking at humans or mice or toxicology models. What we call Parkinson’s disease, singular, is probably Parkinson’s diseases, plural.”
“Some of the genes we found had already been implicated in other studies, but many of them were brand new, so this study opens up many avenues for further investigation of how these other genes are connected to Parkinson’s,” Bernstein said.
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