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Supplements For Parkinson’s Disease

Vitamins C And E Linked To Reduced Risk For Parkinson’s Disease

Can supplements have an affect on Parkinson’s Disease?

Erik Greb

Higher intake of vitamins C and E was associated with a reduced risk for Parkinson’s disease in an analysis of a national cohort study. Higher intake of both vitamins, as opposed to one, strengthened the association with lower PD risk.

In addition, body mass index and coffee consumption appeared to influence the magnitude of these vitamins’ effect on PD risk. Dietary beta-carotene and dietary nonenzymatic antioxidant capacity had no effect on this risk, however.

Dr Essi Hantikainen

“Our findings suggest that the protective effect of dietary vitamins on Parkinson’s disease risk might be limited to specific vitamins, such as vitamin E and C,” Essi Hantikainen, PhD, a postdoctoral researcher at the University of Milano-Bicocca, Milan, Italy, told Medscape Medical News. “Therefore, implementing foods in the diet that are rich in vitamin E and C might help to prevent the development of Parkinson’s disease,” she said.

More research is needed to confirm these findings, she added. “In addition, it is not yet clear what are the most beneficial amounts of vitamin E and C intake to reduce the risk of Parkinson’s disease.”

The research was January 6 in Neurology.

Vitamin C And Vitamin E

Vitamin C and vitamin E are both antioxidants. One study that evaluated these vitamins found they helped delay the need for PD drugs. Taking vitamin E alone did not seem to have the same benefit. However, vitamin E supplements can increase the risk of bleeding, especially in those who take blood thinners. Vitamin E has also been studied for its potential to reduce the risk of developing PD. However, dietary intake of vitamin E did not show any reduction in the risk of developing PD.3,5

Does Iron Supplements Can Exacerbate Parkinsons Disease

February 15, 2016 | Tags: Iron supplements > pathognomonic de-pigmentationCategories for this post are: Parkinsons Disease

There is some suggestion that free radicals made by iron can worsen Parkinsons disease by furthering damage to neurons. After iron is ingested, it is absorbed into the blood and bound to the protein transferrin. Transferrin travels through the blood and binds to specific receptors on certain cellsincluding the neurons in the substantia nigra. Once bound, the transferrin-iron complex is transported into the cell and broken apart for storage. As the pigmented granules within these neurons are lost, producing the pathognomonic de-pigmentation of the substantia nigra seen in Parkinsons disease, unbound iron is released. If this comes in contact with the naturally-occurring reactive oxygen species within the mitochondria of the billions of neurons, there is potential to make free radicals of the iron molecules. If this unnatural iron species goes unchecked, it will readily damage cellular components.

Drugs like rasagiline may be effective in reducing excessive iron from the damaged neurons by both chelating iron stores and blocking the enzyme monoamine oxidase b . This permits less free radical reactions to occur and will serve to retard the degradation of neurons and consequently the development of Parkinsons Disease.

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How To Use Optimize Parkinsons Disease Medications With Nutrition

There are a number of ways to optimize your response to oral medications for Parkinsons disease. One of the first is to make sure that youre digesting and absorbing those medications adequately. For PD medications, in particular, there are several nutritional considerations you must factor in when designing a medication plan that works for you.

Vitamin C Genetic Variants With Pd And Pd Aao

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We successfully extracted the summary statistics corresponding to the 11 vitamin C genetic variants in PD and PD AAO GWAS datasets, respectively. It is noted that rs56738967 =0.321) is an ambiguous palindromic variant . Hence, we selected the allele frequency to distinguish the effect allele in both GWAS datasets. More detailed information about the association of these 11 vitamin C genetic variants with PD and PD AAO is proved in Table .

Table 4 Association of 11 vitamin C genetic variants in PD and PD AAO

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Dopamines Role In The Brain And Body

Dopamine is the reward neurotransmitter that helps us feel motivated to do things like get outside, cook healthy meals, and exercise. It also helps us coordinate movement. When people with Parkinsons dont have enough dopamine, they can get symptoms like depression, apathy, fatigue, tremor, and poor balance. They can even experience freezinga phenomenon in Parkinsons disease where people feel stuck or unable to move.

Its not hard to imagine how the symptom list above would make it difficultif not impossibleto go out for a run, take medications consistently, or want to go to the grocery store to look for ingredients for a new plant-based recipe . These symptoms can even make it hard to take supplements or eat healthy foods since a lack of dopamine can cause difficulties with swallowing. For that reason, we need to make sure dopamine levels are optimized first before we try other natural treatment options in PD.

Dopaminergic drugs and in particular Levodopa , are the closest things to our own bodys dopamine that we can make in a lab. They work. Ive seen people with Parkinsons who couldnt stand up, take a step, or smile become completely transformed within hours of taking their first dose of Levodopa. In my opinion and the opinions of most neurologists, PD specialists, and PD patients, dopaminergic drugs are effective medications. They just have to be taken the right way and with the right nutrients to make them work for you.

A Word About Natural Dopamine Replacement

Clients often ask me if they can use mucuna pruriens to help treat their PD instead of dopaminergic pharmaceuticals like Levodopa. The answer is that it depends.

Mucuna is a plant that contains significant amounts of L-Dopa. Some studies suggest that it can be as effective as Levodopa for controlling motor symptoms in PD and that it can have fewer side effects. These studies have mainly been conducted in remote areas where access to pharmaceutical medications is limited.

Currently, mucuna is not available as a prescription. This means that it is not subject to the same purity and safety regulations as pharmaceutical drugs are in the U.S. Taking it means that youre accepting the risk that it might be contaminated or that it may contain more or less of a product that is on the label. It also isnt covered by insurance, so the cost of taking mucuna daily is often prohibitive for many of my clients when compared to the cost of Levodopa.

If youre willing to accept these risks and drawbacks, then mucuna could be a good herbal medicine for you to include in your PD treatment program. You have to work closely with a doctor to determine and continually adjust your ideal dose of it.

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Green Tea Polyphenols Or Gtps

GTPs have antioxidant properties along with free radical scavenging activities. There are current studies being conducted, which suggest that GTPs have a neuroprotective impact with the potential of treating Parkinson’s disease. Ongoing studies are being conducted by the Chinese Ministry of Health along with the Michael J. Fox Foundation whether GTPs can slow down the progression of Parkinson’s disease.

How Does Fibre Help

Can Natural Supplements Help With Parkinson’s Disease?

Fibre absorbs fluid as it moves through your bowel, forming a soft stool that can be passed more easily.

It is very important to increase your fluid intake if you increase the fibre in your diet, because too much fibre without enough fluid can increase constipation.

A dietitian can give you more information and advice.

How can I increase my fibre intake?

Fibre is found in cereals, seeds, nuts, fruit, vegetables and pulses, such as peas, beans and lentils. To increase your fibre intake you can try:

  • eating high-fibre varieties of foods, such as wholemeal bread, pasta or brown rice
  • altering recipes to use some wholemeal flour instead of all white flour
  • choosing a breakfast cereal containing wheat, wheatbran or oats, such as Weetabix, porridge or bran flakes
  • eating more vegetables. They can be raw or cooked, fresh or frozen. Try using more peas, beans or lentils
  • eating more fruit. It can be fresh, stewed, tinned or dried. Try bananas, oranges or prunes
  • gradually introducing ground linseeds. You can add 1 teaspoon to cereals, salads or yoghurts to start with and increase this over time to 1 tablespoon. If you do this, make sure you drink an extra glass of fluid a day, otherwise it wont work and may make constipation worse

When increasing your intake of fibre, it is important to do so gradually to avoid bloating or flatulence . Aim to introduce 1 new high-fibre food every 3 days.

Find out about speech and language therapy and keeping a diary.

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Vitamin B12 And Folate Deficiency

Some people who take levodopa may have lower levels of vitamin B12 and vitamin B9 . Symptoms of vitamin B12 and folate deficiency can include pins and needles , a sore, red tongue, mouth ulcers and disturbed vision.

If youre worried about any symptoms youre experiencing, you should speak to your specialist or Parkinsons nurse.

Eating a well-balanced diet will give you a good amount of vitamins and minerals.

For many vitamin and mineral supplements, theres no clear scientific evidence they have any health benefits .

So, if you feel you need more of a particular vitamin or mineral, it is advisable to try to eat more of the foods containing it, rather than to buy expensive vitamin and mineral supplements.

You also need to be aware that some vitamins, when taken in large doses, can have side effects.

Some supplements, for example vitamin B6 and iron supplements, may also affect the absorption of your Parkinson’s medication.

Before purchasing any ‘over the counter’ mineral and vitamin supplements from chemists or health food shops, consult your GP, specialist, Parkinson’s nurse or registered dietitian for advice.

Antioxidants Linked To Reduced Risk

Participants in the highest tertile of intake of vitamins and NEAC were generally older, more educated, and consumed greater amounts of fruit and vegetables. Participants in the lowest tertile were more likely to be smokers and had higher total dairy intake.

After adjusting the data for potential confounders, the researchers found that the risk for PD was 32% lower among people in the highest tertile of vitamin E intake, compared with those in the lowest tertile. Participants in the highest tertile of vitamin C intake, compared with those in the lowest tertile, also had a 32% lower risk for PD.

Furthermore, participants in the highest tertile of vitamin E and C intake had a 38% lower risk for PD compared with those in the lowest tertile. The researchers found no association, however, between dietary beta-carotene or NEAC and risk for PD.

Subgroup analyses indicated that vitamin E had a stronger effect on people who were overweight or obese. Such patients who were in the highest tertile of vitamin E intake had a 56% lower risk for PD.

In addition, among participants with low coffee consumption, those in the highest tertile of vitamin C intake had a 46% reduced risk for PD.

Among overweight and obese participants, those in the highest tertile of vitamin C intake had a 48% lower risk for PD.

None of the sensitivity analyses altered the researchers’ findings.

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Coffee & Tea For Parkinsons

Multiple studies have shown an association between caffeine intake and reduced PD risk. Different studies have noted this association across a range of dietary exposures including coffee, black tea, green tea and total caffeine intake.

The relationship between coffee or tea drinking and lower rates of PD is an association that is, the two tend to co-exist. We do not yet know if coffee and tea are the cause of the lower rates of PD. In addition, there are other potentially beneficial compounds in coffee and tea besides caffeine, some with anti-oxidant properties.

Researchers are exploring if there are contributions from these other substances that may contribute to the lower risk of PD. Recent research published by Dr. M. Maral Mouradian, interim director of one of APDAs Centers for Advanced Research at Rutgers-Robert Wood Johnson Medical School and member of APDAs Scientific Advisory Board, demonstrated how caffeine and Eicosanoyl-5-hydroxytryptamide may work together to prevent biochemical changes linked to development of PD. Although more research is necessary to test these compounds in humans and to determine how much of these substances are necessary to achieve the protective benefit, the research is pointing in the direction of coffee being beneficial.

Whether caffeine, coffee or tea is helpful to a person who already has PD is even less clear. That is, in addition to being associated with a lower risk of developing PD, could caffeine help PD symptoms?

Vitamins C And E Tied To Lower Risk For Parkinsons Disease

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Consuming foods high in vitamins C and E may help protect against the onset of Parkinsons later in life, a Swedish study suggests.

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By Nicholas Bakalar

People who consume a diet rich in vitamins C and E may be at reduced risk for Parkinsons disease.

Researchers followed 41,058 Swedish men and women for an average of 18 years, gathering data on their health and diet. They assessed intake of vitamins C and E as well as beta-carotene and a measure called NEAC, which takes into account all antioxidants from food and their interactions with each other.

Over the course of the study, published in Neurology, there were 465 cases of Parkinsons disease.

After adjusting for age, sex, B.M.I., education, smoking, alcohol consumption and other characteristics, they found that compared with the one-third of people with the lowest intake of vitamin C or E, the one-third with the highest intake had a 32 percent reduced risk for Parkinsons disease. Those in the highest one-third in consumption of both vitamins together had a 38 percent reduced risk. There was no effect for beta-carotene or the NEAC measure.

Still, she said, Implementation of a diet that includes foods rich in vitamins C and E might help protect against the development of Parkinsons later in life. In any case, its never wrong to implement a healthy diet.

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Clinical Studies Regarding Vitamin E In Pd

The DATATOP experiment is a multicentre-controlled clinical trial to investigate the long-term efficacy of treatment with deprenyl and/or copherol and to explore whether it is possible to extend the time before the application of levodopa treatment. At 28 US and Canadian sites, 800 eligible patients with untreated early-stage PD were enrolled in DATATOP and randomized to four groups: deprenyl 10mg/d, copherol 2000IU/d, placebo-controlled, and deprenyl 10mg/d and copherol 2000IU/d. Deprenyl can delay the development of functional disorders, delay the application of levodopa, and improve motor symptoms, but vitamin E is disappointing . Similarly, another two population-based studies also did not find the association between vitamin E intake and risk of PD .

However, a large community-based study showed that high intake of dietary vitamin E may reduce the occurrence of PD . Another pilot trail suggests that long-term treatment with vitamin E may delay the use of levodopa in patients with PD . Further research is needed to verify these results.

Which Vitamins Are Good For Parkinsons Disease

Nutritional interventions, which act via different types of mechanisms may slow or avoid the accumulation of damaged brain cells associated with the production of Parkinsons disease. Particularly, nutrients responsible to increase the utilization of brain energy, prevention of mitochondrial dysfunction, protection against oxidation damages and inflammation of tame are few leading contenders associated with anti-Parkinsons therapies.

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Drink Enough Water And Electrolytes To Avoid Orthostatic Hypotension

One of the most common side effects of dopaminergic medications is orthostatic hypotension. Symptoms of orthostatic hypotension including feeling dizzy when you stand up, feeling fatigued due to low blood pressure, and frequent brain fog. Orthostatic hypotension also increases the chances of falling while walking. To help to reduce the chances of experiencing orthostatic hypotension when taking dopaminergic medication, make sure to drink enough fluids like water, decaffeinated teas, and low-sugar sports drinks, consume adequate electrolytes, and to consume enough protein. These factors combined help to ensure your best chances of maintaining normal blood pressure.

Foods High In Saturated Fat

How can changes to diet help people with Parkinson’s?

The role that foods high in saturated fats play in Parkinsons progression is still under investigation and is often conflicting. We might eventually discover that there are certain types of saturated fats that actually help people with Parkinsons.

Some limited research does show that ketogenic, low-protein diets were beneficial for some with Parkinsons. Other research finds high saturated fat intake worsened risk.

But in general, foods that have been fried or heavily processed alter your metabolism, increase blood pressure, and impact your cholesterol. None of those things are good for your body, especially if youre trying to treat Parkinsons.

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I Am Underweight Or Losing Too Much Weight What Should I Do

If you are underweight or have difficulty putting weight on, it may be because of the side effects of Parkinsons medication or difficulties with chewing or swallowing.

Weight loss is caused by your body using more calories than youre consuming. This may be due to increased movement caused by tremors or dyskinesia. It may also be due to practical problems, such as food shopping, preparation or keeping your food hot while youre eating.

You may find the following tips useful:

  • Make the most of adding extras to foods, such as extra cream, butter, oil or honey where you can. These will make the food more energy-dense and tasty.
  • Try to have 3 meals a day and 2 to 3 snacks between your meals. Its important to try to eat every 2 to 3 hours during the day.
  • Instead of snacks, try having a milkshake, malted drink or smoothie. These may be used to supplement your usual diet. But, if you find you are replacing your meals with these, it is important to seek help from a dietitian.

If you are finding it difficult to maintain your weight or reach a healthy weight, your GP, specialist or Parkinsons nurse can refer you to a dietitian.

They may recommend tailored changes to your diet and special high-calorie products that are available on prescription.

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