Monday, December 11, 2023

Non Invasive Treatment For Parkinson’s Disease

Inclusion/exclusion Criteria For Study Selection

UM School Of Medicine Develops Non-Invasive Treatment For Parkinson’s Disease

Figure shows the flow diagram for study inclusion/exclusion in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Articles identified from the search were exported into reference management software and screened for duplication. Following the removal of duplicates, titles and abstracts were screened to identify relevant studies. The inclusion criteria included:

  • 1.

    Study population included people with idiopathic PD

  • 2.

    Interventions using rTMS or TES

  • 3.

    Sham stimulation as a control

  • 4.

    Outcome measures for motor function including:

  • a.

    Clinical motor assessments including UPDRS-III, H& Y, ADL, AIMS, CDRS, PPT, TUG and FOG-Q

  • b.

    Gait kinematic as measured using a force platform, accelerometers or 3D motion capture

  • c.

    Finger and/or wrist movement using custom-made systems such as goniometers and touchpads.

  • 5.

    Validated neuropsychological tests to assess:

  • cross-over or parallel study design

  • The exclusion criteria included:

  • No data available to determine effect sizes,

  • TES intensity 1mA vs. 2mA

  • 8.

    TES mode Anodal vs. tACS.

  • Heterogeneity was measured using the I2 statistic, which indicates the percentage variance between studies with cut off points corresponding to low , moderate and high heterogeneity. Funnel plots assessed publication bias using Eggers regression test . All statistical analyses were performed using Comprehensive Meta-Analysis using an alpha level of p< 0.05 was used to determine significance.

    Fda Approval Clears Way For Incisionless Brain Surgery As An Effective Non

    A non-invasive ultrasound treatment for Parkinson’s disease that was tested in a pivotal trial led by University of Maryland School of Medicine researchers is now more broadly available at the University of Maryland Medical Center . Recent FDA approval of a device used in the procedure effectively opens up access to focused ultrasound beyond clinical trial participation.

    The device, called Exablate Neuro and manufactured by Insightec, was approved in late 2021 by the U.S. Food and Drug Administration to treat advanced Parkinson’s disease on one side of the brain. UMMC is one of only several sites in the Mid-Atlantic region with the capabilities and expertise to perform focused ultrasound for Parkinson’s disease and other movement disorders. The procedure requires a multi-disciplinary team, including a neurosurgeon, movement disorder neurologist, and neuroradiologist.

    Technology Holds Potential To Change Surgical Trends

    Meanwhile, INSIGHTEC is exploring a much bigger canvas. The company has identified over a hundred different diseases that it could target with its Exablate Neuro technology, says Ferré.

    “The trend is to try to treat diseases earlier in their cycle,” he says, adding that focused ultrasound treatment may become a tool in this regard. In addition, “This technology, as a platform, has the capabilities of transforming the way we look at surgery. If you look at the trends of surgeries, you’ve seen it go from open surgery, to laparoscopic surgery, to robotic surgery. We think we’re now the next generationincisionless surgery which is completely noninvasive.”

    Mandy Roth is the innovations editor at HealthLeaders.

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    Mechanisms Of Action Of Non

    The biological effects of NIBS are essentially determined by two types of factors: extrinsic and intrinsic . On one hand, extrinsic factors are related to the amount of energy and to the pattern of current flow delivered to the brain. These include specific parameters that can be actively controlled by the operator, such as current intensity, stimulation frequency, number of pulses, number of sessions, coil design, electrode montage, etc. However, for the same dose of energy delivered, different intrinsic factors inherent to the stimulated subject contribute to the individuals biological outcome. For instance, the subjects pharmacological profile can affect the brains activation state and connectivity by modulating neuronal propensity to fire and undergo plastic phenomena. In patients with Parkinsons disease , this is particularly noteworthy, as changes in cortical excitability and neuroplasticity are critically influenced by dopamine bioavailability, and the institution of a dopaminergic therapy can influence the subsequent neurophysiologic and behavioral effects of stimulation .

    Dementia With Lewy Bodies

    New, non
    • Dementia with Lewy bodies is a progressive, neurodegenerative disorder in which abnormal deposits of a protein called alpha-synuclein build up in multiple areas of the brain.
    • DLB first causes progressive problems with memory and fluctuations in thinking, as well as hallucinations. These symptoms are joined later in the course of the disease by parkinsonism with slowness, stiffness and other symptoms similar to PD.
    • While the same abnormal protein is found in the brains of those with PD, when individuals with PD develop memory and thinking problems it tends to occur later in the course of their disease.
    • There are no specific treatments for DLB. Treatment focuses on symptoms.

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    Minimally Invasive Procedure Relieves Tremors In Parkinson’s Patients

    Radiological Society of North America
    A procedure that applies pulses of focused ultrasound to the brain is safe and effective for reducing tremors and improving quality of life in people with essential tremor or Parkinson’s disease tremor, according to a new study.

    A procedure that applies pulses of focused ultrasound to the brain is safe and effective for reducing tremors and improving quality of life in people with essential tremor or Parkinson’s disease tremor, according to a new study being presented next week at the annual meeting of the Radiological Society of North America .

    Tremors are rhythmic, involuntary muscle movements that cause shaking in one or more parts of the body, usually in the hands. They are characteristic of movement disorders like ET and PD, two progressive conditions that affect millions of people worldwide.

    Previous treatment options for reducing tremors in patients who have not responded to medical therapy include deep brain stimulation, a surgical procedure that involves implanting a small electrode in the brain connected to a pulse generator that is implanted in the chest like a pacemaker.

    “Another advantage is the immediate effect this treatment provides, unlike deep brain stimulation which requires a break-in period for the electrostimulation,” he said. “Additionally, treatment with MRgFUS requires shorter hospitalization and is a fairly well-tolerated procedure even by more fragile patients.”

    Story Source:

    Transcranial Alternating Current Stimulation

    Transcranial alternating current stimulation provides a sinusoidal external current stimulation that could either synchronize or desynchronize with the internal cortical rhythm . Dissimilar to tDCS, tACS has more viable parameters, such as amplitude, frequency, and phase. Hence, tACS is capable of specifically correcting natural brain oscillations back to normal.

    Parkinsonâs disease patients suffer from pathological changes in internal brain oscillation frequency ranges. Higher theta , delta activities and lower alpha , beta activities in the basal ganglia were detected in PD patients . Additionally, PD patients also exhibit a reduced power of gamma band oscillation as well as deviated task-specific neuronal oscillation activity .

    Additionally, tACS can be applied to probe and detect the causal relationship between behavior and neuron activity. In a randomized crossover tACS study, the associations between bradykinesia and abnormally altered beta/gamma oscillations in primary motor cortex were exposed when 1 mA tACS at 20 Hz or 7 Hz was delivered to patients. The stimulation electrode was centered over the first dorsal interosseous hotspot, while the return electrode was centered over the PZ according to the EEG 10â20 system. As a result, the increased beta power led to aggravated bradykinesia, while gamma synchronization entrained by tACS mitigated these symptoms .

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    Home Pemf Therapy Mat For Parkinsons Disease Treatment

    MiraMate Big Magic is one of the most advanced PEMF mats on the market. It is popular amongst our customers because its effective, affordable and easy to use. Big Magic copies the natural frequency of the earth, which is called the Schumann resonance. It balances the cellular metabolism in Parkinsons Disease patients in a natural and safe way.

    Big magic works on deep nerves in the brain to help with PD. You will receive the best results when you lay the back of your head on the mat. If you would like to do an overnight treatment, placing the mat under a thin pillow sheet would be a nice idea.

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    Exercise and Fitnessphysical activityExercisePhysical Fitness Sarasota Memorial’s HealthFIT YMCANeuro Challenge FoundationPhysical, Occupational and Speech TherapyPhysical TherapistOccupational Therapist SpeechDrug InterventionsmedicationNeuropsychology & Support GroupsAssistance with Daily LivingBluehost

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    When Its Not Parkinsons: Non

    Everyone has some amount of tremor. Physiologic tremors are common, barely noticeable amounts of shakiness that worsen when people are stressed, anxious, or have had too much caffeine. As long as the tremors are not significant and do not affect your day-to-day activities, they may be completely normal.

    Even tremors that are not normal are not always caused by Parkinsons. They can be caused by a range of other conditions, which together are known as movement disorders.

    What Are The Benefits Of Focused Ultrasound

    • It is non-invasive, with lower risks and a shorter recovery time
    • It is carried out as a single treatment. Patients typically recover rapidly and quickly return to their usual daily activities
    • Compared to a radiofrequency ablation or deep brain stimulation, focused ultrasound is less risky, offering a reduced risk of infection, collateral damage, or bleeding
    • Focused ultrasound offers rapid resolution of symptoms. Other technologies such as Gamma Knife radiosurgery have a significant delay before clinical improvement is seen, and deep brain stimulation requires regular programming of the electrical device, and either frequent recharging or further surgery to replace the battery when it expires
    • In contrast to stereotactic radiosurgery lesioning, focused ultrasound does not use radiation, thereby avoiding the side effects of radiotherapy.
    • No anaesthetic is required, therefore patient with significant medical comorbidity are eligible for this treatment

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    What Is The Process To Be Assessed

    Step 1 Register your interestYou can contact our office by phone , email or via our appointment request form to register your interest and begin the assessment process.

    Step 2 Phone ConsultationA member of our team will call you to obtain some relevant information, screen you for suitability, and arrange the medical and radiological assessments .

    Step 3 Medical Assessment

    The key medical assessments are:a) Consultation with a movement disorder neurologistb) CT & MRI Scanc) Consultation with neurosurgeon, Prof Richard Bittar

    The information obtained during your consultations and scans are collated and assessed by our multidisciplinary team, and a treatment recommendation is made.

    Step 4 Scheduling the Procedure

    Outlook For Transcranial Electrical Stimulation Combined With Other Interventions

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    Since different interventions act through distinct mechanisms to alleviate PD symptoms, combined interventions can modulate multiple pathways with higher efficiency. Future studies might be able to provide individualized combination schemes according to patientsâ symptoms and pathogenic factors, leading to maximized improvements and minimized side-effects in individuals.

    Nevertheless, some limitations in combined interventions need to be considered.

    First, TMS itself has already faced the problems of tolerability and unblinding toward patients and adding on TMS might worsen the situation.

    In addition, although many have applied combination interventions for PD, few of them include control groups to assess the improvement of dual therapy interventions compared to single intervention. Therefore, in some studies, it is uncertain whether these combinations are better, more studies and a larger number of subjects are required for further validation of their effects.

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    Transcranial Random Noise Stimulation

    Transcranial random noise stimulation delivers alternating currents of random frequencies and amplitudes within a specific range of the spectrum . tRNS has been used as an active control in several neuromodulation studies nevertheless, tRNS itself can also serve as a possible therapeutic stimulation method for PD. Like tACS, tRNS can also interfere with internal brain oscillations and neuronal activities. In healthy controls, weak tRNS over M1 increased corticospinal excitability during and after stimulation . In addition, tRNS exhibits a higher perception threshold and is more effective activating M1 than anodal tDCS in healthy controls.

    In order to assess the potential of tRNS toward PD, a study has combined tRNS with intermittent theta burst stimulation to detect neuron activity alterations. In this study, PD patients who received a maximum 640 Hz 0.5 mA tRNS over M1 showed an adverse effect on the excitability of M1. In contrast, in healthy controls, M1 cortical excitability was enhanced after stimulation, while PD patients exhibited decreased cortical activity . This study revealed a difference in tRNS efficacy among different populations. Thus, further assessment of the efficacy of tRNS as a rehabilitation strategy for PD is needed.

    Transcranial Direct Current Stimulation

    Although most NIBS studies on PD have employed TMS, tDCS remains a prospective therapeutic tool. Anodal tDCS is thought to restore reduced activity in motor and prefrontal cortices in PD . In a RCT, anodal tDCS applied to the motor and prefrontal cortices in 8 sessions over 2.5 weeks improved bradykinesia for 3 months and exerted beneficial effects on gait, but had no effects on the UPDRS, reaction time, physical and mental well-being, and self-assessed mobility . The observed effect on bradykinesia was small, and needs to be confirmed in a larger study. TDCS promotes motor learning and consolidation, and may enhance long-term retention . This provides the rationale for combining tDCS with a rehabilitative intervention, and has been shown to promote motor recovery in chronic stroke . In a cross-over RCT, 5 sessions of anodal tDCS of M1 in 10 patients had a beneficial effect on gait, freezing of gait and motor performance, and these effects lasted for the observation period of 1 month .

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    Transcranial Magnetic Stimulation General Safety

    Different side effects resulting from the application of TMS have been reported in the literature. The international safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research have listed them according to their respective frequency. Common side effects include transient headache, local pain, neck pain, toothache, and paresthesia. Pain duration is usually limited, lasting up to few hours after the session, and it can be commonly relieved with acetaminophen or other over-the-counter medications. Less common adverse effects include transient hearing changes, transient cognitive/neuropsychological changes, syncope , and transient acute hypomania . Rare adverse effects reported include changes in blood levels of thyroid stimulating hormone and lactate, and seizures. Seizure activity has been reported mostly with high-frequency rTMS. TMS-induced seizures are self-limited and are not reported to have permanent sequelae. High frequency TMS has 1.4% crude risk estimate of inducing seizures in epileptic patients and less than 1% in non-epileptic subjects . There is a theoretical risk of inducing currents in electrical circuits when TMS is delivered in close proximity of electric devices which can cause malfunction of these devices.

    Transcranial Pulsed Current Stimulation

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    Different from conventional tDCS, tPCS provides discontinuous direct current interrupted by either short or long periodical inter-pulse intervals , thus adding two additional parameters: inter-pulse intervals and pulse durations. Although phosphene might also be induced by tPCS, the overall tolerability toward tPCS is better than tDCS in healthy subjects, with a significantly reduced feeling of itching, tingling, and eye flashing .

    In a Parkinsonian study, a combined tPCS and treadmill strategy was applied for 10 PD freezing of gait patients, with both pulse duration and inter-pulse interval of tPCS being 33.3 μs. The tPCS targeted M1 provided 20 min of stimulation with or without concurrent treadmill training. The gait speed and gait amplitude, however, were found to be improved after a single tPCS session but not in the combined group or treadmill alone group . However, this study did not include sham tPCS as a placebo control, and the reliability of its results was therefore dented. Further studies should take place to further assess the efficacy of tPCS toward PD.

    There was a study toward healthy population implicated that the duration of tPCS was not aligned with the lasting time of aftereffects . Thus, the non-linear effects of tPCS together with its unclear mechanisms complicate the process of selecting proper tPCS parameters. Consequently, few PD studies have focused on tPCS.

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    What Are The Costs Involved With The Assessment For This Treatment

    Consultations with the neurologist and neurosurgeon take place in their consulting suites and are billed at their standard specialist rates. This information, together with the likely Medicare rebates, will be provided to you before your booking is confirmed. In order to be certain that you receive a Medicare rebate, please ensure that you obtain a referral from your GP or neurologist.

    The assessment process includes dedicated CT and MRI scans, both of which are undertaken at specific radiology clinics. The prices may vary according to which clinic, and this information will be provided to you at around the time of your initial enquiry.

    Request An Initial Consultation

    If you are suffering from Essential Tremor, Parkinsons disease or another type of tremor or movement disorder and would like to know whether you might be suitable for treatment with focused ultrasound, please request a consultation and our clinical care coordinator will contact you:

    Alternatively, please email your referral or enquiry to

    Our assessment process includes:

    • Confirmation of your diagnosis and its impact on your quality of life.
    • Other relevant medical condition and medications you are on.
    • Brain scanning with MRI and CT

    Our clinical assessment team includes a movement disorder neurologist and neurosurgeon. Our clinical care coordinator will coordinate all aspects of your assessment from the time we receive your referral. If you have any questions, please contact us.

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    How Can I Be Assessed For Suitability For This Treatment

    Patients with various types of tremor, as well as Parkinsons Disease and dystonia, may be assessed for suitability for Neuravive.

    Typically the assessment includes:

    • Diagnostic confirmation of the type of movement disorder
    • Measurement of skull density on CT, and brain morphology on MRI
    • Assessment with the standard rating scales
    • Consideration of quality of life issues
    • Assessment of other health problems which may be relevant

    The assessment team includes a neurologist, neurosurgeon, neuroradiologist, and sometimes a rehabilitation physician and neuropsychologist.

    Essential Tremor Vs Parkinsons Disease

    Deep Brain Stimulation for Parkinsonâs Disease

    Essential tremor and Parkinsons disease are both adult-onset tremor disorders that can be characterized by shaking that affects daily life. If you have one of these conditions, you may find it difficult to hold onto items, struggle to write normally, and notice your hands shaking uncontrollably. However, beyond that, there are many key differences.

    If you believe you may suffer from one of these conditions, this guide can help you better understand the signs that you may have Parkinsons disease or essential tremor, how each is diagnosed, and what the treatment process entails. If you have questions about a certain aspect of these conditions, use the links below to navigate to its specific section:

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