Wednesday, August 3, 2022

Is There Any Treatment For Parkinson’s Disease

Natural Treatment For Parkinsons #3 Turmeric And Otherherbs And Spices:

Will there be any effective treatments for Parkinson’s in my lifetime?

A recent study published in the journal Stem Cell Research & Therapy, foundthat the extracts in turmeric, particularly curcumin and the newly discovered Ar-turmerone,can regenerate a damaged brain and reverse neurological disorders. Researchers said Ar-turmerone is a promising candidate to supportregeneration in neurologic disease. Michigan State University researcherBasir Ahmad also found that a compound in turmeric may help fight Parkinsonsdisease by disrupting the proteins responsible for the disease.

Another study published in the Pharmacognosy Magazine found that tumeric can prevent and evenreverse the toxic effects exerted on the brain from fluoride exposure. Fluorideis a nasty and dangerous heavy metal that destroys brain cells and the intricateworkings of the central nervous system. Fluoride poisoning has also beenimplicated in the development of neurological diseases such as Alzheimers,Parkinsons, ALS and multiple sclerosis. 7

Turmeric is also a very potent anti-inflammatory spice. Because Parkinsons is aninflammation type disease, turmeric will help immensely. A heaped teaspoon ofhigh quality turmeric powder taken 3 times daily in asmoothie will do the trick. Just make sure you combine it with 10-12 blackpeppercorns for enhanced absorption Turmeric is also fat soluble so youll need tocombine it with some coconut oil, red palm oil or fish/krill oil as well.

Gene Therapy For Parkinsons Disease

Biotech companies Voyager Therapeutics and Neurocrine teamed up in January to bring an experimental gene therapy for Parkinsons disease to market. In this case, Neurocrine is investing $165 million in cash and equity into Voyager for a piece of its pipeline, including its flagship gene therapy, VY-AADC for Parkinsons. The treatment involves inserting the gene that makes AADC, an enzyme in the brain that converts levodopa into dopamine, directly into the neuron. If successful, the treatment could provide clinically meaningful improvements by restoring motor function in patients and improving symptoms following a single administration.

In fact, an earlier clinical trial showed so much promise that Voyager received a Regenerative Medicine Advanced Therapy designation for VY-AADC from the Food and Drug Administration. Only about 30 products have received an RMAT designation, which can shorten the time to market for innovative medicines. Voyager stands to make as much as $1.7 billion if all goes according to plan with VY-AADC and its other pipeline therapies, according to Xconomy.

Parkinsons Surveys And Clinical Trials

If youd like to be part of early research efforts that are looking into the efficacy of service dogs for those living with Parkinsons, you can take this survey here.

Park Test University of Rochester

LSVT Global and Project Euphonia

BouNDless Phase 3 trial to investigate the efficacy, safety, and tolerability of ND0612, a continuous subcutaneous levodopa/carbidopa delivery system in comparison to oral levodopa/carbidopa in people with Parkinsons experiencing motor fluctuations

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Conformational Transition Of Inhibited

Component #2 A Neuroprotective Agent

Once a drug or a treatment has been determined to slow down the progression of Parkinsons, it will be necessary to protect the remaining cells and provide a nurturing environment for the third part of the cure .

But there has been the hint of a potential neuroprotective effect in one class of drugs for Parkinsons: GLP-1R agonists.

Neuroprotective approach: GLP-1R agonists

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What Kinds Of Genetic Research Is Being Done

Researchers are investigating genes that code proteins responsible for producing dopamine. By increasing the amount of dopamine in the brain, Parkinson’s symptoms can be minimized if not prevented.

What other treatments are being researched?

  • Drug treatments. Researchers are investigating drugs that block the action of glutamate, an amino acid that destroys nerve cells, as well as the role of the antioxidant coenzyme Q-10 in slowing the progression of Parkinson’s disease.
  • Neural growth factor. Preliminary studies have shown that neural growth factor revives the dormant cells needed to produce dopamine, dramatically improving symptoms.
  • Deep brain stimulation. Research is underway to better understand how deep brain stimulation works in Parkinson’s disease. Researchers are also studying improved ways of stimulating the brain.

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Naturaltreatment For Parkinsons #6 Magnesium & Iodine:

Treatment for Parkinson

Magnesium is vital for the health of the entire nervoussystem, especially the protective layer that surrounds the nerves . Magnesiumis also essential for the production of dopamine and helps protect dopaminergicneurons in the substantia nigra from degeneration. In addition to this, new evidence is showing that low levels of magnesium in the brain causes a build-up ofheavy metals a major factor in the development of Parkinsons, Alzheimers,epilepsy and MS. In a recent trial, 30 epileptics were given 450 mg ofmagnesium daily and this successfully controlled their seizures. Ifmagnesium can help epilepsy patients, it can certainly help Parkinsons sufferers. Worldrenowned magnesium expert and author, Dr Carolyn Dean, has both Parkinsons andAlzheimers disease in her top 55 health conditions caused by amagnesium deficiency list and says that magnesium is 100% essential for the preventionand treatment of both of these diseases Dr Carolyn Dean Interview

In regards to iodine, well-known researcher and author,Dr James Howenstein, says

Iodineis found in large quantities in the brain and the ciliary body of the eye. A lackof iodine may be involved in the production of Parkinson’s disease andglaucoma.

Inthe brain, iodine concentrates in the substantia nigra, an area of the brainthat has been associated with Parkinson’s disease.

David Brownstein M.D. 9

Best Sources of Magnesium and Iodine

-What Youll Need

1 cup of Magnesium Chloride Flakes

1 cup of Distilled Water

Also Check: On And Off Phenomenon

Homeopathic Treatment For Parkinsons Disease By Dr Tsan

Mercurius Solubilus in experimentally induced Dementia in rats, this homeopathic remedy progresses cerebral blood flow and memory. Mercurius is the most common Homoeopathic Treatment forParkinsons disease.

A weakness of arms and legs, unsteady gait, and especially shaking hands are the most common symptoms for which homeopathic doctors will prescribe it.

Zincum Metallicum is another common homeopathic remedy forParkinsons disease when Violent shaking of the whole body as a result of stress and emotional events is the main manifestation of the disease.

Gelsemium focusing on the central nervous system and thus triggering different levels of paralysis as well as sleepiness, tiredness, dreariness, and trembling. On the list of the most common homeopathic remedies forParkinsons disease,Gelsemium will take 3rd place.

How We’re Speeding Up The Search For A Cure

We believe that new and better treatments are possible in years, not decades. We have a clear strategy for making this happen. This includes:

Also Check: On Off Phenomenon

Icipating In Clinical Trials

Clinical trials and their participants have revolutionized Parkinsons treatment, and have changed the lives dramatically of those affected. They have helped make available many new treatments in addition to improving the delivery methods of medications and new deep brain stimulation techniques.

Clinical trials are essential to the future of Parkinsons research, and APDA is committed to this vital effort.

What Are The Symptoms Of Parkinson’s Disease

Is there a cure for Parkinson’s disease? How is is treated?

The main symptoms of Parkinson’s disease are:

  • tremor or shaking, often when resting or tired. It usually begins in one arm or hand
  • muscle rigidity or stiffness, which can limit movement and may be painful
  • slowing of movement, which may lead to periods of freezing and small shuffling steps
  • stooped posture and balance problems

The symptoms of Parkinson’s disease vary from person to person as well as over time. Some people also experience:

  • loss of unconscious movements, such as blinking and smiling
  • difficulties with handwriting
  • drop in blood pressure leading to dizziness
  • difficulty swallowing
  • sweating

Many of the symptoms of Parkinson’s disease could be caused by other conditions. For example, stooped posture could be caused by osteoporosis. But if you are worried by your symptoms, it is a good idea to see your doctor.

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Treatment For Parkinsons Disease

Treatment for Parkinsons disease is always challenging, and according to modern medical science, this condition cannot be cured, but medication can help control your symptoms, often dramatically. In some more aggressive cases, surgical intervention may be recommended.

Your attending physician and neurologist may also advise some important lifestyle changes, especially exercising and occupational therapy. Physical therapy modalities that emphases on balance and stretching are also important. A speech therapist can help improve your language problems.

What Causes Parkinsons Disease

Parkinsons comes under the dementia umbrella. Its adegenerative disease of the nervous system that causes a loss of motor skillsand intentional movement. When someone has Parkinsons, the part of the brainthat controls muscular movements and mood function doesnt receive enough ofthe crucial dopamine chemical. Without enough dopamine, bodily movements,learning abilities and mood levels are severely affected. So-called normalfunctions such as speaking, writing, swallowing, walking and sleeping become difficultto perform. These challenges, combined with a lowering of mood levels is whymany Parkinsons patients suffer with depression.

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What Is Parkinsons Disease

Parkinsons disease is a progressive brain disorder that causes shaking and muscle stiffness, and slows movement. It develops when neurons in a particular part of the brain stop working properly and are lost over time. These neurons produce an important chemical called dopamine. Dopamine is used by the brain to send messages across brain areas to help control movement. Eventually, the brain cannot make enough dopamine to control the movement properly.1,2

Neurosurgical Treatments Of Parkinsons Disease

Treatment for Parkinson

It is beyond the scope of this manuscript to comprehensively review neurosurgical treatment of PD. Only a brief review will be provided here and the reader is referred to other published literature on for additional information about this important therapeutic strategy. The renewed interest in surgical treatment of movement disorders has been stimulated in part by improved understanding of the functional anatomy underlying motor control, as well as refinement of methods and techniques in neurosurgery, neurophysio logy, and neuroimaging .

Besides thalamotomy and pallidotomy, another promising surgical approach for the treatment of tremors and other movement disorders is high-frequency DBS via electrodes implanted in the VIM nucleus of the thalamus, GPi, STN or other subcortical nuclei. The mechanism of electrical stimulation is not known, but the following explanations have been offered: 1) disruption of the network , 2) depolarization block, 3) preferential activation of inhibitory neurons, and 4) a functional ablation by desynchronizing a tremorogenic pacemaker.

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What Are Lewy Bodies

The affected neurons of people with Parkinsons disease have been found to contain clumped proteins called Lewy bodies. Researchers arent yet sure why Lewy bodies form or what role they play in the disease, but Lewy bodies are believed to be toxic.

Lewy bodies are clumps of a protein called alpha-synuclein . Neurons cant break down these protein clumps, which may lead to the death of these cells.

Some other theoretical causes of brain cell death in people with Parkinsons disease include free-radical damage, inflammation, or toxins.

What Medications Are Used To Treat Parkinsons Disease

Medications are the main treatment method for patients with Parkinsons disease. Your doctor will work closely with you to develop a treatment plan best suited for you based on the severity of your disease at the time of diagnosis, side effects of the drug class and success or failure of symptom control of the medications you try.

Medications combat Parkinsons disease by:

  • Helping nerve cells in the brain make dopamine.
  • Mimicking the effects of dopamine in the brain.
  • Blocking an enzyme that breaks down dopamine in the brain.
  • Reducing some specific symptoms of Parkinsons disease.

Levodopa: Levodopa is a main treatment for the slowness of movement, tremor, and stiffness symptoms of Parkinsons disease. Nerve cells use levodopa to make dopamine, which replenishes the low amount found in the brain of persons with Parkinsons disease. Levodopa is usually taken with carbidopa to allow more levodopa to reach the brain and to prevent or reduce the nausea and vomiting, low blood pressure and other side effects of levodopa. Sinemet® is available in an immediate release formula and a long-acting, controlled release formula. Rytary® is a newer version of levodopa/carbidopa that is a longer-acting capsule. The newest addition is Inbrija®, which is inhaled levodopa. It is used by people already taking regular carbidopa/levodopa for when they have off episodes .

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What Are The Symptoms Of Parkinsons Disease

Symptoms of Parkinsons disease and the rate of decline vary widely from person to person. The most common symptoms include:

Other symptoms include:

  • Speech/vocal changes: Speech may be quick, become slurred or be soft in tone. You may hesitate before speaking. The pitch of your voice may become unchanged .
  • Handwriting changes: You handwriting may become smaller and more difficult to read.
  • Depression and anxiety.
  • Sleeping disturbances including disrupted sleep, acting out your dreams, and restless leg syndrome.
  • Pain, lack of interest , fatigue, change in weight, vision changes.
  • Low blood pressure.

Deep Brain Stimulation And Parkinsons Disease

Are there any interactions with non-Parkinson’s disease medications?

Remember our recent article on electroceuticals zapping different parts of the body to treat things like headaches and backaches? Well, theres been some promising research on using small electrical pulses for easing Parkinsons symptoms, a technique known as deep brain stimulation .

A Swiss startup called Aleva Neurotherapeutics has raised $57 million in disclosed funding since it was founded in 2008. Its flagship product is directSTIM, a Directional DBS System for long-term therapy in Parkinsons disease. The device must be surgically implanted in order to deliver small electric pulses into the head, which helps reduce symptoms like tremors and stiffness. Unlike similar systems, directSTIM uses an array of directional microelectrodes to focus electrical stimulation, potentially decreasing the need for exact positioning, so you dont need a surgeon with a very steady hand.

New, unrelated research published just last month provided some insight into how DBS helps Parkinsons patients. Researchers believe the treatment boosts the number and strength of mitochondria, the power plant of the cell. More juice to power the brain cells may help reduce problems like tremors. Only about 300 patients per year receive DBS treatment, according to the study.

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Types Of Medications To Treat Parkinsons Disease

Medications in the research pipeline can be divided into two main categories: those that treat the symptoms of PD and those that are disease modifying . Of note, all medications currently available for PD are symptomatic treatments. There is no medication at this time that can affect the progression of the disease. Of course, the PD research community is extremely eager to find a medication that is disease modifying or neuroprotective . There have been many attempts over the past number of years to demonstrate through clinical trials that particular compounds have neuroprotective effects but, to date, these attempts have not been successful.

If you are interested in getting involved in a clinical trial, Clinicaltrials.gov is a database of all clinical trials for all diseases worldwide. When a clinical trial is registered with the site, it is assigned a unique number called the National Clinical Trial number or NCT number. Where available, I will provide the NCT number for each clinical trial that I reference in case you are interested in learning more.

Green Tea Polyphenols Or Gtps

GTPs have antioxidant properties along with free radical scavenging activities. There are current studies being conducted, which suggest that GTPs have a neuroprotective impact with the potential of treating Parkinson’s disease. Ongoing studies are being conducted by the Chinese Ministry of Health along with the Michael J. Fox Foundation whether GTPs can slow down the progression of Parkinson’s disease.

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Editorial Note On The Review Process

Traveling the Rocky Treatment Path with Parkinsons Disease

F1000 Faculty Reviews are commissioned from members of the prestigiousF1000 Faculty and are edited as a service to readers. In order to make these reviews as comprehensive and accessible as possible, the referees provide input before publication and only the final, revised version is published. The referees who approved the final version are listed with their names and affiliations but without their reports on earlier versions .

The referees who approved this article are:

  • Fredric P. Manfredsson, Parkinson’s Disease Research Unit, Department of Neurobiology, Barrow Neurological Institute, Phoenix, Arizona, USA

    No competing interests were disclosed.

  • Tipu Z. Aziz, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK

    No competing interests were disclosed.

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Treatment Of Neurobehavioral Features

Treatment of cognitive deficits associated with PD is as challenging as the treatment of Alzheimers disease and other dementias. While the general assumption has been that cognitive deficits are a feature of late-stage PD, clinically inapparent cognitive changes on neuropsychiatric testing may be found . With the introduction of cholinesterase inhibitors such as donepezil , rivastigmine , and galantamine and the NDMA antagonist memantine , it is possible that cognition, orientation and language function will improve, and that such improvement will lead to a meaningful improvement in function. Both donepezil and rivastigmine improve cognition to the same effect, but donepezil is better tolerated . The largest and best-designed study of rivastigmine in dementia associated with PD involved 541 patients enrolled in a 24-week randomized, multicenter, double-blind clinical trial . The patients had a relatively mild dementia , with onset of dementia about 2 years after onset of PD symptoms. The mean ADAS-cog score, the primary efficacy variable, improved by 2.1 points in the rivastigmine group, compared to 0.7 in the placebo group , and the MMSE improved by 0.8 in the rivastigmine group and worsened by 0.2 in the placebo group . At the end of the study, 55.5% were receiving 9 to 12 mg. The adverse effects that were significantly more frequent in the rivastigmine group were nausea, vomiting, dizziness, and tremor.

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